Developmental Origin of Reproductive and Metabolic Dysfunctions: Androgenic Versus Estrogenic Reprogramming

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Seminars in Reproductive Medicine

• Publication date

  2011-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1055/s-0031-1275519PMID 21710394PMCID PMC3674484
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Developmental Programming: Impact of Excess Prenatal Testosterone on Intrauterine Fetal Endocrine Milieu and Growth in Sheep1

  2011cited by this paper
• Prenatal androgen exposure programs metabolic dysfunction in female mice.

  2010influential reference
• Endocrine traits of polycystic ovary syndrome in prenatally androgenized female Sprague-Dawley rats.

  2010cited by this paper
• The kisspeptin/neurokinin B/dynorphin (KNDy) cell population of the arcuate nucleus: sex differences and effects of prenatal testosterone in sheep.

  2010cited by this paper
• Developmental Programming: Effect of Prenatal Steroid Excess on Intraovarian Components of Insulin Signaling Pathway and Related Proteins in Sheep1

  2010cited by this paper
• Developmental programming: impact of prenatal testosterone excess and postnatal weight gain on insulin sensitivity index and transfer of traits to offspring of overweight females.

  2010cited by this paper
• Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.

  2010cited by this paper
• Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society.

  2010cited by this paper
• Developmental programming: insulin sensitizer treatment improves reproductive function in prenatal testosterone-treated female sheep.

  2010cited by this paper
• Metabolic and reproductive features before and during puberty in daughters of women with polycystic ovary syndrome.

  2009cited by this paper
• Developmental programming: prenatal androgen excess disrupts ovarian steroid receptor balance.

  2009cited by this paper
• Developmental Programming: Contribution of Prenatal Androgen and Estrogen to Estradiol Feedback Systems and Periovulatory Hormonal Dynamics in Sheep1

  2009cited by this paper
• Is Epigenetics an Important Link between Early Life Events and Adult Disease?

  2009cited by this paper
• Developmental Programming: Differential Effects of Prenatal Testosterone and Dihydrotestosterone on Follicular Recruitment, Depletion of Follicular Reserve, and Ovarian Morphology in Sheep1

  2009cited by this paper
• Endocrine-disrupting chemicals: an Endocrine Society scientific statement.

  2009cited by this paper
• Developmental programming: excess weight gain amplifies the effects of prenatal testosterone excess on reproductive cyclicity--implication for polycystic ovary syndrome.

  2009cited by this paper
• Present status of understanding on the genetic etiology of polycystic ovary syndrome.

  2008cited by this paper
• Transient prenatal androgen exposure produces metabolic syndrome in adult female rats.

  2008cited by this paper
• Mood and sexual function in polycystic ovary syndrome.

  2008cited by this paper
• Polycystic Ovary Syndrome and Endometrial Cancer

  2008cited by this paper
• Developmental Programming: Impact of Prenatal Testosterone Excess on Pre- and Postnatal Gonadotropin Regulation in Sheep1

  2008cited by this paper
• An alternate pathway for androgen regulation of brain function: activation of estrogen receptor beta by the metabolite of dihydrotestosterone, 5alpha-androstane-3beta,17beta-diol.

  2008cited by this paper
• Developmental Programming: Deficits in Reproductive Hormone Dynamics and Ovulatory Outcomes in Prenatal, Testosterone-Treated Sheep1

  2008cited by this paper
• Dietary therapy in polycystic ovary syndrome.

  2008cited by this paper
• Endocrine Antecedents of Polycystic Ovary Syndrome in Fetal and Infant Prenatally Androgenized Female Rhesus Monkeys1

  2008cited by this paper
• Pregnancy complications in women with polycystic ovary syndrome.

  2008cited by this paper
• Cardiometabolic features of polycystic ovary syndrome

  2008cited by this paper
• Neonatal Exposure to Estradiol Valerate Programs Ovarian Sympathetic Innervation and Follicular Development in the Adult Rat1

  2008cited by this paper
• Predictors of ovarian response: progress towards individualized treatment in ovulation induction and ovarian stimulation.

  2008cited by this paper
• Disordered follicle development in ovaries of prenatally androgenized ewes.

  2007cited by this paper
• Metabolic syndrome in polycystic ovary syndrome.

