Cellular and molecular mechanisms of synaptic specificity.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  Annual Review of Cell and Developmental Biology

• Publication date

  2014-10-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1146/annurev-cellbio-100913-012953PMID 25150010
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2006cited by this paper
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