AMPKα-like proteins as LKB1 downstream targets in cell physiology and cancer

No abstract is available for this paper.

• Publication year

  2021

• Venue

  Journal of molecular medicine

• Publication date

  2021-03-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00109-021-02040-yPMID 33661342
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SIK1 Regulates CRTC2-Mediated Gluconeogenesis Signaling Pathway in Human and Mouse Liver Cells

  2020cited by this paper
• Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis.

  2020cited by this paper
• Growth Hormone Supplementation May Not Improve Live Birth Rate in Poor Responders

  2020cited by this paper
• LKB1/AMPK Pathway and Drug Response in Cancer: A Therapeutic Perspective

  2019cited by this paper
• γ-tubulin as a signal-transducing molecule and meshwork with therapeutic potential

  2018cited by this paper
• DNA methylation profile is associated with the osteogenic potential of three distinct human odontogenic stem cells

  2018cited by this paper
• BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity

  2017cited by this paper
• Calcium signalling links MYC to NUAK1

  2017cited by this paper
• Evidence of cancer‐promoting roles for AMPK and related kinases

  2015cited by this paper
• Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction.

  2015cited by this paper
• Molecular Pathways: Is AMPK a Friend or a Foe in Cancer?

  2015cited by this paper
• A Mouse Model Uncovers LKB1 as an UVB-Induced DNA Damage Sensor Mediating CDKN1A (p21WAF1/CIP1) Degradation

  2014cited by this paper
• NIH Public Access

  2014cited by this paper
• Decreased expression and prognostic role of cytoplasmic BRSK1 in human breast carcinoma: correlation with Jab1 stability and PI3K/Akt pathway.

  2014cited by this paper
• Regulation of Focal Adhesion Kinase Activation, Breast Cancer Cell Motility, and Amoeboid Invasion by the RhoA Guanine Nucleotide Exchange Factor Net1

  2013cited by this paper
• The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling.

  2013cited by this paper
• AMPK: a nutrient and energy sensor that maintains energy homeostasis

  2012cited by this paper
• Synapses of Amphids Defective (SAD-A) Kinase Promotes Glucose-stimulated Insulin Secretion through Activation of p21-activated Kinase (PAK1) in Pancreatic β-Cells*

  2012cited by this paper
• The dark face of AMPK as an essential tumor promoter

  2012cited by this paper
• Regulation of SIK1 abundance and stability is critical for myogenesis

  2012cited by this paper
• Brain-selective Kinase 2 (BRSK2) Phosphorylation on PCTAIRE1 Negatively Regulates Glucose-stimulated Insulin Secretion in Pancreatic β-Cells*

  2012cited by this paper
• Gastric lactobezoar - a rare disorder?

  2012cited by this paper
• ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure

  2012cited by this paper
• Molecular mechanisms of tumor suppression by LKB1

  2011cited by this paper
• The role of AMP-activated protein kinase in the functional effects of vascular endothelial growth factor-A and -B in human aortic endothelial cells

  2011cited by this paper
• Brain specific kinase-1 BRSK1/SAD-B associates with lipid rafts: modulation of kinase activity by lipid environment.

  2011cited by this paper
• Chemical genetic screen for AMPKα2 substrates uncovers a network of proteins involved in mitosis.

  2011cited by this paper
• The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis

  2011cited by this paper
• AMP kinase-related kinase NUAK2 affects tumor growth, migration, and clinical outcome of human melanoma

  2011cited by this paper
• A new role of NUAK1: directly phosphorylating p53 and regulating cell proliferation

  2011cited by this paper
• The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

  2011cited by this paper
• Persistence of the cell-cycle checkpoint kinase Wee1 in SadA- and SadB-deficient neurons disrupts neuronal polarity

  2010cited by this paper
• Regulation of ploidy and senescence by the AMPK‐related kinase NUAK1

  2010cited by this paper
• Spectrum of LKB1, EGFR, and KRAS Mutations in Chinese Lung Adenocarcinomas

  2010cited by this paper
• SADB phosphorylation of γ-tubulin regulates centrosome duplication

  2009cited by this paper
• The LKB1–AMPK pathway: metabolism and growth control in tumour suppression

  2009cited by this paper
• SIRT1, Is It a Tumor Promoter or Tumor Suppressor?

