Impedance in the evaluation of the esophagus

The aim of this paper is to review esophageal electrical impedance technologies and to discuss the use of these technologies for physiological measurements, diagnostics, and therapy of esophageal disease. In order to develop a better understanding of the pathophysiology of and improve the diagnosis of esophageal disorders, such as gastroesophageal reflux disease (GERD) and achalasia, several new diagnostic tests, including intraluminal impedance, esophageal mucosal impedance, and the functional luminal imaging probe, have been developed. These technologies have proven valuable for assessment of the esophagus in recent years. They provide information on esophageal flow properties, mucosal integrity, lumen shape, and distensibility in esophageal disorders, in particular for GERD and achalasia. Despite their promise and novel clinical studies, the potential of these technologies has been far from realized. New multidisciplinary approaches will contribute to our understanding and interpretation of esophageal impedance data and disease mechanisms.

• Publication year

  2020

• Venue

  Annals of the New York Academy of Sciences

• Publication date

  2020-06-17

• Fields of study

  Medicine, Engineering

• Identifiers
  DOI 10.1111/nyas.14408PMID 32557676
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Efficacy and safety of pneumatic dilation in achalasia: A systematic review and meta‐analysis

  2019cited by this paper
• Safety of Proton Pump Inhibitors Based on a Large, Multi-year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin.

  2019cited by this paper
• Esophageal motility classification can be established at the time of endoscopy: a study evaluating real-time functional luminal imaging probe panometry.

  2019cited by this paper
• 1143 – Functional Lumen Imaging Probe Demonstrates Reduced Cricopharyngeal Distensibility and Myotomy-Induced Improvement in Zenker's Diverticulum Patients

  2019cited by this paper
• Normal Values of Esophageal Distensibility and Distension‐Induced Contractility Measured by Functional Luminal Imaging Probe Panometry

  2019cited by this paper
• Intraoperative assessment of esophageal motility using FLIP during myotomy for achalasia

  2019cited by this paper
• FUNCTIONAL LUMINAL IMAGING PROBE PANOMETRY IDENTIFIES ACHALASIA-TYPE ESOPHAGOGASTRIC JUNCTION OUTFLOW OBSTRUCTION.

  2019cited by this paper
• Esophagogastric Junction Distensibility on Functional Lumen Imaging Probe Topography Predicts Treatment Response in Achalasia-Anatomy Matters!

  2019cited by this paper
• Development and Validation of a Mucosal Impedance Contour Analysis System to Distinguish Esophageal Disorders.

  2019cited by this paper
• Discontinuing Long-Term PPI Therapy: Why, With Whom, and How?

  2018cited by this paper
• Inter‐rater agreement of novel high‐resolution impedance manometry metrics: Bolus flow time and esophageal impedance integral ratio

  2018cited by this paper
• Ambulatory pH-impedance-pressure monitoring as a diagnostic tool for the reflux-cough syndrome.

  2018cited by this paper
• A study of dysphagia symptoms and esophageal body function in children undergoing anti-reflux surgery

  2018cited by this paper
• Novel Intra-Procedural Distensibility Measurement Accurately Predicts Immediate Outcome of Pneumatic Dilatation for Idiopathic Achalasia

  2018cited by this paper
• Improved Assessment of Bolus Clearance in Patients With Achalasia Using High‐Resolution Impedance Manometry

  2018cited by this paper
• Modern diagnosis of GERD: the Lyon Consensus

  2018cited by this paper
• The role of esophageal pH-impedance testing in clinical practice

  2018cited by this paper
• Ambulatory reflux monitoring for diagnosis of gastro‐esophageal reflux disease: Update of the Porto consensus and recommendations from an international consensus group

  2017cited by this paper
• Esophagogastric junction distensibility identifies achalasia subgroup with manometrically normal esophagogastric junction relaxation

  2017cited by this paper
• Esophageal Mucosal Impedance Patterns Discriminate Patients With Eosinophilic Esophagitis From Patients With GERD

  2017cited by this paper
• Clinical utility of a functional lumen imaging probe in management of dysphagia following head and neck cancer therapies

  2017cited by this paper
• Utility of esophageal mucosal impedance as a diagnostic test for esophageal disease

  2017cited by this paper
• Clinical Mechanics in the Gut: An Introduction

  2017cited by this paper
• Assessing Old and New Diagnostic Tests for Gastroesophageal Reflux Disease.

  2017cited by this paper
• Esophagogastric junction in systemic sclerosis: A study with the functional lumen imaging probe

  2017cited by this paper
• Determinants of reflux-induced chronic cough

  2017cited by this paper
• Functional Lumen Imaging Probe for the Management of Esophageal Disorders: Expert Review From the Clinical Practice Updates Committee of the AGA Institute

  2017cited by this paper
• The Risks and Benefits of Long-term Use of Proton Pump Inhibitors: Expert Review and Best Practice Advice From the American Gastroenterological Association.

