The LKB1 tumor suppressor kinase in human disease.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Biochimica et Biophysica Acta

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.BBCAN.2006.08.003PMID 17010524
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Generalized intestinal polyposis and melanin spots of the oral mucosa, lips and digits; a syndrome of diagnostic significance.

  2010cited by this paper
• The cell-centered database

  2007cited by this paper
• Inhibition of germline proliferation during C. elegans dauer development requires PTEN, LKB1 and AMPK signalling

  2006cited by this paper
• Activation of Protein Kinase Cζ by Peroxynitrite Regulates LKB1-dependent AMP-activated Protein Kinase in Cultured Endothelial Cells*

  2006cited by this paper
• PAR proteins and the cytoskeleton: a marriage of equals.

  2006cited by this paper
• TOR signaling in growth and metabolism.

  2006cited by this paper
• DNA damage checkpoints in mammals.

  2006cited by this paper
• Structure of the catalytic and ubiquitin-associated domains of the protein kinase MARK/Par-1.

  2006cited by this paper
• Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

  2006cited by this paper
• Cancer risks in LKB1 germline mutation carriers

  2006cited by this paper
• Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/−p53−/− compound mutant mice

  2006cited by this paper
• Increased Cancer-Related Mortality for Patients With Type 2 Diabetes Who Use Sulfonylureas or Insulin

  2006cited by this paper
• The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation.

  2006cited by this paper
• Hamartin and tuberin: Working together for tumour suppression

  2006cited by this paper
• LKB1-dependent signaling pathways.

  2006cited by this paper
• A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen.

  2006cited by this paper
• Identification of pathways regulating cell size and cell-cycle progression by RNAi

  2006cited by this paper
• A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma

  2006cited by this paper
• Identification of the sucrose non‐fermenting related kinase SNRK, as a novel LKB1 substrate

  2005cited by this paper
• Mammalian SAD Kinases Are Required for Neuronal Polarization

  2005cited by this paper
• Ubiquitin-binding domains

  2005cited by this paper
• Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis.

  2005cited by this paper
• High proportion of large genomic STK11 deletions in Peutz‐Jeghers syndrome

  2005cited by this paper
• STRAD in Peutz-Jeghers syndrome and sporadic cancers

  2005cited by this paper
• Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

  2005cited by this paper
• AMP-activated protein kinase: balancing the scales.

  2005cited by this paper
• Calmodulin-dependent protein kinase kinase-beta is an alternative upstream kinase for AMP-activated protein kinase.

  2005cited by this paper
• Hereditary colorectal cancer syndromes

  2005cited by this paper
• Functional analysis of Peutz-Jeghers mutations reveals that the LKB1 C-terminal region exerts a crucial role in regulating both the AMPK pathway and the cell polarity.

  2005cited by this paper
• Selective COX-2 Inhibitors and Risk of Myocardial Infarction

  2005cited by this paper
• Rapamycin: an anti-cancer immunosuppressant?

  2005cited by this paper
• Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADα, and MO25α, in Peutz–Jeghers syndrome

  2005cited by this paper
• The Ca2+/Calmodulin-dependent Protein Kinase Kinases Are AMP-activated Protein Kinase Kinases*

  2005cited by this paper
• Full-genome RNAi profiling of early embryogenesis in Caenorhabditis elegans

  2005cited by this paper
• Exonic STK11 deletions are not a rare cause of Peutz-Jeghers syndrome

  2005cited by this paper
• The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

  2005cited by this paper
• AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism.

  2005cited by this paper
• AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.

  2005cited by this paper
• Somatic mutations of the protein kinase gene family in human lung cancer.

  2005cited by this paper
• Germline Mutation of the LKB1/STK11 Gene with Loss of the Normal Allele in an Aggressive Breast Cancer of Peutz-Jeghers Syndrome

  2005cited by this paper
• Metformin and reduced risk of cancer in diabetic patients

  2005cited by this paper
• The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

  2005cited by this paper
• PAR proteins and the establishment of cell polarity during C. elegans development

  2005cited by this paper
• Upstream and downstream of mTOR.

  2004cited by this paper
• aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity.

  2004cited by this paper
• Signaling control of mRNA translation in cancer pathogenesis

  2004cited by this paper
• Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2.

