X:A ratio, the primary sex-determining signal in Drosophila, is transduced by helix-loop-helix proteins.

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Cell

• Publication date

  1990-12-21

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0092-8674(90)90414-APMID 2124516
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The link between dosage compensation and sex differentiation in Drosophila melanogaster

  2004cited by this paper
• Sex determination compared in Drosophila and Caenorhabditis

  1990cited by this paper
• extramacrochaetae, a negative regulator of sensory organ development in Drosophila, defines a new class of helix-loop-helix proteins.

  1990cited by this paper
• The protein Id: a negative regulator of helix-loop-helix DNA binding proteins.

  1990cited by this paper
• The Drosophila extramacrochaetae locus, an antagonist of proneural genes that, like these genes, encodes a helix-loop-helix protein.

  1990cited by this paper
• The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation.

  1990cited by this paper
• Genetic control of sex determination in Drosophila.

  1990cited by this paper
• The Drosophila hairy protein acts in both segmentation and bristle patterning and shows homology to N‐myc.

  1989cited by this paper
• The role of the hairy gene during Drosophila morphogenesis: stripes in imaginal discs

  1989cited by this paper
• The zygotic control of Drosophila pair-rule gene expression. I. A search for new pair-rule regulatory loci.

  1989cited by this paper
• Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence.

  1989cited by this paper
• A non-radioactive in situ hybridization method for the localization of specific RNAs in Drosophila embryos reveals translational control of the segmentation gene hunchback

  1989cited by this paper
• Analysis of maternal effect mutant combinations elucidates regulation and function of the overlap of hunchback and Krüppel gene expression in the Drosophila blastoderm embryo.

  1989cited by this paper
• A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins.

  1989cited by this paper
• Expression of achaete and scute genes in Drosophila imaginal discs and their function in sensory organ development.

  1989cited by this paper
• Drosophila sex determination: a cascade of regulated splicing.

  1989cited by this paper
• The Drosophila female-specific sex-determination gene, Sex-lethal, has stage-, tissue-, and sex-specific RNAs suggesting multiple modes of regulation.

  1989cited by this paper
• Spatial control of hairy protein expression during embryogenesis.

  1989cited by this paper
• Sex in flies: the splice of life

  1989cited by this paper
• The scute (T4) gene acts as a numerator element of the X:a signal that determines the state of activity of sex‐lethal in Drosophila.

  1989cited by this paper
• The determination of sense organs in Drosophila: interaction of scute with daughterless

  1988cited by this paper
• The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster.

  1988cited by this paper
• Differential regulation of the two transcripts from the Drosophila gap segmentation gene hunchback.

  1988cited by this paper
• MyoD1: a nuclear phosphoprotein requiring a Myc homology region to convert fibroblasts to myoblasts.

  1988cited by this paper
• The role of the leucine zipper in the fos–jun interaction

  1988cited by this paper
• daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex.

  1988cited by this paper
• Genetic evidence that the sans fille locus is involved in Drosophila sex determination.

  1988cited by this paper
• The achaete‐scute gene complex of Drosophila melanogaster comprises four homologous genes.

  1988cited by this paper
• DNA binding activities of three murine Jun proteins: stimulation by Fos.

  1988cited by this paper
• Extramacrochaetae, a trans-acting gene of the achaete-scute complex of Drosophila involved in cell communication

  1988cited by this paper
• Sex determination in Drosophila: the X‐chromosomal gene liz is required for Sxl activity.

  1988cited by this paper
• Expression, function, and regulation of the hairy segmentation protein in the Drosophila embryo.

  1988cited by this paper
• c-Jun dimerizes with itself and with c-Fos, forming complexes of different DNA binding affinities.

  1988cited by this paper
• The maternal sex determination gene daughterless has zygotic activity necessary for the formation of peripheral neurons in Drosophila.

  1988cited by this paper
• Microinjected DNA from the X chromosome affects sex determination in Caenorhabditis elegans.

  1988cited by this paper
• Evidence that sisterless-a and sisterless-b are two of several discrete "numerator elements" of the X/A sex determination signal in Drosophila that switch Sxl between two alternative stable expression states.

  1988cited by this paper
• A unitary basis for different Hairy‐wing mutations of Drosophila melanogaster.