  2009cited by this paper
• Somatic LKB1 Mutations Promote Cervical Cancer Progression

  2009cited by this paper
• Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas.

  2008cited by this paper
• Investigating the Regulation of Brain-specific Kinases 1 and 2 by Phosphorylation*

  2008cited by this paper
• Tuberous sclerosis complex proteins control axon formation.

  2008cited by this paper
• SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

  2008cited by this paper
• AMPK phosphorylation of raptor mediates a metabolic checkpoint.

  2008cited by this paper
• Energy-dependent regulation of cell structure by AMP-activated protein kinase

  2007cited by this paper
• Lipid raft microdomains and neurotransmitter signalling

  2007cited by this paper
• LKB1 modulates lung cancer differentiation and metastasis

  2007cited by this paper
• LKB1/STRAD promotes axon initiation during neuronal polarization.

  2007cited by this paper
• LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons.

  2007cited by this paper
• Prevalence and specificity of LKB1 genetic alterations in lung cancers

  2007cited by this paper
• A role for LKB1 gene in human cancer beyond the Peutz–Jeghers syndrome

  2007cited by this paper
• AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha.

  2007cited by this paper
• AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1α

  2007cited by this paper
• The LKB1 tumor suppressor kinase in human disease.

  2007cited by this paper
• TOR signaling in growth and metabolism.

  2006cited by this paper
• LKB1-dependent signaling pathways.

  2006cited by this paper
• The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation.

  2006cited by this paper
• LKB1 is recruited to the p21/WAF1 promoter by p53 to mediate transcriptional activation.

  2006cited by this paper
• AMP-activated protein kinase regulates the assembly of epithelial tight junctions

  2006cited by this paper
• Frequency and Spectrum of Cancers in the Peutz-Jeghers Syndrome

  2006cited by this paper
• BRSK2 is activated by cyclic AMP-dependent protein kinase A through phosphorylation at Thr260.

  2006cited by this paper
• 5′-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments

  2006cited by this paper
• Mammalian SAD Kinases Are Required for Neuronal Polarization

  2005influential reference
• Ca2+/calmodulin-dependent protein kinase kinase-beta acts upstream of AMP-activated protein kinase in mammalian cells.

  2005cited by this paper
• Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.

  2005cited by this paper
• The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases*

  2005cited by this paper
• Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.

  2005cited by this paper
• Salt-inducible kinase (SIK) isoforms: their involvement in steroidogenesis and adipogenesis.

  2004cited by this paper
• Analysis of the LKB1-STRAD-MO25 complex

  2004cited by this paper
• Human SAD1 Kinase Is Involved in UV-induced DNA Damage Checkpoint Function*

  2004cited by this paper
• The LKB1 tumor suppressor negatively regulates mTOR signaling.

  2004cited by this paper
• LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

  2004cited by this paper
• Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations

  2004cited by this paper
• Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.

  2004cited by this paper
• AMP-activated Protein Kinase Plays a Role in the Control of Food Intake*

  2004cited by this paper
• MARKK, a Ste20‐like kinase, activates the polarity‐inducing kinase MARK/PAR‐1

  2003cited by this paper
• Activation of the tumour suppressor kinase LKB1 by the STE20‐like pseudokinase STRAD

  2003cited by this paper
• Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

  2003cited by this paper
• Adipose-specific Expression, Phosphorylation of Ser794 in Insulin Receptor Substrate-1, and Activation in Diabetic Animals of Salt-inducible Kinase-2*

  2003cited by this paper
• TSC2 mediates cellular energy response to control cell growth and survival.

  2003cited by this paper
• A homologue of AMP-activated protein kinase in Drosophila melanogaster is sensitive to AMP and is activated by ATP depletion.

  2002cited by this paper
• Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK).

  2002cited by this paper
• Critical roles of AMP-activated protein kinase in constitutive tolerance of cancer cells to nutrient deprivation and tumor formation

  2002cited by this paper
• Centrosome aberrations: cause or consequence of cancer progression?

  2002cited by this paper
• Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.

  2002cited by this paper
• Centrosome duplication. a centriolar pas de deux.

  2001cited by this paper
• The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.

  2001cited by this paper
• "It takes two to tango": understanding how centrosome duplication is regulated throughout the cell cycle.

