Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2014-11-11

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1073/pnas.1412689111PMID 25389312PMCID PMC4250169
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• H2S and NO cooperatively regulate vascular tone by activating a neuroendocrine HNO–TRPA1–CGRP signalling pathway

  2014cited by this paper
• Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six.

  2014cited by this paper
• A genetic program promotes C. elegans longevity at cold temperatures via a thermosensitive TRP channel.

  2013cited by this paper
• TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids.

  2013cited by this paper
• Species differences and molecular determinant of TRPA1 cold sensitivity

  2013cited by this paper
• Residues in the pore region of Drosophila transient receptor potential A1 dictate sensitivity to thermal stimuli

  2013cited by this paper
• Benzoquinone Reveals a Cysteine-Dependent Desensitization Mechanism of TRPA1

  2013cited by this paper
• Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1)

  2012cited by this paper
• Quantifying and modeling the temperature-dependent gating of TRP channels.

  2012cited by this paper
• Species Comparison and Pharmacological Characterization of Human, Monkey, Rat, and Mouse TRPA1 Channels

  2012cited by this paper
• Differential Expression and Functionality of TRPA1 Protein Genetic Variants in Conditions of Thermal Stimulation*

  2012cited by this paper
• Prostaglandin metabolite induces inhibition of TRPA1 and channel-dependent nociception

  2012cited by this paper
• Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli

  2011cited by this paper
• Modulation of TRPA1 thermal sensitivity enables sensory discrimination in Drosophila

  2011cited by this paper
• Identification of in Vivo Disulfide Conformation of TRPA1 Ion Channel*

  2011cited by this paper
• TRPA1 mediates spinal antinociception induced by acetaminophen and the cannabinoid Δ(9)-tetrahydrocannabiorcol.

  2011cited by this paper
• Molecular Architecture and Subunit Organization of TRPA1 Ion Channel Revealed by Electron Microscopy*

  2011cited by this paper
• A thermodynamic framework for understanding temperature sensing by transient receptor potential (TRP) channels

  2011cited by this paper
• Irritating channels: the case of TRPA1

  2011cited by this paper
• A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome

  2010cited by this paper
• Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception

  2010cited by this paper
• Molecular Basis of Infrared Detection by Snakes

  2010cited by this paper
• Infrared Snake Eyes: TRPA1 and the Thermal Sensitivity of the Snake Pit Organ

  2010cited by this paper
• Gating of Transient Receptor Potential Melastatin 8 (TRPM8) Channels Activated by Cold and Chemical Agonists in Planar Lipid Bilayers

  2010cited by this paper
• TRPA1 acts as a cold sensor in vitro and in vivo

  2009cited by this paper
• Inhibition of transient receptor potential A1 channel by phosphatidylinositol-4,5-bisphosphate.

  2008cited by this paper
• TRPA1 Mediates the Noxious Effects of Natural Sesquiterpene Deterrents*

  2008cited by this paper
• Identification of Transmembrane Domain 5 as a Critical Molecular Determinant of Menthol Sensitivity in Mammalian TRPA1 Channels

  2008influential reference
• Direct activation of the ion channel TRPA1 by Ca2+

  2007cited by this paper
• Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines

  2007influential reference
• Cold sensitivity of recombinant TRPA1 channels.

  2007cited by this paper
• Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment

  2007cited by this paper
• A Hot-Sensing Cold Receptor: C-Terminal Domain Determines Thermosensation in Transient Receptor Potential Channels

  2006cited by this paper
• Structural mechanism of plant aquaporin gating

  2006cited by this paper
• TRP channel activation by reversible covalent modification

  2006influential reference
• Pungent products from garlic activate the sensory ion channel TRPA1.

  2005cited by this paper
• The pungency of garlic: activation of TRPA1 and TRPV1 in response to allicin.

  2005cited by this paper
• Sensing with TRP channels

  2005cited by this paper
• Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin.

  2004cited by this paper
• Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

  2004cited by this paper
• ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.