  2007cited by this paper
• Prostaglandins and the initiation of blastocyst implantation and decidualization.

  2007cited by this paper
• Developmental programming in sheep: administration of testosterone during 60-90 days of pregnancy reduces breeding success and pregnancy outcome.

  2007cited by this paper
• International estimates of infertility prevalence and treatment-seeking: potential need and demand for infertility medical care.

  2007cited by this paper
• Polycystic ovary syndrome and its developmental origins

  2007cited by this paper
• Role of obesity and adiposity in polycystic ovary syndrome

  2007cited by this paper
• Pioglitazone improves insulin action and normalizes menstrual cycles in a majority of prenatally androgenized female rhesus monkeys.

  2007influential reference
• Childhood obesity--the shape of things to come.

  2007cited by this paper
• A new rat model exhibiting both ovarian and metabolic characteristics of polycystic ovary syndrome.

  2007cited by this paper
• Developmental programming: follicular persistence in prenatal testosterone-treated sheep is not programmed by androgenic actions of testosterone.

  2007cited by this paper
• Postnatal testosterone exposure results in insulin resistance, enlarged mesenteric adipocytes, and an atherogenic lipid profile in adult female rats: comparisons with estradiol and dihydrotestosterone.

  2007cited by this paper
• Hypertension caused by prenatal testosterone excess in female sheep.

  2007cited by this paper
• Microscopic characterization of follicular structures in letrozole-induced polycystic ovarian syndrome in the rat.

  2006cited by this paper
• Epigenetic modification of the X chromosome influences susceptibility to polycystic ovary syndrome.

  2006influential reference
• Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline.

  2006cited by this paper
• Heritability of polycystic ovary syndrome in a Dutch twin-family study.

  2006cited by this paper
• Follicle luteinization in hyperandrogenic follicles of polycystic ovary syndrome patients undergoing gonadotropin therapy for in vitro fertilization.

  2006cited by this paper
• Prenatal growth restraint followed by catch-up of weight: a hyperinsulinemic pathway to polycystic ovary syndrome.

  2006cited by this paper
• Fetal programming: prenatal testosterone treatment leads to follicular persistence/luteal defects; partial restoration of ovarian function by cyclic progesterone treatment.

  2006cited by this paper
• Polycystic Ovary Syndrome and Mental Health: A Review

  2006cited by this paper
• The metabolic syndrome in polycystic ovary syndrome

  2006cited by this paper
• Obesity and polycystic ovary syndrome

  2006cited by this paper
• β-Cell Dysfunction, Glucose Intolerance, and Diabetes in the Polycystic Ovary Syndrome

  2006cited by this paper
• The Endocrine Impact of Obesity and Body Habitus in the Polycystic Ovary Syndrome

  2006cited by this paper
• Postnatal developmental consequences of altered insulin sensitivity in female sheep treated prenatally with testosterone.

  2005cited by this paper
• Fetal programming: excess prenatal testosterone reduces postnatal luteinizing hormone, but not follicle-stimulating hormone responsiveness, to estradiol negative feedback in the female.

  2005cited by this paper
• Fetal programming: prenatal testosterone treatment causes intrauterine growth retardation, reduces ovarian reserve and increases ovarian follicular recruitment.

  2005cited by this paper
• Ovulation induction: a mini review.

  2005cited by this paper
• Prenatal Programming of Reproductive Neuroendocrine Function: The Effect of Prenatal Androgens on the Development of Estrogen Positive Feedback and Ovarian Cycles in the Ewe1

  2005cited by this paper
• Polycystic ovaries and ovarian hyperstimulation syndrome: a systematic review *

  2005cited by this paper
• Follicular arrest in polycystic ovary syndrome is associated with deficient inhibin A and B biosynthesis.

  2005cited by this paper
• Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?

  2005cited by this paper
• Neuroendocrine Consequences of Prenatal Androgen Exposure in the Female Rat: Absence of Luteinizing Hormone Surges, Suppression of Progesterone Receptor Gene Expression, and Acceleration of the Gonadotropin-Releasing Hormone Pulse Generator1

  2005influential reference
• Prenatal androgens alter GABAergic drive to gonadotropin-releasing hormone neurons: implications for a common fertility disorder.

