Initiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1)

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Proceedings of the National Academy of Sciences of the United States of America

• Publication date

  2010-10-04

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1073/pnas.1009269107PMID 20921384PMCID PMC2964218
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Autoregulatory systems controlling translation factor expression: thermostat-like control of translational accuracy.

  2010cited by this paper
• Eukaryotic translation initiation factor 1 (eIF1), the inspector of good AUG context for translation initiation, has an extremely bad AUG context.

  2010cited by this paper
• The mechanism of eukaryotic translation initiation and principles of its regulation

  2010cited by this paper
• Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling

  2009cited by this paper
• eIF1 controls multiple steps in start codon recognition during eukaryotic translation initiation.

  2009cited by this paper
• Kinetic and thermodynamic analysis of the role of start codon/anticodon base pairing during eukaryotic translation initiation.

  2008cited by this paper
• Should I Stay or Should I Go? Eukaryotic Translation Initiation Factors 1 and 1A Control Start Codon Recognition*

  2008cited by this paper
• uORFs with unusual translational start codons autoregulate expression of eukaryotic ornithine decarboxylase homologs

  2008cited by this paper
• The eukaryotic translation initiation factors eIF1 and eIF1A induce an open conformation of the 40S ribosome.

  2007cited by this paper
• Dissociation of eIF1 from the 40S ribosomal subunit is a key step in start codon selection in vivo.

  2007cited by this paper
• The fidelity of translation initiation: reciprocal activities of eIF1, IF3 and YciH

  2006cited by this paper
• A conformational change in the eukaryotic translation preinitiation complex and release of eIF1 signal recognition of the start codon.

  2005cited by this paper
• Interactions of Eukaryotic Translation Initiation Factor 3 (eIF3) Subunit NIP1/c with eIF1 and eIF5 Promote Preinitiation Complex Assembly and Regulate Start Codon Selection

  2004cited by this paper
• Position of eukaryotic initiation factor eIF1 on the 40S ribosomal subunit determined by directed hydroxyl radical probing.

  2003cited by this paper
• The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection.

  2002cited by this paper
• Pushing the limits of the scanning mechanism for initiation of translation

  2002cited by this paper
• 12 Genetic Approaches to Translation Initiation in Saccharomyces cerevisiae

  2000cited by this paper
• A dual-luciferase reporter system for studying recoding signals.

  1998cited by this paper
• The role of the AUU initiation codon in the negative feedback regulation of the gene for translation initiation factor IF3 in Escherichia coli

  1996cited by this paper
• The suil suppressor locus in Saccharomyces cerevisiae encodes a translation factor that functions during tRNA(iMet) recognition of the start codon

  1992cited by this paper
• Efficient initiation of translation at non-AUG triplets in plant cells.

  1992cited by this paper
• Genetic characterization of the Saccharomyces cerevisiae translational initiation suppressors sui1, sui2 and SUI3 and their effects on HIS4 expression.

  1990cited by this paper
• Translation initiation at non-AUG triplets in mammalian cells.

  1989cited by this paper
• Context effects and inefficient initiation at non-AUG codons in eucaryotic cell-free translation systems

  1989cited by this paper
• Genetic selection for mutations that reduce or abolish ribosomal recognition of the HIS4 translational initiator region

  1988cited by this paper
• Efficiency of translation initiation by non-AUG codons in Saccharomyces cerevisiae

  1988cited by this paper
• AUU-to-AUG mutation in the initiator codon of the translation initiation factor IF3 abolishes translational autocontrol of its own gene (infC) in vivo.

  1987cited by this paper
• Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes.

  1986cited by this paper
• Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs.

  1984cited by this paper

• 5′ UTR length regulates alternative N-terminal protein isoform production in health and disease

  2026cites this paper
• Dual Luciferase Reporter Assay in Schizosaccharomyces pombe.

  2025cites this paper
• Translation Initiation Fidelity Defective Mutations in eIF5 and eIF2β Show Distinct Sensitivity to the Sequence Context for Recognition of the UUG Start Codon.

  2025cites this paper
• The earliest changes in the translatome upon human T cell activation

  2025cites this paper
• eIF1 and eIF5 dynamically control translation start site fidelity

  2025cites this paper
• Molecular basis for the interactions of eIF2β with eIF5, eIF2B, and 5MP1 and their regulation by CK2.

  2025cites this paper
• Exploring the interaction dynamics of eukaryotic translation initiation factor 2

  2025cites this paper
• The implication of non-AUG-initiated N-terminally extended proteoforms in cancer

  2025cites this paper
• Potential therapeutic targets of eukaryotic translation initiation factors in tumor therapy.

  2025cites this paper
• Distinct uS11/Rps14 interactions with the translation preinitiation complex differentially alter the accuracy of start codon recognition.

