Significant longevity-extending effects of EGCG on Caenorhabditis elegans under stress.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Free Radical Biology & Medicine

• Publication date

  2009-02-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1016/j.freeradbiomed.2008.10.041PMID 19061950
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• (-)Epigallocatechin gallate hampers collagen destruction and collagenase activation in ultraviolet-B-irradiated human dermal fibroblasts: involvement of mitogen-activated protein kinase.

  2008cited by this paper
• Oxidative stress in Caenorhabditis elegans: protective effects of the Omega class glutathione transferase (GSTO‐1)

  2008cited by this paper
• Attenuation of senescence‐induced oxidative exacerbations in aged rat brain by (−)‐epigallocatechin‐3‐gallate

  2008cited by this paper
• Protective effects of green tea polyphenols in the 6-OHDA rat model of Parkinson's disease through inhibition of ROS-NO pathway.

  2007cited by this paper
• Green tea catechins upregulate superoxide dismutase and catalase in fruit flies.

  2007cited by this paper
• The search for Methuselah

  2007cited by this paper
• Proposed mechanisms of (-)-epigallocatechin-3-gallate for anti-obesity.

  2007cited by this paper
• Genetic control of longevity in C. elegans.

  2007cited by this paper
• Neurorescue activity, APP regulation and amyloid-beta peptide reduction by novel multi-functional brain permeable iron- chelating- antioxidants, M-30 and green tea polyphenol, EGCG.

  2007cited by this paper
• Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans

  2007cited by this paper
• Neuroprotective effects of green and black teas and their catechin gallate esters against β‐amyloid‐induced toxicity

  2006cited by this paper
• Beneficial Effects of Green Tea—A Review

  2006cited by this paper
• Epigallocatechin gallate supplementation alleviates diabetes in rodents.

  2006cited by this paper
• Reduction of iron‐regulated amyloid precursor protein and β‐amyloid peptide by (–)‐epigallocatechin‐3‐gallate in cell cultures: implications for iron chelation in Alzheimer's disease

  2006cited by this paper
• Biology of Aging

  2006cited by this paper
• Caloric restriction in humans: potential pitfalls and health concerns.

  2006cited by this paper
• Beneficial effects of natural antioxidants EGCG and alpha-lipoic acid on life span and age-dependent behavioral declines in Caenorhabditis elegans.

  2006cited by this paper
• Tea, obesity, and diabetes.

  2006cited by this paper
• Protective effect of green tea polyphenols on the SH-SY5Y cells against 6-OHDA induced apoptosis through ROS-NO pathway.

  2005cited by this paper
• Soy isoflavone glycitein protects against beta amyloid-induced toxicity and oxidative stress in transgenic Caenorhabditis elegans

  2005cited by this paper
• A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans

  2005cited by this paper
• Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3.

  2005cited by this paper
• New Genes Tied to Endocrine, Metabolic, and Dietary Regulation of Lifespan from a Caenorhabditis elegans Genomic RNAi Screen

  2005cited by this paper
• Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation

  2005cited by this paper
• Sirtuin activators mimic caloric restriction and delay ageing in metazoans

  2004cited by this paper
• The biology of aging.

  2003cited by this paper
• SKN-1 links C. elegans mesendodermal specification to a conserved oxidative stress response.

  2003cited by this paper
• Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

  2003cited by this paper
• Antioxidant flavonoids from leaves of Polygonum hydropiper L.

  2003cited by this paper
• Expression of the small heat‐shock protein Hsp‐16‐2 in Caenorhabditis elegans is suppressed by Ginkgo biloba extract EGb 761

  2003cited by this paper
• Tea Catechins and Polyphenols: Health Effects, Metabolism, and Antioxidant Functions

  2003cited by this paper
• Protective effects of green tea polyphenols and their major component, (–)-epigallocatechin-3-gallate (EGCG), on 6-hydroxydopamine-induced apoptosis in PC12 cells

  2002cited by this paper
• Distinct effects of tea catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells.

  2002cited by this paper
• Epigallocatechin Gallate, a Constituent of Green Tea, Represses Hepatic Glucose Production*

  2002cited by this paper
• Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

  2001cited by this paper
• Increased carbon disulfide-stimulated chemiluminescence in the pyrogallol-luminol system.

  2001cited by this paper
• Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

  2001cited by this paper
• Localized Rac activation dynamics visualized in living cells.

  2000cited by this paper
• The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

  1995influential reference
• Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress.

  1995cited by this paper
• A C. elegans mutant that lives twice as long as wild type

  1993cited by this paper
• [Genetics of Caenorhabditis elegans].

  1989influential reference
• Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation.

  1983cited by this paper
• The genetics of Caenorhabditis elegans.

  1974cited by this paper
• Aging: a theory based on free radical and radiation chemistry.

