SLAIN2 links microtubule plus end–tracking proteins and controls microtubule growth in interphase

SLAIN2’s interactions with multiple different microtubule plus end–tracking proteins stimulate processive microtubule polymerization and ensure proper microtubule organization.

• Publication year

  2011

• Venue

  Journal of Cell Biology

• Publication date

  2011-06-13

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.201012179PMID 21646404PMCID 3115796
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• The role of TOG domains in microtubule plus end dynamics.

  2009influential reference
• TOGp regulates microtubule assembly and density during mitosis and contributes to chromosome directional instability.

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• An EB1-binding motif acts as a microtubule tip localization signal.

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  2008influential reference
• Capturing protein tails by CAP-Gly domains.

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• Tracking the ends: a dynamic protein network controls the fate of microtubule tips

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