Arginine-Specific Gingipains from Porphyromonas gingivalis Stimulate Production of Hepatocyte Growth Factor (Scatter Factor) through Protease-Activated Receptors in Human Gingival Fibroblasts in Culture1

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Journal of Immunology

• Publication date

  2005-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.4049/jimmunol.175.9.6076PMID 16237103
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2002influential reference
• Hepatocyte growth factor in cerebrospinal fluid in neurologic disease

  2002cited by this paper
• Agonists of proteinase-activated receptor 2 induce cytokine release and activation of nuclear transcription factor kappaB in human dermal microvascular endothelial cells.

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• Hepatocyte growth factor in gingival crevicular fluid and the distribution of hepatocyte growth factor-activator in gingival tissue from adult periodontitis.

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• Hepatocyte growth factor (HGF) in periodontal disease: detection of HGF in gingival crevicular fluid.

  2002cited by this paper
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  2001influential reference
• Arginine-Specific Protease fromPorphyromonas gingivalis Activates Protease-Activated Receptors on Human Oral Epithelial Cells and Induces Interleukin-6 Secretion

  2001influential reference
• Protease activated receptors: theme and variations

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  2001cited by this paper
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  2000influential reference
• Enhancement of hepatocyte growth factor (scatter factor) production by human gingival fibroblasts in culture stimulated with Porphyromonas gingivalis fimbriae.

  2000cited by this paper
• Thrombin signalling and protease-activated receptors

  2000cited by this paper
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  2000cited by this paper
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  2000cited by this paper
• Development of highly sensitive enzyme-linked immunosorbent assays for hepatocyte growth factor/scatter factor (HGF/SF): determination of HGF/SF in serum and urine from normal human subjects.

  2000cited by this paper
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• Genetic Analyses of Proteolysis, Hemoglobin Binding, and Hemagglutination of Porphyromonas gingivalis

  1999cited by this paper
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  1998cited by this paper
• Heterogeneous Expression and Release of CD14 by Human Gingival Fibroblasts: Characterization and CD14-Mediated Interleukin-8 Secretion in Response to Lipopolysaccharide

  1998cited by this paper
• Arg-gingipain Acts as a Major Processing Enzyme for Various Cell Surface Proteins in Porphyromonas gingivalis*

  1998cited by this paper
• Interactions between scatter factors and their receptors: hints for therapeutic applications

  1998cited by this paper
• Elevated serum concentrations of hepatocyte growth factor in patients with multiple myeloma. The Nordic Myeloma Study Group.

  1998cited by this paper
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  1998cited by this paper
• Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase.

  1998cited by this paper
• Comparative Properties of Two Cysteine Proteinases (Gingipains R), the Products of Two Related but Individual Genes ofPorphyromonas gingivalis *

  1998cited by this paper
• Proteinase-activated receptors: novel mechanisms of signaling by serine proteases.

  1998cited by this paper
• Titration and Mapping of the Active Site of Cysteine Proteinases from Porphyromonas gingivalis (Gingipains) Using Peptidyl Chloromethanes

  1997cited by this paper
• Urinary and tissue levels of scatter factor in transitional cell carcinoma of bladder.

  1997cited by this paper
• Activation of Blood Coagulation Factor X by Arginine-specific Cysteine Proteinases (Gingipain-Rs) from Porphyromonas gingivalis *

  1997cited by this paper
• Hepatocyte growth factor and hepatocyte growth factor receptor in the lacrimal gland, tears, and cornea.

  1996cited by this paper
• Mechanisms of Hepatocyte Growth Factor Stimulation of Keratinocyte Metalloproteinase Production*

  1996cited by this paper
• Proteolytic inactivation of the leukocyte C5a receptor by proteinases derived from Porphyromonas gingivalis

  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Lipoteichoic acid and interleukin 1 stimulate synergistically production of hepatocyte growth factor (scatter factor) in human gingival fibroblasts in culture

  1996cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Pathogenic strategies of the oral anaerobe, Porphyromonas gingivalis.

  1995cited by this paper
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  1995cited by this paper
• Proteolytically active streptococcal pyrogenic exotoxin B cleaves monocytic cell urokinase receptor and releases an active fragment of the receptor from the cell surface.

  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1989cited by this paper
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  1988cited by this paper

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  2018cites this paper
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  2014cites this paper
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  2009cites this paper
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  2008cites this paper
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  2006cites this paper
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