Control of microtubule organization and dynamics: two ends in the limelight

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Nature reviews. Molecular cell biology

• Publication date

  2015-11-12

• Fields of study

  Biology, Medicine, Physics

• Identifiers
  DOI 10.1038/nrm4084PMID 26562752
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mechanistic Origin of Microtubule Dynamic Instability and Its Modulation by EB Proteins.

  2015cited by this paper
• Microtubule-associated proteins control the kinetics of microtubule nucleation

  2015cited by this paper
• +TIP EB1 downregulates paclitaxel‑induced proliferation inhibition and apoptosis in breast cancer cells through inhibition of paclitaxel binding on microtubules.

  2015cited by this paper
• Photoswitchable Inhibitors of Microtubule Dynamics Optically Control Mitosis and Cell Death.

  2015cited by this paper
• A proteomic study of mitotic phase-specific interactors of EB1 reveals a role for SXIP-mediated protein interactions in anaphase onset

  2015cited by this paper
• The C-terminal region of the motor protein MCAK controls its structure and activity through a conformational switch

  2015cited by this paper
• CLASP2-dependent microtubule capture at the neuromuscular junction membrane requires LL5β and actin for focal delivery of acetylcholine receptor vesicles

  2015cited by this paper
• Minus-end-directed Kinesin-14 motors align antiparallel microtubules to control metaphase spindle length.

  2014cited by this paper
• Spectraplakins.

  2014cited by this paper
• Microtubule +TIP protein EB1 binds to GTP and undergoes dissociation from dimer to monomer on binding GTP.

  2014cited by this paper
• Reconstitution of dynein transport to the microtubule plus end by kinesin

  2014cited by this paper
• Microtubule organization and microtubule-associated proteins in plant cells.

  2014cited by this paper
• PTRN-1, a microtubule minus end-binding CAMSAP homolog, promotes microtubule function in Caenorhabditis elegans neurons

  2014cited by this paper
• Actin–microtubule coordination at growing microtubule ends

  2014cited by this paper
• The Kinesin-4 Protein KIF7 Regulates Mammalian Hedgehog Signaling by Organizing the Cilia Tip Compartment

  2014cited by this paper
• CLASPs link focal adhesion-associated microtubule capture to localized exocytosis and adhesion site turnover

  2014cited by this paper
• CLASPs are required for proper microtubule localization of end-binding proteins.

  2014cited by this paper
• Micropattern-guided assembly of overlapping pairs of dynamic microtubules.

  2014cited by this paper
• Structural basis of microtubule stabilization by laulimalide and peloruside A.

  2014cited by this paper
• Nucleotide exchange in dimeric MCAK induces longitudinal and lateral stress at microtubule ends to support depolymerization.

  2014cited by this paper
• Peptide aptamers define distinct EB1- and EB3-binding motifs and interfere with microtubule dynamics

  2014cited by this paper
• Mechanical and geometrical constraints control kinesin-based microtubule guidance.

  2014cited by this paper
• Regulation of microtubule minus-end dynamics by CAMSAPs and Patronin

  2014cited by this paper
• The microtubule minus-end-binding protein patronin/PTRN-1 is required for axon regeneration in C. elegans.

  2014cited by this paper
• EB1 Accelerates Two Conformational Transitions Important for Microtubule Maturation and Dynamics

  2014cited by this paper
• The Caenorhabditis elegans microtubule minus-end binding homolog PTRN-1 stabilizes synapses and neurites

  2014cited by this paper
• The contribution of αβ-tubulin curvature to microtubule dynamics

  2014cited by this paper
• End-binding 1 protein overexpression correlates with glioblastoma progression and sensitizes to Vinca-alkaloids in vitro and in vivo

  2014cited by this paper
• Pre-anaphase chromosome oscillations are regulated by the antagonistic activities of Cdk1 and PP1 on Kif18A

  2014cited by this paper
• Promoting microtubule assembly: A hypothesis for the functional significance of the +TIP network

  2014cited by this paper
• Microtubule minus-end binding protein CAMSAP2 controls axon specification and dendrite development.

