In vivo evaluation of acid-induced changes in oesophageal mucosa integrity and sensitivity in non-erosive reflux disease

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Gut

• Publication date

  2012-06-21

• Fields of study

  Medicine

• Identifiers
  DOI 10.1136/gutjnl-2012-302645PMID 22722617
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Refractory Heartburn: Comparison of Intercellular Space Diameter in Documented GERD vs. Functional Heartburn

  2011cited by this paper
• Assessment of functional oesophageal mucosal integrity in biopsies of patients with refractory gord

  2011cited by this paper
• Evaluation of oesophageal mucosa integrity by the intraluminal impedance technique

  2011cited by this paper
• Esophageal Acid Exposure Decreases Intraluminal Baseline Impedance Levels

  2011cited by this paper
• Assessment of Functional Esophageal Mucosal Integrity in Biopsies of Patients With Refractory NERD

  2011cited by this paper
• Role of E-cadherin in the Pathogenesis of Gastroesophageal Reflux Disease

  2011cited by this paper
• Dissociation and dispersion of claudin-3 from the tight junction could be one of the most sensitive indicators of reflux esophagitis in a rat model of the disease

  2011cited by this paper
• Proteinase-Activated Receptor-2 in the Pathogenesis of Gastroesophageal Reflux Disease

  2010cited by this paper
• Functional heartburn has more in common with functional dyspepsia than with non-erosive reflux disease

  2009cited by this paper
• HCl-activated neural and epithelial vanilloid receptors (TRPV1) in cat esophageal mucosa.

  2009cited by this paper
• Acid and weakly acidic solutions impair mucosal integrity of distal exposed and proximal non-exposed human oesophagus

  2009cited by this paper
• Epidemiology of Non-Erosive Reflux Disease

  2008cited by this paper
• Short exposure of oesophageal mucosa to bile acids, both in acidic and weakly acidic conditions, can impair mucosal integrity and provoke dilated intercellular spaces

  2008cited by this paper
• Determinants of gastro-oesophageal reflux perception in patients with persistent symptoms despite proton pump inhibitors

  2007cited by this paper
• The Montreal Definition and Classification of Gastroesophageal Reflux Disease: A Global Evidence-Based Consensus

  2006cited by this paper
• Altered localization and expression of tight-junction proteins in a rat model with chronic acid reflux esophagitis

  2005cited by this paper
• The pathogenesis of heartburn in nonerosive reflux disease: a unifying hypothesis.

  2005cited by this paper
• Acid Perfusion Test: A Useful Test for Evaluating Esophageal Acid Sensitivity

  2005cited by this paper
• Determinants of perception of heartburn and regurgitation

  2005cited by this paper
• Esophageal Visceral Sensitivity to Bile Salts in Patients with Functional Heartburn and in Healthy Control Subjects

  2005cited by this paper
• Twenty-Four Hour Ambulatory Simultaneous Impedance and pH Monitoring: A Multicenter Report of Normal Values From 60 Healthy Volunteers

  2004cited by this paper
• Dilated Intercellular Spaces and Shunt Permeability in Nonerosive Acid-Damaged Esophageal Epithelium

  2004cited by this paper
• Non‐erosive reflux disease (NERD) — acid reflux and symptom patterns

  2003cited by this paper
• Direct measurement of acid permeation into rat oesophagus

  2003cited by this paper
• Endoscopic assessment of oesophagitis: clinical and functional correlates and further validation of the Los Angeles classification

  1999cited by this paper
• Dilated intercellular spaces: a morphological feature of acid reflux--damaged human esophageal epithelium.

  1996cited by this paper
• The symptom-association probability: an improved method for symptom analysis of 24-hour esophageal pH data.

  1994cited by this paper
• Sensitivity of the esophageal mucosa to pH in gastroesophageal reflux disease.

  1989cited by this paper
• The symptom index: a clinically important parameter of ambulatory 24-hour esophageal pH monitoring.

  1988cited by this paper
• The physiology of heartburn.

  1961cited by this paper

• Incidence, risk factors, recovery duration, and prognostic implications of gastroparesis following radical distal gastrectomy for gastric cancer: a large retrospective cohort study.

  2026cites this paper
• Pathophysiology of GERD.

  2025cites this paper
• Efficacy and safety of Jianpi Qinghua granules for non-erosive reflux disease with spleen deficiency and damp-heat syndrome: a multicenter, randomized, double-blind, placebo-controlled clinical trial

  2025cites this paper
• Mucosal integrity and acid sensitivity predict proton pump inhibitor response in patients with heartburn and normal acid exposure.

