Physiologic Oxygen Enhances Human Embryonic Stem Cell Clonal Recovery and Reduces Chromosomal Abnormalities

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Cloning and Stem Cells

• Publication date

  2006-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/clo.2006.8.16PMID 16571074
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Routine culture and differentiation of human embryonic stem cells.

  2006cited by this paper
• Oxygen‐regulated expression of GLUT‐1, GLUT‐3, and VEGF in the mouse blastocyst

  2005cited by this paper
• Preserving the genetic integrity of human embryonic stem cells

  2005cited by this paper
• Low O2 tensions and the prevention of differentiation of hES cells.

  2005cited by this paper
• Modeling for Lesch‐Nyhan Disease by Gene Targeting in Human Embryonic Stem Cells

  2004cited by this paper
• Transient Changes in Oxygen Tension Inhibit Osteogenic Differentiation and Runx2 Expression in Osteoblasts*

  2004cited by this paper
• Recurrent gain of chromosomes 17q and 12 in cultured human embryonic stem cells

  2004cited by this paper
• Effects of oxygen tension in the gas atmosphere during in vitro maturation, in vitro fertilization and in vitro culture on the efficiency of in vitro production of mouse embryos.

  2004cited by this paper
• The promise of human embryonic stem cells.

  2004cited by this paper
• Effects of oxygen tension on the development and quality of porcine in vitro fertilized embryos.

  2004cited by this paper
• Influence of oxygen tension on apoptosis and hatching in bovine embryos cultured in vitro.

  2003cited by this paper
• Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture

  2003cited by this paper
• Homologous recombination in human embryonic stem cells

  2003cited by this paper
• Developmental differences in the immortalization of lung fibroblasts by telomerase

  2003influential reference
• Oxygen metabolism causes chromosome breaks and is associated with the neuronal apoptosis observed in DNA double-strand break repair mutants.

  2002cited by this paper
• BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection.

  2001cited by this paper
• Feeder-free growth of undifferentiated human embryonic stem cells

  2001cited by this paper
• Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture.

  2000cited by this paper
• The human embryonal carcinoma marker antigen TRA-1-60 is a sialylated keratan sulfate proteoglycan.

  1999cited by this paper
• Embryonic stem cell lines derived from human blastocysts.

  1998cited by this paper
• Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits.

  1993cited by this paper
• The effect of oxygen tension on colony formation and cell proliferation of amniotic fluid cellsin vitro

  1984cited by this paper
• Stage‐specific embryonic antigens (SSEA‐3 and ‐4) are epitopes of a unique globo‐series ganglioside isolated from human teratocarcinoma cells.

  1983cited by this paper

• A 13-week repeated oral dose toxicity evaluation and a 4-week recovery evaluation of rosemary concentrate containing 50% ursolic acid in male and female rats.

  2025cites this paper
• Establishment of an efficient electroporation-based knock-in system in chicken primordial germ cells and a rapid method for positive cell selection

  2025cites this paper
• Morphologic, Proliferative, and Cytogenetic Changes during In Vitro Propagation of Cat Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells

  2024cites this paper
• TERT Promoter Methylation Is Oxygen-Sensitive and Regulates Telomerase Activity

  2024cites this paper
• Developing Humanized Animal Models with Transplantable Human iPSC-Derived Cells.

  2024cites this paper
• Physioxia rewires mitochondrial complex composition to protect stem cell viability

  2024cites this paper
• Hypoxic conditions promote a proliferative, poorly differentiated phenotype in COPD lung tissue progenitor cells in vitro

  2023cites this paper
• Isolation and characterization of feline dental pulp stem cells

  2023cites this paper
• Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research

  2023cites this paper
• Chemokine CCL2 Activates Hypoxia Response Factors Regulating Pluripotency and Directed Endothelial Differentiation of Human Pluripotent Stem Cells

  2023cites this paper
• Oxygen toxicity causes cyclic damage by destabilizing specific Fe-S cluster-containing protein complexes.

  2023cites this paper
• The role of oxygen tension in cell fate and regenerative medicine: implications of hypoxia/hyperoxia and free radicals

  2023cites this paper
• Physoxia Influences Global and Gene-Specific Methylation in Pluripotent Stem Cells

  2022cites this paper
• Standardization of Cell Culture Conditions and Routine Genomic Screening under a Quality Management System Leads to Reduced Genomic Instability in hPSCs

  2022cites this paper
• Rho-Associated Protein Kinase Inhibitor and Hypoxia Synergistically Enhance the Self-Renewal, Survival Rate, and Proliferation of Human Stem Cells

  2022cites this paper
• Glucose-6-Phosphate Dehydrogenase, Redox Homeostasis and Embryogenesis

  2022cites this paper
• Rho-Associated Protein Kinase Inhibitor and Hypoxia Synergistically Enhance the Self-Renewal, Survival Rate, and Proliferation of Human Stem Cells

  2022cites this paper
• Hypoxic conditions promote a proliferative, poorly differentiated, and pro-secretory phenotype in COPD lung tissue progenitor cells in vitro

  2022cites this paper
• Hypoxia facilitates proliferation of smooth muscle cells derived from pluripotent stem cells for vascular tissue engineering

  2022cites this paper
• An update on clinical applications of iPSCs from a genomic point of view

  2022cites this paper
• Mechanisms of oxidative stress in Methylmercury-induced neurodevelopmental toxicity.

