Unlocking the mechanisms of transcription factor YY1: are chromatin modifying enzymes the key?

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Gene

• Publication date

  1999-08-20

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/S0378-1119(99)00261-9PMID 10452940
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Identification of a New Family of Higher Eukaryotic Histone Deacetylases

  1999cited by this paper
• Multiple interactions of the transcription factor YY1 with human histone H4 gene regulatory elements

  1999cited by this paper
• Histone acetylation and transcriptional regulatory mechanisms.

  1998cited by this paper
• SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex.

  1998cited by this paper
• A Role for CREB Binding Protein and p300 Transcriptional Coactivators in Ets-1 Transactivation Functions

  1998cited by this paper
• Yeast heterochromatin: regulation of its assembly and inheritance by histones.

  1998cited by this paper
• Chromatin deacetylation by an ATP-dependent nucleosome remodelling complex

  1998cited by this paper
• A role for histone deacetylase activity in HDAC1-mediated transcriptional repression.

  1998cited by this paper
• Characterization of a human RPD3 ortholog, HDAC3.

  1998cited by this paper
• Regulation of activity of the transcription factor GATA-1 by acetylation

  1998cited by this paper
• Identification of YY1 sequences necessary for association with the nuclear matrix and for transcriptional repression functions

  1998cited by this paper
• Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex

  1998cited by this paper
• Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases.

  1998cited by this paper
• Structure and function of the core histone N-termini: more than meets the eye.

  1998cited by this paper
• Repression of Human Immunodeficiency Virus Type 1 through the Novel Cooperation of Human Factors YY1 and LSF

  1998cited by this paper
• Role for a YY1-Binding Element in Replication-Dependent Mouse Histone Gene Expression

  1998cited by this paper
• NURD, a novel complex with both ATP-dependent chromatin-remodeling and histone deacetylase activities.

  1998cited by this paper
• YY1 can inhibit c-Myc function through a mechanism requiring DNA binding of YY1 but neither its transactivation domain nor direct interaction with c-Myc

  1998cited by this paper
• Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells.

  1998cited by this paper
• The Drosophila Polycomb group gene pleiohomeotic encodes a DNA binding protein with homology to the transcription factor YY1.

  1998cited by this paper
• The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities.

  1998cited by this paper
• A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase.

  1998cited by this paper
• Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

  1998cited by this paper
• SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors.

  1998cited by this paper
• Repression of human immunodeficiency virus type 1 through the novel cooperation of human factors YY1 and LSF

  1997cited by this paper
• A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

  1997cited by this paper
• Histone acetylation in chromatin structure and transcription

  1997cited by this paper
• Characterization of the CHD family of proteins.

  1997cited by this paper
• Identification of maize histone deacetylase HD2 as an acidic nucleolar phosphoprotein.

  1997cited by this paper
• What's up and down with histone deacetylation and transcription?

  1997cited by this paper
• Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression.

  1997cited by this paper
• Histone deacetylase activity is required for full transcriptional repression by mSin3A.

  1997cited by this paper
• Acetylation of general transcription factors by histone acetyltransferases.

  1997cited by this paper
• Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.

  1997cited by this paper
• Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C

  1997cited by this paper
• Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.

  1997cited by this paper
• Characterization of the Transcriptional Regulator YY1

  1997cited by this paper
• Nuclear histone acetylases and deacetylases and transcriptional regulation: HATs off to HDACs.

  1997cited by this paper
• Isolation and Characterization of cDNAs Corresponding to an Additional Member of the Human Histone Deacetylase Gene Family*

  1997cited by this paper
• Regulatory domains of the A-Myb transcription factor and its interaction with the CBP/p300 adaptor molecules.

  1997cited by this paper
• Histone acetylation: chromatin in action.

  1997cited by this paper
• The multifunctional role of the co-activator CBP in transcriptional regulation.

  1997cited by this paper
• Multiple mechanisms of transcriptional repression by YY1

  1997cited by this paper
• Regulation of cell growth by the Myc-Max-Mad network: role of Mad proteins and YY1.

  1997cited by this paper
• Everything you have ever wanted to know about Yin Yang 1......

  1997cited by this paper
• The transcriptional coactivators p300 and CBP are histone acetyltransferases.

