Role of p53 and reactive oxygen species in apoptotic response to copper and zinc in epithelial breast cancer cells

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Apoptosis

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1007/s10495-005-6066-7PMID 15711927
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Differential regulation of signal transduction pathways in wild type and mutated p53 breast cancer epithelial cells by copper and zinc.

  2004cited by this paper
• Zinc inhibition of cellular energy production: implications for mitochondria and neurodegeneration

  2003cited by this paper
• Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription.

  2003cited by this paper
• The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

  2003cited by this paper
• Modulation of mitochondrial membrane potential and reactive oxygen species production by copper in astrocytes

  2003cited by this paper
• p53 has a direct apoptogenic role at the mitochondria.

  2003cited by this paper
• Zinc Is a Potent Inhibitor of Thiol Oxidoreductase Activity and Stimulates Reactive Oxygen Species Production by Lipoamide Dehydrogenase*

  2002cited by this paper
• Requirement of caspase and p38MAPK activation in zinc-induced apoptosis in human leukemia HL-60 cells.

  2002cited by this paper
• Potential role of p53 on metallothionein induction in human epithelial breast cancer cells

  2002cited by this paper
• Mediation of Poly(ADP-Ribose) Polymerase-1-Dependent Cell Death by Apoptosis-Inducing Factor

  2002cited by this paper
• Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341

  2002cited by this paper
• Apoptosis-inducing factor is involved in the regulation of caspase-independent neuronal cell death

  2002cited by this paper
• A polymorphic microsatellite that mediates induction of PIG3 by p53

  2002cited by this paper
• Translocation of apoptosis‐inducing factor in cerebellar granule cells exposed to neurotoxic agents inducing oxidative stress

  2002cited by this paper
• Mitochondrial release of apoptosis-inducing factor occurs downstream of cytochrome c release in response to several proapoptotic stimuli

  2002cited by this paper
• PUMA, a novel proapoptotic gene, is induced by p53.

  2001cited by this paper
• Bax‐dependent apoptosis induced by ceramide in HL‐60 cells

  2001cited by this paper
• PUMA induces the rapid apoptosis of colorectal cancer cells.

  2001cited by this paper
• p53 Signaling and cell cycle checkpoints.

  2001cited by this paper
• p53 Induces Apoptosis by Caspase Activation through Mitochondrial Cytochrome c Release*

  2000cited by this paper
• A comparison of hepatocyte cytotoxic mechanisms for Cu2+ and Cd2+.

  2000cited by this paper
• Crystallographic location of two Zn(2+)-binding sites in the avian cytochrome bc(1) complex.

  2000cited by this paper
• Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.

  2000cited by this paper
• Two Distinct Pathways Leading to Nuclear Apoptosis

  2000cited by this paper
• Cytochrome c release from mitochondria: all or nothing

  2000cited by this paper
• The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures.

  2000cited by this paper
• Mitochondrio‐nuclear translocation of AIF in apoptosis and necrosis

  2000cited by this paper
• Copper sensitizes the mitochondrial permeability transition to carboxyatractyloside and oleate

  2000cited by this paper
• Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator

  2000cited by this paper
• Death Signal-induced Localization of p53 Protein to Mitochondria

  2000cited by this paper
• Apoptosis‐inducing factor (AIF): a ubiquitous mitochondrial oxidoreductase involved in apoptosis

  2000cited by this paper
• Inhibitory effect of zinc on human prostatic carcinoma cell growth

  1999cited by this paper
• Bcl-2 family proteins regulate the release of apoptogenic cytochrome c by the mitochondrial channel VDAC

  1999cited by this paper
• Preferential Zn2+ influx through Ca2+-permeable AMPA/kainate channels triggers prolonged mitochondrial superoxide production.

