Blockade of the Mitochondrial Permeability Transition Pore Diminishes Infarct Size in the Rat after Transient Middle Cerebral Artery Occlusion

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Journal of Cerebral Blood Flow and Metabolism

• Publication date

  1999-07-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/00004647-199907000-00002PMID 10413027
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ischemic penumbra in a model of reversible middle cerebral artery occlusion in the rat

  2004cited by this paper
• Differences in the Activation of the Mitochondrial Permeability Transition Among Brain Regions in the Rat Correlate with Selective Vulnerability

  1999cited by this paper
• Molecular characterization of mitochondrial apoptosis-inducing factor

  1999cited by this paper
• Bax directly induces release of cytochrome c from isolated mitochondria.

  1998cited by this paper
• Elucidating the molecular mechanism of the permeability transition pore and its role in reperfusion injury of the heart.

  1998cited by this paper
• Caspases: enemies within.

  1998cited by this paper
• From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state.

  1998cited by this paper
• Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia

  1998cited by this paper
• Cyclosporin A, But Not FK 506, Protects Mitochondria and Neurons against Hypoglycemic Damage and Implicates the Mitochondrial Permeability Transition in Cell Death

  1998cited by this paper
• Bax-induced Cytochrome C Release from Mitochondria Is Independent of the Permeability Transition Pore but Highly Dependent on Mg2+ Ions

  1998cited by this paper
• Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases.

  1998cited by this paper
• The mitochondrial death/life regulator in apoptosis and necrosis.

  1998cited by this paper
• Mitochondrial control of apoptosis: the role of cytochrome c.

  1998cited by this paper
• Cyclosporin inhibition of apoptosis induced by mitochondrial complex I toxins.

  1998cited by this paper
• Cytosolic Redistribution of Cytochrome C after Transient Focal Cerebral Ischemia in Rats

  1998cited by this paper
• Amelioration by cyclosporin A of brain damage in transient forebrain ischemia in the rat.

  1998cited by this paper
• A revolution in apoptosis: from a nucleocentric to a mitochondriocentric perspective.

  1998cited by this paper
• The mitochondrial permeability transition in cell death: a common mechanism in necrosis, apoptosis and autophagy.

  1998cited by this paper
• Protection by cyclosporine A against normothermic liver ischemia-reperfusion in pigs.

  1998cited by this paper
• Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis.

  1998cited by this paper
• Mitochondrial permeability transition in pH-dependent reperfusion injury to rat hepatocytes.

  1997cited by this paper
• The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

  1997cited by this paper
• Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

  1997cited by this paper
• Mitochondrial Permeability Transition in the Central Nervous System: Induction by Calcium Cycling‐Dependent and ‐Independent Pathways

  1997cited by this paper
• Neuroprotective Actions of FK506 in Experimental Stroke: In Vivo Evidence against an Antiexcitotoxic Mechanism

  1997cited by this paper
• Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis

  1996cited by this paper
• Mitochondrial Dysfunction Is a Primary Event in Glutamate Neurotoxicity

  1996cited by this paper
• Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c.

  1996cited by this paper
• The mitochondrial permeability transition.

  1995cited by this paper
• Recruitment of mitochondrial cyclophilin to the mitochondrial inner membrane under conditions of oxidative stress that enhance the opening of a calcium-sensitive non-specific channel.

  1994cited by this paper
• Transport of calcium by mitochondria

  1994cited by this paper
• Hyperthermia complicates middle cerebral artery occlusion induced by an intraluminal filament.

  1994cited by this paper
• Protection by Cyclosporin A of ischemia/reperfusion-induced damage in isolated rat hearts.

  1993cited by this paper
• Inhibition of T cell signaling by immunophilin-ligand complexes correlates with loss of calcineurin phosphatase activity.

  1992cited by this paper
• The Evolution of Brain Infarcts. A Review

  1992cited by this paper
• Cyclosporin A protects against ischemia-reperfusion injury in the brain.

  1992cited by this paper
• Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes.

  1991cited by this paper
• Rapid Isolation of Metabolically Active Mitochondria from Rat Brain and Subregions Using Percoll Density Gradient Centrifugation

  1990cited by this paper
• Inhibition by cyclosporin A of a Ca2+-dependent pore in heart mitochondria activated by inorganic phosphate and oxidative stress.

  1988cited by this paper
• Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

  1986cited by this paper
• Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats.