  1996cited by this paper
• Human p300 Protein Is a Coactivator for the Transcription Factor MyoD (*)

  1996cited by this paper
• A Mammalian Histone Deacetylase Related to the Yeast Transcriptional Regulator Rpd3p

  1996cited by this paper
• CREB-binding Protein Activates Transcription through Multiple Domains*

  1996cited by this paper
• Differential Interactions of the CREB/ATF Family of Transcription Factors with p300 and Adenovirus E1A*

  1996cited by this paper
• A novel C/EBP beta-YY1 complex controls the cell-type-specific activity of the human papillomavirus type 18 upstream regulatory region

  1996cited by this paper
• YY1 and c-Myc associate in vivo in a manner that depends on c-Myc levels.

  1996cited by this paper
• Transcriptional repression by YY1 is mediated by interaction with a mammalian homolog of the yeast global regulator RPD3.

  1996cited by this paper
• The p55 subunit of Drosophila chromatin assembly factor 1 is homologous to a histone deacetylase-associated protein

  1996cited by this paper
• Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator.

  1996cited by this paper
• Editorial

  1995cited by this paper
• Cloning of an intrinsic human TFIID subunit that interacts with multiple transcriptional activators

  1995cited by this paper
• Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300.

  1995cited by this paper
• Transcriptional repression of the c-fos gene by YY1 is mediated by a direct interaction with ATF/CREB

  1995cited by this paper
• CBP‐induced stimulation of c‐Fos activity is abrogated by E1A.

  1995cited by this paper
• Adenovirus E1A proteins interact with the cellular YY1 transcription factor

  1995cited by this paper
• Characterization of Functional Domains within the Multifunctional Transcription Factor, YY1 (*)

  1995cited by this paper
• Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP

  1995cited by this paper
• The nuclear matrix protein NMP-1 is the transcription factor YY1.

  1995cited by this paper
• DNA binding sites for the transcriptional activator/repressor YY1.

  1995cited by this paper
• Modulation of Chromatin Folding by Histone Acetylation (*)

  1995cited by this paper
• High affinity YY1 binding motifs: identification of two core types (ACAT and CCAT) and distribution of potential binding sites within the human beta globin cluster.

  1995cited by this paper
• Functional interactions between YY1 and adenovirus E1A.

  1995cited by this paper
• Stimulation of c-Jun activity by CBP: c-Jun residues Ser63/73 are required for CBP induced stimulation in vivo and CBP binding in vitro.

  1995cited by this paper
• Cyclophilin A and FKBP12 Interact with YY1 and Alter Its Transcriptional Activity (*)

  1995cited by this paper
• Nuclear protein CBP is a coactivator for the transcription factor CREB

  1994cited by this paper
• Nucleosome structural changes due to acetylation.

  1994cited by this paper
• TATA-binding protein-independent initiation: YY1, TFIIB, and RNA polymerase II direct basal transcription on supercoiled template DNA.

  1994cited by this paper
• Bifunctional transcriptional properties of YY1 in regulating muscle actin and c-myc gene expression during myogenesis.

  1994cited by this paper
• Relief of YY1-induced transcriptional repression by protein-protein interaction with the nucleolar phosphoprotein B23.

  1994cited by this paper
• An analysis of genes regulated by the multi-functional transcriptional regulator Yin Yang-1.

  1994cited by this paper
• Studies of the DNA binding properties of histone H4 amino terminus. Thermal denaturation studies reveal that acetylation markedly reduces the binding constant of the H4 "tail" to DNA.

  1993cited by this paper
• Identification of a transcriptional initiator element in the cytochrome c oxidase subunit Vb promoter which binds to transcription factors NF-E1 (YY-1, delta) and Sp1.

  1993cited by this paper
• Interaction between transcription factors Spl and YY1

  1993cited by this paper
• Evidence for physical interaction between the zinc-finger transcription factors YY1 and Sp1.

  1993cited by this paper
• Yin-yang 1 activates the c-myc promoter

  1993cited by this paper
• Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc.

  1993cited by this paper
• Cloning of a negative transcription factor that binds to the upstream conserved region of Moloney murine leukemia virus

  1992cited by this paper
• Purification, sequence, and cellular localization of a novel chromosomal protein that binds to methylated DNA.

  1992cited by this paper
• Displacement of BrdUrd-induced YY1 by serum response factor activates skeletal alpha-actin transcription in embryonic myoblasts.

  1992cited by this paper
• Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.

  1991cited by this paper
• YY1 is an initiator sequence-binding protein that directs and activates transcription in vitro

  1991cited by this paper
• Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein.

  1991cited by this paper
• Delta, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein.

  1991cited by this paper
• Histone acetylation reduces nucleosome core particle linking number change.

