Alzheimer's disease amyloid beta-protein forms Zn(2+)-sensitive, cation-selective channels across excised membrane patches from hypothalamic neurons.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Biophysical Journal

• Publication date

  1997-07-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/S0006-3495(97)78048-2PMID 9199772PMCID PMC1180909
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Molecular Pathology of Alzheimer's Disease

  2013cited by this paper
• Ionic effects of the Alzheimer's disease beta-amyloid precursor protein and its metabolic fragments.

  1997cited by this paper
• Immortalized GnRH neurons express large-conductance calcium-activated potassium channels.

  1996cited by this paper
• Zn2+ interaction with Alzheimer amyloid beta protein calcium channels.

  1996cited by this paper
• L-type Ca2+ channels mediate joint modulation by gamma-amino-butyric acid and glutamate of [Ca2+]i and neuropeptide secretion in immortalized gonadodropin-releasing hormone neurons.

  1995cited by this paper
• Soluble amyloid beta-protein is a marker of Alzheimer amyloid in brain but not in cerebrospinal fluid.

  1994cited by this paper
• beta-Amyloid Ca(2+)-channel hypothesis for neuronal death in Alzheimer disease.

  1994cited by this paper
• A geometric sequence that accurately describes allowed multiple conductance levels of ion channels: the "three-halves (3/2) rule".

  1994cited by this paper
• Theoretical models of the ion channel structure of amyloid beta-protein.

  1994cited by this paper
• Rapid induction of Alzheimer A beta amyloid formation by zinc.

  1994cited by this paper
• Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide

  1993cited by this paper
• Three-dimensional visualization of the smooth endoplasmic reticulum in Purkinje cell dendrites

  1993cited by this paper
• Alzheimer disease amyloid beta protein forms calcium channels in bilayer membranes: blockade by tromethamine and aluminum.

  1993cited by this paper
• Inositol 1,4,5-trisphosphate receptors: immunohistochemical localization to discrete areas of rat central nervous system.

  1993cited by this paper
• Giant multilevel cation channels formed by Alzheimer disease amyloid beta-protein [A beta P-(1-40)] in bilayer membranes.

  1993cited by this paper
• Cellular processing of beta-amyloid precursor protein and the genesis of amyloid beta-peptide.

  1993cited by this paper
• A novel zinc(II) binding site modulates the function of the beta A4 amyloid protein precursor of Alzheimer's disease.

  1993cited by this paper
• In vivo neurotoxicity of beta-amyloid [beta(1-40)] and the beta(25-35) fragment.

  1992cited by this paper
• Alzheimer's disease: a cell biological perspective.

  1992cited by this paper
• Effect of beta amyloid peptides on neurons in hippocampal slice cultures.

  1992cited by this paper
• Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

  1992cited by this paper
• Alzheimer's disease: the amyloid cascade hypothesis.

  1992cited by this paper
• beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

  1992cited by this paper
• Commentary and perspective on studies of beta amyloid neurotoxicity.

  1992cited by this paper
• Ryanodine and inositol trisphosphate receptors coexist in avian cerebellar Purkinje neurons

  1991cited by this paper
• Effects of injected Alzheimer beta-amyloid cores in rat brain.

  1991cited by this paper
• The molecular pathology of Alzheimer's disease.

  1991cited by this paper
• Genetics and biology of the Alzheimer amyloid precursor.

  1990cited by this paper
• Immortalization of hypothalamic GnRH neurons by genetically targeted tumorigenesis.

  1990cited by this paper
• Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides.

  1990cited by this paper
• Identification and localization of ryanodine binding proteins in the avian central nervous system.

  1990cited by this paper
• A new class of calcium channels activated by glucose in human pancreatic beta-cells.

  1990cited by this paper
• A new class of calcium channels activated by glucose in human pancreatic β‐cells

  1990cited by this paper
• Amyloid β protein gene: cDNA, mRNA distribution and genetic linkage near the Alzheimer locus

  1988cited by this paper
• Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's disease.

  1987cited by this paper
• Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locus.

  1987cited by this paper
• Amyloid plaque core protein in Alzheimer disease and Down syndrome.