  2025cites this paper
• Baseline Impedance via Manometry Predicts Pathological Mean Nocturnal Baseline Impedance in Isolated Laryngopharyngeal Reflux Symptoms

  2025cites this paper
• Topical Protection of Esophageal Mucosa as a New Treatment of GERD

  2025cites this paper
• Impairment of Esophageal Barrier Integrity: New Insights into Esophageal Symptoms in Post-COVID-19

  2025cites this paper
• Mucosal neuroimmune mechanisms in gastro-oesophageal reflux disease (GORD) pathogenesis

  2024cites this paper
• Oesophageal pH testing: everything you wanted to know but were too afraid to ask

  2024cites this paper
• Validation of the Japanese version of the Esophageal Hypervigilance and Anxiety Scale for esophageal symptoms

  2024cites this paper
• Esophageal Mucosal Impedance Assessment for the Diagnosis of Gastroesophageal Reflux Disease

  2024cites this paper
• Non-Acid GERC: Pathogenesis, Diagnosis and Management

  2024cites this paper
• Bidirectional correlation between gastroesophageal reflux disease and sleep problems: a systematic review and meta-analysis

  2024cites this paper
• Pathophysiology of gastro-oesophageal reflux disease: implications for diagnosis and management

  2024cites this paper
• Mean nocturnal baseline impedance: Influencing factors and diagnostic value in gastroesophageal reflux disease

  2023cites this paper
• Esophageal Reflux Hypersensitivity: A Comprehensive Review

  2023cites this paper
• Esophageal secondary peristalsis following acid infusion and chemical clearance correlate with mucosal integrity and acid sensitivity in GERD patients

  2023cites this paper
• Lemborexant Attenuates Regurgitation without Worsening Objective Parameters on Reflux Monitoring in Patients with Gastroesophageal Reflux Disease and Insomnia: A Single-Arm Proof-of-Concept Study

  2023cites this paper
• The Protease Inhibitor Amprenavir Protects against Pepsin-Induced Esophageal Epithelial Barrier Disruption and Cancer-Associated Changes

  2023cites this paper
• Distal Mean Nocturnal Baseline Impedance Predicts Pathological Reflux of Isolated Laryngopharyngeal Reflux Symptoms

  2023cites this paper
• Sensory Phenotype of the Oesophageal Mucosa in Gastro-Oesophageal Reflux Disease

  2023cites this paper
• Actualización en la fisiopatología de la enfermedad por reflujo gastroesofágico

  2022cites this paper
• The Role of Mean Nocturnal Baseline Impedance and Post-Reflux Swallow-Induced Peristaltic Wave Index in the Diagnosis and Treatment of Gastroesophageal Reflux Disease

  2022cites this paper
• Mean nocturnal baseline impedance and endoscopic mucosal impedance measurements in patients with eosinophilic esophagitis: a new tool for follow up and management?

  2022cites this paper
• Clinical use of mean nocturnal baseline impedance and post-reflux swallow-induced peristaltic wave index for the diagnosis of gastro-esophageal reflux disease

  2022cites this paper
• Network pharmacology-based prediction and verification of the active ingredients and potential targets of Huagan Decoction for reflux esophagitis.

  2022cites this paper
• Current advances in the diagnosis and management of gastroesophageal reflux disease

  2022cites this paper
• Alginates for Protection Against Pepsin‐Acid Induced Aerodigestive Epithelial Barrier Disruption

  2022cites this paper
• Measurement of low-grade inflammation of the esophageal mucosa with electrical conductivity shows promise in assessing PPI responsiveness in patients with GERD.

  2021cites this paper
• Response of eosinophilic oesophagitis to proton pump inhibitors is associated with impedance‐pH parameters implying anti‐reflux mechanism of action

  2021cites this paper
• Gastro-oesophageal reflux disease

  2021cites this paper
• Heartburn Sensation in Non-Erosive Reflux Disease: Pattern of Superficial Sensory Nerves Expressing TRPV1 and Epithelial Cells Expressing ASIC3 Receptors.

  2021cites this paper
• Identification of Unique Transcriptomic Signatures and Hub Genes Through RNA Sequencing and Integrated WGCNA and PPI Network Analysis in Nonerosive Reflux Disease

  2021cites this paper
• Esophageal Nocturnal Baseline Impedance and Post-reflux Swallow-induced Peristaltic Wave Index in Identifying Proton Pump Inhibitor-refractory Non-erosive Reflux Disease

  2021cites this paper
• Pathophysiology of Pediatric Gastroesophageal Reflux Disease: Similarities and Differences With Adults.