  1999cited by this paper
• p53 regulates mitochondrial membrane potential through reactive oxygen species and induces cytochrome c‐independent apoptosis blocked by Bcl‐2

  1999cited by this paper
• Haploid loss of bax leads to accelerated mammary tumor development in C3(1)/SV40‐TAg transgenic mice: reduction in protective apoptotic response at the preneoplastic stage

  1999cited by this paper
• Role of Reactive Oxygen Species and p53 in Chromium(VI)-induced Apoptosis*

  1999cited by this paper
• Hydrogen peroxide induces nuclear translocation of p53 and apoptosis in cells of oligodendroglia origin.

  1999cited by this paper
• Apoptosis: Key to the mitochondrial gate

  1999cited by this paper
• Molecular characterization of mitochondrial apoptosis-inducing factor

  1999cited by this paper
• Mitochondria and apoptosis.

  1998cited by this paper
• Bax and adenine nucleotide translocator cooperate in the mitochondrial control of apoptosis.

  1998cited by this paper
• Mitochondria as regulators of apoptosis: doubt no more.

  1998cited by this paper
• Caspase-3 Is Required for DNA Fragmentation and Morphological Changes Associated with Apoptosis*

  1998cited by this paper
• Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a.

  1997cited by this paper
• A model for p53-induced apoptosis

  1997cited by this paper
• A Reappraisal of the Role of Zinc in Life and Death Decisions of Cells

  1997cited by this paper
• Mitochondrial control of nuclear apoptosis

  1996cited by this paper
• Liver copper storage and transport during development: implications for cytotoxicity.

  1996cited by this paper
• Why are mitochondria involved in apoptosis? Permeability transition pores and apoptosis as selective mechanisms to eliminate superoxide‐producing mitochondria and cell

  1996cited by this paper
• The influence of zinc on apoptosis.

  1995cited by this paper
• Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline.

  1995cited by this paper
• A novel form of Epstein-Barr virus latency in normal B cells in vivo.

  1995cited by this paper
• Persistent oxidative stress in cancer

  1995cited by this paper
• Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.

  1995cited by this paper
• Reduction in mitochondrial potential constitutes an early irreversible step of programmed lymphocyte death in vivo

  1995cited by this paper
• Preferential induction of apoptosis in mouse CD4+CD8+αβTCRIoCD3εIo thymocytes by zinc

  1995cited by this paper
• The influence of zinc on apoptosis

  1995cited by this paper
• Preferential induction of apoptosis in mouse CD4+CD8+ alpha beta TCRloCD3 epsilon lo thymocytes by zinc.

  1995cited by this paper
• Induction of WAF1/CIP1 by a p53-independent pathway.

  1994cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993cited by this paper
• Inhibition of apoptosis by zinc: a reappraisal.

  1992cited by this paper
• Interaction of Zn2+ with the bovine-heart mitochondrial bc1 complex.

  1991cited by this paper
• Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.

  1984cited by this paper
• Inhibition of the respiratory chain by zinc ions.

  1967cited by this paper

• A novel mechanism of selenium deficiency driving aberrant Th17 cell differentiation via GPX3-targeted PIG3: mitophagy blockade exacerbates mtDNA release.

  2026cites this paper
• Role of cuproptosis in digestive system tumors (Review)

  2026cites this paper
• Cu(II), Ag(I), and Au(I) complexes of imidazole derivatives as emerging anti-cancer agents: A comprehensive review

  2026cites this paper
• Copper-instigated modulatory cell mortality mechanisms and progress in kidney diseases

  2025cites this paper
• Copper homeostasis and cuproptosis: implications for neurodegenerative diseases

  2025cites this paper
• The relationship between copper metabolism and p53 activity in tumors.

  2025cites this paper
• Targeting cu metabolism as a potential therapeutic strategy for pulmonary fibrosis.

  2025cites this paper
• The emerging role of cuproptosis in spinal cord injury

  2025cites this paper
• Effects of Long-Term Blue Light Exposure on Body Fat Synthesis and Body Weight Gain in Mice and the Inhibitory Effect of Tranexamic Acid

  2025cites this paper
• The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer

  2025cites this paper
• AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple‐Negative Breast Cancer

  2025cites this paper
• Copper-Based Biomaterials for Anti-Tumor Therapy: Recent Advances and Perspectives.