  2017cited by this paper
• The effect of incremental distal gastric myotomy lengths on EGJ distensibility during POEM for achalasia

  2016cited by this paper
• Lifestyle Intervention in Gastroesophageal Reflux Disease.

  2016cited by this paper
• Esophagogastric junction distensibility in hiatus hernia.

  2016cited by this paper
• Airway Hypersensitivity, Reflux, and Phonation Contribute to Chronic Cough.

  2016cited by this paper
• Evaluation of Esophageal Motility Utilizing the Functional Lumen Imaging Probe

  2016cited by this paper
• Intraoperative measurement of esophagogastric junction cross-sectional area by impedance planimetry correlates with clinical outcomes of peroral endoscopic myotomy for achalasia: a multicenter study

  2016cited by this paper
• The Esophagiome: concept, status, and future perspectives

  2016cited by this paper
• Severity of endoscopically identified esophageal rings correlates with reduced esophageal distensibility in eosinophilic esophagitis

  2016cited by this paper
• The virtual esophagus: investigating esophageal functions in silico

  2016cited by this paper
• Measurement of peak esophageal luminal cross‐sectional area utilizing nadir intraluminal impedance

  2015cited by this paper
• Functional lumen imaging of the gastrointestinal tract

  2015cited by this paper
• Utilizing functional lumen imaging probe topography to evaluate esophageal contractility during volumetric distention: a pilot study

  2015cited by this paper
• The Functional Lumen Imaging Probe Detects Esophageal Contractility Not Observed With Manometry in Patients With Achalasia.

  2015cited by this paper
• Hydraulic dilation with a shape-measuring balloon in idiopathic achalasia: a feasibility study

  2015cited by this paper
• The Chicago Classification of esophageal motility disorders, v3.0

  2015cited by this paper
• Long-term Outcomes of Patients With Normal or Minor Motor Function Abnormalities Detected by High-resolution Esophageal Manometry.

  2015cited by this paper
• Mucosal impedance discriminates GERD from non-GERD conditions.

  2015cited by this paper
• Assessment of bolus transit with intraluminal impedance measurement in patients with esophageal motility disorders

  2015cited by this paper
• Esophageal intraluminal baseline impedance differentiates gastroesophageal reflux disease from functional heartburn.

  2015cited by this paper
• Esophagogastric junction distensibility in the management of achalasia patients: relation to treatment outcome

  2015cited by this paper
• Esophagogastric junction distensibility measurements during Heller myotomy and POEM for achalasia predict postoperative symptomatic outcomes

  2014cited by this paper
• Inter‐ and intra‐rater reproducibility of automated and integrated pressure‐flow analysis of esophageal pressure‐impedance recordings

  2014cited by this paper
• Esophageal baseline impedance levels in patients with pathophysiological characteristics of functional heartburn

  2014cited by this paper
• Acid-Based Parameters on pH-Impedance Testing Predict Symptom Improvement With Medical Management Better Than Impedance Parameters

  2014cited by this paper
• Parameters for quantifying bolus retention with high‐resolution impedance manometry

  2014cited by this paper
• Impedance as an adjunct to manometric testing to investigate symptoms of dysphagia: What it has failed to do and what it may tell us in the future

  2014cited by this paper
• Objective Manometric Criteria for the Rumination Syndrome

  2014cited by this paper
• The four phases of esophageal bolus transit defined by high-resolution impedance manometry and fluoroscopy.

  2014cited by this paper
• Comparison of esophagogastric junction distensibility changes during POEM and Heller myotomy using intraoperative FLIP

  2013cited by this paper
• Functional luminal imaging probe topography: an improved method for characterizing esophageal distensibility in eosinophilic esophagitis

  2013cited by this paper
• Measurement of esophago‐gastric junction cross‐sectional area and distensibility by an endolumenal functional lumen imaging probe for the diagnosis of gastro‐esophageal reflux disease

  2013cited by this paper
• What's Hot in the Red Journal This Month

  2013cited by this paper
• Distensibility of the esophagogastric junction assessed with the functional lumen imaging probe (FLIP™) in achalasia patients

  2013cited by this paper
• Oesophageal baseline impedance values are decreased in patients with eosinophilic oesophagitis

  2013cited by this paper
• Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review

  2013cited by this paper
• Automated impedance‐manometry analysis detects esophageal motor dysfunction in patients who have non‐obstructive dysphagia with normal manometry

  2013cited by this paper
• Esophageal distensibility as a measure of disease severity in patients with eosinophilic esophagitis.

  2013cited by this paper
• Rumination variations: aetiology and classification of abnormal behavioural responses to digestive symptoms based on high‐resolution manometry studies

  2013cited by this paper
• Reflux disease and achalasia: Failure of the gatekeeper

  2013cited by this paper
• ACG Clinical Guideline: Diagnosis and Management of Achalasia

  2013cited by this paper
• Intraoperative assessment of esophagogastric junction distensibility during per oral endoscopic myotomy (POEM) for esophageal motility disorders

  2013cited by this paper
• Effect of peroral endoscopic myotomy on esophagogastric junction physiology in patients with achalasia.