  2014cited by this paper
• The XMAP215 family drives microtubule polymerization using a structurally diverse TOG array

  2014cited by this paper
• A tethered delivery mechanism explains the catalytic action of a microtubule polymerase

  2014cited by this paper
• A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

  2014cited by this paper
• Dynamic microtubules catalyze formation of navigator-TRIO complexes to regulate neurite extension.

  2014cited by this paper
• Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition.

  2014cited by this paper
• High-resolution microtubule structures reveal the structural transitions in αβ-tubulin upon GTP hydrolysis.

  2014cited by this paper
• Regulation of microtubule motors by tubulin isotypes and posttranslational modifications

  2014cited by this paper
• Reconstitution of a hierarchical +TIP interaction network controlling microtubule end tracking of dynein

  2014cited by this paper
• Superresolution imaging reveals structural features of EB1 in microtubule plus-end tracking

  2014cited by this paper
• Ordered Recruitment of Dynactin to the Microtubule Plus-End is Required for Efficient Initiation of Retrograde Axonal Transport

  2013cited by this paper
• Aurora B inhibits MCAK activity through a phosphoconformational switch that reduces microtubule association.

  2013cited by this paper
• Molecular Mechanism of Action of Microtubule-Stabilizing Anticancer Agents

  2013cited by this paper
• Cell Cycle Regulation of Microtubule Interactomes: Multi-layered Regulation Is Critical for the Interphase/Mitosis Transition

  2013cited by this paper
• Kinetochore kinesin CENP-E is a processive bi-directional tracker of dynamic microtubule tips

  2013cited by this paper
• Patronin mediates a switch from kinesin-13–dependent poleward flux to anaphase B spindle elongation

  2013cited by this paper
• Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration.

  2013cited by this paper
• CFEOM1-associated kinesin KIF21A is a cortical microtubule growth inhibitor.

  2013cited by this paper
• Overexpression, purification, and functional analysis of recombinant human tubulin dimer

  2013cited by this paper
• Structural insights into the EB1–APC interaction

  2013cited by this paper
• Aurora B spatially regulates EB3 phosphorylation to coordinate daughter cell adhesion with cytokinesis

  2013cited by this paper
• End-binding proteins sensitize microtubules to the action of microtubule-targeting agents

  2013cited by this paper
• Dynactin Subunit p150Glued Is a Neuron-Specific Anti-Catastrophe Factor

  2013cited by this paper
• Branching microtubule nucleation in Xenopus egg extracts mediated by augmin and TPX2.

  2013cited by this paper
• The human kinesin‐14 HSET tracks the tips of growing microtubules in vitro

  2013cited by this paper
• Synergy between XMAP215 and EB1 increases microtubule growth rates to physiological levels

  2013cited by this paper
• Mechanisms of spindle positioning

  2013cited by this paper
• Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.

  2013cited by this paper
• A TOG:αβ-tubulin Complex Structure Reveals Conformation-Based Mechanisms for a Microtubule Polymerase

  2012cited by this paper
• Amer2 Protein Interacts with EB1 Protein and Adenomatous Polyposis Coli (APC) and Controls Microtubule Stability and Cell Migration*

  2012cited by this paper
• Dissecting the Nanoscale Distributions and Functions of Microtubule-End-Binding Proteins EB1 and ch-TOG in Interphase HeLa Cells

  2012cited by this paper
• A Proteome-wide screen for mammalian SxIP motif-containing microtubule plus-end tracking proteins.

  2012cited by this paper
• Dynein tethers and stabilizes dynamic microtubule plus ends.

  2012cited by this paper
• EBs Recognize a Nucleotide-Dependent Structural Cap at Growing Microtubule Ends

  2012cited by this paper
• Fission yeast Alp14 is a dose-dependent plus end–tracking microtubule polymerase

  2012cited by this paper
• Reconstitution of dynamic microtubules with Drosophila XMAP215, EB1, and Sentin

  2012cited by this paper
• Spectraplakins Promote Microtubule-Mediated Axonal Growth by Functioning As Structural Microtubule-Associated Proteins and EB1-Dependent +TIPs (Tip Interacting Proteins)

  2012cited by this paper
• Nezha/CAMSAP3 and CAMSAP2 cooperate in epithelial-specific organization of noncentrosomal microtubules

  2012cited by this paper
• Move in for the kill: motile microtubule regulators.