  1988cited by this paper
• Molecular characterization of daughterless, a Drosophila sex determination gene with multiple roles in development.

  1988cited by this paper
• Sex-lethal, a Drosophila sex determination switch gene, exhibits sex-specific RNA splicing and sequence similarity to RNA binding proteins.

  1988cited by this paper
• Dosage Compensation in Drosophila: Evidence That daughterless and Sex-lethal Control X Chromosome Activity at the Blastoderm Stage of Embryogenesis.

  1987cited by this paper
• The achaete‐scute complex is expressed in neurogenic regions of Drosophila embryos

  1987cited by this paper
• Finger protein of novel structure encoded by hunchback, a second member of the gap class of Drosophila segmentation genes

  1987cited by this paper
• Pattern abnormalities induced by ectopic expression of the Drosophila gene hairy are associated with repression of ftz transcription.

  1987cited by this paper
• The expression of three members of the achaete-scute gene complex correlates with neuroblast segregation in Drosophila.

  1987cited by this paper
• Primary sex determination in the nematode C. elegans.

  1987cited by this paper
• The Drosophila sex determination gene daughterless has different functions in the germ line versus the soma.

  1987cited by this paper
• Cloning and characterization of a dispersed, multicopy, X chromosome sequence in Drosophila melanogaster.

  1987cited by this paper
• Regulation of sexual differentiation in D. melanogaster via alternative splicing of RNA from the transformer gene.

  1987cited by this paper
• Functional changes associated with structural alterations induced by mobilization of a P element inserted in the Sex-lethal gene of Drosophila.

  1987cited by this paper
• Expression of a single transfected cDNA converts fibroblasts to myoblasts.

  1987cited by this paper
• Sex determination and dosage compensation in Caenorhabditis elegans.

  1987cited by this paper
• The achaete-scute gene complex of D. melanogaster: conserved domains in a subset of genes required for neurogenesis and their homology to myc.

  1987cited by this paper
• Zygotically active genes that affect the spatial expression of the fushi tarazu segmentation gene during early Drosophila embryogenesis.

  1986cited by this paper
• Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm.

  1986cited by this paper
• A molecular gradient in early Drosophila embryos and its role in specifying the body pattern

  1986cited by this paper
• The relationship of relative gene dose to the complex phenotype of the daughterless locus in Drosophila.

  1986cited by this paper
• A female-specific lethal lesion in an X-linked positive regulator of the Drosophila sex determination gene, Sex-lethal.

  1986cited by this paper
• Transcription pattern of the Drosophila segmentation gene hairy

  1985cited by this paper
• Sex determination: a hypothesis based on noncoding DNA.

  1985cited by this paper
• The Sex-lethal gene of Drosophila: DNA alterations associated with sex-specific lethal mutations.

  1985cited by this paper
• A transposable P vector that confers selectable G418 resistance to Drosophila larvae

  1985cited by this paper
• Genetic Analysis of the Hairy Locus in DROSOPHILA MELANOGASTER.

  1985cited by this paper
• Molecular genetics of the achaete-scute gene complex of D. melanogaster.

  1985cited by this paper
• Genetic regulation of theAchaete-scute complex ofDrosophila melanogaster

  1984cited by this paper
• Cell interactions in the generation of chaetae pattern inDrosophila

  1984cited by this paper
• Autoregulatory functioning of a Drosophila gene product that establish es and maintains the sexually determined state.

  1984cited by this paper
• Two types of sex determination in a nematode

  1983cited by this paper
• Evolution of sex determining mechanisms

  1983cited by this paper
• The interaction between daughterless and sex-lethal in triploids: a lethal sex-transforming maternal effect linking sex determination and dosage compensation in Drosophila melanogaster.

  1983cited by this paper
• Sex determination and dosage compensation in Drosophila melanogaster.

  1983cited by this paper
• Sex determination and dosage compensation in Drosophila melanogaster: production of male clones in XX females

  1983cited by this paper
• Gene‐dose titration analysis in the search of trans‐regulatory genes in Drosophila.

  1982cited by this paper
• Maternal and zygotic sex-specific gene interactions in Drosophila melanogaster.

  1980cited by this paper
• A male-specific lethal mutation in Drosophila melanogaster that transforms sex.