  1989cited by this paper
• Equipotent mouse ribosomal protein promoters have a similar architecture that includes internal sequence elements.

  1989cited by this paper

• Epigenetic Suppression of RASAL1 by HDAC3 and Cofactor YY1 Promotes Fibroblast–Myofibroblast Transition and Renal Fibrosis

  2025cites this paper
• Yin Yang 1: Function, Mechanisms, and Glia

  2025cites this paper
• Role of YY1 in pancreatic ductal adenocarcinoma: Mechanisms and therapeutic perspectives.

  2025cites this paper
• Yin Yang 1 (YY1) as a Central Node in Drug Resistance Pathways: Potential for Combination Strategies in Cancer Therapy

  2025cites this paper
• A novel mechanism of radiation-induced lung injury: METTL3 mediates fibrogenesis through N6-methyladenosine modification of YY1

  2025cites this paper
• Glucosamine hinders IL-1β-induced CHON-001 cell injury and inflammation by inhibiting YY1-mediated TLR8

  2025cites this paper
• Unstructured but critical: The role of YY1 and YY2 disorder in promoter recognition networks, transcriptional control, and oncogenesis.

  2025cites this paper
• Lactate Metabolism and Lactylation Modification: New Opportunities and Challenges in Cardiovascular Disease

  2025cites this paper
• Induction of yin Yang 1 (YY1) overexpression in mature adipocytes promotes dysfunctional adipose tissue and systemic insulin resistance in mice.

  2025cites this paper
• The YY1-CPT1C signaling axis modulates the proliferation and metabolism of pancreatic tumor cells under hypoxia.

  2024cites this paper
• Mechanical Activation of cPLA2 Impedes Fatty Acid β‐Oxidation in Vein Grafts

  2024cites this paper
• Clinical Potential of YY1-Hypoxia Axis for Vascular Normalization and to Improve Immunotherapy

  2024cites this paper
• TPTEP1 impedes the reprogramming of fatty acid metabolism in triple negative breast cancer via miR-1343-3p/SIRT3 axis.

  2024cites this paper
• Activation of the YY1-UGT2B7 Axis Promotes Mammary Estrogen Homeostasis Dysregulation and Exacerbates Breast Tumor Metastasis

  2024cites this paper
• YY1 knockout in pro-B cells impairs lineage commitment, enabling unusual hematopoietic lineage plasticity

  2024cites this paper
• Cereblon regulates the production of hepatic fibroblast growth factor 23 in diabetes

  2024cites this paper
• YY1 is a transcriptional activator of the mouse LINE-1 Tf subfamily

  2024cites this paper
• YY1 is a transcriptional activator of mouse LINE-1 Tf subfamily

  2024cites this paper
• The New Youngest Case of Grange Syndrome with a Novel Biallelic Pathogenic Variant in YY1AP1

  2023cites this paper
• Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats

  2023cites this paper
• Depletion of enhancer zeste homolog 2 (EZH2) directs transcription factors associated with T cell differentiation through epigenetic regulation of Yin Yang 1(YY1) in combating non-small cell lung cancer (NSCLC)

  2023cites this paper
• YY1's longer DNA-binding motifs

  2023cites this paper
• Deciphering Hierarchical Chromatin Domains and Preference of Genomic Position Forming Boundaries in Single Mouse Embryonic Stem Cells

  2023cites this paper
• SETD7 promotes metastasis of triple-negative breast cancer by YY1 lysine methylation.

  2023cites this paper
• Long non‑coding RNA BLACAT2/miR‑378a‑3p/YY1 feedback loop promotes the proliferation, migration and invasion of uterine corpus endometrial carcinoma

  2023cites this paper
• YY1 is regulated by ALKBH5-mediated m6A modification and promotes autophagy and cancer progression through targeting ATG4B

  2023cites this paper
• Assessing the dynamics and macromolecular interactions of the intrinsically disordered protein YY1

  2023influential citation
• Yin Yang 1 promotes the neuroendocrine differentiation of prostate cancer cells via the non‐canonical WNT pathway (FYN/STAT3)

  2023cites this paper
• Correction to: YY1 inactivated transcription co‐regulator PGC‐1α to promote mitochondrial dysfunction of early diabetic nephropathy‐associated tubulointerstitial fibrosis

  2023cites this paper
• Suppressive effect of YY1-mediated RGS22 regulation on the proliferation, migration and invasion of pancreatic ductal adenocarcinoma