  2012cited by this paper
• Multisite Phosphorylation Disrupts Arginine-Glutamate Salt Bridge Networks Required for Binding of Cytoplasmic Linker-associated Protein 2 (CLASP2) to End-binding Protein 1 (EB1)*

  2012cited by this paper
• Microtubule attachment and spindle assembly checkpoint signalling at the kinetochore

  2012cited by this paper
• A mutation of the fission yeast EB1 overcomes negative regulation by phosphorylation and stabilizes microtubules.

  2012cited by this paper
• EB1 acetylation by P300/CBP-associated factor (PCAF) ensures accurate kinetochore–microtubule interactions in mitosis

  2012cited by this paper
• Cortical dynein controls microtubule dynamics to generate pulling forces that position microtubule asters.

  2012cited by this paper
• The kinesin-14 Klp2 is negatively regulated by the SIN for proper spindle elongation and telophase nuclear positioning

  2012cited by this paper
• Phase Transitions in the Assembly of Multi-Valent Signaling Proteins

  2012cited by this paper
• Conformational changes in tubulin in GMPCPP and GDP-taxol microtubules observed by cryoelectron microscopy

  2012cited by this paper
• +TIPs: SxIPping along microtubule ends.

  2012cited by this paper
• The microtubule lattice and plus-end association of Drosophila Mini spindles is spatially regulated to fine-tune microtubule dynamics

  2011cited by this paper
• Kif18A uses a microtubule binding site in the tail for plus-end localization and spindle length regulation.

  2011cited by this paper
• Drosophila katanin is a microtubule depolymerase that regulates cortical-microtubule plus-end interactions and cell migration

  2011cited by this paper
• K-fibre minus ends are stabilized by a RanGTP-dependent mechanism essential for functional spindle assembly

  2011cited by this paper
• Design, overexpression, and purification of polymerization-blocked yeast αβ-tubulin mutants.

  2011cited by this paper
• MAP4 and CLASP1 operate as a safety mechanism to maintain a stable spindle position in mitosis

  2011cited by this paper
• Microtubule nucleation by γ-tubulin complexes

  2011cited by this paper
• Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP.

  2011cited by this paper
• GTPγS microtubules mimic the growing microtubule end structure recognized by end-binding proteins (EBs)

  2011cited by this paper
• A tethering mechanism controls the processivity and kinetochore-microtubule plus-end enrichment of the kinesin-8 Kif18A.

  2011cited by this paper
• XMAP215 polymerase activity is built by combining multiple tubulin-binding TOG domains and a basic lattice-binding region

  2011cited by this paper
• Insights into EB1 structure and the role of its C-terminal domain for discriminating microtubule tips from the lattice

  2011cited by this paper
• Mechanisms underlying the dual-mode regulation of microtubule dynamics by Kip3/kinesin-8.

  2011cited by this paper
• Purification of tubulin from the fission yeast Schizosaccharomyces pombe.

  2011cited by this paper
• A complex of Kif18b and MCAK promotes microtubule depolymerization and is negatively regulated by Aurora kinases.

  2011cited by this paper
• The determinants that govern microtubule assembly from the atomic structure of GTP-tubulin.

  2011cited by this paper
• SLAIN2 links microtubule plus end–tracking proteins and controls microtubule growth in interphase

  2011cited by this paper
• Depolymerizing kinesins Kip3 and MCAK shape cellular microtubule architecture by differential control of catastrophe.

  2011cited by this paper
• Directed microtubule growth, +TIPs, and kinesin-2 are required for uniform microtubule polarity in dendrites.

  2010cited by this paper
• Microtubule-binding agents: a dynamic field of cancer therapeutics

  2010cited by this paper
• Membrane Invaginations Reveal Cortical Sites that Pull on Mitotic Spindles in One-Cell C. elegans Embryos

  2010cited by this paper
• The kinesin-8 Kif18A dampens microtubule plus-end dynamics.

  2010cited by this paper

• Loss of meningeal lymphatic endothelial cells results in formation of a newly forming vascular network with scavenging function.

