Neferine isolated from Nelumbo nucifera enhances anti-cancer activities in Hep3B cells: molecular mechanisms of cell cycle arrest, ER stress induced apoptosis and anti-angiogenic response.

No abstract is available for this paper.

• Publication year

  2013

• Venue

  Phytomedicine

• Publication date

  2013-08-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/j.phymed.2013.03.024PMID 23746959
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells

  2011cited by this paper
• Neferine enhances insulin sensitivity in insulin resistant rats.

  2009cited by this paper
• Preparative separation and purification of liensinine, isoliensinine and neferine from seed embryo of Nelumbo nucifera GAERTN using high-speed counter-current chromatography.

  2009cited by this paper
• Targeting the endoplasmic reticulum-stress response as an anticancer strategy.

  2009influential reference
• Dysregulation of apoptosis in hepatocellular carcinoma cells.

  2009cited by this paper
• Regulation mechanisms and signaling pathways of autophagy.

  2009cited by this paper
• Blockade of HERG K+ channel by isoquinoline alkaloid neferine in the stable transfected HEK293 cells

  2009cited by this paper
• The new approach in development of anti-Alzheimer's disease drugs via the cholinergic hypothesis.

  2008cited by this paper
• Hepatocellular carcinoma: epidemiology, risk factors and pathogenesis.

  2008cited by this paper
• Effects of plant extract neferine on cyclic adenosine monophosphate and cyclic guanosine monophosphate levels in rabbit corpus cavernosum in vitro.

  2008cited by this paper
• The effect of neferine on foam cell formation by anti-low density lipoprotein oxidation

  2008cited by this paper
• Intracellular death platform steps‐in: Targeting prostate tumors via endoplasmic reticulum (ER) apoptosis

  2008cited by this paper
• From Molecular Biology to Targeted Therapies for Hepatocellular Carcinoma: The Future Is Now

  2007cited by this paper
• Lotus - A potential nutraceutical source

  2007cited by this paper
• Molecular cloning and characterization of rat LC3A and LC3B--two novel markers of autophagosome.

  2006cited by this paper
• Antiangiogenesis response of endothelial cells to the antitumour drug 10-methoxy-9-nitrocamptothecin.

  2006cited by this paper
• Cell Cycle Arrest by a Natural Product via G2/M Checkpoint

  2005cited by this paper
• Recent advances in understanding the cell death pathways activated by anticancer therapy

  2005cited by this paper
• Death by design: apoptosis, necrosis and autophagy.

  2004cited by this paper
• LC3, GABARAP and GATE16 localize to autophagosomal membrane depending on form-II formation

  2004influential reference
• Multidrug resistance reversal in human gastric carcinoma cells by neferine.

  2004cited by this paper
• Primary liver cancer: worldwide incidence and trends.

  2004cited by this paper
• NMR spectroscopic analysis of neferine and isoliensinine

  2004cited by this paper
• Epigallocatechin-3-gallate increases intracellular [Ca2+] in U87 cells mainly by influx of extracellular Ca2+ and partly by release of intracellular stores

  2004cited by this paper
• Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis

  2003cited by this paper
• Effect of neferine on toxicodynamics of dichlorvos for inhibiting rabbit cholinesterase.

  2003cited by this paper
• Cardiovascular pharmacological effects of bisbenzylisoquinoline alkaloid derivatives.

  2002cited by this paper
• Programmed cell death: many ways for cells to die decently

  2002cited by this paper
• Coupling Endoplasmic Reticulum Stress to the Cell Death Program

  2001cited by this paper
• Cross-Talk between Two Cysteine Protease Families

  2000cited by this paper
• The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation.

  1999cited by this paper
• Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls.

  1999cited by this paper
• Characterization of a Novel Cis-element That Regulates Fas Ligand Expression in Corneal Endothelial Cells*

  1999cited by this paper
• Caspase-3 Is the Primary Activator of Apoptotic DNA Fragmentation via DNA Fragmentation Factor-45/Inhibitor of Caspase-activated DNase Inactivation*

  1999cited by this paper
• The nuclear lamina: molecular organization and interaction with chromatin.

  1999cited by this paper
• Immune Pathogenesis of Hepatocellular Carcinoma

  1998cited by this paper
• The effect of neferine on foam cell formation by anti-low density lipoprotein oxidation.

  1998cited by this paper
• [Effects of neferine on platelet aggregation in rabbits].

  1997cited by this paper
• Principles of CDK regulation

  1995cited by this paper
• Hepatitis B virus immunopathogenesis.

  1995cited by this paper
• Myc-Max-Mad: a transcription factor network controlling cell cycle progression, differentiation and death.

  1994cited by this paper
• Integration pattern of hepatitis B virus DNA sequences in human hepatoma cell lines

  1981cited by this paper
• Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line

  1979cited by this paper
• Anti‐Angiogenesis: New Concept for Therapy of Solid Tumors

  1972cited by this paper

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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2023cites this paper
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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
• Herbal biomolecules: anticancer agents

  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2022cites this paper
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  2021cites this paper
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  2021cites this paper
• Roles of Therapeutic Bioactive Compounds in Hepatocellular Carcinoma

  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2021cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015influential citation
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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