  2025cites this paper
• A Portrait of Three Mammalian Bicistronic mRNA Transcripts, Derived from the Genes ASNSD1, SLC35A4, and MIEF1

  2025cites this paper
• Discovery of paradoxical genes: reevaluating the prognostic impact of overexpressed genes in cancer

  2025cites this paper
• Triple coding in human SRD5A1 mRNA

  2024cites this paper
• Critical cis-parameters influence STructure assisted RNA translation (START) initiation on non-AUG codons in eukaryotes

  2024cites this paper
• Nuclear release of eIF1 restricts start-codon selection during mitosis

  2024influential citation
• Exploiting Translation Machinery for Cancer Therapy: Translation Factors as Promising Targets

  2024cites this paper
• JUN mRNA translation regulation is mediated by multiple 5’ UTR and start codon features

  2024cites this paper
• Translational regulation enhances distinction of cell types in the nervous system

  2024cites this paper
• Nuclear release of eIF1 globally increases stringency of start-codon selection to preserve mitotic arrest physiology

  2024cites this paper
• eIF1 and eIF5 dynamically control translation start site fidelity

  2024cites this paper
• Tiny but mighty: Diverse functions of uORFs that regulate gene expression

  2024cites this paper
• The Mitogenomic Characterization and Phylogenetic Analysis of the Plant Pathogen Phyllosticta yuccae

  2024cites this paper
• Structural basis of AUC codon discrimination during translation initiation in yeast

  2024cites this paper
• SARS-CoV-2 Nsp1 cooperates with initiation factors EIF1 and 1A to selectively enhance translation of viral RNA

  2024cites this paper
• Translation initiation at AUG and non-AUG triplets in plants.

  2023cites this paper
• Increased levels of eIF2A inhibit translation by sequestering 40S ribosomal subunits

  2023influential citation
• Human Tissues Exhibit Diverse Composition of Translation Machinery

  2023cites this paper
• Chloroplasts evolved an additional layer of translational regulation based on non-AUG start codons for proteins with different turnover rates

  2023cites this paper
• PRRC2 proteins impact translation initiation by promoting leaky scanning

  2023cites this paper
• Translational regulation enhances distinction of cell types in the 2 nervous system 3

  2023cites this paper
• Alternative CDC20 translational isoforms tune mitotic arrest duration

  2023cites this paper
• Impact of eIF2α phosphorylation on the translational landscape of mouse embryonic stem cells

  2023cites this paper
• The Tox Gene Encodes Two Proteins with Distinct and Shared Roles in Gene Regulation.

  2023cites this paper
• The Roles of eIF4G2 in Leaky Scanning and Reinitiation on the Human Dual-Coding POLG mRNA

  2023cites this paper
• Functional analysis of the AUG initiator codon context reveals novel conserved sequences that disfavor mRNA translation in eukaryotes

  2023cites this paper
• JUN mRNA Translation Regulation is Mediated by Multiple 5’ UTR and Start Codon Features

  2023cites this paper
• Mycobacterium bovis BCG dodecin gene codes a functional protein despite of a start codon mutation.

  2023cites this paper
• Translational regulation by uORFs and start codon selection stringency

  2023influential citation
• Making sense of mRNA translational "noise".

  2023cites this paper
• Specific mechanisms of translation initiation in higher eukaryotes: the eIF4G2 story

  2022cites this paper
• PRRC2 proteins regulate translation initiation by promoting leaky scanning

  2022cites this paper
• Partners in crime: Proteins implicated in RNA repeat expansion diseases

  2022cites this paper
• Inhibitors of eIF4G1–eIF1 uncover its regulatory role of ER/UPR stress-response genes independent of eIF2α-phosphorylation

  2022cites this paper
• Modeling the ribosomal small subunit dynamic in Saccharomyces cerevisiae based on TCP-seq data

  2022cites this paper
• Evolutionarily conserved inhibitory uORFs sensitize Hox mRNA translation to start codon selection stringency

  2022influential citation
• The effect of the nucleotides immediately upstream of the AUG start codon on the efficiency of translation initiation in sperm cells

  2022cites this paper
• Non-AUG translation initiation in mammals

  2022cites this paper
• Translational recoding by chemical modification of non-AUG start codon ribonucleotide bases

  2022cites this paper
• EIF1A depletion restrains human pituitary adenoma progression

  2021cites this paper
• Comparative Proteomic Study Shows the Expression of Hint-1 in Pituitary Adenomas

  2021cites this paper
• Genome-wide identification of Arabidopsis non-AUG-initiated upstream ORFs with evolutionarily conserved regulatory sequences that control protein expression levels

  2021cites this paper
• Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.

  2021cites this paper
• Combinatorial analysis of translation dynamics reveals eIF2 dependence of translation initiation at near-cognate codons

  2021cites this paper
• Characterizing the molecular etiology of arthrogryposis multiplex congenita in patients with LGI4 mutations

  2021cites this paper
• Mechanistic convergence across initiation sites for RAN translation in fragile X associated tremor ataxia syndrome.

  2021cites this paper
• Post-transcriptional and translational control of the morphology and virulence in human fungal pathogens.

  2021cites this paper
• uS5/Rps2 residues at the 40S ribosome entry channel enhance initiation at suboptimal start codons in vivo.

  2021cites this paper
• eIF2α interactions with mRNA control accurate start codon selection by the translation preinitiation complex.

