Genetic mechanisms underlying male sex determination in mammals

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Journal of Applied Genetics

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/BF03195693PMID 19875885
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

  2008cited by this paper
• Human SRY inhibits beta-catenin-mediated transcription.

  2008cited by this paper
• A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation

  2008cited by this paper
• Loss of Fgfr2 leads to partial XY sex reversal.

  2008cited by this paper
• Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

  2008influential reference
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  2007cited by this paper
• Heterozygous missense mutations in steroidogenic factor 1 (SF1/Ad4BP, NR5A1) are associated with 46,XY disorders of sex development with normal adrenal function.

  2007cited by this paper
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  2007influential reference
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  2007cited by this paper
• R-spondin1--discovery of the long-missing, mammalian female-determining gene?

  2007cited by this paper
• Sry and the hesitant beginnings of male development.

  2007influential reference
• Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination

  2007cited by this paper
• SOX9 Regulates Prostaglandin D Synthase Gene Transcription in Vivo to Ensure Testis Development*

  2007cited by this paper
• Long-range upstream and downstream enhancers control distinct subsets of the complex spatiotemporal Sox9 expression pattern.

  2006cited by this paper
• R-spondin1 is essential in sex determination, skin differentiation and malignancy

  2006cited by this paper
• Fgf9 and Wnt4 Act as Antagonistic Signals to Regulate Mammalian Sex Determination

  2006influential reference
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  2006cited by this paper
• SRY and human sex determination: the basic tail of the HMG box functions as a kinetic clamp to augment DNA bending.

  2006cited by this paper
• Homozygous Inactivation of Sox9 Causes Complete XY Sex Reversal in Mice1

  2006cited by this paper
• Expression profiling of purified mouse gonadal somatic cells during the critical time window of sex determination reveals novel candidate genes for human sexual dysgenesis syndromes.

  2006cited by this paper
• Expression of SRY proteins in both normal and sex‐reversed XY fetal mouse gonads

  2005cited by this paper
• Gene expression during sex determination reveals a robust female genetic program at the onset of ovarian development.

  2005cited by this paper
• Sox9 is sufficient for functional testis development producing fertile male mice in the absence of Sry.

  2005cited by this paper
• NHERF2/SIP-1 Interacts with Mouse SRY via a Different Mechanism than Human SRY*

  2005cited by this paper
• Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice.

  2005influential reference
• Sertoli cell differentiation is induced both cell-autonomously and through prostaglandin signaling during mammalian sex determination.

  2005cited by this paper
• Sry Associates with the Heterochromatin Protein 1 Complex by Interacting with a KRAB Domain Protein1

  2005cited by this paper
• Gonadal sex reversal in mutant Dax1 XY mice: a failure to upregulate Sox9 in pre-Sertoli cells

  2005cited by this paper
• Delayed Sry and Sox9 expression in developing mouse gonads underlies B6-Y(DOM) sex reversal.

  2005influential reference
• Nuclear receptors Sf1 and Dax1 function cooperatively to mediate somatic cell differentiation during testis development

  2005influential reference
• Prostaglandin D2 induces nuclear import of the sex‐determining factor SOX9 via its cAMP‐PKA phosphorylation

  2005cited by this paper
• Regulation of human SRY subcellular distribution by its acetylation/deacetylation

  2004cited by this paper
• Functional analysis of Sox8 and Sox9 during sex determination in the mouse

  2004cited by this paper
• SOX9 is up-regulated by the transient expression of SRY specifically in Sertoli cell precursors.

  2004cited by this paper
• Long-range activation of Sox9 in Odd Sex (Ods) mice.

  2004cited by this paper
• One tissue, two fates: molecular genetic events that underlie testis versus ovary development

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  2004cited by this paper
• Wnt4 is required for proper male as well as female sexual development.

  2004influential reference
• Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination

  2004influential reference
• The endless quest for sex determination genes

  2004cited by this paper
• Testis determination requires insulin receptor family function in mice

  2003cited by this paper
• Dax1 is required for testis determination

  2003influential reference
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  2003cited by this paper
• Sex-specific apoptosis regulates sexual dimorphism in the Drosophila embryonic gonad.

  2003cited by this paper
• Defective importin β recognition and nuclear import of the sex-determining factor SRY are associated with XY sex-reversing mutations

  2003cited by this paper
• A SOX9 Defect of Calmodulin-dependent Nuclear Import in Campomelic Dysplasia/Autosomal Sex Reversal*

  2003cited by this paper
• Sry expression level and protein isoform differences play a role in abnormal testis development in C57BL/6J mice carrying certain Sry alleles.

  2003cited by this paper
• Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad

  2003cited by this paper
• Porcine SRY Promoter Is a Target for Steroidogenic Factor 11

  2003cited by this paper
• Regulation of the orphan nuclear receptor steroidogenic factor 1 by Sox proteins.

  2002cited by this paper
• A nuclear export signal within the high mobility group domain regulates the nucleocytoplasmic translocation of SOX9 during sexual determination

  2002cited by this paper
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  2002cited by this paper
• Sry and sex determination: how lazy can it be?

  2002influential reference
• Lipocalin-type and hematopoietic prostaglandin D synthases as a novel example of functional convergence.

  2002cited by this paper
• Gonadal differentiation, sex determination and normal Sry expression in mice require direct interaction between transcription partners GATA4 and FOG2.

  2002cited by this paper
• Sexually dimorphic development of mouse primordial germ cells: switching from oogenesis to spermatogenesis.

  2002influential reference
• Sexually dimorphic gene expression in the developing mouse gonad.

