Identification of Amino Acid Residues in APOBEC3G Required for Regulation by Human Immunodeficiency Virus Type 1 Vif and Virion Encapsidation

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Journal of Virology

• Publication date

  2007-01-31

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/JVI.02795-06PMID 17267497PMCID PMC1866099
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The APOBEC-2 crystal structure and functional implications for the deaminase AID

  2007cited by this paper
• APOBEC3F Can Inhibit the Accumulation of HIV-1 Reverse Transcription Products in the Absence of Hypermutation

  2007cited by this paper
• Antiviral Potency of APOBEC Proteins Does Not Correlate with Cytidine Deamination

  2006cited by this paper
• A Zinc-binding Region in Vif Binds Cul5 and Determines Cullin Selection*

  2006cited by this paper
• Differential Requirement for Conserved Tryptophans in Human Immunodeficiency Virus Type 1 Vif for the Selective Suppression of APOBEC3G and APOBEC3F

  2006cited by this paper
• Identification of APOBEC3DE as Another Antiretroviral Factor from the Human APOBEC Family

  2006cited by this paper
• Mutational Alteration of Human Immunodeficiency Virus Type 1 Vif Allows for Functional Interaction with Nonhuman Primate APOBEC3G

  2006cited by this paper
• Crystal structure of Staphylococcus aureus tRNA adenosine deaminase TadA in complex with RNA

  2006cited by this paper
• APOBEC3 Proteins Inhibit Human LINE-1 Retrotransposition*

  2006cited by this paper
• Assembly of HIV-1 Vif-Cul5 E3 ubiquitin ligase through a novel zinc-binding domain-stabilized hydrophobic interface in Vif.

  2006cited by this paper
• High-molecular-mass APOBEC3G complexes restrict Alu retrotransposition

  2006cited by this paper
• Reversed Functional Organization of Mouse and Human APOBEC3 Cytidine Deaminase Domains*

  2006cited by this paper
• APOBEC3B and APOBEC3F Inhibit L1 Retrotransposition by a DNA Deamination-independent Mechanism*

  2006cited by this paper
• APOBEC3A and APOBEC3B are potent inhibitors of LTR-retrotransposon function in human cells

  2006cited by this paper
• Biochemical and structural studies of A-to-I editing by tRNA:A34 deaminases at the wobble position of transfer RNA.

  2005cited by this paper
• Natural Variation in Vif: Differential Impact on APOBEC3G/3F and a Potential Role in HIV-1 Diversification

  2005cited by this paper
• Crystal Structure of tRNA Adenosine Deaminase (TadA) from Aquifex aeolicus*

  2005cited by this paper
• Differential Sensitivity of Murine Leukemia Virus to APOBEC3-Mediated Inhibition Is Governed by Virion Exclusion

  2005influential reference
• Regulation of Apobec3F and Human Immunodeficiency Virus Type 1 Vif by Vif-Cul5-ElonB/C E3 Ubiquitin Ligase

  2005cited by this paper
• Antiviral function of APOBEC3G can be dissociated from cytidine deaminase activity.

  2005influential reference
• APOBEC3G cytidine deaminase inhibits retrotransposition of endogenous retroviruses

  2005cited by this paper
• Cytidine deamination and resistance to retroviral infection: towards a structural understanding of the APOBEC proteins.

  2005cited by this paper
• Inositol Hexakisphosphate Is Bound in the ADAR2 Core and Required for RNA Editing

  2005cited by this paper
• Complementary function of the two catalytic domains of APOBEC3G.

  2005cited by this paper
• Inhibition of a yeast LTR retrotransposon by human APOBEC3 cytidine deaminases.

  2005influential reference
• APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast.

  2005cited by this paper
• A Single Amino Acid Determinant Governs the Species-specific Sensitivity of APOBEC3G to Vif Action*

  2004influential reference
• A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV‐1 and HIV‐2 Vif proteins

  2004influential reference
• A single amino acid substitution in human APOBEC3G antiretroviral enzyme confers resistance to HIV-1 virion infectivity factor-induced depletion.

  2004cited by this paper
• A single amino acid of APOBEC3G controls its species-specific interaction with virion infectivity factor (Vif).

  2004influential reference
• Retroviral restriction by APOBEC proteins

  2004cited by this paper
• APOBEC3G Incorporation into Human Immunodeficiency Virus Type 1 Particles

  2004influential reference
• Cytidine deamination of retroviral DNA by diverse APOBEC proteins.

  2004influential reference
• The Interaction between HIV-1 Gag and APOBEC3G*

  2004influential reference
• Vif Overcomes the Innate Antiviral Activity of APOBEC3G by Promoting Its Degradation in the Ubiquitin-Proteasome Pathway*

  2004cited by this paper
• A single amino acid difference in the host APOBEC3G protein controls the primate species specificity of HIV type 1 virion infectivity factor.

  2004influential reference
• Amino-Terminal Region of the Human Immunodeficiency Virus Type 1 Nucleocapsid Is Required for Human APOBEC3G Packaging

  2004influential reference
• Selective assembly of HIV-1 Vif-Cul5-ElonginB-ElonginC E3 ubiquitin ligase complex through a novel SOCS box and upstream cysteines.