  2003cited by this paper

• Temporal regulation of TRP channels during partial sciatic nerve ligation is modulated by PLC□ in male mice

  2026cites this paper
• Effects of Thermal Stress on Growth and Reproduction of Procambarus clarkii and Aquaculture Best Practices

  2026cites this paper
• It takes two: intranasal trigeminal chemosensation and its role in odor processing.

  2025cites this paper
• Understanding animal temperature sensation: from molecular thermosensors to physiological impacts

  2025cites this paper
• Effects of transient receptor potential channel activation during myogenic progression and skeletal muscle function during voluntary exercise.

  2025cites this paper
• Molecular mediators of cold adaptation in mammalian cells

  2025cites this paper
• Desensitization of TRPA1 by dimethyl itaconate attenuates acute and chronic pain in mice

  2025cites this paper
• Interaction between thermosensitive TRP channels and anoctamin 1

  2025cites this paper
• Human Mutations in the TRPV1 Channel: Implications for Noxious Cold Sensation.

  2025cites this paper
• Menthol, a consumer product additive, adversely affects human embryonic stem cells via activation of TRPM8 and TRPA1 channels

  2025cites this paper
• Lysosomal Ion Channels and Transporters: Recent Findings, Therapeutic Potential, and Technical Approaches

  2025cites this paper
• Deficiency of KIF15 contributes to oxaliplatin-induced cold hypersensitivity by limiting Annexin A2 and enhancing TRPA1 localization in DRG neuronal membrane.

  2025cites this paper
• TRPA1 and thermosensitivity

  2025cites this paper
• PPARγ ligands activate the ion channel TRPA1.

  2025cites this paper
• Convergent evolution of noxious heat sensing by TRPA5, a novel class of heat sensor in Rhodnius prolixus

  2024cites this paper
• Temperature-Dependent Activation of Thermosensitive Transient Receptor Potential Channels.

  2024cites this paper
• Role of TRPA1 in Painful Cold Hypersensitivity.

  2024cites this paper
• Construction of a molecular diagnostic system for neurogenic rosacea by combining transcriptome sequencing and machine learning

  2024cites this paper
• Ion channels of cold transduction and transmission

  2024cites this paper
• Human Transient Receptor Potential Ankyrin 1 Channel: Structure, Function, and Physiology.

  2024cites this paper
• Broadening the Genetic Spectrum of Painful Small-Fiber Neuropathy through Whole-Exome Study in Early-Onset Cases

  2024cites this paper
• Evaluation of heterologous expression in Pichia pastoris of Pine Weevil TRPA1 by GFP and flow cytometry

  2024influential citation
• TRPA5 encodes a thermosensitive ankyrin ion channel receptor in a triatomine insect

  2024cites this paper
• Neuronal gene expression in two generations of the marine parasitic worm, Cryptocotyle lingua

  2023cites this paper
• hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA.

  2023cites this paper
• Canine, mouse, and human transient receptor potential ankyrin 1 (TRPA1) channels show different sensitivity to menthol or cold stimulation

  2023cites this paper
• Aedes aegypti salivary gland extract alleviates acute itching by blocking TRPA1 channels

  2023cites this paper
• When offspring outsmarting parents: Neuronal genes expression in two generations of marine parasitic worm

  2023cites this paper
• Epigenetic Connections of the TRPA1 Ion Channel in Pain Transmission and Neurogenic Inflammation — a Therapeutic Perspective in Migraine?

  2023cites this paper
• Transient Receptor Potential Ankyrin 1 (TRPA1) Channel as a Sensor of Oxidative Stress in Cancer Cells

  2023influential citation
• The role of TRPA1 channels in thermosensation

  2022cites this paper
• IQGAP1 promotes chronic pain by regulating the trafficking and sensitization of TRPA1 channels

  2022cites this paper
• Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function

  2022influential citation
• Biochemical and Structural Insights into FIH‐Catalysed Hydroxylation of Transient Receptor Potential Ankyrin Repeat Domains

  2022cites this paper
• TRPA1 analgesia is mediated by kappa opioid receptors

  2022cites this paper
• Analysis of Structural Determinants of Peptide MS 9a-1 Essential for Potentiating of TRPA1 Channel

  2022influential citation
• Neuronal and non-neuronal TRPA1 as therapeutic targets for pain and headache relief

  2022cites this paper
• Regulation of Ion Channel Function by Gas Molecules.