  1956cited by this paper
• Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2 2 DD C T Method

  year unknowncited by this paper

• Antioxidant and Anti-aging Effects of Quercetin 3-O-rhamnoside isolated from Houttuynia cordata Thunb extract on Caenorhabditis elegans.

  2025cites this paper
• Caenorhabditis elegans in the biological activity research of tea: From “little transparent” to “big star”

  2025cites this paper
• Anti-aging effect of tea and its phytochemicals.

  2025cites this paper
• Potential dietary geroprotectors and their impact on key mechanisms of aging

  2025cites this paper
• EGCG alleviates aging-related metabolic dysregulation caused by excessive methionine intake via the formation of N-EGCG and activation of DAF-16/FOXO

  2025cites this paper
• Unraveling the ROS-Inflammation-Immune Balance: A New Perspective on Aging and Disease

  2025cites this paper
• A rice SOUL family heme-binding protein REAC1 enhances the antioxidative capacity of C. elegans through modulation of ROS-related gene expression

  2025cites this paper
• Photoaged polystyrene nanoplastics exposure results in reproductive toxicity due to oxidative damage in Caenorhabditis elegans.

  2024cites this paper
• Protective effects of EGCG on acrolein-induced Caenorhabditis elegans and its mechanism of life extension.

  2024cites this paper
• Anti-Aging and Neurorescue Effects of Loquat in Caenorhabditis elegans and Electrochemical Quantification of Dopamine Neurotransmitter

  2024cites this paper
• L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed Caenorhabditis elegans

  2024cites this paper
• Leaf extract of Garcinia atroviridis promotes anti-heat stress and antioxidant effects in Caenorhabditis elegans

  2024cites this paper
• Low‐Molecular Weight Compounds that Extend the Chronological Lifespan of Yeasts, Saccharomyces cerevisiae, and Schizosaccharomyces pombe

  2024cites this paper
• Senolytics and Dietary Phytochemicals: Exploring Anti-Aging Strategies and Mechanisms in Aging and Disease

  2024influential citation
• Rosmarinic acid ameliorated oxidative stress, neuronal injuries, and mitochondrial dysfunctions mediated by polyglutamine and ɑ-synuclein in Caenorhabditis elegans models

  2024cites this paper
• A critical appraisal of geroprotective activities of flavonoids in terms of their bio-accessibility and polypharmacology.

  2024cites this paper
• Exploring the Therapeutic Potential of Green Tea (Camellia sinensis L.) in Anti-Aging: A Comprehensive Review of Mechanisms and Findings.

  2024cites this paper
• Unveiling the impact of Aging on BBB and Alzheimer's disease: Factors and Therapeutic implications.

  2024cites this paper
• Abl depletion via autophagy mediates the beneficial effects of quercetin against Alzheimer pathology across species

  2023cites this paper
• Mitochondrial targets exploration of epigallocatechin gallate and theaflavin in regards to differences in stress protection under different temperatures.

  2023cites this paper
• Dietary antioxidants and lifespan: Relevance of environmental conditions, diet, and genotype of experimental models.

  2023influential citation
• Effect of Sodium Hyaluronate on Antioxidant and Anti-Ageing Activities in Caenorhabditis elegans

  2023cites this paper
• A REPORT ON GREEN EXTRACTION PROCEDURES FOR SEPARATION OF FLAVONOIDS AND ITS BIO ACTIVITIES

  2023cites this paper
• Araçá (Psidium Cattleianum Sabine) ethanol extracts increase lifespan and alleviate oxidative stress in Caenorhabditis elegans

  2023cites this paper
• Anti-aging effects of dietary phytochemicals: From Caenorhabditis elegans, Drosophila melanogaster, rodents to clinical studies

  2023cites this paper
• Neurotoxicity of bisphenol A exposure on Caenorhabditis elegans induced by disturbance of neurotransmitter and oxidative damage.

  2023cites this paper
• Caenorhabditis elegans as an in vivo model for the identification of natural antioxidants with anti-aging actions.

  2023cites this paper
• Ageing, Metabolic Dysfunction, and the Therapeutic Role of Antioxidants.

  2023cites this paper
• Targeting Mitochondrial Oxidative Stress as a Strategy to Treat Aging and Age-Related Diseases

  2023cites this paper
• Exosome-mediated delivery of superoxide dismutase for anti-aging studies in Caenorhabditis elegans.

  2023cites this paper
• The Endogenous Metabolite Glycerophosphocholine Promotes Longevity and Fitness in Caenorhabditis elegans

  2022cites this paper
• Antiaging agents: safe interventions to slow aging and healthy life span extension

  2022cites this paper
• The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background

  2022cites this paper
• Ultrasonic-assisted extraction of swertisin from sour Jujube seed and comprehensive revelation of its antioxidant activity.

