Mitochondria and calcium in health and disease.

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Cell Calcium

• Publication date

  2008-04-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.ceca.2008.02.001PMID 18378306
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mitochondria as generators and targets of nitric oxide.

  2007cited by this paper
• ‘Mild Uncoupling’ does not decrease mitochondrial superoxide levels in cultured cerebellar granule neurons but decreases spare respiratory capacity and increases toxicity to glutamate and oxidative stress

  2007cited by this paper
• Ca2+‐dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP‐ribose) polymerase‐1 activation during glutamate excitotoxicity

  2007cited by this paper
• Regulation of store-operated calcium channels by the intermediary metabolite pyruvic acid.

  2007cited by this paper
• Uncoupling is without an effect on the production of reactive oxygen species by in situ synaptic mitochondria

  2007cited by this paper
• T cell activation requires mitochondrial translocation to the immunological synapse

  2007cited by this paper
• The role of mitochondria in oxidative and nitrosative stress during ischemia/reperfusion in the rat kidney.

  2007cited by this paper
• Mitochondrial transporters as novel targets for intracellular calcium signaling.

  2007cited by this paper
• Voltage-dependent anion channels are dispensable for mitochondrial-dependent cell death

  2007cited by this paper
• Calcium, mitochondria and reperfusion injury: a pore way to die.

  2006cited by this paper
• Microdomains of intracellular Ca2+: molecular determinants and functional consequences.

  2006cited by this paper
• Mitochondrial redox state and Ca2+ sparks in permeabilized mammalian skeletal muscle

  2005cited by this paper
• Properties of the Permeability Transition Pore in Mitochondria Devoid of Cyclophilin D*

  2005cited by this paper
• Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3.

  2005cited by this paper
• Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death

  2005cited by this paper
• Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

  2005cited by this paper
• Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia.

  2005cited by this paper
• Sperm-triggered [Ca2+] oscillations and Ca2+ homeostasis in the mouse egg have an absolute requirement for mitochondrial ATP production

  2004cited by this paper
• Control of mitochondrial motility and distribution by the calcium signal

  2004cited by this paper
• Mitochondrial calcium uptake stimulates nitric oxide production in mitochondria of bovine vascular endothelial cells.

  2004cited by this paper
• Mitochondrial permeability: Dual role for the ADP/ATP translocator?

  2004cited by this paper
• The ADP/ATP translocator is not essential for the mitochondrial permeability transition pore

  2004cited by this paper
• The mitochondrial calcium uniporter is a highly selective ion channel

  2004cited by this paper
• Cyclophilin-D promotes the mitochondrial permeability transition but has opposite effects on apoptosis and necrosis.

  2004cited by this paper
• Production of endogenous matrix superoxide from mitochondrial complex I leads to activation of uncoupling protein 3

  2004cited by this paper
• Intra-mitochondrial Poly(ADP-ribosylation) Contributes to NAD+ Depletion and Cell Death Induced by Oxidative Stress*

  2003cited by this paper
• Superoxide activates mitochondrial uncoupling proteins

  2002cited by this paper
• Treatment of Ischemic Brain Damage by Perturbing NMDA Receptor- PSD-95 Protein Interactions

  2002cited by this paper
• NMDA But Not Non-NMDA Excitotoxicity is Mediated by Poly(ADP-Ribose) Polymerase

  2000cited by this paper
• Ca(2+) activation of heart mitochondrial oxidative phosphorylation: role of the F(0)/F(1)-ATPase.

  2000cited by this paper
• Mitochondria Shape Hormonally Induced Cytoplasmic Calcium Oscillations and Modulate Exocytosis*

  2000cited by this paper
• Control of InsP3‐induced Ca2+ oscillations in permeabilized blowfly salivary gland cells: contribution of mitochondria

  2000cited by this paper
• Ca2+ activation of heart mitochondrial oxidative phosphorylation: role of the F0/F1-ATPase

  2000cited by this paper
• Respiring mitochondria determine the pattern of activation and inactivation of the store‐operated Ca2+ current ICRAC

  2000cited by this paper
• Excitotoxic mitochondrial depolarisation requires both calcium and nitric oxide in rat hippocampal neurons

  1999cited by this paper
• Mitochondria Exert a Negative Feedback on the Propagation of Intracellular Ca2+ Waves in Rat Cortical Astrocytes

  1999cited by this paper
• Regulation of mitochondrial ATP synthesis by calcium: evidence for a long-term metabolic priming.