  2022cites this paper
• HDAC1/3-dependent moderate liquid–liquid phase separation of YY1 promotes METTL3 expression and AML cell proliferation

  2022cites this paper
• Transcription factor YY1 contributes to human melanoma cell growth through modulating the p53 signalling pathway

  2022cites this paper
• Yin Yang 1 promotes aggressive cell growth in high‐grade breast cancer by directly transactivating kinectin 1

  2022cites this paper
• Interaction between endogenous microRNAs and virus-derived small RNAs controls viral replication in insect vectors

  2022cites this paper
• YY1 inactivated transcription co-regulator PGC-1α to promote mitochondrial dysfunction of early diabetic nephropathy-associated tubulointerstitial fibrosis

  2022cites this paper
• Deciphering Hierarchical Chromatin Structures and Preference of Genomic Positions in Single Mouse Embryonic Stem Cells

  2022cites this paper
• YY1 and tumor metastasis regulation

  2021cites this paper
• YY1 expression and PD-1 regulation in CD8 T lymphocytes

  2021cites this paper
• Yin and Yang of YY1 regulation on tumor metabolic reprogramming

  2021cites this paper
• Truncated YY1 interacts with BASP1 through a 339KLK341 motif in YY1 and suppresses vascular smooth muscle cell growth and intimal hyperplasia after vascular injury.

  2021cites this paper
• GCN5 maintains muscle integrity by acetylating YY1 to promote dystrophin expression

  2021cites this paper
• YY1 regulation by miR-124-3p promotes Th17 cell pathogenicity through interaction with T-bet in rheumatoid arthritis

  2021cites this paper
• LINC02532 Contributes to Radiosensitivity in Clear Cell Renal Cell Carcinoma through the miR-654-5p/YY1 Axis

  2021cites this paper
• YY1 regulated transcription‐based stratification of gastric tumors and identification of potential therapeutic candidates

  2021cites this paper
• Growth hormone promotes hepatic gluconeogenesis by enhancing BTG2–YY1 signaling pathway

  2021cites this paper
• The role of YY1 in drug resistant cancer: Involvement of the YY1/PTEN/PP2A/H2Ax/Rad51 axis

  2021cites this paper
• YY2 in Mouse Preimplantation Embryos and in Embryonic Stem Cells

  2021cites this paper
• YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2

  2021cites this paper
• Yin Yang 1 is critical for mid-hindbrain neuroepithelium development and involved in cerebellar agenesis

  2020cites this paper
• Receptor signaling, transcriptional, and metabolic regulation of T cell exhaustion

  2020cites this paper
• YAP-Mediated Recruitment of YY1 and EZH2 Represses Transcription of Key Cell-Cycle Regulators

  2020cites this paper
• Roles of Histone Deacetylases and Inhibitors in Anticancer Therapy

  2020cites this paper
• CHAPTER 2 C H Zinc Fingers As DNA Binding Domains

  2020cites this paper
• miR-34a-5p suppresses the invasion and metastasis of liver cancer by targeting the transcription factor YY1 to mediate MYCT1 upregulation.

  2020cites this paper
• The biological implications of Yin Yang 1 in the hallmarks of cancer

  2020cites this paper
• miR-132 suppresses transcription of ribosomal proteins to promote protective 1 Th1 immunity 2

  2020cites this paper
• Integrating binding and expression data to predict transcription factors combined function

  2020cites this paper
• Transcriptional regulation of human abraxas brother protein 1 expression by yin yang 1.

  2020cites this paper
• YY1 control of mitochondrial‐related genes does not account for regulation of immunoglobulin class switch recombination in mice

  2020cites this paper
• Therapeutic targeting of YY1/MZF1 axis by MZF1-uPEP inhibits aerobic glycolysis and neuroblastoma progression

  2020cites this paper
• Structural and Biophysical Insights into the Function of the Intrinsically Disordered Myc Oncoprotein

  2020cites this paper
• Transcriptional regulation of human abraxas brother protein

  2020cites this paper
• YY1 mediates TGF-β1-induced EMT and pro-fibrogenesis in alveolar epithelial cells

  2019cites this paper
• YY1: A novel therapeutic target for diabetic nephropathy orchestrated renal fibrosis.

  2019cites this paper
• Bioinformatic Identification of Chinese Hamster Ovary (CHO) Cold-shock Genes and Biological Evidence of their Cold-inducible Promoters.