  2026cites this paper
• Oncogenic β-tubulin mutations disrupt nucleotide-dependent allostery and free energy landscape of tubulin dimer.

  2026cites this paper
• Discovery of New Quinazolinone and Benzimidazole Analogs as Tubulin Polymerization Inhibitors with Potent Anticancer Activities

  2026cites this paper
• FRY Mediates THP1-Driven Ovarian Cancer Invasion Through the PI3K/AKT Pathway

  2026cites this paper
• Tubulin polymerization dynamics are influenced by magnetic isotope effects consistent with the radical pair mechanism

  2026cites this paper
• Insights into Microtubule Nucleation at the Golgi Apparatus.

  2026cites this paper
• A cryo-EM processing pipeline for microtubules using CryoSPARC

  2026cites this paper
• A genetically encoded microtubule bundler for causal dissection of microtubule bundling in cells

  2026cites this paper
• Regulatory effect of inflammatory mediators in spinal cord injury

  2025cites this paper
• 20 years of taxane therapy in prostate cancer - the past, present and future.

  2025cites this paper
• Enhancement Effects of α4/α6‐Targeted Inhibitors on Eg5‐Microtubule Interaction

  2025cites this paper
• An innovative analytical simulation for scale-dependent transverse vibration of isolated protein microtubules

  2025cites this paper
• Distinct liquid-liquid phase separation properties of end-binding proteins EB1 and EB3

  2025cites this paper
• Ultrasound-targeted microbubble destruction disrupts the blood-testis barrier.

  2025cites this paper
• A Fractional Order Standard Linear Solid Model for Extracting the Elastic Moduli of Internal Cell Structures.

  2025cites this paper
• Effects of Microplastic Accumulation on Neuronal Death After Global Cerebral Ischemia

  2025cites this paper
• Chemically-fueled phase transition of a redox-responsive polymer

  2025cites this paper
• The interaction between KATNA1 and CRMP3 modulates microtubule dynamics and neurite outgrowth.

  2025cites this paper
• The Structural Basis of alpha/beta-tubulin Assembly and Disassembly by Tubulin Cofactors

  2025cites this paper
• Dock-and-lock binding of SxIP ligands is required for stable and selective EB1 interactions

  2025cites this paper
• Class II kinesin-12 facilitates cell plate formation by transporting cell plate materials in the phragmoplast

  2025cites this paper
• Transforming an ATP-dependent enzyme into a dissipative, self-assembling system

  2025cites this paper
• A biochemical mechanism for Stu2/XMAP215-family microtubule polymerases

  2025cites this paper
• Phase Separation and a Hydrodynamic Instability Localize Proteins at Growing Microtubule Ends

  2025cites this paper
• Application of temperature replica exchange molecular dynamics: Structure of mitotic spindle-associated protein SHE1 and its binding to dynein

  2025cites this paper
• Development of a Microfluidics-Based Approach for Investigating Microtubule Polymer Mechanics.

  2025cites this paper
• Histone Deacetylase 6 Regulates α-Tubulin to Inhibit the Stimulator of Interferon Genes/NLR Family Pyrin Domain-Containing 3-Mediated Microglial Pyroptosis Induced by Herpes Simplex Virus Type 1 Infection.

  2025cites this paper
• Structural changes of tubulin by interacting with Δ9-tetrahydrocannabinol: in-vitro and theoretical studies

  2025cites this paper
• Discovery of pyrazolo[1,5-a]pyrimidines: Synthesis, in silico insights, and anticancer activity via novel CDK2/Tubulin dual inhibition approach.

  2025cites this paper
• Tubulin targeting agents and their implications in non-cancer disease management.

  2025cites this paper
• A Pyrimidine-Based Tubulin Inhibitor Shows Potent Anti-Glioblastoma Activity In Vitro and In Vivo.

  2025cites this paper
• Kinesin-12 KLP-18 contributes to the kinetochore-microtubule poleward flux during the metaphase of C. elegans one-cell embryo

  2025cites this paper
• Chlamydomonas protein kinase MAK phosphorylates FAP256/CEP104 and regulates axonemal microtubule assembly.

