Hepatocyte growth factor/hepatopoietin A stimulates the growth of rat kidney proximal tubule epithelial cells (RPTE), rat nonparenchymal liver cells, human melanoma cells, mouse keratinocytes and stimulates anchorage-independent growth of SV-40 transformed RPTE.

No abstract is available for this paper.

• Publication year

  1991

• Venue

  Biochemical and Biophysical Research Communications - BBRC

• Publication date

  1991-01-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/0006-291X(91)90524-BPMID 1846541
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Liver regeneration: molecular mechanisms of growth control

  1990cited by this paper
• Deduced primary structure of rat hepatocyte growth factor and expression of the mRNA in rat tissues.

  1990cited by this paper
• Identity of a tumor cytotoxic factor from human fibroblasts and hepatocyte growth factor.

  1990cited by this paper
• Tissue distribution of hepatopoietin-A: a heparin-binding polypeptide growth factor for hepatocytes.

  1990cited by this paper
• The heparin-binding (fibroblast) growth factor family of proteins.

  1989cited by this paper
• NH2-terminal amino acid sequence of rabbit hepatopoietin A, a heparin-binding polypeptide growth factor for hepatocytes.

  1989cited by this paper
• Purification and biological characterization of human hepatopoietin A, a polypeptide growth factor for hepatocytes.

  1989cited by this paper
• Rat kidney proximal tubule cells in defined medium: The roles of cholera toxin, extracellular calcium and serum in cell growth and expression of γ-glutamyltransferase

  1989cited by this paper
• Detection of glucocorticoid sensitive secretory proteins from human melanoma cells.

  1989cited by this paper
• Heparin-binding growth factor type 1 (acidic fibroblast growth factor): a potential biphasic autocrine and paracrine regulator of hepatocyte regeneration.

  1989cited by this paper
• Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor.

  1989cited by this paper
• Molecular cloning and expression of human hepatocyte growth factor

  1989cited by this paper
• High and low affinity binding of heparin-binding growth factor to a 130-kDa receptor correlates with stimulation and inhibition of growth of a differentiated human hepatoma cell.

  1988cited by this paper
• Cholesterol requirement of P3-X63-Ag8 and X63-Ag8.653 mouse myeloma cells for growth in vitro

  1987cited by this paper
• Stimulation of growth of primary cultured adult rat hepatocytes without growth factors by coculture with nonparenchymal liver cells.

  1987cited by this paper
• Long-term serial cultivation and growth requirements for human umbilical vein endothelial cells

  1985cited by this paper
• Cultivation, frozen storage, and clonal growth of normal human epidermal keratinocytes in serum-free media

  1985cited by this paper
• Direct mitogenic effects of insulin, epidermal growth factor, glucocorticoid, cholera toxin, unknown pituitary factors and possibly prolactin, but not androgen, on normal rat prostate epithelial cells in serum-free, primary cell culture.

  1984cited by this paper
• Effects of partial hepatectomy on transplanted hepatocytes.

  1982cited by this paper
• In vitro proliferation and lifespan of human diploid fibroblasts in serum‐free BSA‐containing medium

  1982cited by this paper
• Growth of human foreskin fibroblasts in a serum‐free, defined medium without platelet‐derived growth factor

  1982cited by this paper
• Human hepatocellular carcinoma cell lines secrete the major plasma proteins and hepatitis B surface antigen.

  1980cited by this paper
• HETEROTOPIC PARTIAL AUTOTRANSPLANTATION OF RAT LIVER: TECHNIC AND DEMONSTRATION OF STRUCTURE AND FUNCTION OF THE GRAFT.

  1964cited by this paper

• Therapeutic advances of targeting receptor tyrosine kinases in cancer

  2024cites this paper
• Heterogeneity of cancer-associated fibroblasts in head and neck squamous cell carcinoma: opportunities and challenges

  2023influential citation
• Treatment of critical limb ischaemia by pIRES/VEGF165/HGF administration.

  2019cites this paper
• HGF/c-MET Signaling in Melanocytes and Melanoma

  2018cites this paper
• Evaluation of mRNA/ Gene Expression of Pro-Angiogenic Factors – Ang 1, Ang 2 and HGF in Periodontal Health and Disease

  2017cites this paper
• The Involvement of Hepatocyte Growth Factor-MET-Matrix Metalloproteinase 1 Signaling in Bladder Cancer Invasiveness and Proliferation. Effect of the MET Inhibitor, Cabozantinib (XL184), on Bladder Cancer Cells.

