Downregulation of cell surface receptors by the K3 family of viral and cellular ubiquitin E3 ligases

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Immunological Reviews

• Publication date

  2005-10-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1111/j.0105-2896.2005.00314.xPMID 16181331
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Regulation of CD1d expression and function by a herpesvirus infection.

  2005cited by this paper
• Requirements for the Selective Degradation of Endoplasmic Reticulum-Resident Major Histocompatibility Complex Class I Proteins by the Viral Immune Evasion Molecule mK3

  2005influential reference
• NMR Structure of the First PHD Finger of Autoimmune Regulator Protein (AIRE1)

  2005cited by this paper
• TEB4 is a C4HC3 RING finger-containing ubiquitin ligase of the endoplasmic reticulum.

  2005influential reference
• Ubiquitination on Nonlysine Residues by a Viral E3 Ubiquitin Ligase

  2005cited by this paper
• MARCH-II is a syntaxin-6-binding protein involved in endosomal trafficking.

  2005cited by this paper
• On phylogenetic relationships among major lineages of the Gammaherpesvirinae.

  2005cited by this paper
• Murine Cytomegalovirus Interference with Antigen Presentation Has Little Effect on the Size or the Effector Memory Phenotype of the CD8 T Cell Response1

  2004cited by this paper
• AIRE Functions As an E3 Ubiquitin Ligase

  2004cited by this paper
• Polyubiquitin chains: polymeric protein signals.

  2004cited by this paper
• Ubiquitin: structures, functions, mechanisms.

  2004cited by this paper
• Concurrent Expression of Latent and a Limited Number of Lytic Genes with Immune Modulation and Antiapoptotic Function by Kaposi's Sarcoma-Associated Herpesvirus Early during Infection of Primary Endothelial and Fibroblast Cells and Subsequent Decline of Lytic Gene Expression

  2004cited by this paper
• Ubiquitin and endocytic internalization in yeast and animal cells.

  2004cited by this paper
• Model for the Interaction of Gammaherpesvirus 68 RING-CH Finger Protein mK3 with Major Histocompatibility Complex Class I and the Peptide-Loading Complex

  2004influential reference
• Downregulation of Major Histocompatibility Complex Class I by Human Ubiquitin Ligases Related to Viral Immune Evasion Proteins

  2004influential reference
• Immune evasion by gamma-herpesviruses.

  2004cited by this paper
• Solution Structure of the Kaposi's Sarcoma-associated Herpesvirus K3 N-terminal Domain Reveals a Novel E2-binding C4HC3-type RING Domain*

  2004influential reference
• Viral degradation of the MHC class I peptide loading complex.

  2004influential reference
• The MHC class I antigen presentation pathway: strategies for viral immune evasion

  2003cited by this paper
• A proteomics approach to understanding protein ubiquitination

  2003cited by this paper
• c-MIR, a Human E3 Ubiquitin Ligase, Is a Functional Homolog of Herpesvirus Proteins MIR1 and MIR2 and Has Similar Activity*

  2003cited by this paper
• Surface Downregulation of Major Histocompatibility Complex Class I, PE-CAM, and ICAM-1 following De Novo Infection of Endothelial Cells with Kaposi's Sarcoma-Associated Herpesvirus

  2003cited by this paper
• No evidence for PHD fingers as ubiquitin ligases.

  2003cited by this paper
• Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins.

  2003cited by this paper
• PHD domains and E3 ubiquitin ligases: viruses make the connection.

  2003cited by this paper
• The PHD/LAP-Domain Protein M153R of Myxomavirus Is a Ubiquitin Ligase That Induces the Rapid Internalization and Lysosomal Destruction of CD4

  2003influential reference
• Scores of RINGS but No PHDs in Ubiquitin Signaling

  2003cited by this paper
• The comparative proteomics of ubiquitination in mouse.

  2003cited by this paper
• Virus subversion of the MHC class I peptide-loading complex.

  2003cited by this paper
• A novel ubiquitin ligase is deficient in Fanconi anemia

  2003influential reference
• Hrs function: viruses provide the clue.

  2003cited by this paper
• K3-mediated evasion of CD8+ T cells aids amplification of a latent γ-herpesvirus

  2002influential reference
• A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies

  2002cited by this paper
• Spectrum of Kaposi's Sarcoma-Associated Herpesvirus, or Human Herpesvirus 8, Diseases

  2002cited by this paper
• Kaposi's Sarcoma-Associated Herpesvirus K3 Utilizes the Ubiquitin-Proteasome System in Routing Class I Major Histocompatibility Complexes to Late Endocytic Compartments

  2002cited by this paper
• Ubiquitylation of MHC class I by the K3 viral protein signals internalization and TSG101‐dependent degradation

  2002influential reference
• The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.

  2002influential reference
• Functional Organization of MIR2, a Novel Viral Regulator of Selective Endocytosis*

  2002influential reference
• The molecular pathology of Kaposi's sarcoma-associated herpesvirus.

  2002cited by this paper
• Identification of new herpesvirus gene homologs in the human genome.

  2002cited by this paper
• Multiple endocytic trafficking pathways of MHC class I molecules induced by a Herpesvirus protein

  2002cited by this paper
• Receptor downregulation and multivesicular-body sorting

  2002influential reference
• Myxoma Virus Leukemia-Associated Protein Is Responsible for Major Histocompatibility Complex Class I and Fas-CD95 Down-Regulation and Defines Scrapins, a New Group of Surface Cellular Receptor Abductor Proteins

  2002influential reference
• Physical Association of the K3 Protein of Gamma-2 Herpesvirus 68 with Major Histocompatibility Complex Class I Molecules with Impaired Peptide and β2-Microglobulin Assembly

  2002cited by this paper
• Activation of human herpesvirus 8 open reading frame K5 independent of ORF50 expression.