  2025cites this paper
• A single-component optogenetic toolkit for programmable control of microtubule

  2025cites this paper
• From the Cytoplasm into the Nucleus—Hepatitis B Virus Travel and Genome Repair

  2025cites this paper
• Cryo-EM structures of the tubulin cofactors reveal the molecular basis of alpha/beta-tubulin biogenesis

  2025cites this paper
• Investigation on LASSBio‐1971 and LASSBio‐1974 Cellular Cytotoxic Mechanism and Their Comparative DMPK Profile

  2025cites this paper
• New insights into the influence of temperature on axonal transport and function in myelinated regions of Schwann cells

  2025cites this paper
• Structures, energetics, and dynamics of active tubulin self-organization

  2025cites this paper
• Microtubules and mechanosensing: key players in endothelial responses to mechanical stimuli

  2025cites this paper
• DCLK1 in gastrointestinal cancer: A driver of tumor progression and a promising therapeutic target

  2025cites this paper
• A Benzodiazepine-Derived Molecule That Interferes with the Bio-Mechanical Properties of Glioblastoma-Astrocytoma Cells Altering Their Proliferation and Migration

  2025cites this paper
• Synergistic Adhesion and Shape Deformation in Nanowire‐Structured Liquid Crystal Elastomers

  2025cites this paper
• Diversity of microtubule arrays in animal cells at a glance.

  2025cites this paper
• The dose-dependent effects of dissolved biochar on C. elegans: insights into the physiological and transcriptomic responses

  2025cites this paper
• Vinpocetine Overcomes Paclitaxel Resistance in a Triple‐Negative Breast Cancer Cell Line

  2025cites this paper
• Potential anticancer effects of Peganum harmala in human papillomavirus-related cervical and head and neck cancer cells

  2025cites this paper
• Rotational Diffusion Kinetics of Copper (I) Catalyzed Alkyne-Azide Cycloaddition Reactions ★

  2025cites this paper
• Microtubule acetylation is a biomarker of cytoplasmic health during cellular senescence

  2025cites this paper
• Magnetic Field-dependent Isotope Effect Supports Radical Pair Mechanism in Tubulin Polymerization

  2025cites this paper
• Microtubule-Associated Proteins (MAPs) Are Multifunctional Cytoskeletal Proteins in the Testis That Regulate Spermatogenesis.

  2025cites this paper
• Regulation of the Yolk Microtubule and Actin Cytoskeleton by Dachsous Cadherins during Zebrafish Epiboly

  2025cites this paper
• CKAP5 promotes progression and cisplatin resistance in esophageal squamous cell carcinoma via microtubule-mediated YAP activation.

  2025cites this paper
• Investigation of the Effects of Salinity Exposure on Immune Defense, Morphology, and Gene Expression in the Gills of Macrobrachium nipponense

  2025cites this paper
• The microtubule‐binding domain of spastin participates in microtubule severing through electrostatic interactions

  2025cites this paper
• Did Axons Evolve by Activating Cytokinesis During Interphase? A Hypothesis on the Origin of Neurons.

  2025cites this paper
• Redox-associated phase transition of a marginally stable synthetic polymer.

  2025cites this paper
• Supramolecular Protein Nanotubes with Optical Tunable Properties.

  2025cites this paper
• Gαi2 Interaction with EB1 controls microtubule dynamics and Rac1 activity in Xenopus neural crest cell migration.

  2025cites this paper
• Microtubule lattice defects facilitate spastin-mediated severing

  2025cites this paper
• Analysis of Microtubule Polymerization During Axon Outgrowth Using Fluorescently Labeled Microtubule Plus-End Tracking Proteins.

  2024cites this paper
• Genetically Encoded Microtubule Binders for Single-Cell Interrogation of Cytoskeleton Dynamics and Protein Activity

  2024cites this paper
• Efficient Self-Sorting Behaviours of Metallacages with Subtle Structural Differences.