  2025cites this paper
• Targeting neuronal cuproptosis and neuroinflammation with biomimetic nanoparticle for the therapy of radiotherapy-induced brain injury.

  2025cites this paper
• Unveiling the impact of glutathione (GSH) and p53 gene deletion on tumor cell metabolism by amino acid and proteomics analysis

  2024cites this paper
• The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm

  2024cites this paper
• Copper homeostasis and copper-induced cell death in tumor immunity: implications for therapeutic strategies in cancer immunotherapy

  2024cites this paper
• Zinc Oxide Nanoparticles and Cancer Chemotherapy: Helpful Tools for Enhancing Chemo-sensitivity and Reducing Side Effects?

  2023cites this paper
• Copper metabolism in cell death and autophagy

  2023cites this paper
• A Responsive Nanorobot Modulates Intracellular Zinc Homeostasis to Amplify Mitochondria-Targeted Phototherapy.

  2023cites this paper
• Copper-instigated modulatory cell mortality mechanisms and progress in oncological treatment investigations

  2023cites this paper
• Assessing the Carcinogenic Potential of Low Dose Exposures to Chemical Mixtures in the Environment: Replicative immortality

  2023cites this paper
• The p53 Tumor Suppressor and Copper Metabolism: An Unrevealed but Important Link

  2022cites this paper
• Uncovering the Interaction between Intracellular Telomerase Activity and Hydrogen Peroxide during Cancer Cell Apoptosis Utilizing a Dual-Color Fluorescent Nanoprobe.

  2022cites this paper
• ASSESSMENT OF MAGNESIUM (MG) AND ZINC (ZN) IN CARCINOMA BREAST PATIENTS

  2022cites this paper
• In situ monitoring of the effect of Cu2+ on the membrane permeability of a single living cell with a dual-electrode tip of a scanning electrochemical microscope.

  2021cites this paper
• Redox State and Gene Regulation in Breast Cancer

  2021cites this paper
• High-Dose Vitamin C Exerts Its Anti-cancer Effects in a Xenograft Model of Colon Cancer by Suppressing Angiogenesis.

  2021cites this paper
• Copper: An Intracellular Achilles’ Heel Allowing the Targeting of Epigenetics, Kinase Pathways, and Cell Metabolism in Cancer Therapeutics

  2021cites this paper
• Innovative Therapies for Neuroblastoma: The Surprisingly Potent Role of Iron Chelation in Up-Regulating Metastasis and Tumor Suppressors and Down-Regulating the Key Oncogene, N-myc.

  2021cites this paper
• Zinc, ω-3 polyunsaturated fatty acids and vitamin D: An essential combination for prevention and treatment of cancers.

  2020cites this paper
• Targeting ferroptosis in breast cancer

  2020cites this paper
• Oxidative stress, apoptosis and inflammatory responses involved in copper-induced pulmonary toxicity in mice

  2020cites this paper
• The effect of “Nutramil TM Complex,” food for special medical purpose, on breast and prostate carcinoma cells

  2020cites this paper
• Reactive Oxygen Species Induced p53 Activation: DNA Damage, Redox Signaling, or Both?

  2020cites this paper
• Myricetin Apoptotic Effects on T47D Breast Cancer Cells is a P53-Independent Approach

  2020cites this paper
• Candesartan and valsartan Zn(ii) complexes as inducing agents of reductive stress: mitochondrial dysfunction and apoptosis

  2020cites this paper
• P 53 AND REACTIVE OXYGEN SPECIES : A CONVOLUTED STORY

  2019cites this paper
• Novel Isatin-based activator of p53 transcriptional functions in tumor cells

  2019cites this paper
• Frizzled-7-targeted delivery of zinc oxide nanoparticles to drug-resistant breast cancer cells.

