Preclinical Models for Bladder Cancer Research.

At diagnosis, more than 70% of bladder cancers (BCs) are at the non-muscle-invasive bladder cancer (NMIBC) stages, which are usually treated with transurethral resection followed by intravesical instillation. For the remaining advanced cancers, systemic therapy is the standard of care, with addition of radical cystectomy in cases of locally advanced cancer. Because of the difference in treatment modalities, different models are needed to advance the care of NMIBC and advanced BC. This article gives a comprehensive review of both in vitro and in vivo BC models and compares the advantages and drawbacks of these preclinical systems in BC research.

• Publication year

  2021

• Venue

  Hematology/Oncology Clinics of North America

• Publication date

  2021-06-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.hoc.2021.02.007PMID 33958154PMCID PMC8174399
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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