Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Molecular and Cellular Biology

• Publication date

  1990-07-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.10.7.3806-3809.1990PMID 2162481PMCID PMC360840
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Thrombin stimulates the production of a novel polyphosphoinositide in human platelets.

  1990cited by this paper
• PDGF induction of tyrosine phosphorylation of GTPase activating protein

  1989cited by this paper
• Translocation of the FGR protein-tyrosine kinase as a consequence of neutrophil activation.

  1989cited by this paper
• Phosphorylation of middle T by pp60c-src: a switch for binding of phosphatidylinositol 3-kinase and optimal tumorigenesis.

  1989influential reference
• PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells.

  1989influential reference
• Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor.

  1989cited by this paper
• Tissue-specific expression and developmental regulation of the human fgr proto-oncogene

  1989cited by this paper
• Phosphatidylinositol kinase activity associates with viral p60src protein

  1989cited by this paper
• Phospholipase C-gamma is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro.

  1989cited by this paper
• Identification of fyn-encoded proteins in normal human blood cells.

  1989cited by this paper
• Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.

  1989cited by this paper
• Phospholipase C-γ is a substrate for the PDGF and EGF receptor protein-tyrosine kinases in vivo and in vitro

  1989cited by this paper
• Role of phosphatidylinositol kinase in PDGF receptor signal transduction.

  1989influential reference
• Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets.

  1989influential reference
• Expression of proto-oncogenes in neural tissues.

  1988cited by this paper
• Recombinant retroviruses that transduce middle T antigen cDNAs derived from polyomavirus mutants: separation of focus formation and soft-agar growth in transformation assays and correlations with kinase activities in vitro

  1988cited by this paper
• Acquisition of transforming properties by FYN, a normal SRC-related human gene.

  1988cited by this paper
• Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

  1988influential reference
• Platelet tyrosine-specific protein phosphorylation is regulated by thrombin

  1988cited by this paper
• Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity.

  1987cited by this paper
• Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.

  1986cited by this paper
• Phosphatidylinositol metabolism and polyoma-mediated transformation.

  1986cited by this paper
• Retrovirus shuttle vector for study of kinase activities of pp60c-src synthesized in vitro and overproduced in vivo

  1986cited by this paper
• Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation

  1985cited by this paper

• in platelets δ tyrosine phosphorylation of PKC Molecular mechanism and functional implications of thrombin-mediated

  2013cites this paper
• New insights into the regulation of vascular permeability.

  2011cites this paper
• Papel dos receptores ativados por protease (PARs) na reatividade vascular de ratos espontaneamente hipertensos (SHR)

  2010cites this paper
• ERK1/2 activation by the C. elegans muscarinic acetylcholine receptor GAR-3 in cultured mammalian cells involves multiple signaling pathways

  2010cites this paper
• The production of vascular endothelial growth factor and metalloproteinase via protease-activated receptor in human endometrial stromal cells.

  2009cites this paper
• PAR‐1‐dependent pp60src activation is dependent on protein kinase C and increased [Ca2+]i: evidence that pp60src does not regulate PAR‐1‐dependent Ca2+ entry in human platelets

  2006cites this paper
• Molecular mechanism and functional implications of thrombin-mediated tyrosine phosphorylation of PKCdelta in platelets.

  2005cites this paper
• Molecular mechanism and functional implications of thrombin-mediated tyrosine phosphorylation of PKC (cid:1) in platelets

  2005cites this paper
• PDFlib PLOP: PDF Linearization, Optimization, Protection Page inserted by evaluation version

  2005cites this paper
• Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues.

  2004cites this paper
• Ether Lipid Analogues Cancer Cells by Rationally Designed Phosphatidylinositol Preferential Inhibition of Akt and Killing of Akt-Dependent

  2004cites this paper
• A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells

  2003cites this paper
• Specific β1 Integrin Site Selectively Regulates Akt/Protein Kinase B Signaling via Local Activation of Protein Phosphatase 2A*

  2003cites this paper
• Role of protease-activated receptors in the vascular system.

  2003cites this paper
• Oncogenic transformation induces tumor angiogenesis: a role for PAR1 activation

  2003cites this paper
• Thrombin induces neoangiogenesis in the chick chorioallantoic membrane

  2003cites this paper
• Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A.

  2003cites this paper
• Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-κB

  2002cites this paper
• Involvement of PI3‐kinase and its association with c‐Src in PTH‐stimulated rat enterocytes

  2002cites this paper
• c-Src Activation by the E5 oncoprotein enables transformation independently of PDGF receptor activation

  2002influential citation
• Functional roles of Akt signaling in mouse skin tumorigenesis

  2002cites this paper
• Thrombin induces increased expression and secretion of angiopoietin-2 from human umbilical vein endothelial cells.