  1999cited by this paper
• Blockade of the Mitochondrial Permeability Transition Pore Diminishes Infarct Size in the Rat after Transient Middle Cerebral Artery Occlusion

  1999cited by this paper
• Active mitochondria surrounding the pancreatic acinar granule region prevent spreading of inositol trisphosphate‐evoked local cytosolic Ca2+ signals

  1999cited by this paper
• Glutamate-induced neuron death requires mitochondrial calcium uptake

  1998cited by this paper
• Ca2+ Homeostasis in the Agonist-sensitive Internal Store: Functional Interactions Between Mitochondria and the ER Measured In Situ in Intact Cells

  1998cited by this paper
• Mitochondrial Regulation of Store-operated Calcium Signaling in T Lymphocytes

  1997cited by this paper
• Synchronization of calcium waves by mitochondrial substrates in Xenopus laevis oocytes

  1995cited by this paper
• On the involvement of a cyclosporin A sensitive mitochondrial pore in myocardial reperfusion injury.

  1993cited by this paper
• Role of calcium ions in regulation of mammalian intramitochondrial metabolism.

  1990cited by this paper

• Mitochondrial Transplantation: A Novel Therapeutic Approach for Treating Diseases

  2025cites this paper
• Presynaptic ATP Decreases During Physiological‐Like Activity in Neurons Tuned for High‐Frequency Transmission

  2025cites this paper
• CHTW(R)-system in Ca2+ transport modelling

  2025cites this paper
• Mrs2-mediated mitochondrial magnesium uptake is essential for the regulation of MCU-mediated mitochondrial Ca2+ uptake and viability.

  2024cites this paper
• Management of hypocalcaemia in the critically ill

  2023cites this paper
• Mitochondrial malfunction mediates impaired cholinergic Ca2+ signalling and submandibular salivary gland dysfunction in diabetes.

  2023cites this paper
• Antimicrobial peptide LL-37 disrupts plasma membrane and calcium homeostasis in Candida albicans via the Rim101 pathway

  2023cites this paper
• Goldilocks calcium concentrations and the regulation of oxidative phosphorylation: Too much, too little, or just right

  2023cites this paper
• The mitochondrial calcium signaling, regulation, and cellular functions: A novel target for therapeutic medicine in neurological disorders

  2023cites this paper
• Distinct effects of cardiac mitochondrial calcium uniporter inactivation via EMRE deletion in the short and long term.

  2023cites this paper
• Mitochondrial Magnesium is the cationic rheostat for MCU-mediated mitochondrial Ca2+ uptake

  2023cites this paper
• Structural basis of Ca2+ uptake by mitochondrial calcium uniporter in mitochondria: a brief review

  2022cites this paper
• Goldilocks calcium and the mitochondrial respiratory chain: too much, too little, just right

  2022cites this paper
• Mitochondrial biology and dysfunction in secondary mitochondrial disease

  2022cites this paper
• Effects of bepridil on early cardiac development of zebrafish

  2022cites this paper
• Pathophysiological role of calcium channels and transporters in the multiple myeloma

  2021cites this paper
• Insight of the role of mitochondrial calcium homeostasis in hepatic insulin resistance.

  2021cites this paper
• Mitochondrial Ion Channels of the Inner Membrane and Their Regulation in Cell Death Signaling

  2021cites this paper
• Photobiomodulation Response From 660 nm is Different and More Durable Than That From 980 nm

  2021cites this paper
• Structural characterization of the mitochondrial Ca2+ uniporter provides insights into Ca2+ uptake and regulation

  2021cites this paper
• Regulation of ionized calcium concentration in mitochondria matrix in the absence of exogenous Са(2+)

  2021cites this paper
• Cardioprotective effects of pharmacological blockade of the mitochondrial calcium uniporter on myocardial ischemia-reperfusion injury 1

  2020cites this paper
• Cytoplasmic Calcium Buffering: An Integrative Crosstalk.

  2020cites this paper
• MCU-induced mitochondrial calcium uptake promotes mitochondrial biogenesis and colorectal cancer growth

  2020cites this paper
• The structure of the MICU1‐MICU2 complex unveils the regulation of the mitochondrial calcium uniporter

  2020cites this paper
• Mitochondrial dysfunction in schizophrenia: with a focus on postmortem studies.

  2020cites this paper
• Keratins as regulators of colonocyte mitochondria and intestinal barrier function

  2020influential citation
• Non-Canonical Control of Neuronal Energy Status by the Na+ Pump.

  2019cites this paper
• Dendropanax morbifera Extract Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury by Inhibition of Reactive Oxygen Species Generation and Calcium Perturbation

  2019cites this paper
• Coenzyme Q10 supplementation acts as antioxidant on dystrophic muscle cells

  2019cites this paper
• Pre-synaptic sympathetic calcium channels, cyclic nucleotide-coupled phosphodiesterases and cardiac excitability.