  2004cited by this paper
• Further Investigation of Simian Immunodeficiency Virus Vif Function in Human Cells

  2004cited by this paper
• Human Apolipoprotein B mRNA-editing Enzyme-catalytic Polypeptide-like 3G (APOBEC3G) Is Incorporated into HIV-1 Virions through Interactions with Viral and Nonviral RNAs*

  2004influential reference
• Specific packaging of APOBEC3G into HIV-1 virions is mediated by the nucleocapsid domain of the gag polyprotein precursor.

  2004influential reference
• Comment on "Inhibition of Hepatitis B Virus Replication by APOBEC3G"

  2004cited by this paper
• Human APOBEC3F Is Another Host Factor That Blocks Human Immunodeficiency Virus Type 1 Replication

  2004influential reference
• Inhibition of Hepatitis B Virus Replication by APOBEC3G

  2004cited by this paper
• Crystal Structure of Yeast Cytosine Deaminase

  2003cited by this paper
• HIV-1 Vif protein binds the editing enzyme APOBEC3G and induces its degradation

  2003cited by this paper
• The cytidine deaminase CEM15 induces hypermutation in newly synthesized HIV-1 DNA

  2003cited by this paper
• Species-specific exclusion of APOBEC3G from HIV-1 virions by Vif.

  2003cited by this paper
• HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability.

  2003cited by this paper
• The 1.14 A crystal structure of yeast cytosine deaminase: evolution of nucleotide salvage enzymes and implications for genetic chemotherapy.

  2003cited by this paper
• Induction of APOBEC3G Ubiquitination and Degradation by an HIV-1 Vif-Cul5-SCF Complex

  2003cited by this paper
• DNA deamination mediates innate immunity to retroviral infection.

  2003cited by this paper
• Broad antiretroviral defence by human APOBEC3G through lethal editing of nascent reverse transcripts

  2003cited by this paper
• The antiretroviral enzyme APOBEC3G is degraded by the proteasome in response to HIV-1 Vif

  2003cited by this paper
• The Vif protein of HIV triggers degradation of the human antiretroviral DNA deaminase APOBEC3G.

  2003cited by this paper
• Emergence of Resistant Human Immunodeficiency Virus Type 1 in Patients Receiving Fusion Inhibitor (T-20) Monotherapy

  2002cited by this paper
• AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification

  2002cited by this paper
• Faculty Opinions recommendation of Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein.

  2002influential reference
• High-level and high-throughput recombinant protein production by transient transfection of suspension-growing human 293-EBNA1 cells.

  2002cited by this paper
• Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein

  2002cited by this paper
• Sensitivity of Human Immunodeficiency Virus Type 1 to the Fusion Inhibitor T-20 Is Modulated by Coreceptor Specificity Defined by the V3 Loop of gp120

  2000cited by this paper
• Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1

  1998cited by this paper
• Evolutionary analysis of RNA editing enzymes.

  1998cited by this paper
• The Vif and Gag proteins of human immunodeficiency virus type 1 colocalize in infected human T cells

  1997cited by this paper
• Complementation of vif-defective human immunodeficiency virus type 1 by primate, but not nonprimate, lentivirus vif genes

  1995cited by this paper
• Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme.

  1989cited by this paper
• Crystal Structure of Yeast Cytosine Deaminase INSIGHTS INTO ENZYME MECHANISM AND EVOLUTION*

  year unknowncited by this paper

• Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity

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• Apobec3 shows rapid evolution in house mouse subspecies and unusual hypermutation patterns of endogenous mouse mammary tumor viruses

  2025cites this paper
• Fitness Landscapes of APOBEC3G Antagonism by HIV-1 Vif proteins

  2025cites this paper
• APOBEC3G Antagonism by Vif, or When Structure Meets Biological and Evolutionary Studies.

  2025cites this paper
• The structural basis for HIV-1 Vif antagonism of human APOBEC3G

  2023cites this paper
• Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase

  2023influential citation
• Various strategies for developing APOBEC3G protectors to circumvent human immunodeficiency virus type 1.

  2023cites this paper
• Potent dual block to HIV-1 infection using lentiviral vectors expressing fusion inhibitor peptide mC46- and Vif-resistant APOBEC3G

  2023cites this paper
• Mutagenic Activity of AID/APOBEC Deaminases in Antiviral Defense and Carcinogenesis

  2022cites this paper
• Evolutionary Landscapes of Host-Virus Arms Races.

  2022cites this paper
• Ancestral APOBEC3B Nuclear Localization Is Maintained in Humans and Apes and Altered in Most Other Old World Primate Species

  2022cites this paper
• Interactions of APOBEC3s with DNA and RNA.