  2021cites this paper
• CRISPR/Cas9-mediated Precise SNP Editing in Human iPSC Lines.

  2021cites this paper
• Emerging strategies for scalable human induced pluripotent stem cell expansion and differentiation

  2021cites this paper
• Dissecting the Molecular Response of Human Escs to Iron-Mediated Oxidative Stress by Genetic Silencing of FTH1 Gene

  2021cites this paper
• Uncovering the Metabolic and Stress Responses of Human Embryonic Stem Cells to FTH1 Gene Silencing

  2021cites this paper
• Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism

  2021cites this paper
• Epigenetic features in regulation of telomeres and telomerase in stem cells.

  2021cites this paper
• Physiological Signaling Functions of Reactive Oxygen Species in Stem Cells: From Flies to Man

  2021cites this paper
• Hypoxic regulation of preimplantation embryos: lessons from human embryonic stem cells.

  2020cites this paper
• Hypoxia as a Driving Force of Pluripotent Stem Cell Reprogramming and Differentiation to Endothelial Cells

  2020cites this paper
• Natural Compounds as a Strategy to Optimize “In Vitro” Expansion of Stem Cells

  2020cites this paper
• Modeling genetic epilepsies in a dish

  2020cites this paper
• Energy Metabolism Regulates Stem Cell Pluripotency

  2020cites this paper
• Induction of tenogenic differentiation of equine adipose-derived mesenchymal stem cells by platelet-derived growth factor-BB and growth differentiation factor-6

  2020cites this paper
• Recent advancements of human iPSC derived cardiomyocytes in drug screening and tissue regeneration

  2020cites this paper
• Low rates of mutation in clinical grade human pluripotent stem cells under different culture conditions

  2020cites this paper
• Culture methods and environmental cues of human pluripotent stem cells

  2019cites this paper
• Oxygen and mammalian cell culture: are we repeating the experiment of Dr. Ox?

  2019cites this paper
• Physiologically Relevant Oxygen Concentration (6% O2) as an Important Component of the Microenvironment Impacting Melanoma Phenotype and Melanoma Response to Targeted Therapeutics In Vitro

  2019cites this paper
• iPS-Cell Technology and the Problem of Genetic Instability—Can It Ever Be Safe for Clinical Use?

  2019cites this paper
• Genomic Instability of iPSCs and Challenges in Their Clinical Applications.

  2019cites this paper
• Oxygen Regulates Human Pluripotent Stem Cell Metabolic Flux

  2019cites this paper
• Defining Physiological Normoxia for Improved Translation of Cell Physiology to Animal Models and Humans.

  2019cites this paper
• Sufficiency of hypoxia-inducible 2-oxoglutarate dioxygenases to block chemical oxidative stress-induced differentiation of human embryonic stem cells.

  2019cites this paper
• Characterizing the effects of hypoxia on the metabolic profiles of mesenchymal stromal cells derived from three tissue sources using chemical isotope labeling liquid chromatography-mass spectrometry

  2019cites this paper
• The Role of the Mitochondria in the Evolution of Stem Cells, Including MUSE Stem Cells and Their Biology.

  2018cites this paper
• Simultaneous reprogramming and gene editing of human fibroblasts

  2018cites this paper
• Hypoxia stimulates microenvironment in human embryonic stem cell through inflammatory signalling: An integrative analysis.

  2018cites this paper
• Mimicking Physiological Oxygen in Cell Cultures

  2018cites this paper
• Human pluripotent stem cells in regenerative medicine: where do we stand?

  2018cites this paper
• Human stem cell metabolomics : headspace volatile gas analysis as an indicator of self-renewal and differentiation status

  2018cites this paper
• Pluripotent Stem Cell Platforms for Drug Discovery.

  2018cites this paper
• Exploring the impact of hypoxia mimetic agents on multipotent stem cell biology

  2018cites this paper
• Generating Loss-of-function iPSC Lines with Combined CRISPR Indel Formation and Reprogramming from Human Fibroblasts.

  2018cites this paper
• Human Pluripotent Stem Cell Culture: Current Status, Challenges, and Advancement

  2018cites this paper
• Improving single-cell cloning workflow for gene editing in human pluripotent stem cells.

  2018cites this paper
• Pharmacological Regulation of Oxidative Stress in Stem Cells

  2018cites this paper
• Reactive Oxygen Species Signaling from the Perspective of the Stem Cell

  2017cites this paper
• Pluripotent Stem Cell Metabolism and Mitochondria: Beyond ATP

  2017cites this paper
• Rapid Generation of Human Genetic Loss-of-Function iPSC Lines by Simultaneous Reprogramming and Gene Editing

  2017cites this paper
• Expansion of 3D human induced pluripotent stem cell aggregates in bioreactors: Bioprocess intensification and scaling-up approaches.