  1985cited by this paper
• Zn 2 + interaction with Alzheimer amyloid ( 3 protein calcium channels

  year unknowncited by this paper
• Effects of injected Alzheimer f3-amyloid cores in rat brain

  year unknowncited by this paper

• The structure of tyrosine-10 favors ionic conductance of Alzheimer’s disease-associated full-length amyloid-β channels

  2024cites this paper
• Endogenous Amyloid-formed Ca2+-permeable Channels in Aged 3xTg AD Mice

  2023cites this paper
• The endoplasmic reticulum stress and unfolded protein response in Alzheimer's disease: a calcium dyshomeostasis perspective.

  2023cites this paper
• The interactions of amyloid β aggregates with phospholipid membranes and the implications for neurodegeneration.

  2023cites this paper
• Modeling the kinetics of amyloid beta pores and long-term evolution of their Ca2+ toxicity

  2022cites this paper
• Current understanding of metal-dependent amyloid-β aggregation and toxicity

  2022cites this paper
• Aβ42 and Aβ40 oligomers form transient and persistent pores with different time evolutions and toxicities

  2022cites this paper
• Putative Structures of Membrane-Embedded Amyloid β Oligomers.

  2022cites this paper
• Current views on the possible involvement of aluminum in the etiology of Alzheimer's disease

  2021cites this paper
• Amyloids: The History of Toxicity and Functionality

  2021cites this paper
• Neurometals in the Pathogenesis of Prion Diseases

  2021cites this paper
• Formaldehyde‐Crosslinked Nontoxic Aβ Monomers to Form Toxic Aβ Dimers and Aggregates: Pathogenicity and Therapeutic Perspectives

  2021cites this paper
• An Unbalanced Synaptic Transmission: Cause or Consequence of the Amyloid Oligomers Neurotoxicity?

  2021cites this paper
• Progress toward Alzheimer's disease treatment: Leveraging the Achilles' heel of Aβ oligomers?

  2020cites this paper
• Structure Analysis of amyloid aggregates at lipid bilayers by Supercritical Angle Raman Microscopy.

  2020cites this paper
• On the Role of Platelet-Generated Amyloid Beta Peptides in Certain Amyloidosis Health Complications

  2020cites this paper
• Amyloids: Regulators of Metal Homeostasis in the Synapse

  2020cites this paper
• Accumulation of Amyloid Beta (Aβ) Peptide on Blood Vessel Walls in the Damaged Brain after Transient Middle Cerebral Artery Occlusion

  2019cites this paper
• Hypoxia induces HT-22 neuronal cell death via Orai1/CDK5 pathway-mediated Tau hyperphosphorylation.

  2019cites this paper
• Harnessing ionic mechanisms to achieve disease modification in neurodegenerative disorders.

  2019cites this paper
• Copper imbalance in Alzheimer’s disease: Convergence of the chemistry and the clinic

  2019cites this paper
• Platelet-generated amyloid beta peptides in Alzheimer's disease and glaucoma.

  2019cites this paper
• Amyloid-β Peptide-Lipid Bilayer Interaction investigated by Supercritical Angle Fluorescence.

  2019cites this paper
• A quantitative model of human neurodegenerative diseases involving protein aggregation

  2019cites this paper
• Papel dos canais iônicos na Doença de Alzheimer

  2019cites this paper
• Metal binding to the amyloid-β peptides in the presence of biomembranes: potential mechanisms of cell toxicity

  2019cites this paper
• Tetrameric Aβ40 and Aβ42 β-Barrel Structures by Extensive Atomistic Simulations. I. In a Bilayer Mimicking a Neuronal Membrane.

  2019cites this paper
• Metal Ion Effects on Aβ and Tau Aggregation

  2018cites this paper
• Interactions of amyloid-β peptides on lipid bilayer studied by single molecule imaging and tracking.

  2018cites this paper
• Zinc, Carnosine, and Neurodegenerative Diseases

  2018cites this paper
• MODULATORY ROLE OF MONOMERIC AMYLOID BETA ON NEURONAL EXCITABILITY AND ITS IMPLICATIONS ON SYNAPTIC ACTIVITY OF IMMATURE CORTICAL NEURONS

  2018cites this paper
• Theory of concentric β-barrel structures: models of amyloid beta 42 oligomers, annular protofibrils, and transmembrane channels

  2018cites this paper
• Modulation of Alzheimer's amyloid β peptide oligomerization and toxicity by extracellular Hsp70

  2018cites this paper
• Amyloid Beta Peptide Is Released during Thrombosis in the Skin

  2018cites this paper
• Platelets are responsible for the accumulation of β-amyloid in blood clots inside and around blood vessels in mouse brain after thrombosis.