  2004influential reference
• Letrozole-induced polycystic ovaries in the rat: a new model for cystic ovarian disease.

  2004cited by this paper
• Mechanisms of action of mifepristone and levonorgestrel when used for emergency contraception.

  2004cited by this paper
• Relationship of GnRH‐stimulated LH release to episodic LH secretion and baseline endocrine‐metabolic measures in women with polycystic ovary syndrome

  2004influential reference
• Fetal programming: prenatal testosterone excess leads to fetal growth retardation and postnatal catch-up growth in sheep.

  2004cited by this paper
• Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS).

  2004cited by this paper
• Prenatal programming of reproductive neuroendocrine function: fetal androgen exposure produces progressive disruption of reproductive cycles in sheep.

  2003cited by this paper
• Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome.

  2003cited by this paper
• Gonadotrophin regimens and oocyte quality in women with polycystic ovaries.

  2003cited by this paper
• Formation and early development of follicles in the polycystic ovary.

  2003cited by this paper
• Glucose intolerance, insulin resistance, and hyperandrogenemia in first degree relatives of women with polycystic ovary syndrome.

  2003cited by this paper
• Prepubertal administration of estradiol valerate disrupts cyclicity and leads to cystic ovarian morphology during adult life in the rat: role of sympathetic innervation.

  2003cited by this paper
• Increased adiposity in female rhesus monkeys exposed to androgen excess during early gestation.

  2003cited by this paper
• Ovarian hyperandrogenism in adult female rhesus monkeys exposed to prenatal androgen excess.

  2002cited by this paper
• Fetal Programming: Prenatal Androgen Disrupts Positive Feedback Actions of Estradiol but Does Not Affect Timing of Puberty in Female Sheep1

  2002cited by this paper
• Sexual differentiation of the neuroendocrine control of gonadotrophin secretion: concepts derived from sheep models.

  2002cited by this paper
• Programming and reproductive functioning.

  2002cited by this paper
• The prenatally androgenized female rhesus monkey as a model for polycystic ovary syndrome

  2002cited by this paper
• Impaired developmental competence of oocytes in adult prenatally androgenized female rhesus monkeys undergoing gonadotropin stimulation for in vitro fertilization.

  2002cited by this paper
• Intra-follicular activin availability is altered in prenatally-androgenized lambs.

  2001cited by this paper
• Dynamics of inhibin subunit and follistatin mRNA during development of normal and polycystic ovary syndrome follicles.

  2001influential reference
• Structural and regulatory macromolecules in sex differentiation of gonads.

  2001cited by this paper
• Timing of prenatal androgen excess determines differential impairment in insulin secretion and action in adult female rhesus monkeys.

  2000cited by this paper
• In utero exposure of female lambs to testosterone reduces the sensitivity of the gonadotropin-releasing hormone neuronal network to inhibition by progesterone.

  1999cited by this paper
• Precocious pubarche, hyperinsulinism, and ovarian hyperandrogenism in girls: relation to reduced fetal growth.

  1998cited by this paper
• Imprinting of female offspring with testosterone results in insulin resistance and changes in body fat distribution at adult age in rats.

  1998cited by this paper
• Sexual differentiation of reproductive neuroendocrine function in sheep.

  1998cited by this paper
• Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone.

  1998influential reference
• New concepts of the neuroendocrine regulation of gonadotropin surges in rats.

  1997cited by this paper
• Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis.

  1997cited by this paper
• Current concepts of polycystic ovary syndrome.

  1997cited by this paper
• Prenatal exposure of female rhesus monkeys to testosterone propionate increases serum luteinizing hormone levels in adulthood.

  1997cited by this paper
• Polycystic ovary syndrome: induction of ovulation.

  1996cited by this paper
• Ovarian hyperandrogynism as a result of congenital adrenal virilizing disorders: evidence for perinatal masculinization of neuroendocrine function in women.

  1994cited by this paper
• Ovarian innervation develops before initiation of folliculogenesis in the rat

  1992cited by this paper
• The changing architecture of the neonatal rat ovary during histogenesis

  1992cited by this paper
• Progesterone blocks the estradiol-induced gonadotropin discharge in the ewe by inhibiting the surge of gonadotropin-releasing hormone.

  1992cited by this paper

• Women with polycystic ovary syndrome (PCOS): Likelihood of cooccurring neuropsychiatric conditions and the dual hit hypothesis.