  2017cites this paper
• INDUCED PROLIFERATION AND DIFFERENTIATION OF ERYTHROID CELLS

  2017cites this paper
• A combination of VEGF 165 / HGF genes is more effective in blood vessels formation than ANGPT 1 / VEGF 165 genes in an in vivo rat model

  2016cites this paper
• The crossroads of tissue growth and metabolism in liver regeneration

  2016cites this paper
• The HGF-cMET signaling pathway in conferring stromal-induced BRAF-inhibitor resistance in melanoma

  2015cites this paper
• Mitigation of Tumor-Associated Fibroblast-Facilitated Head and Neck Cancer Progression With Anti-Hepatocyte Growth Factor Antibody Ficlatuzumab.

  2015cites this paper
• Resistance to targeted cancer drugs through hepatocyte growth factor signaling

  2014cites this paper
• Incremento en la expresión del ARNm del receptor c-Met en el cáncer gástrico.

  2013cites this paper
• HGF Accelerates Wound Healing by Promoting the Dedifferentiation of Epidermal Cells through β 1-Integrin/ILK Pathway

  2013cites this paper
• [Increased expression of the c-Met receptor mRNA in gastric cancer].

  2013cites this paper
• Mitogen-activated protein kinases-dependent induction of hepatocyte growth factor production in human dermal fibroblasts by the antibiotic polymyxin B.

  2012cites this paper
• Cytokine network: new targeted therapy for pancreatic cancer.

  2012cites this paper
• Integrin-linked kinase (ILK) modulates wound healing through regulation of hepatocyte growth factor (HGF).

  2012cites this paper
• Current understanding of the molecular mechanisms of kidney cancer: a primer for urologists.

  2012cites this paper
• Differential Specificity of Endocrine FGF19 and FGF21 to FGFR1 and FGFR4 in Complex with KLB

  2012cites this paper
• Growth factor signaling pathways as targets for prevention of epithelial carcinogenesis

  2011cites this paper
• A Systems Level Analysis of the Transcription Factor FoxN2/3 and FGF Signal Transduction in Sea Urchin Larval Skeleton Development and Body Axis Formation

  2011cites this paper
• Protein C Inhibitor

  2011cites this paper
• Cancer cell‐derived IL‐1α promotes HGF secretion by stromal cells and enhances metastatic potential in pancreatic cancer cells

  2010cites this paper
• Hepatocyte growth factor activator (HGFA): its regulation by protein C inhibitor

  2010cites this paper
• The Role of Oncogene Activation in Tumor Progression

  2010cites this paper
• Assessment of the labelling index of cohorts of the pancreatic islet cell population in phenobarbitone-treated male rats using a double immunohistochemical technique for 5-bromo-2′-deoxyuridine and pancreatic hormones

  2009cites this paper
• Id1 Is Down-Regulated by Hepatocyte Growth Factor via ERK-Dependent and ERK-Independent Signaling Pathways, Leading to Increased Expression of p16INK4a in Hepatoma Cells

  2009cites this paper
• Id 1 Is Down-Regulated by Hepatocyte Growth Factor via ERK-Dependent and ERK-Independent Signaling Pathways , Leading to Increased Expression of p 16 INK 4 a in Hepatoma Cells

  2009cites this paper
• Expression of c‐MET, low‐molecular‐weight cytokeratin, matrix metalloproteinases‐1 and ‐2 in spinal chordoma

  2009cites this paper
• Expression of hepatocyte growth factor and c‐MET in skull base chordoma

  2008cites this paper
• Ovarian-type stroma in hepatobiliary cystadenomas and pancreatic mucinous cystic neoplasms: an immunohistochemical study.

  2008cites this paper
• Hepatocyte growth factor gene therapy for hypertension.

  2008cites this paper
• Serum concentration of hepatocyte growth factor (HGF) in oral squamous cell carcinoma before and after surgery. Preliminary report.

  2008cites this paper
• Intercellular Adhesion Molecule 1 (ICAM-1) a Novel Co-Receptor for c-Met

  2008cites this paper
• Involvement of hepatocyte growth factor on hepatocarcinogenesis induced by peroxisome proliferators

  2007cites this paper
• Hepatocyte growth factor establishes autocrine and paracrine feedback loops for the protection of skin cells after UV irradiation.

