The C. elegans vulval induction gene lin-2 encodes a member of the MAGUK family of cell junction proteins.

No abstract is available for this paper.

• Publication year

  1996

• Venue

  Development

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.5167/UZH-352PMID 8565857
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Different levels of the C. elegans growth factor LIN-3 promote distinct vulval precursor fates.

  1995influential reference
• Sequential signalling during Caenorhabditis elegans vulval induction

  1995cited by this paper
• Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells.

  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
• Mosaic analysis of the let-23 gene function in vulval induction of Caenorhabditis elegans.

  1995cited by this paper
• Sequential signalling during Caenorhabditis elegans vulval induction

  1995influential reference
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  1995cited by this paper
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  1995cited by this paper
• Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95.

  1995cited by this paper
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  1994cited by this paper
• 2.2 Mb of contiguous nucleotide sequence from chromosome III of C. elegans

  1994influential reference
• Direct association of occludin with ZO-1 and its possible involvement in the localization of occludin at tight junctions

  1994influential reference
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  1994cited by this paper
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  1994influential reference
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  1994influential reference
• Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1.

  1994cited by this paper
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  1994cited by this paper
• Molecular characterization and tissue distribution of ZO-2, a tight junction protein homologous to ZO-1 and the Drosophila discs-large tumor suppressor protein

  1994cited by this paper
• Structure and function of the SH3 domain.

  1994influential reference
• The multifunctional Ca2+/calmodulin-dependent protein kinases.

  1993cited by this paper
• ZO-1, DlgA and PSD-95/SAP90: homologous proteins in tight, septate and synaptic cell junctions.

  1993influential reference
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992influential reference
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  1992influential reference
• The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions.

  1991cited by this paper
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  1991influential reference
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1991cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
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  1989influential reference
• The combined action of two intercellular signaling pathways specifies three cell fates during vulval induction in C. elegans.

  1989cited by this paper
• [Genetics of Caenorhabditis elegans].

  1989influential reference
• The protein kinase family: conserved features and deduced phylogeny of the catalytic domains.

  1988influential reference
• The nematode Caenorhabditis elegans.

  1988influential reference
• Lateral inhibition during vulval induction in Caenorhabditis elegans

  1988influential reference
• Epidermal growth factor-induced mitogenesis in kidney epithelial cells (LLC-PK1).

  1988cited by this paper
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  1986cited by this paper
• Pattern formation during vulval development in C. elegans.

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• Integrative transformation of Caenorhabditis elegans

  1986cited by this paper
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  1986influential reference
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  1985influential reference
• The embryonic cell lineage of the nematode Caenorhabditis elegans.

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  1981cited by this paper
• Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans.

  1980cited by this paper
• Post-embryonic cell lineages of the nematode, Caenorhabditis elegans.

  1977influential reference
• The genetics of Caenorhabditis elegans.

  1974cited by this paper
• The DNA of Caenorhabditis elegans.

  1974influential reference
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  1972influential reference

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  2003cites this paper
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  2003cites this paper
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  2003cites this paper
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  2002cites this paper
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