  2025cites this paper
• Fundamental mechanisms of cell death for polycystic ovary syndrome

  2025cites this paper
• Mechanism of elevated LH/FSH ratio in lean PCOS revisited: a path analysis

  2024cites this paper
• Developmental programming: Impact of preconceptional and gestational exposure to a real-life environmental chemical mixture on maternal steroid, cytokine and oxidative stress milieus in sheep.

  2023cites this paper
• Endocrine and metabolic interactions in healthy pregnancies and hyperinsulinemic pregnancies affected by polycystic ovary syndrome, diabetes and obesity

  2023cites this paper
• Evidence-based hormonal, mutational, and endocrine-disrupting chemical-induced zebrafish as an alternative model to study PCOS condition similar to mammalian PCOS model.

  2022cites this paper
• Sheep as a model for neuroendocrinology research.

  2022cites this paper
• Chronic androgen excess in female mice does not impact luteinizing hormone pulse frequency or putative GABAergic inputs to GnRH neurons

  2022cites this paper
• Deconstructing a Syndrome: Genomic Insights into PCOS Causal Mechanisms and Classification.

  2022cites this paper
• Chronodisruption and Loss of Female Reproductive Potential Due to Shift Work

  2021cites this paper
• Developmental Programming: Adipose Depot-Specific Transcriptional Regulation by Prenatal Testosterone Excess in a Sheep Model of PCOS.

  2020cites this paper
• Developmental Programming: Prenatal Testosterone Excess on Ovarian SF1/DAX1/FOXO3

  2020cites this paper
• Androgen levels in the fetal cord blood of children born to women with polycystic ovary syndrome: a meta-analysis

  2020cites this paper
• Skin disease related to metabolic syndrome in women☆☆☆

  2019cites this paper
• Developmental programming: Sex‐specific programming of growth upon prenatal bisphenol A exposure

  2019cites this paper
• Prenatal metformin treatment improves ovarian function in offspring of obese rats.

  2018cites this paper
• Neonatal exposure to estradiol valerate reprograms the rat ovary androgen receptor and anti-Müllerian hormone to a polycystic ovary phenotype.

  2018cites this paper
• Developmental Programming of Ovarian Functions and Dysfunctions.

  2018cites this paper
• Female Offspring From Chronic Hyperandrogenemic Dams Exhibit Delayed Puberty and Impaired Ovarian Reserve

  2018cites this paper
• Gestational Hyperandrogenism in Developmental Programming

  2017cites this paper
• eonatal exposure to estradiol valerate reprograms the rat ovary ndrogen receptor and anti-Müllerian hormone to a polycystic ovary henotype

  2017cites this paper
• The impact of postnatal leuprolide acetate treatment on reproductive characteristics in a rodent model of polycystic ovary syndrome.

  2017cites this paper
• Developmental programming: rescuing disruptions in preovulatory follicle growth and steroidogenesis from prenatal testosterone disruption

  2016cites this paper
• Effect of maternal PCOS and PCOS-like phenotype on the offspring's health.

  2016cites this paper
• The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited.

  2016cites this paper
• Increase in endogenous estradiol in the progeny of obese rats is associated with precocious puberty and altered follicular development in adulthood

  2016cites this paper
• Prenatal testosterone exposure decreases colocalization of insulin receptors in kisspeptin/neurokinin B/dynorphin and agouti‐related peptide neurons of the adult ewe

  2016cites this paper
• Expression of matrix metalloproteinases and ovarian morphological changes in androgenized cyclic female guinea pigs.

  2016cites this paper
• Mass spectrometry methods measured androgen and estrogen concentrations during pregnancy and in newborns of mothers with polycystic ovary syndrome.

  2016cites this paper
• Placental STAT3 signaling is activated in women with polycystic ovary syndrome.

  2015cites this paper
• Developmental Programming: Prenatal and Postnatal Androgen Antagonist and Insulin Sensitizer Interventions Prevent Advancement of Puberty and Improve LH Surge Dynamics in Prenatal Testosterone-Treated Sheep.