  2020cites this paper
• eIF1 discriminates against suboptimal initiation sites to prevent excessive uORF translation genome-wide

  2020cites this paper
• Quantitative global studies reveal differential translational control by start codon context across the fungal kingdom

  2020cites this paper
• Non-AUG start codons: Expanding and regulating the small and alternative ORFeome.

  2020cites this paper
• Unprecedentedly efficient CUG initiation of an overlapping reading frame in POLG mRNA yields novel protein POLGARF

  2020cites this paper
• Tailoring translational strength using Kozak sequence variants improves bispecific antibody assembly and reduces product‐related impurities in CHO cells

  2020cites this paper
• Translational gene regulation in plants: A green new deal

  2020cites this paper
• Determination of Reference Genes for Ovine Pulmonary Adenocarcinoma Infected Lung Tissues Using RNA-seq Transcriptome Profiling.

  2020cites this paper
• Translation initiation downstream from annotated start codons in human mRNAs coevolves with the Kozak context

  2020cites this paper
• Conserved Upstream Open Reading Frame Nascent Peptides that Control Translation.

  2020cites this paper
• Unusually efficient CUG initiation of an overlapping reading frame in POLG mRNA yields novel protein POLGARF

  2020cites this paper
• Translational Regulation by Upstream Open Reading Frames and Its Relevance to Human Genetic Disease

  2020cites this paper
• Most non-canonical proteins uniquely populate the proteome or immunopeptidome.

  2020cites this paper
• Conserved uORF Nascent Peptides that Control Translation

  2020cites this paper
• Towards the mechanism(s) of YB-3 synthesis regulation by YB-1

  2020cites this paper
• Near-cognate initiation generates FMRpolyG from CGG repeats in Fragile X associated Tremor Ataxia Syndrome

  2020cites this paper
• Prevalence of alternative AUG and non-AUG translation initiators and their regulatory effects across plants

  2020cites this paper
• eIF4G2 balances its own mRNA translation via a PCBP2-based feedback loop

  2019cites this paper
• Auto-regulatory feedback by RNA-binding proteins

  2019cites this paper
• Start codon context controls translation initiation in the fungal kingdom

  2019cites this paper
• L’usage des codons régule la présentation des peptides associés aux molécules du CMH-I

  2019cites this paper
• DDX3X and specific initiation factors modulate FMR1 repeat‐associated non‐AUG‐initiated translation

  2019cites this paper
• Dynamic Interaction of Eukaryotic Initiation Factor 4G1 (eIF4G1) with eIF4E and eIF1 Underlies Scanning-Dependent and -Independent Translation

  2018cites this paper
• Protein Synthesis Initiation in Eukaryotic Cells.

  2018cites this paper
• Charting DENR-dependent translation reinitiation uncovers predictive uORF features and links to circadian timekeeping via Clock

  2018cites this paper
• Structure of a partial yeast 48S preinitiation complex with eIF5 N-terminal domain (model C1)

  2018cites this paper
• Studying sequence effects of mRNA 5' cap juxtapositions on translation initiation rate using randomization strategy of the extreme 5' end of mRNA

  2018cites this paper
• Polyamine Control of Translation Elongation Regulates Start Site Selection on Antizyme Inhibitor mRNA via Ribosome Queuing.

  2018cites this paper
• Role of aIF1 in Pyrococcus abyssi translation initiation

  2018cites this paper
• eIF1 Loop 2 interactions with Met-tRNAi control the accuracy of start codon selection by the scanning preinitiation complex

  2018cites this paper
• Translational autoregulation of BZW1 and BZW2 expression by modulating the stringency of start codon selection

  2018cites this paper
• Translation initiation by cap‐dependent ribosome recruitment: Recent insights and open questions

  2018cites this paper
• Toward a Kinetic Understanding of Eukaryotic Translation.

  2018influential citation
• Translation control of mRNAs encoding mammalian translation initiation factors.

  2018cites this paper
• Leucine modulates the IPEC-J2 cell proteome associated with cell proliferation, metabolism and phagocytosis

  2018cites this paper
• Translation acrobatics: how cancer cells exploit alternate modes of translational initiation

  2018cites this paper
• Cancer-Associated Eukaryotic Translation Initiation Factor 1A Mutants Impair Rps3 and Rps10 Binding and Enhance Scanning of Cell Cycle Genes

  2018cites this paper
• Translational initiation factor eIF5 replaces eIF1 on the 40S ribosomal subunit to promote start-codon recognition

  2018cites this paper
• A network of eIF2β interactions with eIF1 and Met-tRNAi promotes accurate start codon selection by the translation preinitiation complex

  2018cites this paper
• Complete motif analysis of sequence requirements for translation initiation at non-AUG start codons

  2017cites this paper
• Non-AUG translation: a new start for protein synthesis in eukaryotes

  2017influential citation
• Translation Initiation from Conserved Non-AUG Codons Provides Additional Layers of Regulation and Coding Capacity

  2017cites this paper
• eIF1 modulates the recognition of suboptimal translation initiation sites and steers gene expression via uORFs

  2017cites this paper