  1986cited by this paper
• The Ca2+-induced membrane transition in mitochondria. I. The protective mechanisms.

  1979cited by this paper
• The Ca2+-induced membrane transition in mitochondria. III. Transitional Ca2+ release.

  1979cited by this paper

• Cyclophilin D plays a critical role in the survival of senescent cells

  2024cites this paper
• Imeglimin Is Neuroprotective Against Ischemic Brain Injury in Rats—a Study Evaluating Neuroinflammation and Mitochondrial Functions

  2022cites this paper
• Remodeling of Liver and Plasma Lipidomes in Mice Lacking Cyclophilin D

  2022cites this paper
• Rotenone Decreases Ischemia-Induced Injury by Inhibiting Mitochondrial Permeability Transition: A Study in Brain.

  2022cites this paper
• Different Roles of Mitochondria in Cell Death and Inflammation: Focusing on Mitochondrial Quality Control in Ischemic Stroke and Reperfusion

  2021cites this paper
• Mitochondrial Dynamics: A Potential Therapeutic Target for Ischemic Stroke

  2021cites this paper
• The Age-Dependent Decline in Neuron Growth Potential in the CNS is Associated with an Age-Related Dysfunction of Neuronal Mitochondria

  2021cites this paper
• Mitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition

  2020cites this paper
• Targeting the pathways of regulated necrosis: a potential strategy for alleviation of cardio-cerebrovascular injury

  2020cites this paper
• Anti-inflammatory and Neuroprotective Agents in Clinical Trials for CNS Disease and Injury: Where Do We Go From Here?

  2020cites this paper
• Histological Structure of Dentate Gyrus in Global Cerebral Ischemia/Reperfusion Injury and Role of Nitraetes in Protection

  2020cites this paper
• Cyclosporin A ameliorates cerebral oxidative metabolism and infarct size in the endothelin-1 rat model of transient cerebral ischaemia

  2019cites this paper
• Edaravone and cyclosporine A as neuroprotective agents for acute ischemic stroke

  2018cites this paper
• Mitochondrial-Based Therapeutics for the Treatment of Spinal Cord Injury: Mitochondrial Biogenesis as a Potential Pharmacological Target

  2017cites this paper
• The Mitochondrial Permeability Transition Pore: Molecular Structure and Function in Health and Disease

  2017cites this paper
• Mitochondria-based biosensors with piezometric and RELS transduction for potassium uptake and release investigations.

  2017cites this paper
• Mitochondrial Dysfunction in Ischemic Stroke

  2017cites this paper
• Effect of Trp53 gene deficiency on brain injury after neonatal hypoxia-ischemia

  2017cites this paper
• Co-administration of Cyclosporin A and Ondansetron decreases transient local cerebral ischemic injury in the mouse.

  2017cites this paper
• Effect of Trp 53 gene deficiency on brain injury after neonatal hypoxia-ischemia

  2017cites this paper
• Reversible Disruption of Neuronal Mitochondria by Ischemic and Traumatic Injury Revealed by Quantitative Two-Photon Imaging in the Neocortex of Anesthetized Mice

  2017cites this paper
• Calcium and regulation of the mitochondrial permeability transition.

  2017cites this paper
• Detection of metabolic pattern following decompressive craniectomy in severe traumatic brain injury: A microdialysis study

  2017cites this paper
• Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains.

  2017cites this paper
• Ortho-topolin riboside induces apoptosis in Acute myeloid leukemia HL-60 cells

  2016cites this paper
• Knockout of Cyclophilin-D Provides Partial Amelioration of Intrinsic and Synaptic Properties Altered by Mild Traumatic Brain Injury

  2016influential citation
• Prevention of Cyclophilin D-Mediated mPTP Opening Using Cyclosporine-A Alleviates the Elevation of Necroptosis, Autophagy and Apoptosis-Related Markers Following Global Cerebral Ischemia-Reperfusion

  2016influential citation
• Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats.

  2016cites this paper
• EXPERIMENTAL FOCAL CEREBRAL ISCHEMIA

  2016cites this paper
• Ischemia-reperfusion Injury in the Brain: Mechanisms and Potential Therapeutic Strategies.

  2016cites this paper
• Procyanidin B2 attenuates neurological deficits and blood-brain barrier disruption in a rat model of cerebral ischemia.