  2021cites this paper
• The Value of Reflux Monitoring: The Old and the New for the Diagnosis and Assessment of GERD

  2021cites this paper
• Advances in the diagnosis of GERD

  2020cites this paper
• Enfermedad por reflujo gastroesofágico

  2020cites this paper
• Impedance in the evaluation of the esophagus

  2020cites this paper
• A Role for Pre-Polymerized Sucralfate in the Management of Erosive and Non-Erosive Gastroesophageal Reflux Disease

  2020cites this paper
• Tojapride Reverses Esophageal Epithelial Inflammatory Responses on Reflux Esophagitis Model Rats

  2020cites this paper
• Untangling Non-erosive Reflux Disease From Functional Heartburn.

  2020cites this paper
• Measurement of Esophageal Nocturnal Baseline Impedance: A Simplified Method

  2020cites this paper
• The esophageal mucosal barrier in health and disease: mucosal pathophysiology and protective mechanisms

  2020cites this paper
• Mucosal pathogenesis in gastro‐esophageal reflux disease

  2020cites this paper
• 28 Day Randomized Double-Blind Placebo Controlled Trial using Pre-Polymerized Cross-Linked Sucralfate Barrier (Esolgafate) for Erosive GERD

  2020cites this paper
• The Role for Pre-Polymerized Sucralfate in Management of Erosive and Non-Erosive Gastroesophageal Reflux Disease – High Potency Sucralfate-Mucin Barrier for Enteric Cytoprotection

  2020cites this paper
• Efficacy and Safety of Esolgafate, A Pre-Polymerized Cross-Linked Sucralfate Medical Device for NERD. A Randomized Double-Blind Placebo-Controlled Trial

  2020cites this paper
• Normal values and regional differences in oesophageal impedance-pH metrics: a consensus analysis of impedance-pH studies from around the world

  2020cites this paper
• Новые параметры рН-импедансометрии в постановке диагноза гастроэзофагеальной рефлюксной болезни и прогнозе тяжести течения заболевания

  2019cites this paper
• Evaluation of Baseline Impedance During Water-perfused High Resolution Impedance Manometry in Patients With Symptomatic GERD

  2019cites this paper
• Advances in the Diagnosis and Treatment of GERD: New Tricks for an Old Disease

  2019cites this paper
• Development and Validation of a Mucosal Impedance Contour Analysis System to Distinguish Esophageal Disorders.

  2019cites this paper
• [Gastroesophageal Reflux Disease].

  2019cites this paper
• More than a common acid buffering in the treatment of Non-Erosive GERD-like Clinical Spectrum: A Chios Masthia-based Formulation with (Cyto) Protecting Effect

  2019cites this paper
• Validation in China of a non‐invasive salivary pepsin biomarker containing two unique human pepsin monoclonal antibodies to diagnose gastroesophageal reflux disease

  2019cites this paper
• Esophageal mucosal innervation in functional heartburn: Closer to healthy asymptomatic subjects than to non‐erosive reflux disease patients

  2019cites this paper
• The effect of Heweijiangni-decoction on esophageal morphology in a rat model of OVA-induced visceral hypersensitivity followed by acid exposure.

  2019cites this paper
• Esophageal acid sensitivity in patients with gastroesophageal reflux disease: Does esophageal hypomotility matter?

  2019cites this paper
• Patients with dyspepsia have impaired mucosal integrity both in the duodenum and jejunum: in vivo assessment of small bowel mucosal integrity using baseline impedance

  2019cites this paper
• 24‐hour multi‐pH recording of the postprandial acid pocket and the nocturnal acid distribution at the esophagogastric junction in healthy volunteers

  2019cites this paper
• Rumination Syndrome in Children Presenting with Refractory Gastro-Esophageal Reflux Symptoms.

  2019cites this paper
• A Review of Making the Modern Diagnosis of Gastrointestinal Reflux Disease: the Lyon Consensus

  2019cites this paper
• New Parameters for Impedance–pH Monitoring in Diagnosing Gastroesophageal Reflux Disease and Predicting its Severity

  2019cites this paper
• The role of esophageal pH-impedance testing in clinical practice

  2018cites this paper
• Modern diagnosis of GERD: the Lyon Consensus

  2018cites this paper
• Esophageal baseline impedance levels allow the identification of esophageal involvement in patients with systemic sclerosis.

