Activation of the Wnt pathway plays a pathogenic role in diabetic retinopathy in humans and animal models.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  American Journal of Pathology

• Publication date

  2009-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.2353/ajpath.2009.080945PMID 19893025PMCID PMC2789621
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Diabetic Retinopathy: Current Management and Experimental Therapeutic Targets

  2009cited by this paper
• Molecular pathology of age-related macular degeneration.

  2009cited by this paper
• Proliferative diabetic retinopathy-The influence of diabetes control on the activation of the intraocular molecule system.

  2009cited by this paper
• Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis.

  2009cited by this paper
• Association of vitreous inflammatory factors with diabetic macular edema.

  2009cited by this paper
• Molecular and clinical aspects of endothelial dysfunction in diabetes

  2009cited by this paper
• The role of Dickkopf-1 in bone development, homeostasis, and disease.

  2009cited by this paper
• Vascular endothelial growth factor up‐regulates the expression of intracellular adhesion molecule‐1 in retinal endothelial cells via reactive oxygen species, but not nitric oxide

  2009cited by this paper
• Wnt Signal Amplification via Activity, Cooperativity, and Regulation of Multiple Intracellular PPPSP Motifs in the Wnt Co-receptor LRP6*

  2008cited by this paper
• Adhesion molecules (ICAM-1 and VCAM-1) and diabetic retinopathy in type 2 diabetes

  2008cited by this paper
• Wnt/Frizzled signaling in angiogenesis

  2008cited by this paper
• The role of advanced glycation end products in progression and complications of diabetes

  2008cited by this paper
• Novel regulation of vascular endothelial growth factor-A (VEGF-A) by transforming growth factor (beta)1: requirement for Smads, (beta)-CATENIN, AND GSK3(beta).

  2008cited by this paper
• Wnt pathway: a new role in regulation of inflammation.

  2008cited by this paper
• beta-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma.

  2008cited by this paper
• Role of intestinal subepithelial myofibroblasts in inflammation and regenerative response in the gut.

  2007cited by this paper
• STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review).

  2007cited by this paper
• Wnt5a signaling induces proliferation and survival of endothelial cells in vitro and expression of MMP-1 and Tie-2.

  2006cited by this paper
• RPE65 gene delivery restores isomerohydrolase activity and prevents early cone loss in Rpe65-/- mice.

  2006cited by this paper
• Suppression of STAT3 activity by Duplin, which is a negative regulator of the Wnt signal.

  2006cited by this paper
• Activation of the canonical Wnt/beta-catenin pathway enhances monocyte adhesion to endothelial cells.

  2006cited by this paper
• Diabetic Retinopathy

  2006cited by this paper
• Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction.

  2005cited by this paper
• The Ins2Akita mouse as a model of early retinal complications in diabetes.

  2005cited by this paper
• A dual-kinase mechanism for Wnt co-receptor phosphorylation and activation

  2005cited by this paper
• Casein kinase 1 γ couples Wnt receptor activation to cytoplasmic signal transduction

  2005cited by this paper
• Wnt signalling in rheumatoid arthritis.

  2005cited by this paper
• Wnt signaling in the vasculature

  2004cited by this paper
• Wnt Signaling: Physiology and Pathology

  2004cited by this paper
• LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling: Arrows point the way

  2004cited by this paper
• Regulation of the endogenous VEGF-A gene by exogenous designed regulatory proteins.

  2004cited by this paper
• The Wnt signaling pathway in development and disease.

  2004cited by this paper
• Global prevalence of diabetes: estimates for the year 2000 and projections for 2030.

  2004cited by this paper
• Multiple Roles of Canonical Wnt Signaling in Cell Cycle Progression and Cell Lineage Specification in Neural Development

  2004cited by this paper
• A central role for inflammation in the pathogenesis of diabetic retinopathy

  2004cited by this paper
• Kallikrein-binding protein inhibits retinal neovascularization and decreases vascular leakage

  2003cited by this paper
• beta-Catenin regulates vascular endothelial growth factor expression in colon cancer.

  2003cited by this paper
• Flow cytometric measurement of reactive oxygen species production by normal and thalassaemic red blood cells

  2003cited by this paper
• VEGF164 is proinflammatory in the diabetic retina.

  2003influential reference
• Oxidative Stress in Diabetes

  2003cited by this paper
• Measuring mitochondrial reactive oxygen species.

  2002cited by this paper
• [Diabetic retinopathy].