  2017cites this paper
• Small Maf functions in the maintenance of germline stem cells in the Drosophila testis

  2017cites this paper
• Alpha-Ketoglutarate Influences the Self-Renewal and Differentiation of Pluripotent Stem Cells

  2017cites this paper
• Protein Kinases in Pluripotency-Beyond the Usual Suspects.

  2017cites this paper
• Tenogenic Differentiation of Human Embryonic Stem Cells

  2017cites this paper
• Proteomic analysis of chondromodulin-I-induced differentiation of mesenchymal stem cells into chondrocytes.

  2017cites this paper
• [Research progress on the safety of offsprings conceived by assisted reproductive technology].

  2017cites this paper
• Explorer Efficient Gene Targeting by Homologous Recombination in Rat Embryonic Stem Cells

  2017cites this paper
• Oxidative stress promotes exit from the stem cell state and spontaneous neuronal differentiation

  2017cites this paper
• Oxidative Stress Under Ambient and Physiological Oxygen Tension in Tissue Culture

  2016cites this paper
• Pluripotent and Multipotent Stem Cells Display Distinct Hypoxic miRNA Expression Profiles

  2016cites this paper
• Pluripotent Stem Cells From Livestock

  2016cites this paper
• Oxygen modulates human embryonic stem cell metabolism in the absence of changes in self-renewal.

  2016cites this paper
• Glycerol-3-phosphate acyltransferase-1 upregulation by O-GlcNAcylation of Sp1 protects against hypoxia-induced mouse embryonic stem cell apoptosis via mTOR activation

  2016cites this paper
• Biomaterials control of pluripotent stem cell fate for regenerative therapy

  2016cites this paper
• Qualifying stem cell sources: how to overcome potential pitfalls in regenerative medicine?

  2016cites this paper
• 4 – Low O2 Concentrations and the Maintenance of Stem Cells Ex Vivo

  2016cites this paper
• Nuclear Factor κB1/RelA Mediates Inflammation in Human Lung Epithelial Cells at Atmospheric Oxygen Levels

  2016cites this paper
• Human Adipose‐Derived Stem Cells Expanded Under Ambient Oxygen Concentration Accumulate Oxidative DNA Lesions and Experience Procarcinogenic DNA Replication Stress

  2016cites this paper
• Hypoxia-inducible factor-2 alpha promotes the proliferation of human placenta-derived mesenchymal stem cells through the MAPK/ERK signaling pathway

  2016cites this paper
• Integrated processes for expansion and differentiation of human pluripotent stem cells in suspended microcarriers cultures.

  2016cites this paper
• A Place to Call Home: Bioengineering Pluripotential Stem Cell Cultures

  2015cites this paper
• Oxygen-mediated basic fibroblast growth factor (FGF2) effects on adult human dermal fibroblasts

  2015cites this paper
• Advances in cell culture: anchorage dependence

  2015cites this paper
• Hypoxia accelerates vascular repair of endothelial colony-forming cells on ischemic injury via STAT3-BCL3 axis

  2015cites this paper
• Regulation of Stem Cell Fate by ROS-mediated Alteration of Metabolism

  2015cites this paper
• Stem Cells in Drug Development

  2015cites this paper
• Distinct profiles of human embryonic stem cell metabolism and mitochondria identified by oxygen.

  2015cites this paper
• Bioreactors and the Design of the Stem Cell Niche

  2015cites this paper
• BMP2 repression and optimized culture conditions promote human bone marrow-derived mesenchymal stem cell isolation.

  2015cites this paper
• Chromosomal Abnormalities in Embryonic and Somatic Stem Cells

  2015cites this paper
• Progerin Expression Disrupts Critical Adult Stem Cell Functions that Mediate Tissue Repair Primarily through a Mechanism that Permanently Farnesylates Lamin A

  2015cites this paper
• Assisted reproductive technology results: Why are live‐birth percentages so low?

  2014cites this paper
• Stem cells and the impact of ROS signaling

  2014cites this paper
• Oxygen Transport and Stem Cell Aggregation in Stirred-Suspension Bioreactor Cultures

  2014cites this paper
• Combining Hypoxia and Bioreactor Hydrodynamics Boosts Induced Pluripotent Stem Cell Differentiation Towards Cardiomyocytes

  2014cites this paper
• Derivação de novas linhagens brasileiras de células-tronco embrionárias humanas sob condições fisiológicas de oxigênio

  2014cites this paper
• Concise Review: Genomic Instability in Human Stem Cells: Current Status and Future Challenges

  2014cites this paper
• Low oxygen atmosphere facilitates proliferation and maintains undifferentiated state of umbilical cord mesenchymal stem cells in an hypoxia inducible factor-dependent manner.

  2014cites this paper
• Novel stem cell and PHBHHx approaches to tendon repair

  2014cites this paper