  2018cites this paper
• Evaluation of Esophageal Mucosal Integrity in Patients with Gastroesophageal Reflux Disease

  2018cites this paper
• Role of TRPV1 receptor in inflammation and impairment of esophageal mucosal integrity in a murine model of nonerosive reflux disease

  2018cites this paper
• Esophageal sensitivity to acid in patients with Barrett's esophagus is not related to preserved esophageal mucosal integrity

  2017cites this paper
• Ambulatory reflux monitoring for diagnosis of gastro‐esophageal reflux disease: Update of the Porto consensus and recommendations from an international consensus group

  2017cites this paper
• Patients with Barrett's esophagus are hypersensitive to acid but hyposensitive to other stimuli compared with healthy controls

  2017cites this paper
• Baseline impedance measured during high‐resolution esophageal impedance manometry reliably discriminates GERD patients

  2017cites this paper
• Assessing Old and New Diagnostic Tests for Gastroesophageal Reflux Disease.

  2017cites this paper
• Endoscopic-Guided Measurement of Mucosal Admittance can Discriminate Gastroesophageal Reflux Disease from Functional Heartburn

  2017cites this paper
• Reflux episodes and esophageal impedance levels in patients with typical and atypical symptoms of gastroesophageal reflux disease

  2017cites this paper
• Impairment of chemical clearance and mucosal integrity distinguishes hypersensitive esophagus from functional heartburn

  2017cites this paper
• ASAP3 regulates microvilli structure in parietal cells and presents intervention target for gastric acidity

  2017cites this paper
• The Diagnostic Yield of Novel Parameters in Reflux Monitoring

  2017cites this paper
• The Role of Esophageal Hypersensitivity in Functional Heartburn

  2017cites this paper
• Esophageal chemical clearance and baseline impedance values in patients with chronic autoimmune atrophic gastritis and gastro-esophageal reflux disease.

  2017cites this paper
• Postreflux swallow‐induced peristaltic wave index and nocturnal baseline impedance can link PPI‐responsive heartburn to reflux better than acid exposure time

  2017cites this paper
• Exploration of the Esophageal Mucosal Barrier in Non-Erosive Reflux Disease

  2017cites this paper
• Update on Functional Heartburn.

  2017cites this paper
• High-definition endoscopy with iScan and Lugol's solution for the detection of inflammation in patients with nonerosive reflux disease: histologic evaluation in comparison with a control group.

  2016cites this paper
• Controlled bile acid exposure to oesophageal mucosa causes up-regulation of nuclear γ-H2AX possibly via iNOS induction

  2016cites this paper
• High-definition endoscopy with iScan and Lugol's solution for the detection of inflammation in patients with nonerosive reflux disease: histologic evaluation in comparison with a control group.

  2016cites this paper
• Established and Emerging Treatment Options for Functional Heartburn and Chest Pain

  2016cites this paper
• Between GERD and NERD: the relevance of weakly acidic reflux

  2016cites this paper
• Respiratory disease and the oesophagus: reflux, reflexes and microaspiration

  2016cites this paper
• Esophageal Acid Clearance During Random Swallowing Is Faster in Patients with Barrett’s Esophagus Than in Healthy Controls

  2016cites this paper
• Esophageal Submucosal Injection of Capsaicin but Not Acid Induces Symptoms in Normal Subjects

  2016cites this paper
• Role of altered esophageal intraluminal baseline impedance levels in patients with gatroesophageal reflux disease refractory to proton pump inhibitors

  2016cites this paper
• Adult and paediatric GERD: diagnosis, phenotypes and avoidance of excess treatments

  2016cites this paper
• Morphological and Functional Assessment of Oesophageal Mucosa Integrity in Children With Cystic Fibrosis

  2016cites this paper
• Esophageal mucosal integrity improves after laparoscopic antireflux surgery in children with gastroesophageal reflux disease

  2016cites this paper
• Esophageal acid sensitivity and mucosal integrity in patients with functional heartburn

  2016cites this paper
• Reflux perception and the esophageal mucosal barrier in gastroesophageal reflux disease

  2016cites this paper
• Correlation between hypersensitivity induced by esophageal acid infusion and the baseline impedance level in patients with suspected gastroesophageal reflux

  2015cites this paper
• Distinct afferent innervation patterns within the human proximal and distal esophageal mucosa

  2015cites this paper