  2019cites this paper
• Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets.

  2019cites this paper
• Changes in the Stoichiometry of Uniplex Decrease Mitochondrial Calcium Overload and Contribute to Tolerance of Cardiac Ischemia/Reperfusion Injury in Hypothyroidism

  2019cites this paper
• Mitochondrial calcium signalling and neurodegenerative diseases

  2018cites this paper
• Blocking Ca2+ Channel β3 Subunit Reverses Diabetes

  2018cites this paper
• Metabolic reprogramming and tolerance during sepsis-induced AKI

  2017cites this paper
• The Role of Mitochondria in the Activation/Maintenance of SOCE: The Contribution of Mitochondrial Ca2+ Uptake, Mitochondrial Motility, and Location to Store-Operated Ca2+ Entry.

  2017cites this paper
• Overexpression of Sarcoendoplasmic Reticulum Calcium ATPase 2a Promotes Cardiac Sympathetic Neurotransmission via Abnormal Endoplasmic Reticulum and Mitochondria Ca2+ Regulation

  2017cites this paper
• Postmortem studies on mitochondria in schizophrenia.

  2017influential citation
• The Mitochondrial Ca2+ Uniporter: Structure, Function, and Pharmacology.

  2017cites this paper
• Mechanistic investigations into pro-survival and pro-death neuronal Ca2+ signalling pathways

  2017cites this paper
• PINK1-mediated phosphorylation of LETM1 regulates mitochondrial calcium transport and protects neurons against mitochondrial stress

  2017cites this paper
• Mitochondrial permeability transition pore: sensitivity to opening and mechanistic dependence on substrate availability

  2017cites this paper
• Glutaredoxin-2 Controls Mitochondrial Structure and Energetics in Skeletal Muscle

  2017cites this paper
• MCUR1-Mediated Mitochondrial Calcium Signaling Facilitates Cell Survival of Hepatocellular Carcinoma via Reactive Oxygen Species-Dependent P53 Degradation

  2017cites this paper
• Assembly of ER-PM Junctions: A Critical Determinant in the Regulation of SOCE and TRPC1.

  2017cites this paper
• Tissue transglutaminase (TG2) and mitochondrial function and dysfunction.

  2017cites this paper
• Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in the pathophysiology of insulin resistance and type 2 diabetes

  2017cites this paper
• Neurotoxicity of the steroidal alkaloids tomatine and tomatidine is RIP1 kinase- and caspase-independent and involves the eIF2α branch of the endoplasmic reticulum.

  2017cites this paper
• Store-Operated Ca²⁺ Entry (SOCE) Pathways

  2017cites this paper
• Protection of MICU1 against myocardial hypertrophy induced by angiotensin (cid:264)

  2017cites this paper
• The mitochondrial Ca 2 + uniporter : Regulation by auxiliary subunits and signal 1 transduction pathways 2 3

  2016cites this paper
• Identification of ER-000444793, a Cyclophilin D-independent inhibitor of mitochondrial permeability transition, using a high-throughput screen in cryopreserved mitochondria

  2016cites this paper
• The mitochondrial Ca2+ uniporter: regulation by auxiliary subunits and signal transduction pathways.

  2016cites this paper
• The mitochondrial Ca uniporter: regulation by auxiliary subunits and signal transduction pathways

  2016cites this paper
• Changes in parvalbumin immunoreactive retinal ganglion cells and amacrine cells after optic nerve injury.

  2016cites this paper
• Prognostic value of plasma levels of HIF-1a and PGC-1a in breast cancer

  2016cites this paper
• Privileged crosstalk between TRPV1 channels and mitochondrial calcium shuttling machinery controls nociception.

  2016cites this paper
• The urinary proteome and metabonome differ from normal in adults with mitochondrial disease.

  2015cites this paper
• Role of the Mitochondrial Calcium Uniporter in Rat Hippocampal Neuronal Death After Pilocarpine-Induced Status Epilepticus

  2015cites this paper
• Role of mitochondrial dysfunction and dysregulation of Ca2+ homeostasis in insulin insensitivity of mammalian cells

  2015cites this paper
• Rearrangement of MICU1 multimers for activation of MCU is solely controlled by cytosolic Ca2+

  2015cites this paper
• The edaravone and 3-n-butylphthalide ring-opening derivative 10b effectively attenuates cerebral ischemia injury in rats

  2015cites this paper
• The mitochondrial Ca(2+) uniporter complex.

  2015cites this paper
• Ciências Mitochondrial genetic therapy in Parkinson ’ s disease Cloning mitochondrial gene ND 1

  2015cites this paper
• Low density lipoprotein induction of intracellular oxidants production

  2015cites this paper
• Decreased synaptic and mitochondrial density in the postmortem anterior cingulate cortex in schizophrenia.

