Interleukin-7 restores immunity in athymic T-cell-depleted hosts.

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Blood

• Publication date

  2001-03-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1182/BLOOD.V97.6.1525PMID 11238086
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation.

  2001cited by this paper
• Variable course of patients with plaque psoriasis: lack of transformation into tumorous mycosis fungoides

  2000cited by this paper
• Immune reconstitution in the first year of potent antiretroviral therapy and its relationship to virologic response.

  2000cited by this paper
• Prolonged suppression of human immunodeficiency virus type 1 (HIV-1) viremia in persons with advanced disease results in enhancement of CD4 T cell reactivity to microbial antigens but not to HIV-1 antigens.

  1999cited by this paper
• Immune reconstitution after bone marrow transplantation for combined immunodeficiencies: down-modulation of Bcl-2 and high expression of CD95/Fas account for increased susceptibility to spontaneous and activation-induced lymphocyte cell death

  1999cited by this paper
• Functional T cell reconstitution and human immunodeficiency virus-1-specific cell-mediated immunity during highly active antiretroviral therapy.

  1999cited by this paper
• Mature T lymphocyte apoptosis--immune regulation in a dynamic and unpredictable antigenic environment.

  1999cited by this paper
• Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count

  1999cited by this paper
• IL‐7 promotes the survival and maturation but not differentiation of human post‐thymic CD4+ T cells

  1998cited by this paper
• Functional roles of Fas and Bcl-2-regulated apoptosis of T lymphocytes.

  1998cited by this paper
• Kinetics of CD4+ T cell repopulation of lymphoid tissues after treatment of HIV-1 infection.

  1998cited by this paper
• Cytokine-induced survival of activated T cells in vitro and in vivo.

  1998cited by this paper
• Peripheral expansion of pre-existing mature T cells is an important means of CD4+ T-cell regeneration HIV-infected adults

  1998cited by this paper
• Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir: results of AIDS Clinical Trials Group Protocol 315.

  1998cited by this paper
• Progression of human immunodeficiency virus disease is associated with increasing disruptions within the CD4+ T cell receptor repertoire.

  1998cited by this paper
• IL-7-dependent extrathymic expansion of CD45RA+ T cells enables preservation of a naive repertoire.

  1998cited by this paper
• Constraints on CD4 recovery postchemotherapy in adults: thymic insufficiency and apoptotic decline of expanded peripheral CD4 cells.

  1997cited by this paper
• Restoration of T-cell homeostasis after T-cell depletion.

  1997cited by this paper
• Bcl-x(L) can inhibit apoptosis in cells that have undergone Fas-induced protease activation.

  1997cited by this paper
• Interleukin-7-enhanced cytotoxic T lymphocyte activity after viral infection in marrow transplanted mice

  1997cited by this paper
• T-cell regeneration: all repertoires are not created equal.

  1997cited by this paper
• Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4

  1997cited by this paper
• Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice.

  1997cited by this paper
• Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice.

  1997cited by this paper
• HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies

  1997cited by this paper
• Stimulation of immune reconstitution by interleukin-7 after syngeneic bone marrow transplantation in mice.

  1996cited by this paper
• Thymic-independent T cell regeneration occurs via antigen-driven expansion of peripheral T cells resulting in a repertoire that is limited in diversity and prone to skewing.

  1996cited by this paper
• Up-regulation of Bcl-xL expression protects CD40-activated human B cells from Fas-mediated apoptosis.

  1996cited by this paper
• Antigen‐stimulated apoptotic T‐cell death in HIV infection is selective for CD4+T cells, modulated by cytokines and effected by lymphotoxin

  1996cited by this paper
• Analysis of T-cell repopulation after allogeneic bone marrow transplantation: significant differences between recipients of T-cell depleted and unmanipulated grafts.

  1996cited by this paper
• Hierarchical Control of Lymphocyte Survival

  1996cited by this paper
• Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7.

  1996cited by this paper
• Programmed cell death in peripheral lymphocytes from HIV-infected persons: increased susceptibility to apoptosis of CD4 and CD8 T cells correlates with lymphocyte activation and with disease progression.