  2019cites this paper
• P53 AND REACTIVE OXYGEN SPECIES: A CONVOLUTED STORY

  2019cites this paper
• The effect of “NutramilTM Complex,” food for special medical purpose, on breast and prostate carcinoma cells

  2018cites this paper
• A Promising Role of Lichens, Their Secondary Metabolites and miRNAs on Treatment of Cancer Disease After Exposure to Carcinogenic Heavy Metals

  2018cites this paper
• The role of protein kinase CK2 in metal ion toxicity

  2018cites this paper
• p53 and metabolism: from mechanism to therapeutics

  2018cites this paper
• Environmental pollution and toxic substances: Cellular apoptosis as a key parameter in a sensible model like fish.

  2018cites this paper
• P 53 AND REACTIVE OXYGEN SPECIES : A CONVOLUTED STORY

  2018cites this paper
• ASSESSMENT OF ANIMAL MODELS AS SURROGATES FOR HUMAN TUMORS FROM THREE DIFFERENT ORGANS.

  2018cites this paper
• Anticancer effects of synthetic hexahydrobenzo [g]chromen-4-one derivatives on human breast cancer cell lines

  2017cites this paper
• P 53 AND REACTIVE OXYGEN SPECIES : A CONVOLUTED STORY

  2017cites this paper
• Midline2 is overexpressed and a prognostic indicator in human breast cancer and promotes breast cancer cell proliferation in vitro and in vivo

  2016cites this paper
• In situ clinical evidence that zinc levels are decreased in breast invasive ductal carcinoma

  2016cites this paper
• Copper induced apoptosis in Caco-2 and Hep-G2 cells: Expression of caspases 3, 8 and 9, AIF and p53.

  2016cites this paper
• Anti-oxidant and anti-cancer activities of Angelica dahurica extract via induction of apoptosis in colon cancer cells.

  2016cites this paper
• p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance.

  2016cites this paper
• Treatment Induced Autophagy Associated with Tumor Dormancy and Relapse

  2016cites this paper
• Basal and copper-induced expression of metallothionein isoform 1,2 and 3 genes in epithelial cancer cells: The role of tumor suppressor p53.

  2016cites this paper
• Disruption of apoptosis pathways involved in zebrafish gonad differentiation by 17α-ethinylestradiol and fadrozole exposures.

  2016cites this paper
• Metal toxicity and the p53 protein: an intimate relationship

  2015cites this paper
• Oxidative damage induced by copper in mouse primary hepatocytes by single-cell analysis

  2015cites this paper
• Comparative assessment of the apoptotic potential of silver nanoparticles synthesized by Bacillus tequilensis and Calocybe indica in MDA-MB-231 human breast cancer cells: targeting p53 for anticancer therapy

  2015cites this paper
• Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer

  2015cites this paper
• Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead

  2015cites this paper
• The role of NOS-mediated ROS accumulation in an early phase Cu-induced acute cytotoxicity in MCF-7 cells

  2015influential citation
• The potential for chemical mixtures from the environment to enable the cancer hallmark of sustained proliferative signalling.

  2015cites this paper
• Anti-Proliferative Activities of Sinigrin on Carcinogen-Induced Hepatotoxicity in Rats

  2014cites this paper
• Pyrostegia venusta heptane extract containing saturated aliphatic hydrocarbons induces apoptosis on B16F10-Nex2 melanoma cells and displays antitumor activity in vivo

  2014cites this paper
• Biology of the cell cycle inhibitor p21CDKN1A: molecular mechanisms and relevance in chemical toxicology

  2014cites this paper
• The role of nitric oxide synthase signaling pathway in the Zn-induced cellular responses in MCF-7 cells.

  2014cites this paper
• Differential Responses of Neuronal and Spermatogenic Cells to the Doppel Cytotoxicity

  2013cites this paper
• Copper induces apoptotic cell death through reactive oxygen species-triggered oxidative stress in the intertidal copepod Tigriopus japonicus.

