SIRT1 and AMPK in regulating mammalian senescence: A critical review and a working model

Ageing in mammals remains an unsolved mystery. Anti‐ageing is a recurring topic in the history of scientific research. Lifespan extension evoked by Sir2 protein in lower organisms has attracted a large amount of interests in the last decade. This review summarizes recent evidence supporting the role of a Sir2 mammalian homologue, SIRT1 (Silent information regulator T1), in regulating ageing and cellular senescence. The various signaling networks responsible for the anti‐ageing and anti‐senescence activity of SIRT1 have been discussed. In particular, a counter‐balancing model involving the cross‐talks between SIRT1 and AMP‐activated protein kinase (AMPK), another stress and energy sensor, is suggested for controlling the senescence program in mammalian cells.

• Publication year

  2011

• Venue

  FEBS Letters

• Publication date

  2011-04-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.febslet.2010.11.047PMID 21130086
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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