  2004cited by this paper
• The polarity‐inducing kinase Par‐1 controls Xenopus gastrulation in cooperation with 14‐3‐3 and aPKC

  2004cited by this paper
• Genome-wide survey of protein kinases required for cell cycle progression

  2004cited by this paper
• Genome-Wide RNAi Analysis of Growth and Viability in Drosophila Cells

  2004cited by this paper
• Induced adiposity and adipocyte hypertrophy in mice lacking the AMP-activated protein kinase-alpha2 subunit.

  2004cited by this paper
• Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD.

  2004cited by this paper
• Inaugural Article: The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

  2004cited by this paper
• The LKB1 tumor suppressor negatively regulates mTOR signaling.

  2004cited by this paper
• Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic

  2004cited by this paper
• Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas

  2004cited by this paper
• The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

  2004cited by this paper
• Toward improving Caenorhabditis elegans phenome mapping with an ORFeome-based RNAi library.

  2004cited by this paper
• Knockout of the alpha2 but not alpha1 5'-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranosidebut not contraction-induced glucose uptake in skeletal muscle.

  2004cited by this paper
• An overview of the KIN1/PAR‐1/MARK kinase family

  2004cited by this paper
• LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR‐1

  2004cited by this paper
• AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms.

  2004cited by this paper
• De novo germline mutation in the serine–threonine kinase STK11/LKB1 gene associated with Peutz–Jeghers syndrome

  2004cited by this paper
• Activation of the AMP-activated Protein Kinase by the Anti-diabetic Drug Metformin in Vivo

  2004cited by this paper
• Genetic analysis of the LKB1/STK11 gene in hepatocellular carcinomas.

  2004cited by this paper
• Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome.

  2004cited by this paper
• Relative frequency and morphology of cancers in STK11 mutation carriers.

  2004cited by this paper
• MARKing tau for tangles and toxicity.

  2004cited by this paper
• Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm.

  2004cited by this paper
• Knockout of the α2 but Not α1 5′-AMP-activated Protein Kinase Isoform Abolishes 5-Aminoimidazole-4-carboxamide-1-β-4-ribofuranosidebut Not Contraction-induced Glucose Uptake in Skeletal Muscle*

  2004cited by this paper
• Genome-wide RNAi screening in Caenorhabditis elegans.

  2003cited by this paper
• Increased AMP:ATP Ratio and AMP-activated Protein Kinase Activity during Cellular Senescence Linked to Reduced HuR Function*

  2003cited by this paper
• A functional genomic analysis of cell morphology using RNA interference

  2003cited by this paper
• Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells.

  2003cited by this paper
• Correlation of Staining for LKB1 and COX-2 in Hamartomatous Polyps and Carcinomas from Patients with Peutz–Jeghers Syndrome

  2003cited by this paper
• Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade

  2003cited by this paper
• A role for Drosophila LKB1 in anterior–posterior axis formation and epithelial polarity

  2003cited by this paper
• MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

  2003cited by this paper
• Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'-phosphate kinase/PTEN pathway.

  2003cited by this paper
• Hereditary polyposis syndromes and hereditary non-polyposis colorectal cancer.

  2003cited by this paper
• The AMP-activated protein kinase α2 catalytic subunit controls whole-body insulin sensitivity

  2003cited by this paper
• Overexpression of Cyclooxygenase 2 in Hamartomatous Polyps of Peutz-Jeghers Syndrome

  2003cited by this paper
• Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas.

  2003cited by this paper
• Activation of the tumour suppressor kinase LKB1 by the STE20‐like pseudokinase STRAD

  2003cited by this paper
• MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm.

  2003cited by this paper
• Adipose-specific Expression, Phosphorylation of Ser794 in Insulin Receptor Substrate-1, and Activation in Diabetic Animals of Salt-inducible Kinase-2*

  2003cited by this paper
• Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice.

  2002cited by this paper
• Induction of cyclooxygenase-2 in a mouse model of Peutz–Jeghers polyposis

  2002cited by this paper
• Drosophila 14-3-3/PAR-5 is an essential mediator of PAR-1 function in axis formation.