  1996cited by this paper
• Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

  1995cited by this paper
• Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine

  1995cited by this paper
• Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy.

  1995cited by this paper
• Interleukin-7 rescues human activated T lymphocytes from apoptosis induced by glucocorticoesteroids and regulates bcl-2 and CD25 expression.

  1995cited by this paper
• Bcl‐2 and Fas/APO‐1 regulate distinct pathways to lymphocyte apoptosis.

  1995cited by this paper
• Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division.

  1995cited by this paper
• T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life.

  1995cited by this paper
• Recombinant human IL‐7 administration in mice affects colony‐forming units‐spleen and lymphoid precursor cell localization and accelerates engraftment of bone marrow transplants

  1995cited by this paper
• The effect of thymic function on immunocompetence following bone marrow transplantation.

  1995cited by this paper
• Emergence of oligoclonal T cell populations following therapeutic T cell depletion in rheumatoid arthritis.

  1995cited by this paper
• Differential protective action of cytokines on radiation-induced apoptosis of peripheral lymphocyte subpopulations.

  1995cited by this paper
• Diverse immunological and hematological effects of interleukin 7: implications for clinical application

  1995cited by this paper
• Analysis of apoptosis in lymph nodes of HIV-infected persons. Intensity of apoptosis correlates with the general state of activation of the lymphoid tissue and not with stage of disease or viral burden.

  1995cited by this paper
• Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

  1994cited by this paper
• Circulating T cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping. Correlation with immune status.

  1994cited by this paper
• Inhibition of activation-induced programmed cell death and restoration of defective immune responses of HIV+ donors by cysteine protease inhibitors.

  1994cited by this paper
• T-cell regeneration after bone marrow transplantation: differential CD45 isoform expression on thymic-derived versus thymic-independent progeny.

  1993cited by this paper
• Programmed death of T cells in HIV-1 infection.

  1992cited by this paper
• Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals

  1992cited by this paper
• bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes.

  1991cited by this paper
• Peripheral selection of the T cell repertoire.

  1991cited by this paper
• bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship.

  1991cited by this paper
• Administration of IL-7 to mice with cyclophosphamide-induced lymphopenia accelerates lymphocyte repopulation.

  1991cited by this paper
• Abnormalities of the immune system induced by dysregulated bcl-2 expression in transgenic mice.

  1990cited by this paper
• The distinct leukocyte integrins of mouse spleen dendritic cells as identified with new hamster monoclonal antibodies

  1990cited by this paper
• Reconstitution of T-cell function after CD6-depleted allogeneic bone marrow transplantation.

  1990cited by this paper
• The origin of T cells in permanently reconstituted old athymic nude rats. Analysis using chromosome or allotype markers.

  1989cited by this paper
• Peripheral T lymphocytes: expansion potential and homeostatic regulation of pool sizes and CD4/CD8 ratios in vivo

  1989cited by this paper
• The stable and permanent expansion of functional T lymphocytes in athymic nude rats after a single injection of mature T cells.

  1987cited by this paper
• Recovery of T cell subsets after autologous bone marrow transplantation is mainly due to proliferation of mature T cells in the graft.

  1985cited by this paper
• T cell repopulation from functionally restricted splenic progenitors: 10,000-fold expansion documented by using limiting dilution analyses.

  1984cited by this paper
• Idiotypic Networks and Other Preconceived Ideas

  1984cited by this paper
• The Technique of Free Skin Grafting in Mammals

  1951cited by this paper

• From lymphopenia to restoration: IL-7 immunotherapy for lymphocyte recovery in glioblastoma.

  2024cites this paper
• Cytokines and their role as immunotherapeutics and vaccine Adjuvants: The emerging concepts.