  2013cited by this paper
• Esophageal chemical clearance is impaired in gastro‐esophageal reflux disease – a 24‐h impedance‐pH monitoring assessment

  2013cited by this paper
• Esophageal intraluminal baseline impedance is associated with severity of acid reflux and epithelial structural abnormalities in patients with gastroesophageal reflux disease

  2012cited by this paper
• Susceptibility to dysphagia after fundoplication revealed by novel automated impedance manometry analysis

  2012cited by this paper
• Esophageal distension parameters as potential biomarkers of impaired gastrointestinal function in diabetes patients

  2012cited by this paper
• Characterization of Patients With Low Baseline Impedance on Multichannel Intraluminal Impedance-pH Reflux Testing

  2012cited by this paper
• Use of direct, endoscopic-guided measurements of mucosal impedance in diagnosis of gastroesophageal reflux disease.

  2012cited by this paper
• The prevalence and diagnostic utility of endoscopic features of eosinophilic esophagitis: a meta-analysis.

  2012cited by this paper
• In vivo evaluation of acid-induced changes in oesophageal mucosa integrity and sensitivity in non-erosive reflux disease

  2012cited by this paper
• Traditional reflux parameters and not impedance monitoring predict outcome after fundoplication in extraesophageal reflux

  2011cited by this paper
• The added value of impedance-pH monitoring to Rome III criteria in distinguishing functional heartburn from non-erosive reflux disease.

  2011cited by this paper
• Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique

  2011cited by this paper
• Mechanical properties of the esophagus in eosinophilic esophagitis.

  2011cited by this paper
• Computer analysis of 24-h esophageal impedance signals

  2011cited by this paper
• Model for Electrical Field Distribution in the Human Esophagus during Stimulation with Patch and Ring Electrodes

  2011cited by this paper
• Esophagogastric Junction Distensibility After Fundoplication Assessed with a Novel Functional Luminal Imaging Probe

  2010cited by this paper
• Reflux Events Detected by pH-MII Do Not Determine Fundoplication Outcome

  2010cited by this paper
• Rumination or belching–regurgitation? Differential diagnosis using oesophageal impedance–manometry

  2010cited by this paper
• Inter-observer agreement for multichannel intraluminal impedance-pH testing.

  2010cited by this paper
• Stepwise radiofrequency ablation of Barrett’s esophagus preserves esophageal inner diameter, compliance, and motility

  2009cited by this paper
• Esophageal Motility Disorders in Terms of Pressure Topography: The Chicago Classification

  2008cited by this paper
• Deterioration of Muscle Function in the Human Esophagus with Age

  2008cited by this paper
• Impedance‐pH monitoring: new standard for measuring gastro‐oesophageal reflux

  2008cited by this paper
• The Role of Nonacid Reflux in NERD: Lessons Learned From Impedance-pH Monitoring in 150 Patients off Therapy

  2008cited by this paper
• Computation of flow through the oesophagogastric junction.

  2007cited by this paper
• Esophageal pH-Impedance Monitoring and Symptom Analysis in GERD: A Study in Patients off and on Therapy

  2006cited by this paper
• The Montreal Definition and Classification of Gastroesophageal Reflux Disease: A Global Evidence-Based Consensus

  2006cited by this paper
• Ambulatory 24‐h oesophageal impedance–pH recordings: reliability of automatic analysis for gastro‐oesophageal reflux assessment

  2006cited by this paper
• Combined multichannel intraluminal impedance–pH monitoring to select patients with persistent gastro‐oesophageal reflux for laparoscopic Nissen fundoplication

  2006cited by this paper
• Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive therapy: a multicentre study using combined ambulatory impedance-pH monitoring

  2006cited by this paper
• Impedance measuring system for quantification of cross-sectional area in the gastrointestinal tract

  2006cited by this paper

• Disentangling the hydrological implications of the climate 80s effect and water transfers in a large Mediterranean river

  2026cites this paper
• Development of a flexible balloon sensor for biomechanical-electrical coupling detection in the esophagus

  2025cites this paper
• Endoscopic luminal impedance planimetry of the lower oesophageal sphincter and pylorus in experimental pigs: a pilot study.

  2024cites this paper
• Characterizing Biomarkers of Continuous Peristalsis and Bolus Transit during Oral Feeding in Infants at pH-Impedance Evaluation: Clinical and Research Implications.

  2024cites this paper
• Reconstruction of the human lower esophageal sphincter based on ultra-mill imaging for biomechanical analysis

  2023cites this paper
• Endoluminal Procedures and Devices for Esophageal Tract Investigation: A Critical Review

  2023cites this paper
• Novel gel bolus to improve impedance‐based measurements of esophageal cross‐sectional area during primary peristalsis

  2020cites this paper