  2002cited by this paper
• Role of Lkb1, the causative gene of Peutz–Jegher's syndrome, in embryogenesis and polyposis

  2002cited by this paper
• Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice.

  2002cited by this paper
• The Anti-diabetic Drugs Rosiglitazone and Metformin Stimulate AMP-activated Protein Kinase through Distinct Signaling Pathways*

  2002cited by this paper
• Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung.

  2002cited by this paper
• The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma.

  2002cited by this paper
• A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells.

  2002cited by this paper
• Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.

  2002cited by this paper
• Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation

  2002cited by this paper
• The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism.

  2002cited by this paper
• Growth arrest by the LKB1 tumor suppressor: induction of p21(WAF1/CIP1).

  2002cited by this paper
• AMP-activated Protein Kinase Suppresses Protein Synthesis in Rat Skeletal Muscle through Down-regulated Mammalian Target of Rapamycin (mTOR) Signaling*

  2002cited by this paper

• TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation.

  2024cites this paper
• STK11 Causative Variants and Copy Number Variations Identified in Thai Patients With Peutz-Jeghers Syndrome

  2023cites this paper
• LKB1 loss promotes colorectal cancer cell metastasis through regulating TNIK expression and actin cytoskeleton remodeling

  2023cites this paper
• AMPK induces degradation of the transcriptional repressor PROX1 impairing branched amino acid metabolism and tumourigenesis

  2022cites this paper
• Will We Unlock the Benefit of Metformin for Patients with Lung Cancer? Lessons from Current Evidence and New Hypotheses

  2022cites this paper
• AMPKα-like proteins as LKB1 downstream targets in cell physiology and cancer

  2021cites this paper
• Liver kinase B1 depletion from astrocytes worsens disease in a mouse model of multiple sclerosis

  2020cites this paper
• Role of LKB1 in stem cell fate determination and tumorigenesis

  2020cites this paper
• Development and Therapeutic Potential of NUAKs Inhibitors.

  2020cites this paper
• Liver kinase B1 inhibits smooth muscle calcification via high mobility group box 1

  2020cites this paper
• Phosphoproteomics Reveals the AMPK Substrate Network in Response to DNA Damage and Histone Acetylation

  2020cites this paper
• Metformin : a pharmacological approach integrating hyperinsulinemia and breast cancer at the molecular , cellular and clinical levels *

  2019cites this paper
• Smooth muscle-specific LKB1 deletion exaggerates angiotensin II-induced abdominal aortic aneurysm in mice.

  2019cites this paper
• Stromal Lkb 1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11 – JAK / STAT 3 pathway

  2018cites this paper
• A Rare Case of PeutzJegher Syndrome Presenting with a Solitary Polyp in the Jejunum – A Case Report

  2018cites this paper
• Versatile Roles of LKB1 Kinase Signaling in Neural Development and Homeostasis

  2018cites this paper
• Investigating the therapeutic potential of NUAK1 for the treatment of colorectal cancer

  2018cites this paper
• Deletion of Endothelial Cell-Specific Liver Kinase B1 Increases Angiogenesis and Tumor Growth via Vascular Endothelial Growth Factor

  2017cites this paper
• Prognostic significance of LKB1 promoter methylation in cutaneous malignant melanoma

  2017cites this paper
• LKB1 loss cooperating with BRAF V600E promotes melanoma cell invasion and migration by up-regulation MMP-2 via PI3K/Akt/mTOR pathway

  2017cites this paper
• Stromal Lkb1 deficiency leads to gastrointestinal tumorigenesis involving the IL-11–JAK/STAT3 pathway

  2017cites this paper
• The mTOR-S6K Pathway Links Growth Signaling to DNA Damage Response by Targeting RNF168

  2017cites this paper
• Evidence, Mechanism, and Clinical Relevance of the Transdifferentiation from Lung Adenocarcinoma to Squamous Cell Carcinoma.

  2017cites this paper
• Epithelial cell extrusion: Pathways and pathologies.

  2017cites this paper
• MYC and AMPK–Save Energy or Die!

  2017cites this paper
• Regulation of cell polarity and invasion by TGF-β and BMP signaling

  2017cites this paper
• Peutz-Jeghers Syndrome: Pathobiology, Pathologic Manifestations, and Suggestions for Recommending Genetic Testing in Pathology Reports.