  2007cites this paper
• Protein C inhibitor directly and potently inhibits activated hepatocyte growth factor activator

  2007cites this paper
• Plasminogen Activators uPA and tPA

  2007cites this paper
• Hepatocyte Growth Factor and Transforming Growth Factor-^ Stimulate both Cell Growth and Migration of HumanGastric Adenocarcinoma Cells 1

  2006cites this paper
• Control of Fibroblast Growth Factor (FGF) 7- and FGF1-induced Mitogenesis and Downstream Signaling by Distinct Heparin Octasaccharide Motifs*

  2006cites this paper
• Evaluation of dysregulation of the receptor tyrosine kinases Kit, Flt3, and Met in histiocytic sarcomas of dogs.

  2006cites this paper
• Characterization, expression and function of c-Met in canine spontaneous cancers.

  2005cites this paper
• Adenoviral gene transduction of hepatocyte growth factor elicits inhibitory effects for hepatoma.

  2005cites this paper
• Modulation of hepatocyte growth factor induction in human skin fibroblasts by retinoic acid.

  2005cites this paper
• Hepatocyte Growth Factor / Scatter Factor Is an Autocrine Factor for Human Normal Bronchial Epithelial and Lung Carcinoma Cells 1

  2005cites this paper
• Hepatocyte Growth Factor Induces Redistribution of p21CIP1 and p27KIP1 through ERK-dependent p16INK4a Up-regulation, Leading to Cell Cycle Arrest at G1 in HepG2 Hepatoma Cells*

  2005cites this paper
• Culture Receptors in Human Gingival Fibroblasts in ( Scatter Factor ) through Protease-Activated Production of Hepatocyte Growth Factor Stimulate

  2005cites this paper
• Arginine-Specific Gingipains from Porphyromonas gingivalis Stimulate Production of Hepatocyte Growth Factor (Scatter Factor) through Protease-Activated Receptors in Human Gingival Fibroblasts in Culture1

  2005cites this paper
• Synergistic induction of hepatocyte growth factor in human skin fibroblasts by the inflammatory cytokines interleukin-1 and interferon-gamma.

  2005cites this paper
• Assessment of the influence of subacute phenobarbitone administration on multi-tissue cell proliferation in the rat using bromodeoxyuridine immunocytochemistry

  2005cites this paper
• Involvement of down-regulation of Cdk2 activity in hepatocyte growth factor-induced cell cycle arrest at G1 in the human hepatocellular carcinoma cell line HepG2.

  2004cites this paper
• Expression of HGF mRNA in human rejecting kidney as evidenced by in situ hybridization

  2004cites this paper
• Hepatotrophic activity in mouse serum infected with plerocercoids ofSpirometra erinacei

  2004cites this paper
• Hepatocyte growth factor (HGF) in periodontal disease: detection of HGF in gingival crevicular fluid.

  2002cites this paper
• Early gene expression of hepatocyte growth factor in mononuclear phagocytes of rat liver after administration of carbon tetrachloride.

  2002cites this paper
• Characterization of glomerular cell phenotypes following repeated cycles of benzo[a]pyrene injury in vitro.

  2002cites this paper
• Hepatocyte growth factor (HGF) as a rapid diagnostic marker and its potential in the prevention of acute renal rejection

  2002cites this paper
• Establishment of a new human synovial sarcoma cell line, FU-SY-1, that expresses c-Met receptor and its ligand hepatocyte growth factor.

  2002cites this paper
• Hepatocyte growth factor: renotropic role and potential therapeutics for renal diseases.

  2001cites this paper
• Receptor tyrosine kinase signalling as a target for cancer intervention strategies.

  2001cites this paper
• Detection of Serum and Intrahepatic Human Hepatocyte Growth Factor in Patients with Type C Liver Diseases

  2001cites this paper
• Ductular morphogenesis and functional polarization of normal human biliary epithelial cells in three-dimensional culture.

  2001cites this paper
• Hepatocyte growth factor is predominantly expressed by the carcinoma cells in non-small-cell lung cancer.

  2001cites this paper
• Lipopolysaccharide potentiates the effect of hepatocyte growth factor upon replication in lung, thyroid, spleen, and colon in rats in vivo.

