SCIENCE@home

Potential regulators of the senescence-associated secretory phenotype during senescence and ageing.

Xiaoxiao Han,Qing Lei,Jianhong Xie,Huanhuan Liu,Haoran Sun,Li Jing,Xiaohua Zhang,Tianying Zhang,Xingchun Gou

Published 2022 in The journals of gerontology. Series A, Biological sciences and medical sciences

ABSTRACT

Senescent cells express and secrete a variety of extracellular modulators that include cytokines, chemokines, proteases, growth factors and some enzymes associated with ECM remodeling, defined as the senescence-associated secretory phenotype (SASP). SASP reinforces senescent cell cycle arrest, stimulates and recruits immune cells for immune-mediated clearance of potentially tumorigenic cells, limits or induces fibrosis and promotes wound healing and tissue regeneration. On the other hand, SASP mediates chronic inflammation leading to destruction of tissue structure and function and stimulating the growth and survival of tumour cells. SASP is highly heterogeneous and the role of SASP depends on the context. The regulation of SASP occurs at multiple levels including chromatin remodelling, transcription, mRNA translation, intracellular trafficking and secretion. Several SASP modulators have already been identified setting the stage for future research on their clinical applications. In this review, we summarize in detail the potential signalling pathways that trigger and regulate SASP production during ageing and senescence.

PUBLICATION RECORD

CITATION MAP

EXTRACTION MAP

CLAIMS

  • No claims are published for this paper.

CONCEPTS

  • No concepts are published for this paper.

REFERENCES

Showing 1-100 of 116 references · Page 1 of 2

12
Next

CITED BY

Showing 1-64 of 64 citing papers · Page 1 of 1