Neural Stem Cell-based Gene Therapy for Brain Tumors

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Stem Cell Reviews and Reports

• Publication date

  2011-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s12015-010-9154-1PMID 20521177
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2009cited by this paper
• c-MycERTAM transgene silencing in a genetically modified human neural stem cell line implanted into MCAo rodent brain

  2009cited by this paper
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  2008cited by this paper
• Neural Stem Cell Tropism to Glioma: Critical Role of Tumor Hypoxia

  2008cited by this paper
• Therapeutic stem-cells for cancer treatment: hopes and hurdles in tactical warfare.

  2008cited by this paper
• Production and characterization of immortal human neural stem cell line with multipotent differentiation property.

  2008cited by this paper
• Neural Stem Cell Targeting of Glioma Is Dependent on Phosphoinositide 3‐Kinase Signaling

  2008cited by this paper
• Neural Stem Cell-mediated Therapy of Primary and Metastatic Solid Tumors

  2007cited by this paper
• Intravenously transplanted human neural stem cells migrate to the injured spinal cord in adult mice in an SDF-1- and HGF-dependent manner

  2007influential reference
• Gene therapy clinical trials worldwide to 2007—an update

  2007cited by this paper
• Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma.

  2007influential reference
• Brain Transplantation of Immortalized Human Neural Stem Cells Promotes Functional Recovery in Mouse Intracerebral Hemorrhage Stroke Model

  2007cited by this paper
• Human Neural Stem Cells Over-Expressing VEGF Provide Neuroprotection, Angiogenesis and Functional Recovery in Mouse Stroke Model

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  2007cited by this paper
• Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease

  2007cited by this paper
• Novel method for visualizing and modeling the spatial distribution of neural stem cells within intracranial glioma.

  2007cited by this paper
• Human neural stem cells target and deliver therapeutic gene to experimental leptomeningeal medulloblastoma

  2007influential reference
• Migration of Endothelial Progenitor Cells Mediated by Stromal Cell-Derived Factor-1α/CXCR4 via PI3K/Akt/eNOS Signal Transduction Pathway

  2007cited by this paper
• Intravascular administration of tumor tropic neural progenitor cells permits targeted delivery of interferon-beta and restricts tumor growth in a murine model of disseminated neuroblastoma.

  2007cited by this paper
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  2007cited by this paper
• Development of a Tumor-Selective Approach to Treat Metastatic Cancer

  2006cited by this paper
• Targeting of melanoma brain metastases using engineered neural stem/progenitor cells.

  2006cited by this paper
• Brain transplantation of human neural stem cells transduced with tyrosine hydroxylase and GTP cyclohydrolase 1 provides functional improvement in animal models of Parkinson disease

  2006cited by this paper
• Transplantation of Human Neural Stem Cells Exerts Neuroprotection in a Rat Model of Parkinson's Disease

  2006cited by this paper
• Antitumor efficacy of AAV-mediated systemic delivery of interferon-β

  2006cited by this paper
• Gene therapy: can neural stem cells deliver?

  2006cited by this paper
• Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells: Proliferation, Migration, and Differentiation

  2006cited by this paper
• Human Neural Stem Cells Target Experimental Intracranial Medulloblastoma and Deliver a Therapeutic Gene Leading to Tumor Regression

  2006cited by this paper
• Induction of the interferon response by siRNA is cell type- and duplex length-dependent.

  2006cited by this paper
• Brain tumor tropism of transplanted human neural stem cells is induced by vascular endothelial growth factor.

  2005cited by this paper
• Gene therapy and targeted toxins for glioma : Gene therapy for cancer

  2005cited by this paper
• Stem and progenitor cell–based therapy of the human central nervous system

  2005cited by this paper
• Combined treatment of vascular endothelial growth factor and human neural stem cells in experimental focal cerebral ischemia.

  2005cited by this paper
• Glioma therapy and real‐time imaging of neural precursor cell migration and tumor regression

  2005influential reference
• Intravenous administration of human neural stem cells induces functional recovery in Huntington's disease rat model.

  2005cited by this paper
• Bystander effect-mediated gene therapy of gliomas using genetically engineered neural stem cells

  2005cited by this paper
• Gene therapy and targeted toxins for glioma.

  2005cited by this paper
• PEX-Producing Human Neural Stem Cells Inhibit Tumor Growth in a Mouse Glioma Model

  2005cited by this paper
• Gene therapy and targeted toxins for glioma.

  2005cited by this paper
• Proactive transplantation of human neural stem cells prevents degeneration of striatal neurons in a rat model of Huntington disease.

  2004cited by this paper
• Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1α/CXC chemokine receptor 4 pathway

  2004cited by this paper
• Inducible release of TRAIL fusion proteins from a proapoptotic form for tumor therapy.

  2004influential reference
• Stem cell therapy for human neurodegenerative disorders–how to make it work

  2004cited by this paper
• Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury.

  2004cited by this paper
• MCP-1 induces migration of adult neural stem cells.

  2004cited by this paper
• Interferon-beta gene therapy for cancer: basic research to clinical application.

