Challenges in delivering therapeutic peptides and proteins: A silk-based solution.

Peptide- and protein-based therapeutics have drawn significant attention over the past few decades for the treatment of infectious diseases, genetic disorders, oncology, and many other clinical needs. Yet, protecting peptide- and protein-based drugs from degradation and denaturation during processing, storage and delivery remain significant challenges. In this review, we introduce the properties of peptide- and protein-based drugs and the challenges associated with their stability and delivery. Then, we discuss delivery strategies using synthetic polymers and their advantages and limitations. This is followed by a focus on silk protein-based materials for peptide/protein drug processing, storage, and delivery, as a path to overcome stability and delivery challenges with current systems.

• Publication year

  2022

• Venue

  Journal of Controlled Release

• Publication date

  2022-02-01

• Fields of study

  Medicine, Materials Science

• Identifiers
  DOI 10.1016/j.jconrel.2022.02.011PMID 35157939PMCID PMC9133086
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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