  2001influential reference
• The Wnts

  2001cited by this paper
• Low-density lipoprotein receptor-related protein-5 binds to Axin and regulates the canonical Wnt signaling pathway.

  2001cited by this paper
• LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

  2001cited by this paper
• Altered expression of retinal occludin and glial fibrillary acidic protein in experimental diabetes. The Penn State Retina Research Group.

  2000cited by this paper
• β‐catenin signaling and cancer

  1999cited by this paper
• beta-catenin signaling and cancer.

  1999cited by this paper
• Molecular mechanisms of vascular permeability in diabetic retinopathy.

  1999cited by this paper
• Vascular adhesion molecules in vitreous from eyes with proliferative diabetic retinopathy.

  1999cited by this paper
• Circulating intercellular adhesion molecule-1, vascular cell adhesion molecule-1, and E-selectin in patients with type 2 diabetes mellitus.

  1999cited by this paper
• Diabetic retinopathy.

  1998cited by this paper
• Signal transduction by the Wnt family of ligands.

  1998cited by this paper
• Increased expression of placenta growth factor in proliferative diabetic retinopathy.

  1998cited by this paper
• Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group.

  1998cited by this paper
• Soluble leucocyte adhesion molecules in diabetic retinopathy stimulate retinal capillary endothelial cell migration

  1997cited by this paper
• Oxygen-induced retinopathy in the mouse.

  1994cited by this paper
• Oxidative stress in diabetic retina.

  1992cited by this paper
• Plasminogen activator production by human retinal endothelial cells of nondiabetic and diabetic origin.

  1991cited by this paper
• Oxygen-induced retinopathy in the rat model

  1990cited by this paper

• The Central Role of Oxidative Stress in Diabetic Retinopathy: Advances in Pathogenesis, Diagnosis, and Therapy

  2026cites this paper
• The multifaceted role of kallistatin in human diseases: mechanistic insights and translational potential

  2026cites this paper
• Serial Aqueous Humor Proteomics in Diabetic Macular Edema: Correlation of Novel Targets with Retinal Fluid Volume

  2026cites this paper
• Plasma multi-omics and machine learning reveal predictive biomarkers for type 2 diabetes and retinopathy in Qatar biobank cohort

  2025cites this paper
• YBX1-driven TUBB6 upregulation facilitates ocular angiogenesis via WNT3A-FZD8 pathway

  2025cites this paper
• PDLIM1 suppresses retinal neovascularization by regulating the β‐catenin pathway

  2025cites this paper
• Ref-1 redox activity modulates canonical Wnt signaling in endothelial cells

  2025cites this paper
• Lamb1-mediated Wnt/β-catenin signaling pathway drives endothelial angiogenesis for fracture healing.

  2025cites this paper
• The Therapeutic Effect of a Biodegradable Long-Acting Intravitreal Implant Containing CGK012 on Neovascular Age-Related Macular Degeneration by Promoting β-Catenin Degradation

  2025cites this paper
• Shared signaling pathways and comprehensive therapeutic approaches among diabetes complications

  2025cites this paper
• Potential disease biomarkers for diabetic retinopathy identified through Mendelian randomization analysis

  2024cites this paper
• Functional Roles of Pigment Epithelium-Derived Factor in Retinal Degenerative and Vascular Disorders: A Scoping Review

  2024cites this paper
• Exploring the molecular mechanisms of MSC-derived exosomes in Alzheimer's disease: Autophagy, insulin and the PI3K/Akt/mTOR signaling pathway.

  2024cites this paper
• Design principles and therapeutic applications of novel synthetic WNT signaling agonists

  2024cites this paper
• Neuroretinal Cell Culture Model as a Tool for the Development of New Therapeutic Approaches for Oxidative Stress-Induced Ocular Diseases, with a Focus on Glaucoma

  2024cites this paper
• The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities

  2023cites this paper
• Wg/Wnt1 and Erasp link ER stress to proapoptotic signaling in an autosomal dominant retinitis pigmentosa model

  2023cites this paper
• Pharmacological Modulation of β-Catenin Preserves Endothelial Barrier Integrity and Mitigates Retinal Vascular Permeability and Inflammation

  2023cites this paper
• LMBR1L regulates proliferation and migration of endothelial cells through Norrin/β-catenin signaling.

  2022cites this paper
• Canonical Wnt Signaling in the Pathology of Iron Overload-Induced Oxidative Stress and Age-Related Diseases

  2022cites this paper
• Arterial Stiffness and the Canonical WNT/β-catenin Pathway

  2022cites this paper
• Wnt/frizzled Signaling in Endothelium: A Major Player in Blood-Retinal- and Blood-Brain-Barrier Integrity.