  2017cites this paper
• Chapter 10 Structure and Function of Stefin B Oligomers – Important Role in

  2017cites this paper
• Cross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases.

  2017cites this paper
• Disruption of Metal Homeostasis and the Pathogenesis of Prion Diseases

  2017cites this paper
• Aβ Peptide Originated from Platelets Promises New Strategy in Anti-Alzheimer's Drug Development

  2017cites this paper
• Supercritical angle fluorescence as a tool to study the interaction between lipid bilayer and peptides

  2017cites this paper
• Alzheimer’s disease: How metal ions define β-amyloid function

  2017cites this paper
• Flexible N-Termini of Amyloid β-Protein Oligomers: A Link between Structure and Activity?

  2017cites this paper
• Molecular interactions of amyloid nanofibrils with biological aggregation modifiers: implications for cytotoxicity mechanisms and biomaterial design

  2017cites this paper
• Caractérisation du transporteur de zinc Adc/Lmb de Streptococcus agalactiae

  2017influential citation
• Link Between Metal Homeostasis and Neurodegenerative Diseases: Crosstalk of Metals and Amyloidogenic Proteins at the Synapse

  2017cites this paper
• Alzheimer's disease due to loss of function: A new synthesis of the available data.

  2016cites this paper
• Differential Membrane Toxicity of Amyloid-β Fragments by Pore Forming Mechanisms

  2016cites this paper
• Ion Channel Formation by Amyloid-β42 Oligomers but Not Amyloid-β40 in Cellular Membranes*

  2016cites this paper
• Title : Platelets are responsible for the accumulation of β ‐ amyloid in blood clots inside and around blood vessels in mouse brain after thrombosis

  2016cites this paper
• Comparison of the amyloid pore forming properties of rat and human Alzheimer’s beta-amyloid peptide 1-42: Calcium imaging data

  2016cites this paper
• Broad neutralization of calcium-permeable amyloid pore channels with a chimeric Alzheimer/Parkinson peptide targeting brain gangliosides.

  2016cites this paper
• Distinct Membrane Disruption Pathways Are Induced by 40-Residue β-Amyloid Peptides*

  2016cites this paper
• The therapeutic potential of berberine against the altered intrinsic properties of the CA1 neurons induced by Aβ neurotoxicity.

  2015cites this paper
• Chapter 11 – Alzheimer’s Disease

  2015cites this paper
• α‐Synuclein forms non‐selective cation channels and stimulates ATP‐sensitive potassium channels in hippocampal neurons

  2015cites this paper
• Effect of amyloids on the vesicular machinery: implications for somatic neurotransmission

  2015cites this paper
• Amyloid pore-channel hypothesis: effect of ethanol on aggregation state using frog oocytes for an Alzheimer’s disease study

  2015cites this paper
• Single-cell screening of cytosolic [Ca2+] reveals cell-selective action by the Alzheimer’s Aβ peptide ion channel

  2015cites this paper
• How to Stabilize Both the Proteins and the Membranes: Diverse Effects of sHsps in Neuroprotection

  2015cites this paper
• Cellular Membrane Fluidity in Amyloid Precursor Protein Processing

  2014cites this paper
• Disruption of zinc homeostasis and the pathogenesis of senile dementia.

  2014cites this paper
• Structure and Function of Stefin B Oligomers – Important Role in Amyloidogenesis

  2014cites this paper
• Crosstalk between metals and neurodegenerative diseases.

  2014cites this paper
• Carnosine: A Possible Drug for Vascular Dementia

  2014cites this paper
• Nature of the neurotoxic membrane actions of amyloid-β on hippocampal neurons in Alzheimer's disease.

  2014influential citation
• Structural evolution and membrane interactions of Alzheimer's amyloid‐beta peptide oligomers: New knowledge from single‐molecule fluorescence studies

  2014cites this paper
• Involvement of trace elements in the pathogenesis of prion diseases.