  2023cites this paper
• Whole blood transcriptome profiles of trypanotolerant and trypanosusceptible cattle highlight a differential modulation of metabolism and immune response during infection by Trypanosoma congolense

  2023cites this paper
• Immune Reconstitution After Allogeneic Haematopoietic Cell Transplantation: From Observational Studies to Targeted Interventions

  2022cites this paper
• A Proposed Link Between Acute Thymic Involution and Late Adverse Effects of Chemotherapy

  2022cites this paper
• Lymphopenia and Mechanisms of T-Cell Regeneration

  2022cites this paper
• IL-7/αIL-7 mAb M25 immunocomplexes expand CD8+ T cells but paradoxically abrogate the antitumor activity of CTLA-4 and PD-1 blockage.

  2020cites this paper
• Mouse Models and Genetics of Immunosenescence

  2019cites this paper
• Strategies to Improve Posttransplant Immunity

  2019cites this paper
• Concise Review: Boosting T‐Cell Reconstitution Following Allogeneic Transplantation—Current Concepts and Future Perspectives

  2019cites this paper
• Identification of the peripheral niche controlling CD4 homeostatic proliferation

  2018cites this paper
• IL-15 in Pancreatic Cancer

  2018cites this paper
• Immune Reconstitution After Cord Blood Transplantation

  2017cites this paper
• Microvesicles released by apoptotic human neutrophils suppress proliferation and IL‐2/IL‐2 receptor expression of resting T helper cells

  2017cites this paper
• Imatinib mesylate inhibits STAT5 phosphorylation in response to IL-7 and promotes T cell lymphopenia in chronic myelogenous leukemia patients

  2017cites this paper
• Cord Blood Transplantations

  2017cites this paper
• Imatinib mesylate inhibits STAT5 phosphorylation in response to IL-7 and promotes T cell lymphopenia in chronic myelogenous leukemia patients

  2017cites this paper
• Administration of interleukin-7 increases CD4 T cells in idiopathic CD4 lymphocytopenia.

  2016cites this paper
• Effect of IL-7 Therapy on Naive and Memory T Cell Homeostasis in Aged Rhesus Macaques

  2015cites this paper
• IL-7 and SCF Levels Inversely Correlate with T Cell Reconstitution and Clinical Outcomes after Cord Blood Transplantation in Adults

  2015cites this paper
• Treatment with Interleukin-7 Restores Host Defense against Pneumocystis in CD4+ T-Lymphocyte-Depleted Mice

  2015cites this paper
• Modulation of peripheral T-cell function by interleukin-7 in rheumatoid arthritis

  2014cites this paper
• This Provisional PDF corresponds to the article as it appeared upon acceptance. Fully formatted PDF and full text (HTML) versions will be made available soon.

  2014cites this paper
• Quantifying and Predicting the Effect of Exogenous Interleukin-7 on CD4+T Cells in HIV-1 Infection

  2014cites this paper
• EXPRESSION OF APOPTOSIS AND SURVIVAL GENES IN HUMAN MEMORY T CELL POPULATIONS

  2014cites this paper
• Deregulation of T cell response in sepsis.

  2014cites this paper
• Strategies to improve post-transplant immunity

  2013cites this paper
• expansion after BMT immunity from T-cell populations undergoing homeostatic peripheral oligodeoxynucleotides and IL-2 generate antigen-specific antitumor Vaccination regimens incorporating CpG-containing

  2013cites this paper
• Immune Reconstitution Flt 3 Ligand Enhances Thymic-Dependent and Thymic-Independent

  2013cites this paper
• Interleukin 7 and Patient Selection in Immunotherapy for Prostate Cancer

  2013cites this paper
• Increased Thymopoietic Ability An IL-7 Fusion Protein That Shows

  2013cites this paper
• naive and memory populations depleting therapy affecting - Defective T-helper cell function after T-cell

  2013cites this paper
• expansion of recent thymic emigrants bone marrow transplantation in T-cell-deficient mice by strong Interleukin-7 improves T-cell recovery after experimental T-cell-depleted

  2013cites this paper
• TCR triggering modulates the responsiveness and homeostatic proliferation of CD4+ thymic emigrants to IL-7 therapy.