  2022cites this paper
• Consideration of possible effects of vitamin D on established cancer, with reference to malignant melanoma

  2022cites this paper
• PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of Retinal Endothelial Cells by Regulating the Wnt/β-Catenin Signalling Pathway

  2022cites this paper
• Sustained therapeutic effect of an anti-inflammatory peptide encapsulated in nanoparticles on ocular vascular leakage in diabetic retinopathy

  2022cites this paper
• Selective Activation of the Wnt-Signaling Pathway as a Novel Therapy for the Treatment of Diabetic Retinopathy and Other Retinal Vascular Diseases

  2022cites this paper
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  2022cites this paper
• Effect of bone marrow mesenchymal stem cells-derived exosomes on diabetes-induced retinal injury: Implication of Wnt/ b-catenin signaling pathway.

  2022cites this paper
• Lycopene protects against Bisphenol A induced toxicity on the submandibular salivary glands via the upregulation of PPAR-γ and modulation of Wnt/β-catenin signaling.

  2022cites this paper
• The Contribution of Wnt Signaling to Vascular Complications in Type 2 Diabetes Mellitus

  2022influential citation
• Possible Role of Wnt Signaling Pathway in Diabetic Retinopathy.

  2022cites this paper
• Cellular targets in diabetic retinopathy therapy

  2021cites this paper
• Neurovascular Unit: A New Target for Treating Early Stages of Diabetic Retinopathy

  2021cites this paper
• Antiangiogenic therapy in diabetic nephropathy: A double-edged sword

  2021cites this paper
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  2021cites this paper
• Misregulation of Wnt Signaling Pathways at the Plasma Membrane in Brain and Metabolic Diseases

  2021cites this paper
• Autophagy positively regulates Wnt signaling in mice with diabetic retinopathy

  2021cites this paper
• Role of Inflammation in Diabetic Retinopathy

  2021cites this paper
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  2020cites this paper
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  2020cites this paper
• Association Between Pathophysiological Mechanisms of Diabetic Retinopathy and Parkinson’s Disease

  2020cites this paper
• [Effect of acute insulin therapy on the concentration of vascular endothelial growth factor A (VEGF-A) in the intraocular fluid in an experiment].

  2020cites this paper
• Norrin restores blood-retinal barrier properties after vascular endothelial growth factor–induced permeability

  2020cites this paper
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  2020cites this paper
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  2019cites this paper
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  2019cites this paper
• Role of the Wnt signalling pathway in the development of endothelial disorders in response to hyperglycaemia

  2019cites this paper
• The Presence of Wnt Signaling Mutations in Patients With Diabetic Retinopathy

  2019cites this paper
• Protein Kinase CK2—A Putative Target for the Therapy of Diabetes Mellitus?

  2019cites this paper
• Vascular and Neuronal Protection in the Developing Retina: Potential Therapeutic Targets for Retinopathy of Prematurity

  2019cites this paper
• A Protective Effect of PPARα in Endothelial Progenitor Cells Through Regulating Metabolism

  2019cites this paper
• Canonical Wnt Signaling Promotes Neovascularization Through Determination of Endothelial Progenitor Cell Fate via Metabolic Profile Regulation

  2019cites this paper
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  2019cites this paper
• The identification of differentially expressed genes between extremes of placental efficiency in maternal line gilts on day 95 of gestation

  2019cites this paper
• Wnt Signaling in vascular eye diseases.

  2019cites this paper
• The retinal pigment epithelial response after retinal laser photocoagulation in diabetic mice

  2018cites this paper
• Endothelial Wnt-Pathway Activation Protects the Blood-Retinal-Barrier during Neurodegeneration-Induced Vasoregression

  2018cites this paper
• Changes in transcriptomic profile of trout larvae obtained with frozen sperm

  2018cites this paper
• The Role of Microglia in Diabetic Retinopathy: Inflammation, Microvasculature Defects and Neurodegeneration

  2018influential citation
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
• Therapeutic regulation of VE-cadherin with a novel oligonucleotide drug for diabetic eye complications using retinopathy mouse models

  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017influential citation
• Antibody-Mediated Inhibition of Tspan12 Ameliorates Vasoproliferative Retinopathy Through Suppression of &bgr;-Catenin Signaling

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017influential citation
• Negative regulators of angiogenesis: important targets for treatment of exudative AMD.

  2017cites this paper
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  2017influential citation
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2014cites this paper