  2016cites this paper
• Molecular Bases for Combinatorial Treatment Strategies in Patients with KRAS Mutant Lung Adenocarcinoma and Squamous Cell Lung Carcinoma

  2016cites this paper
• Regulation of triple-negative breast cancer cell metastasis by the tumor-suppressor liver kinase B1

  2015cites this paper
• Oestrogen receptors interact with the α-catalytic subunit of AMP-activated protein kinase

  2015cites this paper
• Estrogen Dependent Regulation of the Amp-Activated Protein Kinase Pathway

  2015cites this paper
• AMP-Activated Protein Kinase Signalling in Cancer and Cardiac Hypertrophy

  2015cites this paper
• Loss of LKB1 leads to impaired epithelial integrity and cell extrusion in the early mouse embryo

  2015cites this paper
• A Single-Nucleotide Polymorphism in Serine-Threonine Kinase 11, the Gene Encoding Liver Kinase B1, Is a Risk Factor for Multiple Sclerosis

  2015cites this paper
• Protein-protein interactions of the nuclear receptor NR4A2

  2014cites this paper
• Phosphorylation of LKB1/Par-4 Establishes Schwann Cell Polarity to Initiate and Control Myelin Extent

  2014cites this paper
• Liver kinase B1 enhances chemoresistance to gemcitabine in breast cancer MDA-MB-231 cells

  2014cites this paper
• Opportunities and challenges of next‐generation DNA sequencing for breast units

  2014cites this paper
• Endothelial Cell–Specific Liver Kinase B1 Deletion Causes Endothelial Dysfunction and Hypertension in Mice In Vivo

  2014cites this paper
• Targeting the LKB1 tumor suppressor.

  2014cites this paper
• Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer.

  2014cites this paper
• Novel mutations and role of the LKB1 gene as a tumor suppressor in renal cell carcinoma

  2014cites this paper
• Identification d’une nouvelle isoforme du gène suppresseur de tumeur LKB1 ayant des propriétés oncogéniques

  2014cites this paper
• Breaking the epithelial polarity barrier in cancer: the strange case of LKB1/PAR-4

  2013cites this paper
• Cellular polarity in aging: role of redox regulation and nutrition

  2013cites this paper
• Liver Kinase B1 Is Required for Thromboxane Receptor-Dependent Nuclear Factor-&kgr;B Activation and Inflammatory Responses

  2013cites this paper
• A genetic screen identifies an LKB1–MARK signalling axis controlling the Hippo–YAP pathway

  2013cites this paper
• Liver Kinase B1 Is Required for White Adipose Tissue Growth and Differentiation

  2013cites this paper
• Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice.

  2013cites this paper
• Par-1 Regulates Tissue Growth by Influencing Hippo Phosphorylation Status and Hippo-Salvador Association

  2013influential citation
• Investigating the role and regulation of the AMPK-related kinase NUAK1

  2013influential citation
• Apicobasal polarity and its role in cancer progression

  2012cites this paper
• Translational advances regarding hereditary breast cancer syndromes

  2012influential citation
• Energy metabolism and proliferation in pancreatic carcinogenesis

  2012cites this paper
• The LKB1 Tumor Suppressor Controls Spindle Orientation and Localization of Activated AMPK in Mitotic Epithelial Cells

  2012cites this paper
• The CRTC1-NEDD9 signaling axis mediates lung cancer progression caused by LKB1 loss.

  2012cites this paper
• Tumor suppressor function of Liver kinase B1 (Lkb1) is linked to regulation of epithelial integrity

  2012cites this paper
• LKB1 Destabilizes Microtubules in Myoblasts and Contributes to Myoblast Differentiation

  2012cites this paper
• Effects of activation of AMPK on human breast cancer cell lines with different genetic backgrounds.

  2012cites this paper
• Tumor suppressor function of Lkb 1 is linked to regulation of epithelial integrity

  2012cites this paper
• Metformin accelerates the growth of BRAF V600E-driven melanoma by upregulating VEGF-A.