  2002cites this paper
• Resistance to thromboembolism in PI3Kγ‐deficient mice

  2001cites this paper
• Thrombin Induces Increased Expression and Secretion of VEGF from Human FS4 Fibroblasts, DU145 Prostate Cells and CHRF Megakaryocytes

  2001cites this paper
• PI3‐kinase in concert with Src promotes the S‐phase entry of oestradiol‐stimulated MCF‐7 cells

  2001cites this paper
• Evidence for a functional association between phosphatidylinositol 3-kinase and c-src in the spreading response of osteoclasts to colony-stimulating factor-1.

  2000cites this paper
• E5 Oncoprotein Mutants Activate Phosphoinositide 3-Kinase Independently of Platelet-derived Growth Factor Receptor Activation*

  2000cites this paper
• Differential activation and redistribution of c-Src and Fyn in platelets, assessed by MoAb specific for C-terminal tyrosine-dephosphorylated c-Src and Fyn.

  2000cites this paper
• A Novel Role for Phosphatidylinositol 3-Kinase β in Signaling from G Protein-coupled Receptors to Akt*

  2000cites this paper
• Activation of the Protein Kinase Akt/PKB by the Formation of E-cadherin-mediated Cell-Cell Junctions

  1999cites this paper
• A role for phosphatidylinositol 3-kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin.

  1999cites this paper
• Human dopamine D(3) receptors mediate mitogen-activated protein kinase activation via a phosphatidylinositol 3-kinase and an atypical protein kinase C-dependent mechanism.

  1999cites this paper
• The p85 and p110 subunits of phosphatidylinositol 3-kinase-alpha are substrates, in vitro, for a constitutively associated protein tyrosine kinase in platelets.

  1998cites this paper
• Adhesion-dependent signalling and the initiation of haemostasis and thrombosis.

  1998cites this paper
• The p85 and p110 Subunits of Phosphatidylinositol 3-Kinase-α Are Substrates, In Vitro, for a Constitutively Associated Protein Tyrosine Kinase in Platelets

  1998cites this paper
• Integrin signaling: the platelet paradigm.

  1998cites this paper
• Density dependent elevation of phosphatidylinositol-3 kinase level in rat 3Y1 cells.

  1998cites this paper
• Structure and function of phosphoinositide 3-kinases.

  1998cites this paper
• Epoxyeicosatrienoic Acids and Their Sulfonimide Derivatives Stimulate Tyrosine Phosphorylation and Induce Mitogenesis in Renal Epithelial Cells*

  1998cites this paper
• Signaling from G-protein-coupled receptors to mitogen-activated protein (MAP)-kinase cascades.

  1998cites this paper
• c-Src Is Required for Stimulation of Gelsolin-associated Phosphatidylinositol 3-Kinase*

  1998cites this paper
• Role of phosphoinositide 3-kinase in platelet responses to platelet-activating factor

  1997influential citation
• Phosphatidylinositol 4,5‐bisphosphate specifically stimulates PP60c‐src catalyzed phosphorylation of gelsolin and related actin‐binding proteins

  1997cites this paper
• Platelet Protein Tyrosine Kinases

  1997cites this paper
• Protein Tyrosine Phosphorylation in Platelets

  1997cites this paper
• Integrin-dependent tyrosine phoshorylation and cytoskeletal translocation of Tec in thrombin-activated platelets.

  1997cites this paper
• The function of src family tyrosine kinases in hematopoietic cells.

  1996cites this paper
• Cellular consequences of thrombin-receptor activation.

  1996cites this paper
• Protein phosphorylation and signal transduction.

  1996cites this paper
• Thrombin stimulates association of src homology domain containing adaptor protein Nck with pp125FAK.

  1996cites this paper
• Platelet-derived Growth Factor-induced Formation of Tensin and Phosphoinositide 3-Kinase Complexes*

  1996cites this paper
• Chapter 13 Integrin Signaling and the Platelet Cytoskeleton

  1996cites this paper
• Phosphoinositide 3-kinase activation and platelet function.

  1996cites this paper
• Platelet activation: new aspects.

  1996cites this paper
• Osteopontin stimulates gelsolin-associated phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl kinase.

  1996cites this paper
• Regulation of phosphatidylinositide 3-kinase, a potential signaling enzyme in platelets.

  1995cites this paper
• Evidence for a Glycoprotein IIb-IIIa- and Aggregation-independent Mechanism of Phosphatidylinositol 3′,4′-Bisphosphate Synthesis in Human Platelets (*)

  1995cites this paper
• Dissociation of phosphatidylinositol-3 kinase activity and mitogenic inhibition in vascular smooth muscle cells.

  1995cites this paper
• Engagement of the Osteoclast Integrin αvβ3 by Osteopontin Stimulates Phosphatidylinositol 3‐Hydroxyl Kinase Activity ab

  1995cites this paper
• Novel functions of phosphatidylinositol 3-kinase in terminally differentiated cells.

  1995cites this paper
• Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase

  1995cites this paper
• Identification of a New Adapter Protein That May Link the Common β Subunit of the Receptor for Granulocyte/Macrophage Colony-stimulating Factor, Interleukin (IL)-3, and IL-5 to Phosphatidylinositol 3-Kinase (*)

  1995cites this paper
• Engagement of the osteoclast integrin alpha v beta 3 by osteopontin stimulates phosphatidylinositol 3-hydroxyl kinase activity.