  1979cited by this paper
• Polyploids and sex determination in Caenorhabditis elegans.

  1979cited by this paper
• Gene dosage compensation and the evolution of sex chromosomes.

  1978cited by this paper
• Two closely linked mutations in Drosophila melanogaster that are lethal to opposite sexes and interact with daughterless.

  1978cited by this paper
• A sex-specific, temperature-sensitive maternal effect of the daughterless mutation of Drosophila melanogaster.

  1976cited by this paper
• A note on the maternal effect mutants daughterless and abnormal oocyte in Drosophila melanogaster.

  1973cited by this paper
• X‐CHROMOSOME INACTIVATION AND DEVELOPMENTAL PATTERNS IN MAMMALS

  1972cited by this paper
• Chromosome studies in selected spontaneous abortions. Polyploidy in man.

  1971cited by this paper
• A Search for a Gene Control System in Drosophila

  1963cited by this paper
• Sex in Relation to Chromosomes and Genes

  1925cited by this paper
• TRIPLOID INTERSEXES IN DROSOPHILA MELANOGASTER.

  1921cited by this paper

• A drug stabilizable GAL80ds for conditional control of gene expression via GAL4-UAS and CRISPR-Cas9 systems in Drosophila

  2024cites this paper
• A history of the genetic and molecular identification of genes and their functions controlling insect sex determination.

  2022cites this paper
• Manipulating Insect Sex Determination Pathways for Genetic Pest Management: Opportunities and Challenges

  2022cites this paper
• A chimeric gene paternally instructs female sex determination in the haplodiploid wasp Nasonia

  2020cites this paper
• Function of Drosophila ovo + in germline sex determination depends on X-chromosome number OLIVER

  2017cites this paper
• Mecanismo de acción del factor represor Capicua, un sensor de señales Ras/MAPK

  2017cites this paper
• A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer

  2017cites this paper
• Origins of Context-Dependent Gene Repression by Capicua

  2015cites this paper
• Control of vein network topology by auxin transport

  2015cites this paper
• Gene Overexpression: Uses, Mechanisms, and Interpretation

  2012cites this paper
• Genetic basis of sex determination in the haplodiploid wasp Nasonia vitripennis

  2011cites this paper
• The Drosophila STUbL protein Degringolade limits HES functions during embryogenesis

  2011cites this paper
• Oxidative Stress Resistance in Drosophila melanogaster

  2010cites this paper
• Role of Repressors in Fine Regulation of Development: Sxl and Its New Repressors Hey and Myc

  2010influential citation
• Investigation of the roX RNAs and the RNA Helicase MLE in Dosage Compensation in Drosophila melanogaster

  2009cites this paper
• Orthologous pair transfer and hybrid Bayes methods to predict the protein-protein interaction network of the Anopheles gambiae mosquitoes

  2008cites this paper
• Molecular titration and ultrasensitivity in regulatory networks.

  2008cites this paper
• Maternal Groucho and bHLH repressors amplify the dose-sensitive X chromosome signal in Drosophila sex determination.

  2008cites this paper
• The creation of sexual dimorphism in the Drosophila soma.

  2008cites this paper
• Purified pre-sertoli cells express genes involved in cell proliferation and cell signalling during a critical window in male sex determination

  2007cites this paper
• The Tailless Nuclear Receptor Acts as a Dedicated Repressor in the Early Drosophila Embryo

  2006cites this paper
• Gene expression and differentiation

  2005cites this paper
• 1.1 – Sex Determination and the Development of the Genital Disc

  2005cites this paper
• The small GTPase Rac plays multiple roles in epithelial sheet fusion--dynamic studies of Drosophila dorsal closure.

  2005cites this paper
• Capsule Consequences of Heteromeric Interadions among Helix-Loop-Helix Proteins

  2005cites this paper
• Rho1 regulates signaling events required for proper Drosophila embryonic development.