  2013cites this paper
• Insights into thymic involution in tumor-bearing mice

  2013cites this paper
• Microparticle delivery of Interleukin‐7 to boost T‐cell proliferation and survival

  2012cites this paper
• of Fungal Sepsis

  2012cites this paper
• A study of regulatory T cells in allogeneic haematopoietic stem cell transplantation

  2012cites this paper
• In-vitro Generation of potent T-lymphoid Progenitors in a feeder-cell-free DL-4 system

  2012cites this paper
• Expression and function of interleukin-7 in secondary and tertiary lymphoid organs.

  2012cites this paper
• Interleukin-7 ameliorates immune dysfunction and improves survival in a 2-hit model of fungal sepsis.

  2012cites this paper
• Multiplex analysis of blood cytokines as a prognostic tool in HIV related non-Hodgkin lymphoma patients: a potential role of interleukin-7.

  2012cites this paper
• The influence of HIV on CD127 expression and its potential implications for IL-7 therapy.

  2012cites this paper
• Harnessing the biology of IL-7 for therapeutic application

  2011cites this paper
• Improvement of Thymopoiesis after Hematopoietic Stem Cell Transplantation by Cytokines: Translational studies in experimental animal models

  2011influential citation
• Extracorporeal photopheresis attenuates murine GVHD via bone marrow-derived IL-10 and preserves responses to dendritic cell vaccination

  2011cites this paper
• Lymphopeniafor T Cell Proliferation in Moderate Elevated IL-7 Availability Does Not Account

  2011cites this paper
• Extracorporeal photopheresis attenuates murine graft-versus-host disease via bone marrow-derived interleukin-10 and preserves responses to dendritic cell vaccination.

  2011cites this paper
• Elevated IL-7 Availability Does Not Account for T Cell Proliferation in Moderate Lymphopenia

  2011cites this paper
• IL-7 and lymphopenia.

  2011cites this paper
• Étude du mécanisme par lequel la thérapie à l'IL7 induit l'expansion homéostatique des lymphocytes T CD4+

  2011cites this paper
• Immune reconstitution: how it should work, what's broken, and why it matters.

  2010cites this paper
• Advances in adoptive immunotherapy to accelerate T-cellular immune reconstitution after HLA-incompatible hematopoietic stem cell transplantation.

  2010cites this paper
• IL-7 Promotes T Cell Viability, Trafficking, and Functionality and Improves Survival in Sepsis

  2010cites this paper
• Cytokine signaling control of naïve CD8⁺ T-cell homeostasis

  2010cites this paper
• Impact of γ‐chain cytokines on T cell homeostasis in HIV‐1 infection: therapeutic implications

  2010cites this paper
• A validated assay to measure soluble IL-7 receptor shows minimal impact of IL-7 treatment.

  2010cites this paper
• Sepsis and Functionality and Improves Survival in IL-7 Promotes T Cell Viability, Trafficking,

  2010cites this paper
• Interleukin -7 and Immunorejuvenation

  2009cites this paper
• Harnessing the physiology of lymphopenia to support adoptive immunotherapy in lymphoreplete hosts.

  2009cites this paper
• Bone marrow deficient in IFN-{gamma} signaling selectively reverses GVHD-associated immunosuppression and enhances a tumor-specific GVT effect.

  2009cites this paper
• Thymic involution and immune reconstitution.

  2009cites this paper
• Novel function for interleukin-7 in dendritic cell development.

  2009cites this paper
• Ex vivo expansion of memory CD8 T cells from lymph nodes or spleen through in vitro culture with interleukin-7.

  2009cites this paper
• Modulating T‐cell homeostasis with IL‐7: preclinical and clinical studies

  2009cites this paper
• The Lack of Epithelial Interleukin-7 and BAFF/BLyS Gene Expression in Prostate Cancer as a Possible Mechanism of Tumor Escape from Immunosurveillance

  2009cites this paper
• Bone marrow deficient in IFN- (cid:1) signaling selectively reverses GVHD-associated immunosuppression and enhances a tumor-specific GVT effect

  2009cites this paper
• Perspective on Potential Clinical Applications of Recombinant Human Interleukin‐7

  2009cites this paper
• Clinical implications of immune reconstitution following hematopoietic stem cell transplantation.

