Hyperpolarized 13C magnetic resonance reveals early- and late-onset changes to in vivo pyruvate metabolism in the failing heart

Impaired energy metabolism has been implicated in the pathogenesis of heart failure. Hyperpolarized 13C magnetic resonance (MR), in which 13C‐labelled metabolites are followed using MR imaging (MRI) or spectroscopy (MRS), has enabled non‐invasive assessment of pyruvate metabolism. We investigated the hypothesis that if we serially examined a model of heart failure using non‐invasive hyperpolarized [13C]pyruvate with MR, the profile of in vivo pyruvate oxidation would change throughout the course of the disease.

• Publication year

  2012

• Venue

  European Journal of Heart Failure

• Publication date

  2012-12-19

• Fields of study

  Medicine

• Identifiers
  DOI 10.1093/eurjhf/hfs192PMID 23258802PMCID 3547367
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Cycling of Acetyl-Coenzyme A Through Acetylcarnitine Buffers Cardiac Substrate Supply: A Hyperpolarized 13C Magnetic Resonance Study

  2012cited by this paper
• Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2‐13C2]pyruvate in vivo

  2012cited by this paper
• Integrated Bloch‐Siegert B1 mapping and multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart

  2012cited by this paper
• Targeting myocardial substrate metabolism in heart failure: potential for new therapies

  2012cited by this paper
• Could 13C MRI assist clinical decision‐making for patients with heart disease?

  2011cited by this paper
• Role of Pyruvate Dehydrogenase Inhibition in the Development of Hypertrophy in the Hyperthyroid Rat Heart: A Combined Magnetic Resonance Imaging and Hyperpolarized Magnetic Resonance Spectroscopy Study

  2011cited by this paper
• Validation of the in vivo assessment of pyruvate dehydrogenase activity using hyperpolarised 13C MRS

  2011cited by this paper
• Hyperpolarized Magnetic Resonance: A Novel Technique for the In Vivo Assessment of Cardiovascular Disease

  2011cited by this paper
• Radiation exposure from cardiac imaging procedures: do the risks outweigh the benefits?

  2010cited by this paper
• Radiation Exposure from Cardiac Imaging Procedures

  2010cited by this paper
• Rapid multislice imaging of hyperpolarized 13C pyruvate and bicarbonate in the heart

  2010cited by this paper
• Substrate–Enzyme Competition Attenuates Upregulated Anaplerotic Flux Through Malic Enzyme in Hypertrophied Rat Heart and Restores Triacylglyceride Content: Attenuating Upregulated Anaplerosis in Hypertrophy

  2009cited by this paper
• Real‐time assessment of Krebs cycle metabolism using hyperpolarized C magnetic resonance spectroscopy

  2009cited by this paper
• The adrenergic-fatty acid load in heart failure.

  2009cited by this paper
• Cardiac metabolism measured noninvasively by hyperpolarized 13C MRI

  2008cited by this paper
• In vivo assessment of pyruvate dehydrogenase flux in the heart using hyperpolarized carbon-13 magnetic resonance

  2008cited by this paper
• Recruitment of Compensatory Pathways to Sustain Oxidative Flux With Reduced Carnitine Palmitoyltransferase I Activity Characterizes Inefficiency in Energy Metabolism in Hypertrophied Hearts

  2007cited by this paper
• Hyperpolarized 13C allows a direct measure of flux through a single enzyme-catalyzed step by NMR

  2007cited by this paper
• The failing heart--an engine out of fuel.

  2007cited by this paper
• Real-time metabolic imaging.

  2006cited by this paper
• Time to address the cardiac metabolic "triple whammy" ischemic heart failure in diabetic patients.

  2006cited by this paper
• Metabolic Modulation With Perhexiline in Chronic Heart Failure: A Randomized, Controlled Trial of Short-Term Use of a Novel Treatment

  2005cited by this paper
• Myocardial substrate metabolism in the normal and failing heart.