  2015cites this paper
• Fine morphological alterations during brain injury and recovery analyzed with intravital microscopy

  2015cites this paper
• Cyclosporine A Reduces Glial Scarring and Facilitates Functional Recovery Following Transient Focal Ischemia

  2015cites this paper
• Mitochondrial neuroprotection in traumatic brain injury: rationale and therapeutic strategies.

  2014cites this paper
• Characterisation of endogenous repair mechanisms following endothelin-1 induced stroke in rats and the effects of human adult stem cell transplant to support brain reconstruction

  2014cites this paper
• Inhibition of cyclophilin D by cyclosporin A promotes retinal ganglion cell survival by preventing mitochondrial alteration in ischemic injury

  2014cites this paper
• LITHUANIAN UNIVERSITY OF HEALTH SCIENCES

  2014cites this paper
• Attenuation of Skeletal Muscle and Renal Injury to the Lower Limb following Ischemia-Reperfusion Using mPTP Inhibitor NIM-811

  2014cites this paper
• Novel Therapeutic Strategies for Traumatic Brain Injury: Acute Antioxidant Reinforcement

  2014cites this paper
• ER–Mitochondrial Calcium Flow Underlies Vulnerability of Mechanosensory Hair Cells to Damage

  2014cites this paper
• N-Acetyl-Serotonin Offers Neuroprotection through Inhibiting Mitochondrial Death Pathways and Autophagic Activation in Experimental Models of Ischemic Injury

  2014cites this paper
• Protective Effect of Boerhaavia diffusa L. against Mitochondrial Dysfunction in Angiotensin II Induced Hypertrophy in H9c2 Cardiomyoblast Cells

  2014cites this paper
• Post-ischemic continuous infusion of erythropoeitin enhances recovery of lost memory function after global cerebral ischemia in the rat

  2013cites this paper
• HSP70 in Damaged Cells

  2013cites this paper
• Mitochondria as a Source of Reactive Oxygen and Nitrogen Species: From Molecular Mechanisms to Human Health

  2013cites this paper
• Diazoxide and cyclosporin A protect primary cholinergic neurons against beta-amyloid (1-42)-induced cytotoxicity

  2013cites this paper
• Pre- and Post-treatment with Cyclosporine a in a Rat Model of Transient Focal Cerebral Ischaemia with Multimodal MRI Screening

  2013cites this paper
• Regulation of the Mitochondrial Permeability Transition Pore: Role of Outer Membrane and of Translocator Protein (Peripheral Benzodiazepine Receptor)

  2013cites this paper
• Ischemic Postconditioning Attenuate Reperfusion Injury of Small Intestine: Impact of Mitochondrial Permeability Transition

  2013cites this paper
• Cyclophilin-D inhibition in neuroprotection: dawn of a new era of mitochondrial medicine.

  2013cites this paper
• p53 opens the mitochondrial permeability transition pore to trigger necrosis.

  2012cites this paper
• Dysfonctions neurovasculaires et mitochondriales dans un modèle néonatal d'ischémie cérébrale focale

  2012cites this paper
• Cyclosporin A and cardioprotection: from investigative tool to therapeutic agent

  2012cites this paper
• Small-molecular inhibitors of Ca²⁺-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene.

  2012cites this paper
• Hypoxic-Ischemic Injury in the Developing Brain: The Role of Reactive Oxygen Species Originating in Mitochondria

  2012cites this paper
• Inhibition of the Mitochondrial Permeability Transition for Cytoprotection: Direct versus Indirect Mechanisms

  2012cites this paper
• Acetyl‐L‐carnitine‐mediated neuroprotection during hypoxia is attributed to ERK1/2‐Nrf2‐regulated mitochondrial biosynthesis

  2012cites this paper
• Shedding light on the mitochondrial permeability transition.

  2011cites this paper
• Targeting Mitochondrial Function for the Treatment of Acute Spinal Cord Injury

  2011cites this paper
• Cyclophilin D-Sensitive Mitochondrial Permeability Transition in Adult Human Brain and Liver Mitochondria

  2011cites this paper
• ¿Cómo reparar el daño cerebral isquémico? Utilidad de los modelos experimentales en la búsqueda de respuestas

  2011cites this paper
• Eficàcia dels tocotrienols com a estratègia de tractament de la fibrosi intestinal

  2011cites this paper
• Neuronal Death and Oxidative Stress in the Developing Brain

  2011cites this paper
• Pharmacological interventions for spinal cord injury: where do we stand? How might we step forward?

  2011cites this paper
• Evaluation of cyclosporine A in a stroke model in the immature rat brain.

