Activation of Inflammasomes Requires Intracellular Redistribution of the Apoptotic Speck-Like Protein Containing a Caspase Recruitment Domain1

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Immunology

• Publication date

  2009-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.0802367PMID 19234215PMCID PMC2652671
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2006influential reference
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  2006cited by this paper
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  2006cited by this paper
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  1998cited by this paper
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  1995cited by this paper
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  1990cited by this paper
• Induction of nuclear transport with a synthetic peptide homologous to the SV40 T antigen transport signal.

  1986cited by this paper
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  1983cited by this paper
• Heterogeneous binding of high mobility group chromosomal proteins to nuclei

  1981cited by this paper
• Serveur Académique Lausannois SERVAL serval.unil.ch

  year unknowncited by this paper

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