Sirtuins in mammals: insights into their biological function.

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Biochemical Journal

• Publication date

  2007-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1042/BJ20070140PMID 17447894PMCID PMC2753453
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dietary restriction in aging nonhuman primates.

  2007cited by this paper
• SIRT1 interacts with p73 and suppresses p73‐dependent transcriptional activity

  2007cited by this paper
• Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.

  2007cited by this paper
• SIRT1 Inhibits Transforming Growth Factor β-Induced Apoptosis in Glomerular Mesangial Cells via Smad7 Deacetylation*

  2007cited by this paper
• SIRT2, a tubulin deacetylase, acts to block the entry to chromosome condensation in response to mitotic stress

  2007cited by this paper
• Microtubule Deacetylases, SirT2 and HDAC6, in the Nervous System

  2007cited by this paper
• Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.

  2006cited by this paper
• Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2

  2006cited by this paper
• Activation of Sirt1 Decreases Adipocyte Formation During Osteoblast Differentiation of Mesenchymal Stem Cells

  2006cited by this paper
• The biochemistry of sirtuins.

  2006cited by this paper
• Progressive loss of SIRT1 with cell cycle withdrawal

  2006cited by this paper
• Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases

  2006cited by this paper
• Caspase-mediated changes in Sir2alpha during apoptosis.

  2006cited by this paper
• SirT1 fails to affect p53‐mediated biological functions

  2006cited by this paper
• SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells.

  2006cited by this paper
• Resveratrol improves health and survival of mice on a high-calorie diet

  2006cited by this paper
• Neuronal SIRT1 Activation as a Novel Mechanism Underlying the Prevention of Alzheimer Disease Amyloid Neuropathology by Calorie Restriction*

  2006cited by this paper
• Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

  2006cited by this paper
• Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate.

  2006cited by this paper
• The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity.

  2006cited by this paper
• Molecular indices of oxidative stress and mitochondrial dysfunction occur early and often progress with severity of Alzheimer's disease

  2006cited by this paper
• Altered sirtuin expression is associated with node-positive breast cancer

  2006cited by this paper
• N-Myc Down-regulated Gene 1 Modulates the Response of Term Human Trophoblasts to Hypoxic Injury*

  2006cited by this paper
• Life table (survival) analysis to generate cumulative pregnancy rates in assisted reproduction: an alternative method of calculating the cumulative pregnancy rate in assisted reproduction technology.

  2006cited by this paper
• Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen.

  2006cited by this paper
• Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFκB-dependent transcription

  2006cited by this paper
• Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators.

  2006cited by this paper
• Histone H2A.z Is Essential for Cardiac Myocyte Hypertrophy but Opposed by Silent Information Regulator 2α*

  2006cited by this paper
• Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO.

  2006cited by this paper
• Caspase‐mediated changes in Sir2α during apoptosis

  2006cited by this paper
• SIRT1 Regulates Adiponectin Gene Expression through Foxo1-C/Enhancer-binding Protein α Transcriptional Complex*

  2006cited by this paper
• Resveratrol--a boon for treating Alzheimer's disease?

  2006cited by this paper
• Control of AIF-mediated Cell Death by the Functional Interplay of SIRT1 and PARP-1 in Response to DNA Damage

  2006cited by this paper
• Metabolite of SIR2 Reaction Modulates TRPM2 Ion Channel*

  2006cited by this paper
• Inhibition of SIRT1 Catalytic Activity Increases p53 Acetylation but Does Not Alter Cell Survival following DNA Damage

  2006cited by this paper
• Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation.

  2006cited by this paper
• Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

  2006cited by this paper
• Hormonal Control of Androgen Receptor Function through SIRT1

  2006cited by this paper
• Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription.

  2006cited by this paper
• Mouse Sir2 Homolog SIRT6 Is a Nuclear ADP-ribosyltransferase*

  2005cited by this paper
• Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins.

  2005cited by this paper
• FoxO1 protects against pancreatic beta cell failure through NeuroD and MafA induction.

  2005cited by this paper
• Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

  2005cited by this paper
• A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages.

  2005cited by this paper
• Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

  2005cited by this paper
• BCL11A-dependent recruitment of SIRT1 to a promoter template in mammalian cells results in histone deacetylation and transcriptional repression.

