THE INHIBITION OF LPS-INDUCED PRODUCTION OF INFLAMMATORY CYTOKINES BY HSP70 INVOLVES INACTIVATION OF THE NF-&kgr;B PATHWAY BUT NOT THE MAPK PATHWAYS

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Shock

• Publication date

  2006-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1097/01.shk.0000223134.17877.adPMID 16912653
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2002cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1999cited by this paper
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  1998cited by this paper
• NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses.

  1998cited by this paper
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  1998cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
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  1996cited by this paper
• Induction of the heat shock response reduces mortality rate and organ damage in a sepsis‐induced acute lung injury model

  1994cited by this paper
• A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells.

  1994cited by this paper
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  1993cited by this paper
• Fitness: Historical perspective

  1992influential reference
• I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retention.

  1992cited by this paper
• Rapid detection of octamer binding proteins with 'mini-extracts', prepared from a small number of cells.

  1989cited by this paper
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  1987cited by this paper
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  1987cited by this paper

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  2008cites this paper