  2005cited by this paper
• Recombinant Glucagon-Like Peptide-1 Increases Myocardial Glucose Uptake and Improves Left Ventricular Performance in Conscious Dogs With Pacing-Induced Dilated Cardiomyopathy

  2004cited by this paper
• The development of myocardial insulin resistance in conscious dogs with advanced dilated cardiomyopathy.

  2004cited by this paper
• Paradoxical downregulation of the glucose oxidation pathway despite enhanced flux in severe heart failure.

  2004cited by this paper
• Is the failing heart energy starved? On using chemical energy to support cardiac function.

  2004cited by this paper
• Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR

  2003cited by this paper
• Effect of Cardiac Resynchronization on Myocardial Efficiency and Regional Oxidative Metabolism

  2003cited by this paper
• Impaired Myocardial Fatty Acid Oxidation and Reduced Protein Expression of Retinoid X Receptor-alpha in Pacing-Induced Heart Failure

  2002cited by this paper
• Impaired Myocardial Fatty Acid Oxidation and Reduced Protein Expression of Retinoid X Receptor-&agr; in Pacing-Induced Heart Failure

  2002cited by this paper
• Metabolic Gene Expression in Fetal and Failing Human Heart

  2001cited by this paper
• Upregulation of the Cardiac Monocarboxylate Transporter MCT1 in a Rat Model of Congestive Heart Failure

  2001cited by this paper
• An evaluation of myocardial fatty acid and glucose uptake using PET with [18F]fluoro-6-thia-heptadecanoic acid and [18F]FDG in Patients with Congestive Heart Failure.

  2001cited by this paper
• Activation and Mitochondrial Translocation of Protein Kinase Cδ Are Necessary for Insulin Stimulation of Pyruvate Dehydrogenase Complex Activity in Muscle and Liver Cells*

  2001cited by this paper
• The Effects of β1-Blockade on Oxidative Metabolism and the Metabolic Cost of Ventricular Work in Patients With Left Ventricular Dysfunction

  2000cited by this paper
• The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.

  2000cited by this paper
• The effects of beta(1)-blockade on oxidative metabolism and the metabolic cost of ventricular work in patients with left ventricular dysfunction: A double-blind, placebo-controlled, positron-emission tomography study.

  2000cited by this paper
• Progressive loss of myocardial ATP due to a loss of total purines during the development of heart failure in dogs: a compensatory role for the parallel loss of creatine.

  1999cited by this paper
• The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation.

  1999cited by this paper
• Reduced nitric oxide production and altered myocardial metabolism during the decompensation of pacing-induced heart failure in the conscious dog.

  1998cited by this paper
• Cardiac and skeletal muscle insulin resistance in patients with coronary heart disease. A study with positron emission tomography.

  1996cited by this paper
• Fatty acid oxidation enzyme gene expression is downregulated in the failing heart.

  1996cited by this paper
• Total-body and myocardial substrate oxidation in congestive heart failure.

  1994cited by this paper
• Altered pyruvate dehydrogenase control and mitochondrial free Ca2+ in hearts of cardiomyopathic hamsters.

  1993cited by this paper
• 31P Magnetic Resonance Spectroscopy in Dilated Cardiomyopathy and Coronary Artery Disease: Altered Cardiac High‐Energy Phosphate Metabolism in Heart Failure

  1992cited by this paper

• Hyperpolarized [1-13C] pyruvate MRSI reveals a diet-dependent metabolic shift in ZSF1 rats.

  2025cites this paper
• Myocardial metabolic flexibility following ketone infusion demonstrated by hyperpolarized [2-13C]pyruvate MRS in pigs

  2025cites this paper
• Pyruvate plus uridine augment mitochondrial respiration and prevent cardiac hypertrophy in zebrafish and H9c2 cells.

