Multiple functions of the E3 ubiquitin ligase CHIP in immunity

No abstract is available for this paper.

• Publication year

  2017

• Venue

  International Reviews of Immunology

• Publication date

  2017-06-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1080/08830185.2017.1309528PMID 28574736
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Ubiquitin System

  2018cited by this paper
• Transcription factor RFX1 is ubiquitinated by E3 ligase STUB1 in systemic lupus erythematosus.

  2016influential reference
• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

  2016cited by this paper
• Treg17 cells are programmed by Stat3 to suppress Th17 responses in systemic lupus.

  2016cited by this paper
• CHIP: A new modulator of human malignant disorders

  2016cited by this paper
• The increasing complexity of the ubiquitin code

  2016cited by this paper
• Cimetidine down-regulates stability of Foxp3 protein via Stub1 in Treg cells

  2016cited by this paper
• E3 ubiquitin ligase CHIP interacts with C-type lectin-like receptor CLEC-2 and promotes its ubiquitin-proteasome degradation.

  2016cited by this paper
• Cytoplasmic STAT4 Promotes Antiviral Type I IFN Production by Blocking CHIP-Mediated Degradation of RIG-I

  2016cited by this paper
• In vivo aspects of protein folding and quality control

  2016cited by this paper
• The epichaperome is an integrated chaperome network that facilitates tumour survival

  2016influential reference
• Ubiquitin‐dependent regulation of Foxp3 and Treg function

  2015cited by this paper
• IL-34 is a Treg-specific cytokine and mediates transplant tolerance.

  2015cited by this paper
• Nitric oxide synthase in innate and adaptive immunity: an update.

  2015cited by this paper
• How hsp70 molecular machines interact with their substrates to mediate diverse physiological functions.

  2015cited by this paper
• E3 Ubiquitin Ligase Cbl-b Regulates Thymic-Derived CD4+CD25+ Regulatory T Cell Development by Targeting Foxp3 for Ubiquitination

  2015influential reference
• A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins.

  2015cited by this paper
• A CHIPotle in physiology and disease.

  2015cited by this paper
• Specific Binding of Tetratricopeptide Repeat Proteins to Heat Shock Protein 70 (Hsp70) and Heat Shock Protein 90 (Hsp90) Is Regulated by Affinity and Phosphorylation.

  2015cited by this paper
• Association analyses confirm five susceptibility loci for systemic lupus erythematosus in the Han Chinese population

  2015cited by this paper
• CHIP: a co-chaperone for degradation by the proteasome.

  2015cited by this paper
• Carboxyl Terminus of HSC70-interacting Protein (CHIP) Down-regulates NF-κB-inducing Kinase (NIK) and Suppresses NIK-induced Liver Injury*

  2015influential reference
• K63 linked ubiquitin chain formation is a signal for HIF1A degradation by Chaperone-Mediated Autophagy

  2015cited by this paper
• The E3 Ligase CHIP: Insights into Its Structure and Regulation

  2014cited by this paper
• HIF transcription factors, inflammation, and immunity.

  2014cited by this paper
• Biallelic loss-of-function mutation in NIK causes a primary immunodeficiency with multifaceted aberrant lymphoid immunity

  2014cited by this paper
• The role of airway epithelial cells and innate immune cells in chronic respiratory disease

  2014cited by this paper
• Enhances Angiogenesis and Restores Cardiac Function After Infarction in Transgenic Mice

  2013cited by this paper
• Regulation of IL-4 receptor signaling by STUB1 in lung inflammation.

  2013cited by this paper
• STUB1 is essential for T‐cell activation by ubiquitinating CARMA1

  2013cited by this paper
• The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation of the transcription factor Foxp3.

  2013cited by this paper
• Hsp70 chaperone dynamics and molecular mechanism.

  2013cited by this paper
• STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy

  2013cited by this paper
• Inhibition of HSP90 molecular chaperones: moving into the clinic.

  2013cited by this paper
• Toll-Like Receptor-2 Ligand Peptidoglycan Upregulates Expression and Ubiquitin Ligase Activity of CHIP through JNK Pathway

  2013cited by this paper
• Intracellular Heat Shock Protein-70 Negatively Regulates TLR4 Signaling in the Newborn Intestinal Epithelium

  2012cited by this paper
• Molecular chaperone complexes with antagonizing activities regulate stability and activity of the tumor suppressor LKB1

  2012cited by this paper
• Regulatory T cells: mechanisms of differentiation and function.

  2012cited by this paper
• Arctigenin promotes degradation of inducible nitric oxide synthase through CHIP-associated proteasome pathway and suppresses its enzyme activity.

  2012cited by this paper
• Carboxyl terminus of heat shock protein 70-interacting protein inhibits angiotensin II-induced cardiac remodeling.

  2012cited by this paper
• Systematic and quantitative assessment of the ubiquitin-modified proteome.