  2011cites this paper
• How to repair an ischemic brain injury? Value of experimental models in search of answers.

  2011cites this paper
• Cysteine 203 of Cyclophilin D Is Critical for Cyclophilin D Activation of the Mitochondrial Permeability Transition Pore*

  2011cites this paper
• Effect of Polyphenols on Oxidative Stress and Mitochondrial Dysfunction in Neuronal Death and Brain Edema in Cerebral Ischemia

  2011cites this paper
• Mitochondrial calcium handling during ischemia-induced cell death in neurons.

  2011cites this paper
• Cyclosporine A attenuates hypoxic-ischemic brain injury in newborn rats.

  2010cites this paper
• Mitochondria as decision‐makers in cell death

  2010cites this paper
• Pretreatment with the ciclosporin derivative NIM811 reduces delayed neuronal death in the hippocampus after transient forebrain ischaemia

  2010cites this paper
• Cyclophilin D in mitochondrial pathophysiology.

  2010cites this paper
• Inhibitory Effects of Adenine Nucleotides on Brain Mitochondrial Permeability Transition

  2010cites this paper
• Mitochondrial chaperone tumour necrosis factor receptor‐associated protein 1 protects cardiomyocytes from hypoxic injury by regulating mitochondrial permeability transition pore opening

  2010cites this paper
• A pore way to die: the role of mitochondria in reperfusion injury and cardioprotection.

  2010cites this paper
• Mitochondria, oxidative metabolism and cell death in stroke.

  2010cites this paper
• Overexpression of mitochondrial transcription factor A (TFAM) ameliorates delayed neuronal death due to transient forebrain ischemia in mice

  2010cites this paper
• Safety and Tolerability of Cyclosporin A in Severe Traumatic Brain Injury Patients: Results from a Prospective Randomized Trial

  2009cites this paper
• The role of Cyclophilin D in learning and memory

  2009cites this paper
• Reversible Cyclosporin A-sensitive Mitochondrial Depolarization Occurs within Minutes of Stroke Onset in Mouse Somatosensory Cortex in Vivo

  2009cites this paper
• Possible mechanisms of Cyclosporin A ameliorated the ischemic microenvironment and inhibited mitochondria stress in tree shrews' hippocampus.

  2009cites this paper
• Ceramide and neurodegeneration: susceptibility of neurons and oligodendrocytes to cell damage and death.

  2009cites this paper
• Developmental Shift of Cyclophilin D Contribution to Hypoxic-Ischemic Brain Injury

  2009cites this paper
• Hypoxic-Ischemic Brain Damage

  2009cites this paper
• Evaluation of putative inhibitors of mitochondrial permeability transition for brain disorders--specificity vs. toxicity.

  2009cites this paper
• Mitochondrial calcium function and dysfunction in the central nervous system.

  2009cites this paper
• Alterations in Membrane Potential in Mitochondria Isolated from Brain Subregions During Focal Cerebral Ischemia and Early Reperfusion: Evaluation Using Flow Cytometry

  2009cites this paper
• The role of mitochondrial transition pore, and its modulation, in traumatic brain injury and delayed neurodegeneration after TBI.

  2009cites this paper
• Mitochondrial membrane permeabilization in neuronal injury

  2009cites this paper
• Targeting post-mitochondrial effectors of apoptosis for neuroprotection.

  2009cites this paper
• 18 HYPOXIC , ISCHEMIC , AND REPERFUSION INJURY TO LIVER

  2009cites this paper
• Calcineurin inhibition enhances motor neuron survival following injury

  2009influential citation
• Acetaminophen confers neuroprotection during early cerebral ischemia -reperfusion

  2009cites this paper
• Kinetic Model for Ca2+-induced Permeability Transition in Energized Liver Mitochondria Discriminates between Inhibitor Mechanisms*

  2008cites this paper
• Brain metabolic and hemodynamic effects of cyclosporin A after human severe traumatic brain injury: a microdialysis study

  2008cites this paper
• Huperzine A attenuates mitochondrial dysfunction after middle cerebral artery occlusion in rats

  2008cites this paper
• Mitochondria and calcium in health and disease.

  2008cites this paper
• Recent progress in elucidating the molecular mechanism of the mitochondrial permeability transition pore.

  2008cites this paper
• Endogenous neuroprotection: mitochondria as gateways to cerebral preconditioning?

  2008cites this paper