  2025cites this paper
• Dilated cardiomyopathy evaluation with Imagenomics: combining multimodal cardiovascular imaging and genetics

  2025cites this paper
• Cardiac substrate metabolism in type 2 diabetes

  2025cites this paper
• Stable electron-irradiated [1-13C]alanine radicals for metabolic imaging with dynamic nuclear polarization

  2025cites this paper
• Gemini SERS for Cross-Category Biomarker Detection and Early Warning of Sudden Cardiac Death in Acute Coronary Syndrome.

  2025cites this paper
• The crosstalk between immune activation and metabolism in heart failure. A scientific statement of the Heart Failure Association of the ESC

  2025cites this paper
• Endosomal Mechanisms in Heart Failure Pathophysiology

  2025cites this paper
• Hyperpolarized [1-13C]pyruvate cardiovascular magnetic resonance imaging identifies metabolic phenotypes in patients with heart failure

  2024cites this paper
• Metabolic Effects of the SGLT2 Inhibitor Dapagliflozin in Heart Failure Across the Spectrum of Ejection Fraction

  2024cites this paper
• Post-translational modifications of pyruvate dehydrogenase complex in cardiovascular disease

  2024cites this paper
• The pig as an optimal animal model for cardiovascular research

  2024cites this paper
• MRI Application and Challenges of Hyperpolarized Carbon-13 Pyruvate in Translational and Clinical Cardiovascular Studies: A Literature Review

  2024cites this paper
• First in‐human evaluation of [1‐13C]pyruvate in D2O for hyperpolarized MRI of the brain: A safety and feasibility study

  2024cites this paper
• Mitochondrial fatty acid oxidation is the major source of cardiac ATP production in heart failure with preserved ejection fraction.

  2024cites this paper
• SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts

  2024cites this paper
• Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF

  2024cites this paper
• Volumetric Patch-Based Super-Resolution Reconstruction of Hyperpolarized 13C Cardiac MRI

  2024cites this paper
• Advances in myocardial energy metabolism: metabolic remodelling in heart failure and beyond

  2024cites this paper
• Advancements, challenges, and future prospects in clinical hyperpolarized magnetic resonance imaging: A comprehensive review

  2024cites this paper
• Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate MRI evaluated in an oral glucose challenge

  2023cites this paper
• Current Methods for Hyperpolarized [1-13C]pyruvate MRI Human Studies

  2023cites this paper
• Regional quantification of cardiac metabolism with hyperpolarized [1-13C]-pyruvate CMR evaluated in an oral glucose challenge

  2023cites this paper
• From Energy Metabolic Change to Precision Therapy: a Holistic View of Energy Metabolism in Heart Failure

  2023cites this paper
• Real‐time influence of intracellular acidification and Na+/H+ exchanger inhibition on in‐cell pyruvate metabolism in the perfused mouse heart: A 31P‐NMR and hyperpolarized 13C‐NMR study

  2023cites this paper
• Metabolic mechanisms in physiological and pathological cardiac hypertrophy: new paradigms and challenges

  2023cites this paper
• Retained Metabolic Flexibility of the Failing Human Heart

  2023cites this paper
• Cardiac Metabolism in Heart Failure and Implications for Uremic Cardiomyopathy

  2023cites this paper
• Developing a metabolic clearance rate framework as a translational analysis approach for hyperpolarized 13C magnetic resonance imaging

  2023cites this paper
• Nicotinamide Adenosine Dinucleotide Phosphate Oxidase-Mediated Signaling in Cardiac Remodeling

  2023cites this paper
• Stimulating cardiac glucose oxidation lessens the severity of heart failure in aged female mice

  2023cites this paper
• The Role of Ranolazine in Heart Failure-Current Concepts.

  2023cites this paper
• Hyperpolarized Metabolic and Parametric CMR Imaging of Longitudinal Metabolic-Structural Changes in Experimental Chronic Infarction.