  2011cited by this paper
• RIG-I like receptors and their signaling crosstalk in the regulation of antiviral immunity

  2011cited by this paper
• E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKCζ

  2011cited by this paper
• Global identification of modular cullin-RING ligase substrates.

  2011cited by this paper
• The Hsc/Hsp70 Co-Chaperone Network Controls Antigen Aggregation and Presentation during Maturation of Professional Antigen Presenting Cells

  2011influential reference
• Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.

  2011cited by this paper
• Differences in Candidate Gene Association between European Ancestry and African American Asthmatic Children

  2011cited by this paper
• Hypoxia Inducible Factor promotes murine allergic airway inflammation and is increased in asthma and rhinitis

  2011cited by this paper
• TLR4 signalling in pulmonary stromal cells is critical for inflammation and immunity in the airways

  2011cited by this paper
• Non-canonical NF-κB signaling pathway

  2011cited by this paper
• Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase.

  2011cited by this paper
• CARMA1 Is Necessary for Optimal T Cell Responses in a Murine Model of Allergic Asthma

  2011cited by this paper
• RIG‐I‐like receptors: cytoplasmic sensors for non‐self RNA

  2011cited by this paper
• Chaperone-assisted degradation: multiple paths to destruction

  2010cited by this paper
• Epigenetics and SLE: RFX1 downregulation causes CD11a and CD70 overexpression by altering epigenetic modifications in lupus CD4+ T cells.

  2010influential reference
• CHIP participates in protein triage decisions by preferentially ubiquitinating Hsp70‐bound substrates

  2010cited by this paper
• The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation

  2010cited by this paper
• RFX1 regulates CD70 and CD11a expression in lupus T cells by recruiting the histone methyltransferase SUV39H1

  2010influential reference
• Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma

  2010cited by this paper
• The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal

  2010cited by this paper
• The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

  2010cited by this paper
• Balance between folding and degradation for Hsp90-dependent client proteins: a key role for CHIP.

  2010influential reference
• Chaperone-assisted selective autophagy is essential for muscle maintenance.

  2010cited by this paper
• The role of HIF in immunity.

  2010cited by this paper
• Essential in Vivo Roles of the C-type Lectin Receptor CLEC-2

  2010cited by this paper
• Interdependence of hypoxic and innate immune responses

  2009cited by this paper
• Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3

  2009cited by this paper
• CHIP facilitates ubiquitination of inducible nitric oxide synthase and promotes its proteasomal degradation.

  2009cited by this paper
• Hsp70 and CHIP Selectively Mediate Ubiquitination and Degradation of Hypoxia-inducible Factor (HIF)-1α but Not HIF-2α*

  2009cited by this paper
• Activation of noncanonical NF-κB requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2, TRAF3 and the kinase NIK

  2008cited by this paper
• Chaperones in control of protein disaggregation

  2008cited by this paper
• Regulatory T cells and immune tolerance.

  2008cited by this paper
• Interleukin-4, interleukin-13, signal transducer and activator of transcription factor 6, and allergic asthma.

  2008influential reference
• Chaperone Functions of the E3 Ubiquitin Ligase CHIP*

  2007cited by this paper
• Nitric oxide and immune response.

  2007cited by this paper
• RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha.

  2007cited by this paper
• RACK1 Competes with HSP90 for Binding to HIF-1α and is Required for O2-independent and HSP90 Inhibitor-induced Degradation of HIF-1α

  2007cited by this paper
• DC-SIGN and CLEC-2 Mediate Human Immunodeficiency Virus Type 1 Capture by Platelets

  2006cited by this paper
• Antigen Presentation and the Ubiquitin‐Proteasome System in Host–Pathogen Interactions

  2006cited by this paper
• Hsp90alpha chaperones large C-terminally extended proteolytic intermediates in the MHC class I antigen processing pathway.

  2006cited by this paper
• The triage of damaged proteins: degradation by the ubiquitin‐proteasome pathway or repair by molecular chaperones

  2006cited by this paper
• Tight Linkage between Translation and MHC Class I Peptide Ligand Generation Implies Specialized Antigen Processing for Defective Ribosomal Products1

  2006cited by this paper
• CHIP Controls the Sensitivity of Transforming Growth Factor-β Signaling by Modulating the Basal Level of Smad3 through Ubiquitin-mediated Degradation*

  2005cited by this paper
• Dendritic Cell Aggresome-Like-Induced Structure Formation and Delayed Antigen Presentation Coincide in Influenza Virus-Infected Dendritic Cells1

  2005cited by this paper
• Chaperoned ubiquitylation--crystal structures of the CHIP U box E3 ubiquitin ligase and a CHIP-Ubc13-Uev1a complex.

  2005cited by this paper
• Specific interaction between Smad1 and CHIP: a surface plasmon resonance study.