  2022cites this paper
• A comprehensive and current review on the role of flavonoids in lung cancer-Experimental and theoretical approaches.

  2022cites this paper
• Anti-aging potency correlates with metabolites from in vitro fermentation of edible fungal polysaccharides using human fecal intestinal microflora.

  2022cites this paper
• DAF-16 is involved in colonic metabolites of Ferulic acid promoted the longevity and stress resistance of C.elegans.

  2022cites this paper
• Phosphorothioate-DNA bacterial diet reduces the ROS levels in C. elegans while improving locomotion and longevity

  2021cites this paper
• Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain-specific lifespan and health effects in Caenorhabditis nematodes

  2021cites this paper
• Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition

  2021cites this paper
• Construction and Application of EGCG-Loaded Lysozyme/Pectin Nanoparticles for Enhancing the Resistance of Nematodes to Heat and Oxidation Stresses

  2021cites this paper
• p21-Activated kinase 1 (PAK1) in aging and longevity: An overview.

  2021cites this paper
• The Review of Anti-aging Mechanism of Polyphenols on Caenorhabditis elegans

  2021cites this paper
• Physiological Dose of EGCG Attenuates the Health Defects of High Dose by Regulating MEMO-1 in Caenorhabditis elegans

  2021cites this paper
• Pterocarpus marsupium extract extends replicative lifespan in budding yeast

  2021cites this paper
• Oolonghomobisflavans from Camellia sinensis increase Caenorhabditis elegans lifespan and healthspan

  2021cites this paper
• Rhodiola extract promotes longevity and stress resistance of Caenorhabditis elegans via DAF-16 and SKN-1.

  2021cites this paper
• Caenorhabditis elegans: an elegant model organism for evaluating the neuroprotective and neurotherapeutic potential of nutraceuticals

  2021cites this paper
• Alternative redox forms of ASNA-1 separate insulin signaling from tail-anchored protein targeting and cisplatin resistance in C. elegans

  2021cites this paper
• G. sinense and P. notoginseng Extracts Improve Healthspan of Aging Flies and Provide Protection in A Huntington Disease Model

  2021cites this paper
• Caffeic and Dihydrocaffeic Acids Promote Longevity and Increase Stress Resistance in Caenorhabditis elegans by Modulating Expression of Stress-Related Genes

  2021cites this paper
• Prospective Selective Mechanism of Emerging Senolytic Agents Derived from Flavonoids.

  2021cites this paper
• Effects of ethyl acetate fractional extract from Portulaca oleracea L. (PO-EA) on lifespan and healthspan in Caenorhabditis elegans.

  2020cites this paper
• Clove essential oil confers antioxidant activity and lifespan extension in C. elegans via the DAF-16/FOXO transcription factor.

  2020cites this paper
• Structural identification and UPLC-ESI-QTOF-MS2 analysis of flavonoids in the aquatic plant Landoltia punctata and their in vitro and in vivo antioxidant activities.

  2020cites this paper
• Plant and fungal products that extend lifespan in Caenorhabditis elegans

  2020cites this paper
• Caenorhabditis elegans: a model to study the anthelmintic effects of polyphenolic compounds on the fertility of parasitic gastrointestinal nematodes?

  2020cites this paper
• Quercetin enhances motility in aged and heat-stressed Caenorhabditis elegans nematodes by modulating both HSF-1 activity, and insulin-like and p38-MAPK signalling

  2020cites this paper
• Protective Effects of Epigallocatechin Gallate (EGCG) on Endometrial, Breast, and Ovarian Cancers

  2020cites this paper
• Caenorhabditis elegans as a Model Organism to Evaluate the Antioxidant Effects of Phytochemicals

  2020cites this paper
• Effects of Orange Extracts on Longevity, Healthspan, and Stress Resistance in Caenorhabditis elegans

  2020cites this paper
• The pros and cons of drinking tea

  2020cites this paper
• Healthspan Maintenance and Prevention of Parkinson’s-like Phenotypes with Hydroxytyrosol and Oleuropein Aglycone in C. elegans

  2020cites this paper
• Nobiletin Delays Aging and Enhances Stress Resistance of Caenorhabditis elegans

  2020cites this paper
• Wellness foods based on the health benefits of fruit: Gold kiwifruit for immune support and reducing symptoms of colds and influenza

  2020cites this paper
• Catechinic acid, a natural polyphenol compound, extends the lifespan of Caenorhabditis elegans via mitophagy pathways.

  2020cites this paper
• Mechanisms underlying food functionality via molecular chaperones: Chemical training hypothesis

  2020cites this paper
• Antioxidant and Antiaging Effects of Licorice on the Caenorhabditis elegans Model

  2020cites this paper
• (-)-Epigallocatechin-3-O-gallate at a high concentration may induce lipolysis via ATP consumption by activation of stress defense mechanisms.