  2022cites this paper
• Metabolic clearance rate modeling: A translational approach to quantifying cerebral metabolism using hyperpolarized [1-13C]pyruvate

  2022cites this paper
• Multinuclear MRI in Drug Discovery

  2022cites this paper
• Deciphering metabolic remodeling of the failing hearts

  2022cites this paper
• Magnetic resonance imaging of cardiac metabolism in heart failure: how far have we come?

  2022cites this paper
• Insights Into the Metabolic Aspects of Aortic Stenosis With the Use of Magnetic Resonance Imaging

  2022cites this paper
• Targeting Myocardial Substrate Metabolism in the Failing Heart: Ready for Prime Time?

  2022cites this paper
• In Vivo Magnetic Resonance Spectroscopy Methods for Investigating Cardiac Metabolism

  2022cites this paper
• Deranged Myocardial Fatty Acid Metabolism in Heart Failure

  2022cites this paper
• Characterization and compensation of f 0 inhomogeneity artifact in spiral hyperpolarized 13C imaging of the human heart

  2021cites this paper
• Hyperpolarized Magnetic Resonance With Dissolution Dynamic Nuclear Polarization: Principles and Applications

  2021cites this paper
• The Importance of Mitochondrial Pyruvate Carrier in Cancer Cell Metabolism and Tumorigenesis

  2021cites this paper
• Cardiac T2∗ measurement of hyperpolarized 13C metabolites using metabolite‐selective multi‐echo spiral imaging

  2021cites this paper
• Novel Views on Heart Function from Dynamic Hyperpolarized NMR

  2021cites this paper
• New Insights into Metabolic Regulation from Hyperpolarized 13C MRS/MRI Studies

  2021cites this paper
• Hyperpolarized Metabolic MRI—Acquisition, Reconstruction, and Analysis Methods

  2021cites this paper
• Cardiac Energy Metabolism in Heart Failure

  2021cites this paper
• Dynamic 13C MR spectroscopy as an alternative to imaging for assessing cerebral metabolism using hyperpolarized pyruvate in humans

  2021cites this paper
• Remodeling after myocardial infarction and effects of heart failure treatment investigated by hyperpolarized [1‐13C]pyruvate magnetic resonance spectroscopy

  2021cites this paper
• Cardio-Oncology

  2021cites this paper
• HP acquisition methods: pulse sequences, reconstruction, and RF coils

  2021cites this paper
• Use of cardiac magnetic resonance to detect changes in metabolism in heart failure.

  2020cites this paper
• MRI of [2‐13C]Lactate without J‐coupling artifacts

  2020influential citation
• Correlation between lactate dehydrogenase/pyruvate dehydrogenase activities ratio and tissue pH in the perfused mouse heart: A potential noninvasive indicator of cardiac pH provided by hyperpolarized magnetic resonance

  2020cites this paper
• Regulation of MPCs and KAT8 During Adipogenesis and Nutritional Regulation

  2020cites this paper
• Cardiac metabolic imaging using hyperpolarized [1-13C]lactate as a substrate

  2020cites this paper
• Increasing carbohydrate oxidation improves contractile reserves and prevents hypertrophy in porcine right heart failure

  2020cites this paper
• Clinical Cardiovascular Applications of Hyperpolarized Magnetic Resonance

  2020cites this paper
• Measuring the link between cardiac mechanical function and metabolism during hyperpolarized 13C-pyruvate magnetic resonance experiments.

  2020cites this paper
• Implications of Altered Ketone Metabolism and Therapeutic Ketosis in Heart Failure

  2020cites this paper
• Adaptations in Protein Expression and Regulated Activity of Pyruvate Dehydrogenase Multienzyme Complex in Human Systolic Heart Failure

  2019cites this paper
• What fuels the failing heart ?