  2005cited by this paper
• SIRT3, a Mitochondrial Sirtuin Deacetylase, Regulates Mitochondrial Function and Thermogenesis in Brown Adipocytes*

  2005cited by this paper
• Upregulation of VEGF-C by androgen depletion: the involvement of IGF-IR-FOXO pathway

  2005cited by this paper
• Uncoupling protein 2 protects dopaminergic neurons from acute 1,2,3,6‐methyl‐phenyl‐tetrahydropyridine toxicity

  2005cited by this paper
• SIRT1 Regulates HIV Transcription via Tat Deacetylation

  2005cited by this paper
• Mitochondrial uncoupling proteins in the cns: in support of function and survival

  2005cited by this paper
• Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses.

  2005cited by this paper
• Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.

  2005cited by this paper
• Suppression of FOXO1 activity by FHL2 through SIRT1‐mediated deacetylation

  2005cited by this paper
• Increased dosage of mammalian Sir2 in pancreatic beta cells enhances glucose-stimulated insulin secretion in mice.

  2005cited by this paper
• Differentially expressed transcripts from phenotypically identified olfactory sensory neurons

  2005cited by this paper
• SIRT1 is critical regulator of FOXO-mediated transcription in response to oxidative stress.

  2005cited by this paper
• Calorie restriction and SIR2 genes--towards a mechanism.

  2005cited by this paper
• Poly(ADP-ribose) Polymerase-1-dependent Cardiac Myocyte Cell Death during Heart Failure Is Mediated by NAD+ Depletion and Reduced Sir2α Deacetylase Activity*

  2005cited by this paper
• A role for SIR-2.1 regulation of ER stress response genes in determining C. elegans life span.

  2005cited by this paper
• Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

  2005cited by this paper
• Mitochondria take center stage in aging and neurodegeneration

  2005cited by this paper
• The Sir 2 family of protein deacetylases.

  2005cited by this paper
• HST2 Mediates SIR2-Independent Life-Span Extension by Calorie Restriction

  2005cited by this paper
• Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress.

  2005cited by this paper
• SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling.

  2005cited by this paper
• Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

  2005cited by this paper
• Regulation of MEF2 by Histone Deacetylase 4- and SIRT1 Deacetylase-Mediated Lysine Modifications

  2005cited by this paper
• SIRT1 Deacetylation and Repression of p300 Involves Lysine Residues 1020/1024 within the Cell Cycle Regulatory Domain 1*

  2005cited by this paper
• SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling*

  2005cited by this paper
• Predominant expression of Sir2α, an NAD‐dependent histone deacetylase, in the embryonic mouse heart and brain 1

  2004cited by this paper
• FOXO4 Is Acetylated upon Peroxide Stress and Deacetylated by the Longevity Protein hSir2SIRT1*

  2004cited by this paper
• Predominant expression of Sir2alpha, an NAD-dependent histone deacetylase, in the embryonic mouse heart and brain.

  2004cited by this paper
• Silent Information Regulator 2&agr;, a Longevity Factor and Class III Histone Deacetylase, Is an Essential Endogenous Apoptosis Inhibitor in Cardiac Myocytes

  2004cited by this paper
• Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization.

  2004cited by this paper
• Mammalian SIRT1 represses forkhead transcription factors.

  2004cited by this paper
• A novel assay for replicative lifespan in Saccharomyces cerevisiae.

  2004cited by this paper
• Human histone deacetylase SIRT2 interacts with the homeobox transcription factor HOXA10.

  2004cited by this paper
• The Sir2 family of protein deacetylases.

  2004cited by this paper
• Sirtuin activators mimic caloric restriction and delay ageing in metazoans

  2004cited by this paper
• Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase

  2004cited by this paper
• Sir2 mediates longevity in the fly through a pathway related to calorie restriction.

  2004cited by this paper
• Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration

  2004cited by this paper
• Modulation of NF‐κB‐dependent transcription and cell survival by the SIRT1 deacetylase

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• Calorie Restriction Promotes Mammalian Cell Survival by Inducing the SIRT1 Deacetylase

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• Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin.

  2004cited by this paper
• Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-γ

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• Role for Human SIRT2 NAD-Dependent Deacetylase Activity in Control of Mitotic Exit in the Cell Cycle

  2003cited by this paper
• The retardation of aging by caloric restriction: its significance in the transgenic era.

  2003cited by this paper
• Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression.

  2003cited by this paper
• The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.

  2003cited by this paper
• Demography of Dietary Restriction and Death in Drosophila

  2003cited by this paper
• Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

  2003cited by this paper
• Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state.

  2003cited by this paper
• Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

  2003cited by this paper
• Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

  2003cited by this paper
• Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

  2003cited by this paper
• The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis.

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• The Mammalian SIR2α Protein Has a Role in Embryogenesis and Gametogenesis

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• Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles.

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• The Role of Sirtuins in Diabetic Nephropathy: A Comprehensive Review.

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