  2020cites this paper
• Medicinal plants, antioxidant potential, and applications to aging

  2020cites this paper
• Sniffer worm, C. elegans, as a toxicity evaluation model organism with sensing and locomotion abilities

  2020cites this paper
• In search of nutritional anti-aging targets: TOR inhibitors, SASP modulators, and BCL-2 family suppressors.

  2019cites this paper
• (-)-Epigallocatechin-3-gallate attenuates the toxicity of methylmercury in Caenorhabditis elegans by activating SKN-1.

  2019cites this paper
• Targeting pro-senescence mitogen activated protein kinase (Mapk) enzymes with bioactive natural compounds.

  2019cites this paper
• The Mechanisms behind the Biological Activity of Flavonoids.

  2019cites this paper
• Treatment of Caenorhabditis elegans with Small Selenium Species Enhances Antioxidant Defense Systems.

  2019cites this paper
• Effect of Green Tea and Its Polyphenols On the Lifespan of Model Organisms: A Systematic Review

  2019cites this paper
• The potential application of rapeseed pomace extracts in the prevention and treatment of neurodegenerative diseases

  2019cites this paper
• ASNA-1 oxidation induced by cisplatin exposure enhances its cytotoxicity by selectively perturbing tail anchored protein targeting

  2019cites this paper
• Mechanisms of aging and potential role of selected polyphenols in extending healthspan.

  2019cites this paper
• Neuroprotective potential of Cucurbita maxima Duchesne ex Poir, Caeselpenia bunduc (L.) Roxb and Bombax ceiba Linn extracts

  2019cites this paper
• 3-Methyl-3-buten-1-ol (isoprenol) confers longevity and stress tolerance in Caenorhabditis elegans

  2019cites this paper
• Recombinant buckwheat glutaredoxin intake increases lifespan and stress resistance via hsf‐1 upregulation in Caenorhabditis elegans

  2018influential citation
• Epigallocatechin gallate suppresses premature senescence of preadipocytes by inhibition of PI3K/Akt/mTOR pathway and induces senescent cell death by regulation of Bax/Bcl-2 pathway

  2018cites this paper
• Epigallocatechin Gallate-Modified Gelatins with Different Compositions Alter the Quality of Regenerated Bones

  2018cites this paper
• Development of transgenic Caenorhabditis elegans expressing human transthyretin as a model for drug screening

  2018cites this paper
• Dietary epicatechin improves survival and delays skeletal muscle degeneration in aged mice

  2018influential citation
• Novel Bioactive Peptides from Meretrix meretrix Protect Caenorhabditis elegans against Free Radical-Induced Oxidative Stress through the Stress Response Factor DAF-16/FOXO

  2018cites this paper
• Kushui Rose (R. Setat x R. Rugosa) decoction exerts antitumor effects in C. elegan by downregulating Ras/MAPK pathway and resisting oxidative stress

  2018cites this paper
• Ocimum Species: A Longevity Elixir

  2018cites this paper
• Calycophyllum spruceanum (Benth.), the Amazonian “Tree of Youth” Prolongs Longevity and Enhances Stress Resistance in Caenorhabditis elegans

  2018cites this paper
• Confirmation of Nanomaterials with Low-Toxicity or Non-toxicity Property

  2018cites this paper
• Epigallocatechin-3-Gallate (EGCG) Promotes Autophagy-Dependent Survival via Influencing the Balance of mTOR-AMPK Pathways upon Endoplasmic Reticulum Stress

  2018cites this paper
• Epigallocatechin-3-Gallate Reduces Fat Accumulation in Caenorhabditis elegans

  2018cites this paper
• Epicatechin modulates stress-resistance in C. elegans via insulin/IGF-1 signaling pathway

  2018cites this paper
• Epigallocatechin-3-gallate promotes healthy lifespan through mitohormesis during early-to-mid adulthood in Caenorhabditis elegans

  2017cites this paper
• Anti-Onchocerca and Anti-Caenorhabditis Activity of a Hydro-Alcoholic Extract from the Fruits of Acacia nilotica and Some Proanthocyanidin Derivatives

  2017cites this paper
• Effect of the Biphenyl Neolignan Honokiol on Aβ42-Induced Toxicity in Caenorhabditis elegans, Aβ42 Fibrillation, Cholinesterase Activity, DPPH Radicals, and Iron(II) Chelation.

  2017cites this paper
• Molecular mechanisms of anti-oxidant and anti-aging effects induced by convallatoxin in Caenorhabditis elegans

  2017cites this paper
• 1,4-Naphthoquinone Triggers Nematode Lethality by Inducing Oxidative Stress and Activating Insulin/IGF Signaling Pathway in Caenorhabditis elegans

  2017cites this paper