Regulation and activation of p53 and its family members

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Cell Death and Differentiation

• Publication date

  1999-12-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.cdd.4400625PMID 10637431
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The ubiquitin system

  2000cited by this paper
• Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2

  1999cited by this paper
• DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation

  1999cited by this paper
• The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

  1999cited by this paper
• p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

  1999cited by this paper
• p73 is regulated by tyrosine kinase c-Abl in the apoptotic response to DNA damage

  1999cited by this paper
• E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways.

  1999cited by this paper
• Regulation of p53 stability

  1999cited by this paper
• Covalent and noncovalent modifiers of the p53 protein

  1999cited by this paper
• Mdm2 binds p73 alpha without targeting degradation.

  1999cited by this paper
• Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis.

  1999cited by this paper
• p73 Function Is Inhibited by Tumor-Derived p53 Mutants in Mammalian Cells

  1999cited by this paper
• MDM2 Suppresses p73 Function without Promoting p73 Degradation

  1999cited by this paper
• Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53

  1999cited by this paper
• Cancer: DNA damage enables p73

  1999cited by this paper
• p 53 Mutants in Mammalian Cells p 73 Function Is Inhibited by Tumor-Derived

  1999cited by this paper
• P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2.

  1999cited by this paper
• Transcription Factor E2F-1 Is Upregulated in Response to DNA Damage in a Manner Analogous to That of p53

  1999influential reference
• Cytoplasmically “Sequestered” Wild Type p53 Protein Is Resistant to Mdm2-mediated Degradation*

  1999cited by this paper
• Differential regulation of p21waf-1/cip-1 and Mdm2 by etoposide: etoposide inhibits the p53-Mdm2 autoregulatory feedback loop

  1999cited by this paper
• Nucleolar Arf sequesters Mdm2 and activates p53

  1999cited by this paper
• Promoter specificity and stability control of the p53-related protein p73

  1999cited by this paper
• RB regulates the stability and the apoptotic function of p53 via MDM2.

  1999cited by this paper
• c-Abl Neutralizes the Inhibitory Effect of Mdm2 on p53*

  1999cited by this paper
• MDM2 and MDMX bind and stabilize the p53-related protein p73.

  1999cited by this paper
• Excess β‐catenin promotes accumulation of transcriptionally active p53

  1999cited by this paper
• The emerging p53 gene family.

  1999cited by this paper
• Comparative study of the p53-mdm2 and p53-MDMX interfaces

  1999cited by this paper
• Mutations in human ARF exon 2 disrupt its nucleolar localization and impair its ability to block nuclear export of MDM2 and p53.

  1999cited by this paper
• RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

  1999cited by this paper
• Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53.

  1999cited by this paper
• Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

  1999cited by this paper
• Mdm2 binds p73α without targeting degradation

  1999cited by this paper
• The E7 Oncoprotein of Human Papillomavirus Type 16 Stabilizes p53 through a Mechanism Independent of p19ARF

  1999cited by this paper
• An inhibitor of nuclear export activates the p53 response and induces the localization of HDM2 and p53 to U1A-positive nuclear bodies associated with the PODs.

  1999cited by this paper
• A leucine‐rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking

  1999cited by this paper
• Regulation of p53 Function and Stability by Phosphorylation

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• p63 is a p53 homologue required for limb and epidermal morphogenesis

  1999cited by this paper
• The proliferation of normal human fibroblasts is dependent upon negative regulation of p53 function by mdm2

  1998cited by this paper
• The potential tumor suppressor p73 differentially regulates cellular p53 target genes.

  1998cited by this paper
• p300/MDM2 complexes participate in MDM2-mediated p53 degradation.

  1998cited by this paper
• p14ARF links the tumour suppressors RB and p53

  1998cited by this paper
• JNK targets p53 ubiquitination and degradation in nonstressed cells.

  1998cited by this paper
• Multisite phosphorylation and the integration of stress signals at p53.

  1998cited by this paper
• The ubiquitin system.

  1998cited by this paper
• Regulation of Mdm2-Directed Degradation by the C Terminus of p53

  1998cited by this paper
• Nucleo‐cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein

  1998influential reference
• Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization.

  1998cited by this paper
• MEKK1/JNK signaling stabilizes and activates p53.

  1998influential reference
• ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways.

  1998cited by this paper
• p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation.

  1998cited by this paper
• E1A signaling to p53 involves the p19(ARF) tumor suppressor.

  1998cited by this paper
• p19ARF links the tumour suppressor p53 to Ras

  1998cited by this paper
• The alternative product from the human CDKN2A locus, p14ARF, participates in a regulatory feedback loop with p53 and MDM2

  1998cited by this paper
• The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53.

  1998cited by this paper
• Suppression of the p300-dependent mdm2 negative-feedback loop induces the p53 apoptotic function.