  2005cites this paper
• An eh1-Like Motif in Odd-skipped Mediates Recruitment of Groucho and Repression In Vivo

  2005cites this paper
• Drosophila Topors Is a RING Finger-containing Protein That Functions as a Ubiquitin-protein Isopeptide Ligase for the Hairy Basic Helix-Loop-Helix Repressor Protein*

  2004cites this paper
• Sex determining signal inDrosophila melanogaster

  2004cites this paper
• Hairy Transcriptional Repression Targets and Cofactor Recruitment in Drosophila

  2004cites this paper
• Inheritance of most X‐linked traits is not dominant or recessive, just X‐linked

  2004cites this paper
• The roles of transcription factors in B lymphocyte commitment, development, and transformation

  2004cites this paper
• Insect basic leucine zipper proteins and their role in cyclic AMP-dependent regulation of gene expression.

  2004cites this paper
• Constructing an organ: the Drosophila salivary gland as a model for tube formation.

  2003cites this paper
• A theoretical model for the regulation of Sex-lethal, a gene that controls sex determination and dosage compensation in Drosophila melanogaster.

  2003cites this paper
• Epithelial tube morphology is determined by the polarized growth and delivery of apical membrane.

  2002cites this paper
• Sex Determination in Flies, Fruitflies and Butterflies

  2002cites this paper
• Drosophila Sir2 is required for heterochromatic silencing and by euchromatic Hairy/E(Spl) bHLH repressors in segmentation and sex determination.

  2002cites this paper
• Sex and the single chromosome.

  2002cites this paper
• Rho1 interacts with p120ctn and alpha-catenin, and regulates cadherin-based adherens junction components in Drosophila.

  2002cites this paper
• The transformer gene in Ceratitis capitata provides a genetic basis for selecting and remembering the sexual fate.

  2002cites this paper
• Brinker requires two corepressors for maximal and versatile repression in Dpp signalling

  2001cites this paper
• Interpretation of X Chromosome Dose at Sex-lethalRequires Non-E-Box Sites for the Basic Helix-Loop-Helix Proteins SISB and Daughterless

  2001cites this paper
• Vertebrate hairy and Enhancer of split related proteins: transcriptional repressors regulating cellular differentiation and embryonic patterning

  2001cites this paper
• Emc, a negative HLH regulator with multiple functions in Drosophila development

  2001cites this paper
• Groucho augments the repression of multiple Even skipped target genes in establishing parasegment boundaries.

  2001cites this paper
• Specific genetic interference with behavioral rhythms in Drosophila by expression of inverted repeats.

  2000cites this paper
• Structure, function and evolution of sex-determining systems in Dipteran insects.

  2000cites this paper
• Control of endodermal endocrine development by Hes-1

  2000cites this paper
• Groucho/TLE family proteins and transcriptional repression.

  2000cites this paper
• Overlapping Expression of Early B-Cell Factor and Basic Helix-Loop-Helix Proteins as a Mechanism To Dictate B-Lineage-Specific Activity of the λ5 Promoter

  2000cites this paper
• Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family

  2000cites this paper
• Drosophila C-terminal Binding Protein Functions as a Context-dependent Transcriptional Co-factor and Interferes with Both Mad and Groucho Transcriptional Repression*

  2000cites this paper
• A Conserved Motif in Goosecoid Mediates Groucho-Dependent Repression in Drosophila Embryos

  1999cites this paper
• Groucho and dCtBP mediate separate pathways of transcriptional repression in the Drosophila embryo.

  1999cites this paper
• Basic helix-loop-helix proteins can act at the E-box within the serum response element of the c-fos promoter to influence hormone-induced promoter activation in Sertoli cells.

  1999cites this paper
• Sequence and expression analysis of Nhlh1: a basic helix-loop-helix gene implicated in neurogenesis.

  1999cites this paper
• Huckebein repressor activity in Drosophila terminal patterning is mediated by Groucho.

  1999cites this paper
• Mutations in the predicted aspartyl tRNA synthetase of Drosophila are lethal and function as dosage-sensitive maternal modifiers of the sex determination gene Sex-lethal

  1999cites this paper
• Ectopic expression systems in Drosophila.

  1999cites this paper
• Mutations in the Rho1 small GTPase disrupt morphogenesis and segmentation during early Drosophila development.

  1999cites this paper
• Drosophila CtBP: a Hairy‐interacting protein required for embryonic segmentation and Hairy‐mediated transcriptional repression

  1998cites this paper
• Early Events Associated with Sex Determination in Drosophila melanogaster

  1998cites this paper
• The function of hairy‐related bHLH repressor proteins in cell fate decisions

  1998cites this paper
• The genetics of the Drosophila achaete-scute gene complex: a historical appraisal.