  2001cited by this paper
• Phosphorylation of the Protein Kinase Mutated in Peutz-Jeghers Cancer Syndrome, LKB1/STK11, at Ser431 by p90RSK and cAMP-dependent Protein Kinase, but Not Its Farnesylation at Cys433, Is Essential for LKB1 to Suppress Cell Growth*

  2001cited by this paper
• The SAD-1 kinase regulates presynaptic vesicle clustering and axon termination.

  2001cited by this paper
• The Salt‐Inducible Kinase, SIK, Is Induced by Depolarization in Brain

  2000cited by this paper
• Expression of Melk, a new protein kinase, during early mouse development

  1999cited by this paper
• Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.

  1998cited by this paper
• Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway.

  1997cited by this paper
• Active and inactive protein kinases: structural basis for regulation.

  1996cited by this paper
• A kinase from fission yeast responsible for blocking mitosis in S phase

  1995cited by this paper
• Fission yeast chkl protein kinase links the rad checkpoint pathway to cdc2

  1993cited by this paper
• γ-Tubulin: the microtubule organizer?

  1992cited by this paper
• Gamma-tubulin: the microtubule organizer?

  1992cited by this paper
• A comparison of phenformin and metformin in the treatment of maturity onset diabetes.

  1977cited by this paper

• Exploring the role and potential mechanisms of SIK1 in cartilage damage in osteoarthritis based on metabolomics.

  2026cites this paper
• α-Tocopherol ameliorates allergic airway inflammation by regulating ILC2 ferroptosis in an LKB1-dependent manner.

  2025cites this paper
• CPS1-promoted the progression of lung adenocarcinoma via suppressing ammonia induced the activation of ROS/AMPK/P53/LKB1 signaling pathway

  2025cites this paper
• Transcriptomic Analysis of the Heart Tissue in Spontaneously Hypertensive Rats Exposed to Acute Hypobaric Hypoxia.

  2025cites this paper
• TRIM27 promotes ovarian cancer progression through destabilizing AMPK and thus inactivating the cGAS/STING signaling pathway.

  2025cites this paper
• Targeting LKB1/STK11-mutant cancer: distinct metabolism, microenvironment, and therapeutic resistance.

  2025cites this paper
• Endocrine regulation of metabolic crosstalk between liver and brown adipose tissue by natural active ingredients

  2025cites this paper
• Role of Liver Kinase 1B in Platelet Activation and Host Defense During Klebsiella pneumoniae-Induced Pneumosepsis

  2025cites this paper
• Construction of a radiogenomic signature based on endoplasmic reticulum stress for predicting prognosis and systemic combination therapy response in hepatocellular carcinoma

  2025cites this paper
• Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

  2025cites this paper
• Discovery of the Natural Bibenzyl Compound Erianin in Dendrobium Inhibiting the Growth and EMT of Gastric Cancer through Downregulating the LKB1-SIK2/3-PARD3 Pathway

  2024cites this paper
• The role of AMPKα subunit in Alzheimer's disease: In-depth analysis and future prospects

  2024cites this paper
• Sensory neuron LKB1 mediates ovarian and reproductive function

  2024cites this paper
• AMPK-like proteins and their function in female reproduction and gynecologic cancer.

  2023cites this paper
• LKB1 and CRMP1 cooperatively promote the repair of the sciatic nerve injury

  2023cites this paper
• Mitochondrial Dynamics in Ovarian Cancer: Pathophysiology and Therapeutic Implications

  2023cites this paper
• Exogenous NADPH exerts a positive inotropic effect and enhances energy metabolism via SIRT3 in pathological cardiac hypertrophy and heart failure

  2023cites this paper
• Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street

  2023cites this paper
• Sensory neuron LKB1 mediates ovarian and reproductive function

  2023cites this paper
• Functions of LKB1 in neural crest development: The story unfolds

  2023cites this paper
• Molecular Characterization of LKB1 of Triploid Crucian Carp and Its Regulation on Muscle Growth and Quality

  2022cites this paper
• Gene of the month: STK11

  2021cites this paper
• LKB1 Regulates Vascular Macrophage Functions in Atherosclerosis

  2021cites this paper
• NUAK Kinases: Brain–Ovary Axis

  2021cites this paper