Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Oncogene

• Publication date

  2003-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1206678PMID 12947386
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2001cited by this paper
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  2001cited by this paper
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  2001cited by this paper
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  1999cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1998cited by this paper
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  1997cited by this paper
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  1996cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1990cited by this paper
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