  2015influential citation
• Mitochondrial dynamics in aging and disease.

  2014cites this paper
• Synergism of ochratoxin B and calcium-channel antagonist verapamil caused mitochondrial dysfunction

  2014cites this paper
• Adrenergic Signaling Regulates Mitochondrial Ca2+ Uptake Through Pyk2-Dependent Tyrosine Phosphorylation of the Mitochondrial Ca2+ Uniporter

  2014cites this paper
• Regulation of the mitochondrial Ca(2+) uniporter by MICU1 and MICU2.

  2014cites this paper
• Neuroprotective effect of schizandrin A on oxygen and glucose deprivation/reperfusion-induced cell injury in primary culture of rat cortical neurons

  2014cites this paper
• Activity-dependent regulation of NMDA receptors in substantia nigra dopaminergic neurones

  2014cites this paper
• SERCA2a gene therapy in heart failure: an anti‐arrhythmic positive inotrope

  2014influential citation
• The coupling of plasma membrane calcium entry to calcium uptake by endoplasmic reticulum and mitochondria

  2014cites this paper
• The Ca(2+)/H(+) antiporter TMEM165 expression, localization in the developing, lactating and involuting mammary gland parallels the secretory pathway Ca(2+) ATPase (SPCA1).

  2014cites this paper
• Cisd 2 modulates the differentiation and functioning of adipocytes by regulating intracellular Ca 2 1 homeostasis

  2014cites this paper
• Calcium signalling in sensory neurones and peripheral glia in the context of diabetic neuropathies.

  2014cites this paper
• Cell signalling mechanisms for insect stress tolerance

  2014cites this paper
• Cisd2 modulates the differentiation and functioning of adipocytes by regulating intracellular Ca2+ homeostasis.

  2014cites this paper
• Astroglial Calcium Signaling and Calcium Waves

  2013cites this paper
• A single compartment model of pacemaking in dissasociated Substantia nigra neurons

  2013cites this paper
• An Interaction between Bcl-xL and the Voltage-dependent Anion Channel (VDAC) Promotes Mitochondrial Ca2+ Uptake*

  2013cites this paper
• L-3-n-butylphthalide protects against vascular dementia via activation of the Akt kinase pathway

  2013cites this paper
• MCUR1 is an essential component of mitochondrial Ca(2+) uptake that regulates cellular metabolism.

  2013cites this paper
• Silencing of Maternal Heme-binding Protein Causes Embryonic Mitochondrial Dysfunction and Impairs Embryogenesis in the Blood Sucking Insect Rhodnius prolixus*

  2013cites this paper
• F1FO ATPase vesicle preparation and technique for performing patch clamp recordings of submitochondrial vesicle membranes.

  2013cites this paper
• Cortical astroglial atrophy in ageing and Alzheimer's disease

  2013cites this paper
• Eccentric exercise transiently affects mice skeletal muscle mitochondrial function.

  2013cites this paper
• Where the endoplasmic reticulum and the mitochondrion tie the knot: the mitochondria-associated membrane (MAM).

  2013cites this paper
• Ebselen Alters Mitochondrial Physiology and Reduces Viability of Rat Hippocampal Astrocytes

  2013cites this paper
• The Role of the Parkinson’s Disease associated Protein DJ-1 in the Development of Diet-induced Obesity in Mice

  2013cites this paper
• Uptake 2 + Promotes Mitochondrial Ca ( VDAC ) Voltage-dependent Anion Channel and theLAn Interaction between Bcl-x Molecular Biophysics :

  2013cites this paper
• Role of TRPM2 in cell proliferation and susceptibility to oxidative stress.

  2013cites this paper
• Rhodnius prolixus the Blood Sucking Insect Dysfunction and Impairs Embryogenesis in Protein Causes Embryonic Mitochondrial Silencing of Maternal Heme-binding Metabolism :

  2013cites this paper
• The role of mitochondrial calcium uniporter in neuroprotection in traumatic brain injury.

  2013cites this paper
• MICU1 motifs define mitochondrial calcium uniporter binding and activity.

  2013influential citation
• The TR (i)P to Ca²⁺ signaling just got STIMy: an update on STIM1 activated TRPC channels.

  2012cites this paper
• MICU1 is an essential gatekeeper for MCU-mediated mitochondrial Ca(2+) uptake that regulates cell survival.

  2012cites this paper
• Martin Picard , Russell T . Hepple and Yan Burelle optimal function and oxidative muscle fibers : tailoring the organelle for Mitochondrial functional specialization in glycolytic

  2012cites this paper