  2021cites this paper
• A molecular perspective on identifying TRPV1 thermosensitive regions and disentangling polymodal activation

  2021cites this paper
• TRPA1 Expression and Pathophysiology in Immune Cells

  2021cites this paper
• Atomistic mechanisms of human TRPA1 activation by electrophile irritants through molecular dynamics simulation and mutual information analysis

  2021cites this paper
• Mini-review: The nociceptive sensory functions of the polymodal receptor Transient Receptor Potential Ankyrin Type 1 (TRPA1)

  2021cites this paper
• Reevaluating tear gas toxicity and safety

  2021cites this paper
• Crayfish (Procambarus clarkii) TRPA1 is required for the defense against Aeromonas hydrophila infection under high temperature conditions and contributes to heat sensing.

  2021cites this paper
• The human TRPA1 intrinsic cold and heat sensitivity involves separate channel structures beyond the N-ARD domain

  2021influential citation
• Transient receptor potential ankyrin 1 channel: An evolutionarily tuned thermosensor.

  2021cites this paper
• Nociceptive TRP Channels and Sex Steroids

  2021cites this paper
• Interactions between Chemesthesis and Taste: Role of TRPA1 and TRPV1

  2021cites this paper
• The Agonist Action of Alkylphenols on TRPA1 Relates to Their Effects on Membrane Lipid Order: Implications for TRPA1-Mediated Chemosensation

  2021cites this paper
• Transient receptor potential channels in sensory mechanisms of the lower urinary tract

  2021cites this paper
• "Combining topical agonists with the recording of event-related brain potentials to probe the functional involvement of TRPM8, TRPA1 and TRPV1 in heat and cold transduction in the human skin".

  2021cites this paper
• Calcium activates purified human TRPA1 with and without its N-terminal ankyrin repeat domain in the absence of calmodulin

  2020cites this paper
• Mammalian transient receptor potential TRPA1 channels: from structure to disease.

  2020cites this paper
• Human TRPA1 is an inherently mechanosensitive bilayer-gated ion channel

  2020cites this paper
• Hyperthermia induced by transient receptor potential vanilloid-1 (TRPV1) antagonists in human clinical trials: Insights from mathematical modeling and meta-analysis.

  2020cites this paper
• Proximal C-Terminus Serves as a Signaling Hub for TRPA1 Channel Regulation via Its Interacting Molecules and Supramolecular Complexes

  2020cites this paper
• TRPA1-mediated inflammatory response of alveolar epithelial cells in vitro experiment

  2020cites this paper
• Sonogenetic control of mammalian cells using exogenous Transient Receptor Potential A1 channels

  2020cites this paper
• TP53-Associated Ion Channel Genes Serve as Prognostic Predictor and Therapeutic Targets in Head and Neck Squamous Cell Carcinoma

  2020cites this paper
• TRPA1-опосредованная воспалительная реакция клеток альвеолярного эпителия в эксперименте in vitro

  2020cites this paper
• Transgenic Chlamydomonas Expressing Human Transient Receptor Potential Ankyrin 1 (TRPA1) Channels to Assess the Effect of Agonists and Antagonists

  2020cites this paper
• Electrophile-Induced Conformational Switch of the Human TRPA1 Ion Channel Detected by Mass Spectrometry

  2020cites this paper
• The Role of Cold-Sensitive Ion Channels in Peripheral Thermosensation

  2020cites this paper
• Ecological Sensing Through Taste and Chemosensation Mediates Inflammation: A Biological Anthropological Approach.