  2009cites this paper
• Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

  2009cites this paper
• Immune Reconstitution After Allogeneic Transplantation

  2008cites this paper
• Priming of T cells to Fas-mediated proliferative signals by interleukin-7.

  2008cites this paper
• Transplantation in remission improves the disease-free survival of patients with advanced myelodysplastic syndromes treated with myeloablative T cell-depleted stem cell transplants from HLA-identical siblings.

  2008cites this paper
• Interleukin-7 in rheumatoid arthritis.

  2008cites this paper
• Effects of IL-7 on memory CD8 T cell homeostasis are influenced by the timing of therapy in mice.

  2008cites this paper
• Interleukin-7 and hematopoietic stem cell transplantation: beyond the thymus

  2007cites this paper
• Infected Macaquesmac 251 Level in Simian Immunodeficiency Virus VirusAbrogates Vaccine-Induced Decrease in Interleukin-15 but Not Interleukin-7

  2007cites this paper
• T cell immune reconstitution following lymphodepletion.

  2007cites this paper
• Hematopoietic growth factors including keratinocyte growth factor in allogeneic and autologous stem cell transplantation.

  2007cites this paper
• Thymomegaly, Microsplenia, and Defective Homeostatic Proliferation of Peripheral Lymphocytes in p51-Ets1 Isoform-Specific Null Mice

  2007cites this paper
• Immune reconstitution prevents metastatic recurrence of murine osteosarcoma

  2007cites this paper
• Vaccination regimens incorporating CpG-containing oligodeoxynucleotides and IL-2 generate antigen-specific antitumor immunity from T-cell populations undergoing homeostatic peripheral expansion after BMT.

  2007cites this paper
• Short communication: Immune reconstitution after autologous peripheral blood stem cell transplantation in HIV-infected patients: might be better than expected?

  2007cites this paper
• Perspectives on interleukin-7 therapy in HIV infection

  2007cites this paper
• Cell Apoptosis During HIV Infection Potential Role for IL-7 in Fas-Mediated

  2007cites this paper
• Potential Role for IL-7 in Fas-Mediated T Cell Apoptosis During HIV Infection1

  2007cites this paper
• Low and Undetectable Breast Milk Interleukin-7 Concentrations Are Associated With Reduced Risk of Postnatal HIV Transmission

  2007cites this paper
• Interleukin-15 but Not Interleukin-7 Abrogates Vaccine-Induced Decrease in Virus Level in Simian Immunodeficiency Virusmac251-Infected Macaques1

  2007cites this paper
• Co-transplantation of bone marrow stromal cells transduced with IL-7 gene enhances immune reconstitution after allogeneic bone marrow transplantation in mice

  2006cites this paper
• Utilizing IL-12, IL-15 and IL-7 as Mucosal Vaccine Adjuvants.

  2006cites this paper
• The IL-7/IL-7 receptor axis: understanding its central role in T-cell homeostasis and the challenges facing its utilization as a novel therapy.

  2006cites this paper
• Increased plasma interleukin-7 level correlates with decreased CD127 and Increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection.

  2006cites this paper
• IL-7 in allogeneic transplant: Clinical promise and potential pitfalls

  2006cites this paper
• Immune Reconstitution in Pediatric Patients Following Hematopoietic Stem-Cell Transplantation

  2006cites this paper
• T-cell homeostasis alteration in HIV-1 infected subjects with low CD4 T-cell count despite undetectable virus load during HAART

  2006cites this paper
• Interleukin-7 is a survival factor for CD4+ CD25+ T-cells and is expressed by diabetes-suppressive dendritic cells.

  2006cites this paper
• Loss of IL-7Rα is associated with CD4 T-cell depletion, high interleukin-7 levels and CD28 down-regulation in HIV infected patients

  2005cites this paper
• The Many Faces of IL-7: From Lymphopoiesis to Peripheral T Cell Maintenance

  2005cites this paper
• T Cell Proliferation In Vivo Antigen-Induced for Homeostasis-Driven and E2F1 and E2F2 Are Differentially Required

  2005cites this paper
• Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool.

  2005cites this paper