  2014cites this paper
• Methods for Studying and Structure–Function Relationships of Non-Fibrillar Protein Assemblies in Alzheimer's Disease and Related Disorders

  2014cites this paper
• Oligomerization of Proteins and Neurodegenerative Diseases

  2014cites this paper
• Zinc Chemical Biology: The Pursuit of the Intracellular Targets of Zinquin

  2013cites this paper
• Single Molecule Characterization of the Interactions between Amyloid-β Peptides and the Membranes of Hippocampal Cells

  2013cites this paper
• Synergistic Interactions between Alzheimer’s Aβ40 and Aβ42 on the Surface of Primary Neurons Revealed by Single Molecule Microscopy

  2013cites this paper
• Ionic and Molecular Mechanisms of β-Amyloid-Induced Depolarization in Mouse Skeletal Muscle Fibers

  2013cites this paper
• Modeling the short time-scale dynamics of β-amyloid-neuron interactions.

  2013cites this paper
• Single-molecule imaging reveals aβ42:aβ40 ratio-dependent oligomer growth on neuronal processes.

  2013cites this paper
• Amyloid β‐protein suppressed nicotinic acetylcholine receptor‐mediated currents in acutely isolated rat hippocampal CA1 pyramidal neurons

  2013cites this paper
• The Molecular Mechanisms of Zinc Neurotoxicity and the Pathogenesis of Vascular Type Senile Dementia

  2013cites this paper
• Zinc and Neurodegenerative Diseases

  2013cites this paper
• Thermodynamically stable amyloid-β monomers have much lower membrane affinity than the small oligomers

  2013influential citation
• Differing modes of interaction between monomeric Aβ(1-40) peptides and model lipid membranes: an AFM study.

  2012cites this paper
• Probing Structural Features of Alzheimer’s Amyloid-β Pores in Bilayers Using Site-Specific Amino Acid Substitutions

  2012cites this paper
• Pore formation by human stefin B in its native and oligomeric states and the consequent amyloid induced toxicity

  2012cites this paper
• Aggregation and fibril morphology of the Arctic mutation of Alzheimer's Aβ peptide by CD, TEM, STEM and in situ AFM.

  2012cites this paper
• Antimicrobial properties of amyloid peptides.

  2012cites this paper
• Preparation and Structural Characterization of Pre-fibrillar Assemblies of Amyloidogenic Proteins

  2012cites this paper
• Overview of Fibrillar and Oligomeric Assemblies of Amyloidogenic Proteins

  2012cites this paper
• The Amyloid _-Protein and Alzheimer's Disease

  2012cites this paper
• Pore formation by human stefin B in its native and oligomeric states and the consequent amyloid induced toxicity

  2012cites this paper
• CB1 Cannabinoid Receptor Activation Rescues Amyloid β-Induced Alterations in Behaviour and Intrinsic Electrophysiological Properties of Rat Hippocampal CA1 Pyramidal Neurones

  2012cites this paper
• Two-step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation.

  2012cites this paper
• Multivariate Analyses of Amyloid-Beta Oligomer Populations Indicate a Connection between Pore Formation and Cytotoxicity

  2012cites this paper
• Membrane pores in the pathogenesis of neurodegenerative disease.

  2012cites this paper
• Zinc Neurotoxicity and the Pathogenesis of Vascular-Type Dementia:Involvement of Calcium Dyshomeostasis and Carnosine

  2011cites this paper
• Disruption of Calcium Homeostasis in Alzheimer’s Disease: Role of Channel Formation by β Amyloid Protein

  2011cites this paper
• Title Single-channel Ca ( 2 + ) imaging implicates Aβ 1-42 amyloid pores in Alzheimer ' s disease pathology

  2011cites this paper
• Single-channel Ca2+ imaging implicates Aβ1–42 amyloid pores in Alzheimer’s disease pathology

  2011influential citation
• Structural basis for Aβ1–42 toxicity inhibition by Aβ C-terminal fragments: discrete molecular dynamics study.

  2011cites this paper
• Recent Understanding of the Molecular Mechanisms of Alzheimer's Disease

  2011cites this paper
• Link between Aluminum and the Pathogenesis of Alzheimer's Disease: The Integration of the Aluminum and Amyloid Cascade Hypotheses

  2011cites this paper
• Impacts of Membrane Biophysics in Alzheimer's Disease: From Amyloid Precursor Protein Processing to Aβ Peptide-Induced Membrane Changes

  2011cites this paper