  2021cites this paper
• Characterization of an A3G-VifHIV-1-CRL5-CBFβ Structure Using a Cross-linking Mass Spectrometry Pipeline for Integrative Modeling of Host–Pathogen Complexes

  2021cites this paper
• Examination of the APOBEC3 Barrier to Cross Species Transmission of Primate Lentiviruses

  2021cites this paper
• Host Restriction Factor A3G Inhibits the Replication of Enterovirus D68 by Competitively Binding the 5′ Untranslated Region with PCBP1

  2021cites this paper
• APOBEC3F Constitutes a Barrier to Successful Cross-Species Transmission of Simian Immunodeficiency Virus SIVsmm to Humans

  2021cites this paper
• HIV-1 Vif Gained Breadth in APOBEC3G Specificity after Cross-Species Transmission of Its Precursors

  2021cites this paper
• Structural Insights into APOBEC3-Mediated Lentiviral Restriction

  2020cites this paper
• Crystal structure of a soluble APOBEC3G variant suggests ssDNA to bind in a channel that extends between the two domains.

  2020influential citation
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  2020cites this paper
• Crystal Structure of Full Length APOBEC3G E/Q (pH 5.2)

  2020cites this paper
• Structural perspectives on HIV‐1 Vif and APOBEC3 restriction factor interactions

  2020cites this paper
• Understanding the structural basis of HIV-1 restriction by the full length double-domain APOBEC3G

  2020cites this paper
• Loop 1 of APOBEC3C regulates its antiviral activity against HIV-1

  2020cites this paper
• Retrocopying expands the functional repertoire of APOBEC3 antiviral proteins in primates

  2020cites this paper
• Structural Determinants of the APOBEC3G N-Terminal Domain for HIV-1 RNA Association

  2019influential citation
• Regulation of Antiviral Innate Immunity Through APOBEC Ribonucleoprotein Complexes.

  2019cites this paper
• The Role of RNA in HIV-1 Vif-Mediated Degradation of APOBEC3H.

  2019cites this paper
• Structural basis of antagonism of human APOBEC3F by HIV-1 Vif

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• Enterovirus 71 antagonizes the inhibition of the host intrinsic antiviral factor A3G

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• The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by an RNA-Mediated Dimerization Mechanism.

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• Immunohistochemical investigation of prognostic biomarkers in resected colorectal liver metastases: a systematic review and meta-analysis

  2018cites this paper
• Feline APOBEC3s, Barriers to Cross-Species Transmission of FIV?

  2018cites this paper
• Modeling the Embrace of a Mutator: APOBEC Selection of Nucleic Acid Ligands

  2018cites this paper
• APOBEC3H Subcellular Localization Determinants Define Zipcode for Targeting HIV-1 for Restriction

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• APOBEC3H structure reveals an unusual mechanism of interaction with duplex RNA

  2017cites this paper
• The Antiviral and Cancer Genomic DNA Deaminase APOBEC3H Is Regulated by a RNA-Mediated Dimerization Mechanism

  2017cites this paper
• Mapping Region of Human Restriction Factor APOBEC3H Critical for Interaction with HIV-1 Vif.

  2017cites this paper
• Deep sequencing of HIV-1 reverse transcripts reveals the multifaceted anti-viral functions of APOBEC3G

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• Identification and characterization of loop7 motif and its role in regulating biological function of human APOBEC3G through molecular modeling and biological assay

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• Enhancing the Catalytic Deamination Activity of APOBEC3C Is Insufficient to Inhibit Vif-Deficient HIV-1.

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• APOBEC: From mutator to editor.

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• CBFß and HIV Infection.

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• The evolutionary history and activity of a gain-of-function polymorphism in a human antiviral gene

  2016cites this paper
• The double-domain cytidine deaminase APOBEC3G is a cellular site-specific RNA editing enzyme

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• RNA binding to APOBEC deaminases; Not simply a substrate for C to U editing

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• The APOBEC Protein Family: United by Structure, Divergent in Function.

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• A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses

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• Vif Proteins from Diverse Human Immunodeficiency Virus/Simian Immunodeficiency Virus Lineages Have Distinct Binding Sites in A3C

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• Apobec3G-Based Strategies to Defeat HIV Infection.

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  2016influential citation
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• Identification of the HIV-1 Vif and Human APOBEC3G Protein Interface.

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• Redoxal, an inhibitor of de novo pyrimidine biosynthesis, augments APOBEC3G antiviral activity against human immunodeficiency virus type 1.

  2015cites this paper
• RNA binding to APOBEC3G induces the disassembly of functional deaminase complexes by displacing single-stranded DNA substrates

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• Identification of a Novel HIV-1 Inhibitor Targeting Vif-dependent Degradation of Human APOBEC3G Protein*

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• Structure of the Vif-binding domain of the antiviral enzyme APOBEC3G

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• Human APOBEC3F incorporation into human immunodeficiency virus type 1 particles.

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  2014influential citation
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• [Multifunctional HIV accessory proteins are hub proteins antagonizing host antiviral factors].

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• Vif Proteins from Diverse Primate Lentiviral Lineages Use the Same Binding Site in APOBEC3G

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• Crystal structure of the DNA cytosine deaminase APOBEC3F: the catalytically active and HIV-1 Vif-binding domain.

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• Prototype Foamy Virus Bet Impairs the Dimerization and Cytosolic Solubility of Human APOBEC3G

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