  2020cites this paper
• Bioelectronic Skin Based on Nociceptive Ion Channel for Human-Like Perception of Cold Pains.

  2020cites this paper
• Calcium activates purified human TRPA1 with and without its N-terminal ankyrin repeat domain in the absence of calmodulin.

  2020cites this paper
• Lipid Raft Destabilization Impairs Mouse TRPA1 Responses to Cold and Bacterial Lipopolysaccharides

  2020cites this paper
• Functional evolution of vertebrate sensory receptors.

  2020cites this paper
• TRPA1 gene variants hurting our feelings

  2020cites this paper
• Nociceptor Signalling through ion Channel Regulation via GPCRs

  2019cites this paper
• TRPA1: a molecular view.

  2019cites this paper
• TRPA1 Sensitization Produces Hyperalgesia to Heat but not to Cold Stimuli in Human Volunteers

  2019cites this paper
• TRPA1 Channel as a Regulator of Neurogenic Inflammation and Pain: Structure, Function, Role in Pathophysiology, and Therapeutic Potential of Ligands

  2019cites this paper
• Aging of mouse intervertebral disc and association with back pain.

  2019cites this paper
• Regulation of Nociceptor Signaling by Serotonin

  2019cites this paper
• Putative interaction site for membrane phospholipids controls activation of TRPA1 channel at physiological membrane potentials

  2019cites this paper
• Structural and Evolutionary Insights Point to Allosteric Regulation of TRP Ion Channels.

  2019cites this paper
• Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

  2019cites this paper
• Epidermal expression of human TRPM8, but not of TRPA1 ion channels, is associated with sensory responses to local skin cooling.

  2019cites this paper
• Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors

  2019cites this paper
• Si-Qi Wei, Zhuo-Ying Tao, Yang Xue and Dong-Yuan Cao

  2019cites this paper
• Mechanisms of Activation and Modulation of Ion Channels Specific for Nociceptive Neurones

  2019cites this paper
• Reciprocal regulation of the Fibroblast Growth Factor Receptor 2 (FGFR2) and the Transient Receptor Potential Ankyrin 1 (TRPA1) through their direct interaction

  2019influential citation
• Comparisons of behavioural and TRPA1 heat sensitivities in three sympatric Cuban Anolis lizards

  2018cites this paper
• Regulation of Pain and Itch by TRP Channels

  2018cites this paper
• TRPs et al.: a molecular toolkit for thermosensory adaptations

  2018cites this paper
• Molecular basis of peripheral innocuous warmth sensitivity.

  2018cites this paper
• Selective Effects of Temperature on the Sensory Irritation but not Taste of NaCl and Citric Acid

  2018cites this paper
• Phosphoinositide-interacting regulator of TRP (PIRT) has opposing effects on human and mouse TRPM8 ion channels

  2018cites this paper
• Polymorphism of Human Thermoreceptor Genes TRPV1 and TRPA1 in Populations of the Altai-Sayan Region and the Far East

  2018cites this paper
• Polymorphism of Human Thermoreceptor Genes TRPV1 and TRPA1 in Populations of the Altai-Sayan Region and the Far East

  2018cites this paper
• Machine‐learned analysis of quantitative sensory testing responses to noxious cold stimulation in healthy subjects

  2018cites this paper
• TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity

  2017cites this paper
• Drugs Affecting TRP Channels.

  2017cites this paper
• Analysis of temporal firing patterns of primary afferent C-fibers for different sensations in mice

  2017cites this paper
• Calmodulin is responsible for Ca2+-dependent regulation of TRPA1 Channels

  2017cites this paper
• Analysis of temporal firing patterns of primary afferent C-fibers for different sensations in mice

  2017cites this paper
• Painfully Energetic: A tale of two proteins potentially connected

  2017influential citation
• Chemical and thermal sensitivity of medaka TRPA1 analyzed in heterologous expression system.

  2017cites this paper
• TRPA1–FGFR2 binding event is a regulatory oncogenic driver modulated by miRNA-142-3p

  2017cites this paper