  2005cited by this paper
• CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

  2005cited by this paper
• Hsp70 chaperones: Cellular functions and molecular mechanism

  2005cited by this paper
• Ubiquitylation of Neuronal Nitric-oxide Synthase by CHIP, a Chaperone-dependent E3 Ligase*

  2004cited by this paper
• The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

  2004cited by this paper
• The cochaperone HspBP1 inhibits the CHIP ubiquitin ligase and stimulates the maturation of the cystic fibrosis transmembrane conductance regulator.

  2004cited by this paper
• Dendritic cell aggresome-like induced structures are dedicated areas for ubiquitination and storage of newly synthesized defective proteins

  2004cited by this paper
• Regulation of Signaling Protein Function and Trafficking by the hsp90/hsp70-Based Chaperone Machinery 1

  2003cited by this paper
• Pathogenesis of systemic lupus erythematosus

  2003cited by this paper
• Chaperone-dependent Regulation of Endothelial Nitric-oxide Synthase Intracellular Trafficking by the Co-chaperone/Ubiquitin Ligase CHIP*

  2003cited by this paper
• CHIP activates HSF1 and confers protection against apoptosis and cellular stress

  2003influential reference
• Ubiquitin ligases and the immune response.

  2003cited by this paper
• CHIP: a link between the chaperone and proteasome systems

  2003cited by this paper
• Protein turnover: a CHIP programmed for proteolysis.

  2002cited by this paper
• Protein quality control: U-box-containing E3 ubiquitin ligases join the fold.

  2002cited by this paper

• The Ubiquitin Ligase CHIP Accelerates Papillary Thyroid Carcinoma Metastasis via the Transgelin-Matrix Metalloproteinase-9 Axis.

  2025cites this paper
• Whole RNA-Seq Analysis Reveals Longitudinal Proteostasis Network Responses to Photoreceptor Outer Segment Trafficking and Degradation in RPE Cells

  2025cites this paper
• STUB1 suppresses paclitaxel resistance in ovarian cancer through mediating HOXB3 ubiquitination to inhibit PARK7 expression

  2024cites this paper
• Novel mechanism of cyclic nucleotide crosstalk mediated by PKG-dependent proteasomal degradation of the Hsp90 client protein phosphodiesterase 3A

  2024cites this paper
• Degradation of CDK9 by Ubiquitin E3 Ligase STUB1 Regulates P-TEFb Level and Its Functions for Global Target Gene Expression within Mammalian Cells

  2023cites this paper
• Silencing of STUB1 relieves osteoarthritis via inducing NRF2-mediated M2 macrophage polarization.

  2023cites this paper
• Relationship between serum CHIP levels with cardiovascular disease in maintenance haemodialysis patients

  2023cites this paper
• STUB1 activates antiviral response in zebrafish by promoting the expression of RIG-I.

  2022cites this paper
• Combination of AURKA inhibitor and HSP90 inhibitor to treat breast cancer with AURKA overexpression and TP53 mutations

  2022cites this paper
• E3 Ubiquitin Ligase CHIP Inhibits the Interaction between Hsp90β and MAST1 to Repress Radiation Resistance in Non-Small-Cell Lung Cancer Stem Cells

  2022cites this paper
• With or without You: Co-Chaperones Mediate Health and Disease by Modifying Chaperone Function and Protein Triage

  2021cites this paper
• Functional analysis of tomato CHIP ubiquitin E3 ligase in heat tolerance

  2021cites this paper
• Conserved and Unique Roles of Chaperone-Dependent E3 Ubiquitin Ligase CHIP in Plants

  2021cites this paper
• CHIP-dependent regulation of the actin cytoskeleton is linked to neuronal cell membrane integrity

  2021cites this paper
• Chaperone-assisted E3 ligase CHIP: A double agent in cancer

  2021cites this paper
• CHIP ameliorates cerebral ischemia-reperfusion injury by attenuating necroptosis and inflammation

  2021cites this paper
• Dominant Steady State Proteome Changes in the Absence of CHIP Highlight a Role in Neuronal Cell Membrane Integrity Linked to the Actin Cytoskeleton

  2020cites this paper
• Merkel Cell Polyomavirus and Merkel Cell Carcinoma

  2020cites this paper
• On the structure and function of Sorghum bicolor CHIP (carboxyl terminus of Hsc70-interacting protein): A link between chaperone and proteasome systems.

  2020cites this paper
• CHIP attenuates lipopolysaccharide‐induced cardiac hypertrophy and apoptosis by promoting NFATc3 proteasomal degradation

  2019cites this paper
• Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways

  2019cites this paper
• AAV/BBB-Mediated Gene Transfer of CHIP Attenuates Brain Injury Following Experimental Intracerebral Hemorrhage

  2019cites this paper
• Dynamic Phosphorylation of the C Terminus of Hsp70 Regulates the Mitochondrial Import of SOD2 and Redox Balance.

  2018cites this paper
• In this issue: Fine tuners of immunity and their role in infectious and non-infectious diseases

  2017cites this paper