  2019cites this paper
• YY1/BCCIP Coordinately Regulates P53-Responsive Element (p53RE)-Mediated Transactivation of p21Waf1/Cip1

  2019cites this paper
• A SAP 30 complex inhibits IFN-beta expression in Rift Valley fever virus infected cells

  2019cites this paper
• Human transcription factor YY1 could upregulate the HIV-1 gene expression

  2019cites this paper
• Yin-Yang 1 transcription factor modulates ST2 expression during adverse cardiac remodeling post-myocardial infarction.

  2019cites this paper
• FAM3C‐YY1 axis is essential for TGFβ‐promoted proliferation and migration of human breast cancer MDA‐MB‐231 cells via the activation of HSF1

  2019cites this paper
• miR‐132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity

  2019cites this paper
• HnRNPM is a potential mediator of YY1 which promotes EMT in prostate cancer cells

  2019cites this paper
• Elucidation for modulation of death receptor (DR) 5 to strengthen apoptotic signals in cancer cells

  2019cites this paper
• hnRNPM, a potential mediator of YY1 in promoting the epithelial-mesenchymal transition of prostate cancer cells.

  2019cites this paper
• REX1 promotes EMT-induced cell metastasis by activating the JAK2/STAT3-signaling pathway by targeting SOCS1 in cervical cancer

  2019cites this paper
• Functional analysis of YY1 zinc fingers through cysteine mutagenesis

  2019cites this paper
• Long noncoding RNAs: regulation, function and cancer

  2018cites this paper
• Long noncoding RNA Sox2ot and transcription factor YY1 co-regulate the differentiation of cortical neural progenitors by repressing Sox2

  2018cites this paper
• Knockdown of Yin Yang 1 enhances anticancer effects of cisplatin through protein phosphatase 2A-mediated T308 dephosphorylation of AKT

  2018cites this paper
• Characterization of interaction between Trim28 and YY1 in silencing proviral DNA of Moloney murine leukemia virus.

  2018influential citation
• Enhancer function regulated by combinations of transcription factors and cofactors

  2018cites this paper
• BCCIP binds to and activates its promoter in a YY1‐dependent fashion in HCT116 cells

  2018cites this paper
• c-Abl phosphorylation of Yin Yang 1's conserved tyrosine 254 in the spacer region modulates its transcriptional activity.

  2018cites this paper
• Conserved RNA binding activity of a Yin-Yang 1 homologue in the ova of the purple sea urchin Strongylocentrotus purpuratus

  2018cites this paper
• YY1 and HDAC9c transcriptionally regulate p38-mediated mesenchymal stem cell differentiation into osteoblasts.

  2018cites this paper
• YinYang1 deficiency ameliorates joint inflammation in a murine model of rheumatoid arthritis by modulating Th17 cell activation.

  2018cites this paper
• The Yin and Yang of YY1 in tumor growth and suppression

  2018cites this paper
• miR-186 reverses cisplatin resistance and inhibits the formation of the glioblastoma-initiating cell phenotype by degrading Yin Yang 1 in glioblastoma.

  2018cites this paper
• YY1 Upregulates Checkpoint Receptors and Downregulates Type I Cytokines in Exhausted, Chronically Stimulated Human T Cells

  2018cites this paper
• Cyclophilin A as a target in the treatment of cytomegalovirus infections

  2018cites this paper
• MeCP2 and CTCF: enhancing the cross-talk of silencers.

  2017cites this paper
• Investigating and exploiting the latency-associated expression of the human cytomegalovirus gene US28 in early myeloid lineage cells.

  2017influential citation
• Inverse correlation between the metastasis suppressor RKIP and the metastasis inducer YY1: Contrasting roles in the regulation of chemo/immuno-resistance in cancer.

  2017cites this paper
• Facioscapulohumeral Muscular Dystrophy.

  2017cites this paper
• Acetylation- and Methylation-Related Epigenetic Proteins in the Context of Their Targets

  2017cites this paper
• YY1 Expression Is Sufficient for the Maintenance of Cardiac Progenitor Cell State

  2017cites this paper
• Role of Litopenaeus vannamei Yin Yang 1 in the Regulation of the White Spot Syndrome Virus Immediate Early Gene ie1

  2017cites this paper
• The Role of Transcription Factor YY1 in the Biology of Cancer.

  2017cites this paper
• Methylation of transcription factor YY2 regulates its transcriptional activity and cell proliferation

  2017cites this paper
• Targeting the Overexpressed YY1 in Cancer Inhibits EMT and Metastasis.

  2017cites this paper