  2012cites this paper
• Molecular mechanisms of tumor suppression by LKB1

  2011influential citation
• LKB1 as the ghostwriter of crypt history

  2011cites this paper
• Role of LKB1‐SAD/MARK pathway in neuronal polarization

  2011cites this paper
• Faulty epithelial polarity genes and cancer.

  2011cites this paper
• A child with an STK11 mutation and Sotos syndrome-like features: can STK11 mutations produce a Sotos syndrome phenocopy?

  2011cites this paper
• Identification of TGFβ signaling, p53, and actin stress fibers as targets of LKB1 tumor suppressor activity

  2011cites this paper
• Liver kinase B1 (LKB1) in the pathogenesis of epithelial cancers.

  2011cites this paper
• LKB1 in lung cancerigenesis: a serine/threonine kinase as tumor suppressor

  2011cites this paper
• AMP-Activated Protein Kinase and Cancer Cell Metabolism

  2011cites this paper
• Insulin Resistance and Cancer: Epidemiology, Cellular and Molecular Mechanisms and Clinical Implications

  2011influential citation
• The tumor suppressor kinase LKB1: lessons from mouse models.

  2011cites this paper
• Mammalian TOR signaling to the AGC kinases

  2011cites this paper
• SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model

  2011cites this paper
• Germline Mutation Analysis of STK11 Gene Using Direct Sequencing and Multiplex Ligation-Dependent Probe Amplification Assay in Korean Children with Peutz-Jeghers Syndrome

  2010cites this paper
• Transcriptome profiling in response to adiponectin in human cancer-derived cells.

  2010cites this paper
• Metformin and energy metabolism in breast cancer: from insulin physiology to tumour-initiating stem cells.

  2010cites this paper
• Metformin: a pharmacological approach integrating hyperinsulinemia breast cáncer at the molecular, cellular clinical levels*

  2010cites this paper
• The link between the centrosome, TSC disease and epithelial differentiation

  2010cites this paper
• Energy dependent regulation of mTOR by LKB1-AMPK

  2010cites this paper
• Synthetic lethal screening as a tool to identify co-dependent pathways for cancer cell survival

  2010cites this paper
• Immunohistological evidence for Wnt-signaling activation in Peutz-Jeghers polyposis

  2010cites this paper
• LKB1 Suppresses p21-activated Kinase-1 (PAK1) by Phosphorylation of Thr109 in the p21-binding Domain*

  2010cites this paper
• Identification of the Serine 307 of LKB1 as a Novel Phosphorylation Site Essential for Its Nucleocytoplasmic Transport and Endothelial Cell Angiogenesis

  2009cites this paper
• Oncogenic B-RAF negatively regulates the tumor suppressor LKB1 to promote melanoma cell proliferation.

  2009cites this paper
• Energy Generating Pathways and the Tumor Suppressor p53

  2009cites this paper
• Peutz-Jeghers syndrome: diagnostic and therapeutic approach.

  2009cites this paper
• Overexpression of the LKB1 gene inhibits lung carcinoma cell proliferation partly through degradation of c-myc protein.

  2009cites this paper
• Crumbs proteins in epithelial morphogenesis.

  2009cites this paper
• Enhanced activity of the CREB co-activator Crtc1 in LKB1 null lung cancer

  2009cites this paper
• Integrated network analysis platform for protein-protein interactions

  2009cites this paper
• LKB 1 and AMPK Family Signaling : The Intimate Link Between Cell Polarity and Energy Metabolism

  2009cites this paper
• 3D view to tumor suppression: lkb1, polarity and the arrest of oncogenic c-myc

  2009cites this paper
• LKB1 and AMPK family signaling: the intimate link between cell polarity and energy metabolism.

  2009cites this paper
• The molecular mechanisms that underlie the tumor suppressor function of LKB1.

  2009cites this paper
• Resveratrol Prevents the Prohypertrophic Effects of Oxidative Stress on LKB1

  2009cites this paper
• Characterization of an Alternative Splice Variant of LKB1*

  2009cites this paper
• Regulation of LKB1/STRAD localization and function by E-cadherin.

  2009cites this paper
• Loss of Lkb1 in adult beta cells increases beta cell mass and enhances glucose tolerance in mice.

  2009cites this paper
• Assessment of chemical coverage of kinome space and its implications for kinase drug discovery.

  2008cites this paper