  1995cites this paper
• Engagement of the osteoclast integrin alpha v beta 3 by osteopontin stimulates phosphatidylinositol 3-hydroxyl kinase activity.

  1995cites this paper
• Effects of growth factors on phosphatidylinositol‐3 kinase in astroglial cells

  1995cites this paper
• On the Structure and Function of Platelet Integrin αIIbβ3, the Fibrinogen Receptor

  1995cites this paper
• Rapid protein tyrosine phosphorylation in the cytoskeleton of stimulated human platelets.

  1995cites this paper
• Activation of Src family kinase activity by the G protein-coupled thrombin receptor in growth-responsive fibroblasts.

  1994cites this paper
• Growth factor-regulated phosphatidylinositol-3-kinase in astrocytes. Involvement of pp60c-src.

  1994cites this paper
• Agonist-selective regulation of polyphosphoinositide metabolism in pulmonary artery smooth muscle cells.

  1994cites this paper
• Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling

  1994influential citation
• p42 mitogen-activated protein kinase and p90 ribosomal S6 kinase are selectively phosphorylated and activated during thrombin-induced platelet activation and aggregation

  1994cites this paper
• The protein tyrosine kinase pp60c-src is activated upon platelet stimulation.

  1994cites this paper
• Activation of phosphatidylinositol-3' kinase by Src-family kinase SH3 binding to the p85 subunit.

  1994cites this paper
• Platelet tyrosine kinases and fibrinogen receptor activation.

  1994cites this paper
• Regulation of protein tyrosine kinases in platelets.

  1994cites this paper
• Functional specificity of cytoplasmic and transmembrane tyrosine kinases: identification of 130- and 75-kilodalton substrates of c-fps/fes tyrosine kinase in macrophages

  1994cites this paper
• Blockage of chemotactic peptide-induced stimulation of neutrophils by wortmannin as a result of selective inhibition of phosphatidylinositol 3-kinase.

  1994cites this paper
• Clues for Understanding the Structure and Function of a Prototypic Human Integrin: The Platelet Glycoprotein IIb/IIIa Complex

  1994cites this paper
• Adhesion receptor activation of phosphatidylinositol 3-kinase. von Willebrand factor stimulates the cytoskeletal association and activation of phosphatidylinositol 3-kinase and pp60c-src in human platelets.

  1994cites this paper
• Structure, regulation and function of phosphoinositide 3-kinases.

  1994cites this paper
• Translocation, activation and association of protein-tyrosine kinase (p72syk) with phosphatidylinositol 3-kinase are early events during platelet activation.

  1994cites this paper
• Involvement of phosphatidylinositol 3-kinase in Fc gamma receptor signaling.

  1994cites this paper
• Acetylcholine muscarinic m1 receptor regulation of cyclic AMP synthesis controls growth factor stimulation of Raf activity

  1994cites this paper
• Human kit ligand (stem cell factor) modulates platelet activation in vitro.

  1994cites this paper
• Calcium signalling in platelets and other cells.

  1994cites this paper
• Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3.

  1994cites this paper
• Synthesis of phosphatidylinositol 3,4-bisphosphate is regulated by protein-tyrosine phosphorylation but the p85 alpha subunit of phosphatidylinositol 3-kinase may not be a target for tyrosine kinases in thrombin-stimulated human platelets.

  1994cites this paper
• PDGF-mediated activation of phosphatidylinositol 3 kinase in human mesangial cells.

  1994cites this paper
• Signalling in the Activation of Immunologically Relevant Cells

  1994cites this paper
• human mesangial cells

  1994cites this paper
• Evidence that protein tyrosine kinase p56-Lck regulates the activity of phosphatidylinositol-3'-kinase in interleukin-2-dependent T-cells.

  1993cites this paper
• Structure of 85 kDa Subunit of Human Phosphatidylinositol 3‐Kinase Analyzed by Using Monoclonal Antibodies

  1993cites this paper
• Tyrosine phosphorylation in platelets Potential roles in intracellular signal transduction.

  1993cites this paper
• Vanadate activates platelets by enhancing arachidonic acid release.

  1993cites this paper
• Increased tyrosine kinase activity in pp60c-src immunoprecipitate from platelet activating factor stimulated human platelets: in vitro phosphorylation of a synthetic peptide.

  1993cites this paper
• Receptor stimulated accumulation of phosphatidylinositol (3,4,5)‐trisphosphate by G‐protein mediated pathways in human myeloid derived cells.

  1993cites this paper
• Substrate affinity of the protein tyrosine kinase pp60c-src is increased on thrombin stimulation of human platelets.

  1993cites this paper
• Inositol lipid metabolism, the cytoskeleton, glycoprotein IIb IIIa and platelets.

  1993cites this paper
• pp60src is an endogenous substrate for calpain in human blood platelets.

  1993cites this paper