  2013cites this paper
• Effects of shear stresses and antioxidant concentrations on the production of reactive oxygen species in lung cancer cells.

  2013cites this paper
• Copper induced upregulation of apoptosis related genes in zebrafish (Danio rerio) gill.

  2013influential citation
• Functional repeats (TGYCC)n in the p53-inducible gene 3 (PIG3) promoter and susceptibility to squamous cell carcinoma of the head and neck.

  2013cites this paper
• Solute carriers (SLCs) in cancer.

  2013cites this paper
• The effect of zinc and the role of p53 in copper‐induced cellular stress responses

  2013cites this paper
• Marijuana smoke condensate induces p53-mediated apoptosis in human lung epithelial cells.

  2013cites this paper
• The Role of Thiamine in Wilson′s Disease: Possible Genetic and Cellular Signaling Mechanisms

  2013cites this paper
• The Role of p53 in Marijuana Smoke Condensates-induced Genotoxicity and Apoptosis

  2012cites this paper
• Redox Regulation of p53, Redox Effectors Regulated by p53: A Subtle Balance

  2012cites this paper
• Cellular Mechanisms of Zinc Dysregulation: A Perspective on Zinc Homeostasis as an Etiological Factor in the Development and Progression of Breast Cancer

  2012influential citation
• Markers of potential malignancy in chronic hyperplastic candidiasis.

  2012cites this paper
• Mammalian metallothioneins: properties and functions.

  2012cites this paper
• Does copper stress lead to spindle misposition-dependent cell cycle arrest?

  2012cites this paper
• Effects of hydroxyapatite nanoparticles on proliferation and apoptosis of human breast cancer cells (MCF-7)

  2012cites this paper
• Role of hepatocyte nuclear factor 4α in controlling copper-responsive transcription.

  2011cites this paper
• Zinc opposes genotoxicity of cadmium and vanadium but not of lead.

  2011cites this paper
• Stem Cell, MicroRNA and Redox Cycling

  2011cites this paper
• Icariin inhibits hydrogen peroxide-induced toxicity through inhibition of phosphorylation of JNK/p38 MAPK and p53 activity.

  2011cites this paper
• DNA molecular recognition and cellular selectivity of anticancer metal(II) complexes of ethylenediaminediacetate and phenanthroline: multiple targets

  2011cites this paper
• Theaflavins retard human breast cancer cell migration by inhibiting NF‐κB via p53‐ROS cross‐talk

  2010cites this paper
• Retraction Note: Late phase activation of nuclear transcription factor kappaB by doxorubicin is mediated by interleukin-8 and induction of apoptosis via FasL

  2010cites this paper
• Zinc pyrithione induces cellular stress signaling and apoptosis in Hep-2 cervical tumor cells: the role of mitochondria and lysosomes

  2010influential citation
• Zinc induced apoptotic death of mouse dendritic cells

  2010cites this paper
• Significance of differential metal loads in normal versus cancerous cadaver tissues - biomed 2010.

  2010cites this paper
• RETRACTED ARTICLE: Late phase activation of nuclear transcription factor kappaB by doxorubicin is mediated by interleukin-8 and induction of apoptosis via FasL

  2010influential citation
• Copper-induced germline apoptosis in Caenorhabditis elegans: the independent roles of DNA damage response signaling and the dependent roles of MAPK cascades.

  2009cites this paper
• Copper toxicity in gills of the teleost fish, Oreochromis niloticus: effects in apoptosis induction and cell proliferation.

  2009cites this paper
• Inhibition of Ref-1 Stimulates the Production of Reactive Oxygen Species and Induces Differentiation in Adult Cardiac Stem Cells

  2009cites this paper
• The important role of the apoptotic effects of zinc in the development of cancers

  2009cites this paper
• Cyclosporin A Inhibits UV-Radiation-Induced Membrane Damage but is Unable to Inhibit Carboxyatractyloside-Induced Permeability Transition

  2009cites this paper