  1998cites this paper
• Equivalence of the fly orthodenticle gene and the human OTX genes in embryonic brain development of Drosophila.

  1998cites this paper
• Sex determination in honey bees (Apinae and Meliponinae) and its consequences

  1997cites this paper
• A C. elegans E/Daughterless bHLH protein marks neuronal but not striated muscle development.

  1997cites this paper
• Gene expression of MASH-1, MATH-1, neuroD and NSCL-2, basic helix-loop-helix proteins, during neural differentiation in P19 embryonal carcinoma cells.

  1997cites this paper
• Genes expressed in neurons of adult male Drosophila.

  1997cites this paper
• FIGalpha, a germ cell specific transcription factor involved in the coordinate expression of the zona pellucida genes.

  1997cites this paper
• Groucho acts as a corepressor for a subset of negative regulators, including Hairy and Engrailed.

  1997cites this paper
• Determinación sexual y compensación de dosis génica en drosophila, caenorhabditis y mamíferos: aspectos comparativos

  1997cites this paper
• NeuroD and neurogenesis.

  1997cites this paper
• A network of interacting transcriptional regulators involved in Drosophila neural fate specification revealed by the yeast two-hybrid system.

  1997cites this paper
• SEXUAL DIMORPHISM IN “ THE FLY ” AND “ THE WORM ” In These Model Organisms , X-Chromosome Dose Determines Sexual Fate , Affecting Nearly Every Feature of the Adult Through a Variety of Developmental Effects

  1997cites this paper
• Gene targeted disruption of murine Clk2 in ES cells

  1997cites this paper
• A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2.

  1996cites this paper
• Cloning and characterization of the scute (sc) gene of Drosophila subobscura.

  1996cites this paper
• Genetic dissection of sexual orientation: behavioral, cellular, and molecular approaches in Drosophila melanogaster.

  1996cites this paper
• An adipogenic basic helix-loop-helix-leucine zipper type transcription factor (ADD1) mRNA is expressed and regulated by retinoic acid in osteoblastic cells.

  1996cites this paper
• A comparison of the properties of So Sox-1 and Sox2

  1996cites this paper
• Vive la différence: males vs females in flies vs worms.

  1996cites this paper
• In vivo interactions of the Drosophila Hairy and Runt transcriptional repressors with target promoters.

  1996cites this paper
• scute (sis-b) function in Drosophila sex determination

  1995influential citation
• Specificity for the hairy/enhancer of split basic helix-loop-helix (bHLH) proteins maps outside the bHLH domain and suggests two separable modes of transcriptional repression

  1995cites this paper
• Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein.

  1995cites this paper
• The dual role of hermaphrodite in the Drosophila sex determination regulatory hierarchy.

  1995cites this paper
• A novel initiator regulates expression of the nontissue-specific helix-loop-helix gene ME1.

  1995cites this paper
• Multiple response elements in the Sex-lethal early promoter ensure its female-specific expression pattern

  1995cites this paper
• The developmental consequences of alternate splicing in sex determination and differentiation in Drosophila.

  1995cites this paper
• Protein-protein interactions among components of theDrosophila primary sex determination signal

  1995cites this paper
• Evolutionary conservation of a cell fate specification gene: the Hydra achaete-scute homolog has proneural activity in Drosophila.

  1995cites this paper
• P Schedl expression pattern . early promoter ensure its female-specific Multiple response elements in the Sex-lethal

  1995cites this paper
• Transcription factors 2: helix-loop-helix.

  1995cites this paper
• The gene virilizer is required for female-specific splicing controlled by Sxl, the master gene for sexual development in Drosophila.

  1995cites this paper
• A genetic analysis of intersex, a gene regulating sexual differentiation in Drosophila melanogaster females.

  1995cites this paper
• Gene expression during testis determination in the mouse.

  1995cites this paper
• Genetic and molecular analysis of the autosomal component of the primary sex determination signal of Drosophila melanogaster.

  1995cites this paper
• sex determination regulatory hierarchy

  1995cites this paper