  2019cites this paper
• Magnetic resonance hyperpolarization imaging detects early myocardial dysfunction in a porcine model of right ventricular heart failure

  2019cites this paper
• Biomedical Applications of the Dynamic Nuclear Polarization and Parahydrogen Induced Polarization Techniques for Hyperpolarized 13C MR Imaging

  2019cites this paper
• Zero-field nuclear magnetic resonance of chemically exchanging systems

  2019cites this paper
• Acquisition strategies for spatially resolved magnetic resonance detection of hyperpolarized nuclei

  2019cites this paper
• [The role of small molecules in metabolism regulation (review).]

  2019cites this paper
• Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease

  2019cites this paper
• Metabolic Imaging in Cardio-oncology

  2019cites this paper
• Hyperpolarized 13C MRI: State of the Art and Future Directions.

  2019cites this paper
• Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.

  2019cites this paper
• Kinetic Analysis of Hepatic Metabolism Using Hyperpolarized Dihydroxyacetone

  2019cites this paper
• 13C Pyruvate Transport Across the Blood-Brain Barrier in Preclinical Hyperpolarised MRI

  2018cites this paper
• Simultaneous multislice acquisition without trajectory modification for hyperpolarized 13C experiments

  2018cites this paper
• Acute hypertensive stress imaged by cardiac hyperpolarized [1‐13C]pyruvate magnetic resonance

  2018cites this paper
• Uncoupling of glycolysis from glucose oxidation accompanies the development of heart failure with preserved ejection fraction

  2018cites this paper
• Technique development of 3D dynamic CS‐EPSI for hyperpolarized 13C pyruvate MR molecular imaging of human prostate cancer

  2018cites this paper
• Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-13C]Pyruvate.

  2018cites this paper
• Hyperpolarised magnetic resonance for in vivo real-time metabolic imaging

  2018cites this paper
• Assessing the influence of isoflurane anesthesia on cardiac metabolism using hyperpolarized [1‐13C]pyruvate

  2018cites this paper
• Dual‐Echo EPI sequence for integrated distortion correction in 3D time‐resolved hyperpolarized 13C MRI

  2018cites this paper
• Probing the cardiac malate–aspartate shuttle non‐invasively using hyperpolarized [1,2‐13C2]pyruvate

  2018cites this paper
• Improved tolerance to off‐resonance in spectral‐spatial EPI of hyperpolarized [1‐13C]pyruvate and metabolites

  2018cites this paper
• Cancer in the crosshairs: targeting cancer metabolism with hyperpolarized carbon‐13 MRI technology

  2018cites this paper
• Loss of Metabolic Flexibility in the Failing Heart

  2018cites this paper
• Mitochondrial metabolism in pulmonary hypertension: beyond mountains there are mountains

  2018cites this paper
• Metabolic and Molecular Imaging with Hyperpolarised Tracers

  2018cites this paper
• The effects of ginsenoside Rb1 on fatty acid β-oxidation, mediated by AMPK, in the failing heart

  2018influential citation
• Heart Failure with Preserved Ejection Fraction : Pathologies , Aetiology and Directions for Treatment

  2018cites this paper
• Hyperpolarized [1‐13C]pyruvate MRI can image the metabolic shift in cardiac metabolism between the fasted and fed state in a porcine model

  2018cites this paper
• Imaging myocardial metabolism

  2018cites this paper
• Ischemic Heart Disease and Heart Failure: Advanced Magnetic Resonance Spectroscopy and Metabolic Imaging

  2018cites this paper
• Myocyte Metabolic Imaging with Hyperpolarised MRI

  2018cites this paper
• Cardiac applications of hyperpolarised magnetic resonance.

  2018cites this paper
• Hyperpolarized carbon-13 magnetic resonance spectroscopic imaging: a clinical tool for studying tumour metabolism.

  2018cites this paper
• PET-CMR in heart failure - synergistic or redundant imaging?

  2017cites this paper
• Accelerated 3D echo‐planar imaging with compressed sensing for time‐resolved hyperpolarized 13C studies

  2017cites this paper