Smoking molecular damage in bronchial epithelium

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Oncogene

• Publication date

  2002-10-21

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1038/sj.onc.1205806PMID 12379874
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Molecular Pathology of Early Cancer

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