  2004cited by this paper
• Human neural stem cells genetically modified for brain repair in neurological disorders

  2004cited by this paper
• Stem cell factor is a chemoattractant and a survival factor for CNS stem cells.

  2004cited by this paper
• lnterferon‐β gene therapy for cancer: Basic research to clinical application

  2004cited by this paper
• Transplantation of prodrug-converting neural progenitor cells for brain tumor therapy

  2003cited by this paper
• In Vivo Tracking of Neural Progenitor Cell Migration to Glioblastomas

  2003cited by this paper
• Human neural stem cells can migrate, differentiate, and integrate after intravenous transplantation in adult rats with transient forebrain ischemia.

  2003cited by this paper
• Suicide gene therapy mediated by the Herpes Simplex virus thymidine kinase gene/Ganciclovir system: fifteen years of application.

  2003cited by this paper
• Brain transplantation of genetically engineered human neural stem cells globally corrects brain lesions in the mucopolysaccharidosis type VII mouse

  2003cited by this paper
• Cellular and genetic characterization of human adult bone marrow-derived neural stem-like cells: a potential antiglioma cellular vector.

  2003cited by this paper
• Intravascular Delivery of Neural Stem Cell Lines to Target Intracranial and Extracranial Tumors of Neural and Non-Neural Origin

  2003cited by this paper
• Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhage.

  2003cited by this paper
• Constitutive EGFR signaling confers a motile phenotype to neural stem cells.

  2003cited by this paper
• Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy.

  2003cited by this paper
• Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia.

  2003cited by this paper
• In vivo growth inhibitory effect of iterative wild-type p53 gene transfer in human head and neck carcinoma xenografts using glucosylated polyethylenimine nonviral vector

  2002cited by this paper
• Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model.

  2002cited by this paper
• The use of interleukin 12-secreting neural stem cells for the treatment of intracranial glioma.

  2002cited by this paper
• Immunologic Targets for the Gene Therapy of Cancer

  2002cited by this paper
• In situ adenoviral interleukin 12 gene transfer confers potent and long-lasting cytotoxic immunity in glioma

  2002cited by this paper
• Interferon-alpha in tumor immunity and immunotherapy.

  2002cited by this paper
• DNA vaccination with AFP-encoding plasmid DNA prevents growth of subcutaneous AFP-expressing tumors and does not interfere with liver regeneration in mice

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  2002cited by this paper
• Induction of glioblastoma apoptosis using neural stem cell-mediated delivery of tumor necrosis factor-related apoptosis-inducing ligand.

  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
• Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12

  2001cited by this paper
• p53-dependent apoptosis pathways.

  2001cited by this paper
• Antitumor activity of cationic lipid complexed with immunostimulatory DNA.

  2001cited by this paper
• The biochemistry of apoptosis

  2000cited by this paper
• Genetic immunotherapy for cancer.

  2000cited by this paper
• Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas.

  2000influential reference
• Mouse alpha-fetoprotein-specific DNA-based immunotherapy of hepatocellular carcinoma leads to tumor regression in mice.

  2000cited by this paper
• Adenovirus-mediated p53 gene transfer in sequence with cisplatin to tumors of patients with non-small-cell lung cancer.

  2000cited by this paper
• Neural precursor cells for delivery of replication-conditional HSV-1 vectors to intracerebral gliomas.

  2000cited by this paper
• Gene Therapy of Cancer

  2000cited by this paper
• Gene therapy of experimental brain tumors using neural progenitor cells

  2000cited by this paper
• Inhibition of ras oncogene: a novel approach to antineoplastic therapy.

  2000cited by this paper
• α-Fetoprotein-specific Genetic Immunotherapy for Hepatocellular Carcinoma

  1999cited by this paper
• Medulloblastoma: clinical and biologic aspects.

  1999cited by this paper
• Eradication of rat malignant gliomas by retroviral-mediated, in vivo delivery of the interleukin 4 gene.

  1999cited by this paper
• Descriptive epidemiology of primary brain and CNS tumors: results from the Central Brain Tumor Registry of the United States, 1990-1994.

  1999cited by this paper

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  2018cites this paper
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  2017cites this paper
• TGF-β1 expression by glioma C6 cells in vitro.

  2017cites this paper
• Human Neural Stem Cell Biodistribution and Predicted Tumor Coverage by a Diffusible Therapeutic in a Mouse Glioma Model

  2017cites this paper
• Morphometric characteristics of TGF-β1-positive cells of fetal rat brain in vitro

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Gene therapy strategies using engineered stem cells for treating gynecologic and breast cancer patients (Review).

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  2015cites this paper
• [THE INFLUENCE OF PROGENITOR NEURO- CELLS SUPERNATANT ON THE LYMPHO- CYTES CYTOTOXIC FUNCTION IN RATS WITH GLIOMA].

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  2015cites this paper
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  2015cites this paper
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• Therapeutic Approaches for Treatment of Gliomas

  2014cites this paper
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  2014influential citation
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
• ["Vicious circles" of glioblastoma tumors: vascularization and invasiveness].

  2012cites this paper
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• Neural Stem Cell Migration: Role of Directional Cues and Electric Fields

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