  1998cited by this paper
• Nuclear Export Is Required for Degradation of Endogenous p53 by MDM2 and Human Papillomavirus E6

  1998cited by this paper
• Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2.

  1998cited by this paper
• The p16INK4a/CDKN2A tumor suppressor and its relatives.

  1998cited by this paper
• p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.

  1998cited by this paper
• Toward an understanding of the functional complexity of the E2F and retinoblastoma families.

  1998cited by this paper
• Synergistic activation of transcription by CBP and p53

  1997cited by this paper
• Interaction between ATM protein and c-Abl in response to DNA damage

  1997cited by this paper
• The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo

  1997cited by this paper
• Mdm2 promotes the rapid degradation of p53

  1997cited by this paper
• Proteolytic cleavage of human p53 by calpain: a potential regulator of protein stability

  1997cited by this paper
• Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

  1997cited by this paper
• Recruitment of p300/CBP in p53-dependent signal pathways.

  1997cited by this paper
• Perturbation of the p53 response by human papillomavirus type 16 E7

  1997cited by this paper
• CREB-binding protein and p300/CBP-associated factor are transcriptional coactivators of the p53 tumor suppressor protein.

  1997cited by this paper
• Differential Regulation of the p21/WAF-1 and mdm2 Genes after High-Dose UV Irradiation: p53-Dependent and p53-Independent Regulation of the mdm2 Gene

  1997cited by this paper
• Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

  1997cited by this paper
• DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2.

  1997cited by this paper
• Proteolysis by calpains: a possible contribution to degradation of p53

  1997cited by this paper
• c-Jun NH2-terminal Kinases Target the Ubiquitination of Their Associated Transcription Factors*

  1997cited by this paper
• p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding

  1997cited by this paper
• p73 is a simian [correction of human] p53-related protein that can induce apoptosis.

  1997cited by this paper
• Inhibition of the growth of WI-38 fibroblasts by benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone: evidence that cleavage of p53 by a calpain-like protease is necessary for G1 to S-phase transition

  1997cited by this paper
• The CDKN2A (p16) Gene and Human Cancer

  1997cited by this paper
• Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF.

  1997cited by this paper
• p73 is a human p53-related protein that can induce apoptosis

  1997cited by this paper
• The carboxy terminus of p53 mimics the polylysine effect of protein kinase CK2-catalyzed MDM2 phosphorylation

  1997cited by this paper
• Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

  1997cited by this paper
• E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.

  1997cited by this paper
• Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame

  1997cited by this paper
• Mdm-2 phosphorylation by DNA-dependent protein kinase prevents interaction with p53.

  1997cited by this paper
• Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation

  1997cited by this paper
• Binding and modulation of p53 by p300/CBP coactivators

  1997cited by this paper
• Regulation of p53 stability by Mdm2

  1997cited by this paper
• Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase.

  1996cited by this paper
• Translational regulation of human p53 gene expression.

  1996cited by this paper
• Structure of the MDM2 Oncoprotein Bound to the p53 Tumor Suppressor Transactivation Domain

  1996cited by this paper
• Degradation of E2F by the ubiquitin-proteasome pathway: regulation by retinoblastoma family proteins and adenovirus transforming proteins.

  1996cited by this paper
• mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

  1996cited by this paper
• Role for c-Abl tyrosine kinase in growth arrest response to DNA damage

  1996cited by this paper
• Cell type‐specific inhibition of p53‐mediated apoptosis by mdm2.

  1996cited by this paper
• In vivo ubiquitination and proteasome-mediated degradation of p53(1).

  1996cited by this paper
• Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer.

  1996cited by this paper
• Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.

  1995cited by this paper
• A novel p16INK4A transcript.

  1995cited by this paper

• Restoration of the Tumor Suppressor Function of Y220C-Mutant p53 by Rezatapopt, a Small-Molecule Reactivator

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• Deferasirox-Dependent Iron Chelation Enhances Mitochondrial Dysfunction and Restores p53 Signaling by Stabilization of p53 Family Members in Leukemic Cells

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• α-Synucleinopathy associated c-Abl activation causes p53-dependent autophagy impairment

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• The Rich World of p53 DNA Binding Targets: The Role of DNA Structure

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• Co-expression of POU4F2/Brn-3b with p53 may be important for controlling expression of pro-apoptotic genes in cardiomyocytes following ischaemic/hypoxic insults

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• Apoptosis and gene expression in the developing mouse brain of fusarenon-X-treated pregnant mice.

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• DESIGN AND SYNTHESIS OF NEW POLYCYCLIC COMPOUNDS WITH POTENTIAL ANTICANCER ACTIVITY

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• Pin1 links the activities of c-Abl and p300 in regulating p73 function.

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• Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo.

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  2003cites this paper
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