  2001cites this paper
• Maintenance of the differentiated type II cell characteristics by culture on an acellular human amnion membrane

  2001cites this paper
• Increase in hepatocyte growth factor receptor tyrosine kinase activity in renal carcinoma cells is associated with increased motility partly through phosphoinositide 3-kinase activation

  2001cites this paper
• High Intensity ERK Signal Mediates Hepatocyte Growth Factor-induced Proliferation Inhibition of the Human Hepatocellular Carcinoma Cell Line HepG2*

  2001cites this paper
• Hepatocyte growth factor/scatter factor in the eye.

  2000cites this paper
• Kinase Inhibitors in Cancer Therapy

  2000cites this paper
• Usefulness of serum hepatocyte growth factor for the diagnosis of amyloidosis.

  2000cites this paper
• Progress in the development of inhibitors of SH2 domains.

  2000cites this paper
• The Tyrosine Phosphatase SHP-2 Is Required for Sustained Activation of Extracellular Signal-Regulated Kinase and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase

  2000cites this paper
• Induction of tumor cell differentiation.

  2000cites this paper
• Production of Functional Hepatocyte Growth Factor (HGF) in Insect Cells Infected with an HGF‐Recombinant Baculovirus in a Serum‐Free Medium

  2000cites this paper
• Met receptor tyrosine kinase: enhanced signaling through adapter proteins

  2000cites this paper
• Expression of hepatocyte growth factor (HGF)/scatter factor and its receptor c-MET correlates with poor prognosis in synovial sarcoma.

  2000cites this paper
• C-Met Protooncogene Expression and Its Regulation by Cytokines in the Regenerating Pancreas and in Pancreatic Cancer Cells

  2000cites this paper
• Mechanism of regulation of HGF/SF gene expression in fibroblasts by TGF-beta1.

  2000cites this paper
• Hepatocyte growth factor/scatter factor‐induced intracellular signalling

  2000influential citation
• Hepatocyte growth factor-stimulated invasiveness of monocytes.

  2000cites this paper
• The role of polypeptide growth factors in human carcinomas: new targets for a novel pharmacological approach.

  2000cites this paper
• C-met protooncogene expression and its regulation by cytokines in the regenerating pancreas and in pancreatic cancer cells.

  2000cites this paper
• c-Src, receptor tyrosine kinases, and human cancer.

  1999cites this paper
• The Gab1 PH Domain Is Required for Localization of Gab1 at Sites of Cell-Cell Contact and Epithelial Morphogenesis Downstream from the Met Receptor Tyrosine Kinase

  1999cites this paper
• Interferon-gamma upregulates the c-Met/hepatocyte growth factor receptor expression in alveolar epithelial cells.

  1999cites this paper
• Urokinase is a positive regulator of epidermal proliferation in vivo.

  1999cites this paper
• Characterization of a functional relationship between hepatocyte growth factor and mouse bone marrow-derived mast cells.

  1999cites this paper
• The role of hepatocyte growth factor and its receptor c-Met in multiple myeloma and other blood malignancies.

  1999cites this paper
• Hepatocyte growth factor and the kidney: it is not just for the liver.

  1999cites this paper
• A Conserved Inositol Phospholipid Binding Site within the Pleckstrin Homology Domain of the Gab1 Docking Protein Is Required for Epithelial Morphogenesis*

  1999cites this paper
• Hepatocyte growth factor induces tubulogenesis of primary renal proximal tubular epithelial cells

  1999cites this paper
• Met-HGF/SF mediates growth arrest and differentiation in T47D breast cancer cells.

  1999cites this paper
• Hepatocyte growth factor enhances the invasion activity of human hepatocellular carcinoma cell lines.

  1998cites this paper
• Activated rat stellate cells express c-met and respond to hepatocyte growth factor to enhance transforming growth factor beta1 expression and DNA synthesis.

  1998cites this paper
• Serum human hepatocyte growth factor (hHGF) is elevated in patients with metastatic gastric carcinoma.

  1998cites this paper
• Mitogenic effects of EGF/TGFα and immunolocalization of cognate receptors in human fetal kidneys

  1998cites this paper
• Possible involvement of p21/waf1 in the growth inhibition of HepG2 cells induced by hepatocyte growth factor

  1998cites this paper
• Growth Factor–dependent Activation of αvβ3 Integrin in Normal Epithelial Cells: Implications for Tumor Invasion

  1998cites this paper
• Crystal structure of the NK 1 fragment of human hepatocyte growth factor at 2 . 0 Å resolution

  1998cites this paper