  2024cites this paper
• CLASP-mediated competitive binding in protein condensates directs microtubule growth

  2024cites this paper
• AlphaFold2-guided engineering of split-GFP technology enables labeling of endogenous tubulins across species while preserving function

  2024cites this paper
• Centrosomal Protein 55 Regulates Chromosomal Instability in Cancer Cells by Controlling Microtubule Dynamics

  2024cites this paper
• A stable microtubule bundle formed through an orchestrated multistep process controls quiescence exit

  2024cites this paper
• CAMSAP3 Forms Dimers via its α-helix Domain that Directly Stabilize Non-centrosomal Microtubule Minus Ends

  2024cites this paper
• Quantitatively Dissecting Triple Roles of Dynactin in Dynein-Driven Transport of Influenza Virus by Quantum Dot-Based Single-Virus Tracking.

  2024cites this paper
• Modulation of microtubule dynamics by monovalent ions

  2024cites this paper
• Advances in understanding the roles of actin scaffolding and membrane trafficking in dendrite development.

  2024cites this paper
• Redox signaling by hydrogen peroxide modulates axonal microtubule organization and induces a specific phosphorylation signature of microtubule proteins distinct from distress

  2024cites this paper
• Liquid–liquid phase separation of microtubule‐binding proteins in the regulation of spindle assembly

  2024cites this paper
• Phase separation of a microtubule plus-end tracking protein into a fluid fractal network

  2024cites this paper
• The Drosophila Nesprin-1 homolog MSP300 is required for muscle autophagy and proteostasis

  2024cites this paper
• Tracking the effects of PLGA-based nanoparticles on protein expression in living cells through quantitative proteomics.

  2024cites this paper
• Functional genetics reveals modulators of anti-microtubule drug sensitivity

  2024cites this paper
• Combretastatins A-4 and A-1 and their derivatives: Review

  2024cites this paper
• Microtubule-Targeting Agents: Disruption of the Cellular Cytoskeleton as a Backbone of Ovarian Cancer Therapy.

  2024cites this paper
• The Microtubule End Binding Protein Mal3 Is Essential for the Dynamic Assembly of Microtubules during Magnaporthe oryzae Growth and Pathogenesis

  2024cites this paper
• Organization of microtubule plus-end dynamics by phase separation in mitosis

  2024cites this paper
• Force-transducing molecular ensembles at growing microtubule tips control mitotic spindle size

  2024cites this paper
• Microtubule specialization by +TIP networks: from mechanisms to functional implications.

  2024cites this paper
• An internally controlled system to study microtubule network diversification links tubulin evolution to the use of distinct microtubule regulators

  2024cites this paper
• CSPP1 stabilizes microtubules by capping both plus and minus ends

  2024cites this paper
• Clostridioides difficile infection: history, epidemiology, risk factors, prevention, clinical manifestations, treatment, and future options

  2024cites this paper
• A structural and dynamic visualization of the interaction between MAP7 and microtubules

  2024cites this paper
• Roles of the tubulin-based cytoskeleton in the Toxoplasma gondii apical complex.

  2024cites this paper
• The planar cell polarity (PCP) protein Fat 1 in Sertoli cell function.

  2024cites this paper
• A network of interacting ciliary tip proteins with opposing activities imparts slow and processive microtubule growth

  2024cites this paper
• Structure of the γ-tubulin ring complex-capped microtubule

  2024cites this paper
• Structure of the native γ-tubulin ring complex capping spindle microtubules

  2024cites this paper
• Damage–repair events increase the instability of cortical microtubules in Arabidopsis

  2024cites this paper
• The Role of the Host Cytoskeleton in the Formation and Dynamics of Rotavirus Viroplasms

  2024cites this paper
• In-Cell Association of a Bioorthogonal Tubulin.

  2024cites this paper
• Tubulin Complexity in Cancer and Metastasis.

  2024cites this paper
• Kojic Acid Derivative as an Antimitotic Agent That Selectively Kills Tumour Cells

  2024cites this paper
• Lithium Promotes Osteogenesis via Rab11a-Facilitated Exosomal Wnt10a Secretion and β-Catenin Signaling Activation.

  2024cites this paper
• End Binding Proteins: Drivers of Cancer Progression

  2024cites this paper
• Benzimidazole inhibits Haemonchus contortus microtubule dynamics by intradimer structural changes observed by in silico modeling

  2024cites this paper