  2015cites this paper
• Developmental Programming: Does Prenatal Steroid Excess Disrupt the Ovarian VEGF System in Sheep?1

  2015cites this paper
• Circadian Clock Function in the Mammalian Ovary

  2015cites this paper
• Análise metabolômica e histomorfométrica do fígado de ratas adultas em modelo experimental da síndrome dos ovários policísticos induzida por exposição neonatal a esteroides sexuais

  2015cites this paper
• Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring

  2015influential citation
• Disorders of follicle development and steroidogenesis in ovaries of androgenised foetal sheep.

  2015cites this paper
• Voluntary Exercise Improves Estrous Cyclicity in Prenatally Androgenized Female Mice Despite Programming Decreased Voluntary Exercise: Implications for Polycystic Ovary Syndrome (PCOS).

  2015cites this paper
• Neonatal androgenization-induced early endocrine-metabolic and ovary misprogramming in the female rat.

  2015cites this paper
• Pathogenesis of polycystic ovary syndrome: multifactorial assessment from the foetal stage to menopause.

  2015cites this paper
• Effect of hyperandrogenism on ovarian function.

  2015cites this paper
• Developmental programing: impact of testosterone on placental differentiation.

  2014cites this paper
• Gamete/Embryo-Fetal Origins of Infertility

  2014cites this paper
• Steroid profiling in pregnancy: a focus on the human fetus.

  2014cites this paper
• Developmental programming: prenatal steroid excess disrupts key members of intraovarian steroidogenic pathway in sheep.

  2014cites this paper
• Steroid metabolome in the umbilical cord: is it necessary to differentiate between arterial and venous blood?

  2014cites this paper
• Developmental programming: prenatal BPA treatment disrupts timing of LH surge and ovarian follicular wave dynamics in adult sheep.

  2014cites this paper
• PCOS from Conception to Menopause: A Review of Our Current Understanding

  2014cites this paper
• Intrauterine Environment and Polycystic Ovary Syndrome

  2014cites this paper
• Exposure to Excess Testosterone and Dihydrotestosterone in Sheep Developmental Programming : Postnatal Estradiol Amplifies Ovarian Follicular Defects Induced by Fetal

  2014cites this paper
• Environmental Control of Biological Rhythms: Effects on Development, Fertility and Metabolism

  2014cites this paper
• Developmental Programming

  2014cites this paper
• Reproductive neuroendocrine dysfunction in polycystic ovary syndrome: insight from animal models.

  2014cites this paper
• Developmental programming: gestational bisphenol-A treatment alters trajectory of fetal ovarian gene expression.

  2013cites this paper
• Polycystic ovary syndrome - Effect of acupuncture on insulin resistance and neuroendocrine function

  2013cites this paper
• Nonhuman primate models of polycystic ovary syndrome.

  2013cites this paper
• Animal models of the polycystic ovary syndrome phenotype.

  2013cites this paper
• Developmental programming: impact of prenatal testosterone excess on insulin sensitivity, adiposity, and free fatty acid profile in postpubertal female sheep.

  2013cites this paper
• Sheep models of polycystic ovary syndrome phenotype.

  2013cites this paper
• Electrical vs Manual Acupuncture Stimulation in a Rat Model of Polycystic Ovary Syndrome: Different Effects on Muscle and Fat Tissue Insulin Signaling

  2013cites this paper
• Fibrillin-3 in the fetal ovary: can it contribute to polycystic ovary syndrome?

  2012cites this paper
• Animal models and the developmental origins of polycystic ovary syndrome: increasing evidence for the role of androgens in programming reproductive and metabolic dysfunction.

  2012cites this paper
• Developmental programming: Impact of prenatal testosterone treatment and postnatal obesity on ovarian follicular dynamics.

  2012cites this paper
• Developmental Programming: Impact of Prenatal Testosterone Excess on Ovarian Cell Proliferation and Apoptotic Factors in Sheep1

  2012cites this paper
• Temporal window in which exposure to estradiol permanently modifies ovarian function causing polycystic ovary morphology in rats.

  2012cites this paper
• Developmental programming: prenatal testosterone excess disrupts anti-Müllerian hormone expression in preantral and antral follicles.

  2012cites this paper
• Developmental programming: prenatal and postnatal contribution of androgens and insulin in the reprogramming of estradiol positive feedback disruptions in prenatal testosterone-treated sheep.

  2011cites this paper