  2002cited by this paper
• The C-terminal Nuclear Localization Signal of the Sex-determining Region Y (SRY) High Mobility Group Domain Mediates Nuclear Import through Importin β1*

  2001cited by this paper
• Steroidogenic Factor-1 Contributes to the Cyclic-Adenosine Monophosphate Down-Regulation of Human SRY Gene Expression1

  2001cited by this paper
• Comparative localization of Dax‐1 and Ad4BP/SF‐1 during development of the hypothalamic‐pituitary‐gonadal axis suggests their closely related and distinct functions

  2001influential reference
• Human Sex Reversal Due to Impaired Nuclear Localization of SRY

  2001cited by this paper
• Male-to-female sex reversal in mice lacking fibroblast growth factor 9.

  2001influential reference
• G protein-coupled prostanoid receptors and the kidney.

  2001cited by this paper
• Evidence that Sry is expressed in pre-Sertoli cells and Sertoli and granulosa cells have a common precursor.

  2001cited by this paper
• Sox9 induces testis development in XX transgenic mice

  2001cited by this paper
• Spatially dynamic expression of Sry in mouse genital ridges

  2001influential reference
• The Human Sex-determining Gene SRY Is a Direct Target of WT1 *

  2001influential reference
• Nuclear Receptor Dax-1 Represses the Transcriptional Cooperation Between GATA-4 and SF-1 in Sertoli Cells1

  2001cited by this paper
• Two splice variants of the Wilms' tumor 1 gene have distinct functions during sex determination and nephron formation.

  2001influential reference
• Gene expression pattern SRY, SOX9, and DAX1 expression patterns during human sex determination and gonadal development

  2000cited by this paper
• Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase.

  2000cited by this paper
• The expression pattern of a mouse doublesex-related gene is consistent with a role in gonadal differentiation.

  2000cited by this paper
• Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation.

  2000cited by this paper
• Male specific expression suggests role of DMRT1 in human sex determination.

  2000cited by this paper
• A transgenic insertion upstream of Sox9 is associated with dominant XX sex reversal in the mouse

  2000cited by this paper
• The LIM homeobox gene Lhx9 is essential for mouse gonad formation

  2000cited by this paper
• Expression and subcellular localization of SF‐1, SOX9, WT1, and AMH proteins during early human testicular development

  2000influential reference
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  1999cited by this paper
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  1999influential reference
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  1999cited by this paper
• Evolution: Conservation of a sex-determining gene

  1999cited by this paper
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  1999cited by this paper
• Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development.

  1999cited by this paper
• The murine Dax-1 promoter is stimulated by SF-1 (steroidogenic factor-1) and inhibited by COUP-TF (chicken ovalbumin upstream promoter-transcription factor) via a composite nuclear receptor-regulatory element.

  1998cited by this paper
• Male-to-female sex reversal in M33 mutant mice

  1998cited by this paper
• Dax1 antagonizes Sry action in mammalian sex determination

  1998influential reference
• Wilms' tumor 1 and Dax-1 modulate the orphan nuclear receptor SF-1 in sex-specific gene expression.

  1998cited by this paper
• A gene involved in XY sex reversal is located on chromosome 9, distal to marker D9S1779.

  1998cited by this paper
• Deletion of long-range regulatory elements upstream of SOX9 causes campomelic dysplasia.

  1998cited by this paper
• Direct Interaction of SRY-Related Protein SOX9 and Steroidogenic Factor 1 Regulates Transcription of the Human Anti-Müllerian Hormone Gene

  1998cited by this paper
• Role of Ahch in gonadal development and gametogenesis

  1998cited by this paper
• Swyer syndrome and 46,XY partial gonadal dysgenesis associated with 9p deletions in the absence of monosomy-9p syndrome.

  1998cited by this paper
• Deletions of distal 9p associated with 46,XY male to female sex reversal: definition of the breakpoints at 9p23.3-p24.1.

  1997cited by this paper
• The Human Testis Determining Factor SRY Binds a Nuclear Factor Containing PDZ Protein Interaction Domains*

  1997cited by this paper
• What is a gene?

  1997cited by this paper
• DAX-1 inhibits SF-1-mediated transactivation via a carboxy-terminal domain that is deleted in adrenal hypoplasia congenita

  1997cited by this paper
• The Wilms' tumor gene WT1 can regulate genes involved in sex determination and differentiation: SRY, Müllerian-inhibiting substance, and the androgen receptor.

  1997influential reference
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  1997cited by this paper
• Sox9 expression during gonadal development implies a conserved role for the gene in testis differentiation in mammals and birds

  1996cited by this paper
• Mouse Dax1 expression is consistent with a role in sex determination as well as in adrenal and hypothalamus function

  1996influential reference

• Gene expression of male pathway genes sox9 and amh during early sex differentiation in a reptile departs from the classical amniote model

  2023cites this paper
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• The 46, XX Ovotesticular Disorder of Sex Development With Xq27.1q27.2 Duplication Involving the SOX3 Gene: A Rare Case Report and Literature Review

  2021cites this paper
• The effect of cellular and physiological indicators on gender determination.

  2021cites this paper
• The Impact of Endocrine-Disrupting Chemicals in Male Fertility: Focus on the Action of Obesogens

  2021cites this paper
• History of The Research on Sex Determination

  2020cites this paper
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  2016cites this paper
• Early Development of the Gonads: Origin and Differentiation of the Somatic Cells of the Genital Ridges.

  2016cites this paper
• Function Analysis of Dmrt1 in Male Sexual Differentiation in Pelodiscus sinensis

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