  2002cited by this paper
• MCMV glycoprotein gp40 confers virus resistance to CD8+ T cells and NK cells in vivo

  2002cited by this paper
• The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum

  2001cited by this paper
• Ubiquitin enters the new millennium.

  2001cited by this paper
• A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition

  2001cited by this paper
• Viral immune evasion strategies and the underlying cell biology.

  2001cited by this paper
• Mechanisms underlying ubiquitination.

  2001cited by this paper
• MHC class I ubiquitination by a viral PHD/LAP finger protein.

  2001influential reference
• A viral protein that selectively downregulates ICAM-1 and B7-2 and modulates T cell costimulation.

  2001cited by this paper
• Dissecting the host response to a gamma-herpesvirus.

  2001cited by this paper
• KSHV-K5 inhibits phosphorylation of the major histocompatibility complex class I cytoplasmic tail.

  2001cited by this paper
• Major histocompatibility complex class I molecules are down-regulated at the cell surface by the K5 protein encoded by Kaposi's sarcoma-associated herpesvirus/human herpesvirus-8.

  2001cited by this paper
• A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation.

  2001cited by this paper
• Downregulation of Major Histocompatibility Complex Class I Molecules by Kaposi's Sarcoma-Associated Herpesvirus K3 and K5 Proteins

  2000influential reference
• Endoplasmic Reticulum Degradation Requires Lumen to Cytosol Signaling

  2000cited by this paper
• Inhibition of MHC class I-restricted antigen presentation by gamma 2-herpesviruses.

  2000influential reference
• Latent murine gamma-herpesvirus infection is established in activated B cells, dendritic cells, and macrophages.

  2000cited by this paper
• Latent Murine γ-Herpesvirus Infection Is Established in Activated B Cells, Dendritic Cells, and Macrophages1

  2000cited by this paper
• Kaposi's sarcoma-associated herpesvirus encodes two proteins that block cell surface display of MHC class I chains by enhancing their endocytosis.

  2000influential reference
• Identification and Analysis of the K5 Gene of Kaposi's Sarcoma-Associated Herpesvirus

  2000influential reference
• RING for destruction?

  2000cited by this paper
• Inhibition of natural killer cell-mediated cytotoxicity by Kaposi's sarcoma-associated herpesvirus K5 protein.

  2000cited by this paper
• RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination.

  1999cited by this paper
• Kinetics of Kaposi’s Sarcoma-Associated Herpesvirus Gene Expression

  1999cited by this paper
• Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.

  1999cited by this paper
• A single 13-kilobase divergent locus in the Kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genome contains nine open reading frames that are homologous to or related to cellular proteins

  1997cited by this paper
• Ubiquitin Lys63 is involved in ubiquitination of a yeast plasma membrane protein

  1997cited by this paper
• Role of Cue1p in ubiquitination and degradation at the ER surface.

  1997cited by this paper
• The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol.

  1996cited by this paper
• Pathogenesis of murine gammaherpesvirus infection in mice deficient in CD4 and CD8 T cells

  1993cited by this paper

• The E3 ubiquitin ligase MARCH2 controls TNF-α mediated inflammation by autoubiquitination

  2025cites this paper
• Model Systems of Gammaherpesvirus Infection, Immunity, and Disease

  2025cites this paper
• Modulation of Lymphotoxin β Surface Expression by Kaposi's Sarcoma‐Associated Herpesvirus K3 Through Glycosylation Interference

  2025cites this paper
• Ubiquitination in viral entry and replication: Mechanisms and implications.

  2024cites this paper
• MARCH8 Restricts RSV Replication by Promoting Cellular Apoptosis Through Ubiquitin-Mediated Proteolysis of Viral SH Protein

  2024cites this paper
• HPV upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer

  2023cites this paper
• RING-finger E3 ligases regulatory network in PI3K/AKT-mediated glucose metabolism

  2022cites this paper
• HPV E6 upregulates MARCHF8 ubiquitin ligase and inhibits apoptosis by degrading the death receptors in head and neck cancer

  2022cites this paper
• MARCH6 promotes hepatocellular carcinoma development through up-regulation of ATF2

  2021cites this paper
• Elucidating the Antiviral Mechanism of Different MARCH Factors

  2021cites this paper
• Targeting the ubiquitination/deubiquitination process to regulate immune checkpoint pathways

  2021cites this paper
• Elucidating the antiviral mechanism of different MARCH factors

  2020influential citation
• How to Inactivate Human Ubiquitin E3 Ligases by Mutation

  2020cites this paper
• Engineering Tolerance toward Allogeneic CAR-T Cells by Regulation of MHC Surface Expression with Human Herpes Virus-8 Proteins.

  2020cites this paper
• MARCH8 Inhibits Ebola Virus Glycoprotein, Human Immunodeficiency Virus Type 1 Envelope Glycoprotein, and Avian Influenza Virus H5N1 Hemagglutinin Maturation

  2020cites this paper
• Lack of CD8+ T-cell co-localization with Kaposi’s sarcoma-associated herpesvirus infected cells in Kaposi’s sarcoma tumors

  2020cites this paper
• Proteolytic regulation of mitochondrial dynamics.

  2019cites this paper
• New insights into the structure of the MHC class I peptide-loading complex and mechanisms of TAP inhibition by viral immune evasion proteins.

  2019cites this paper
• Monitoring MHC Ubiquitination by MARCH Ubiquitin Ligases.

  2019cites this paper
• The Membrane-Associated MARCH E3 Ligase Family: Emerging Roles in Immune Regulation

  2019cites this paper
• The complete genomic sequence of Rhinolophus gammaherpesvirus 1 isolated from a greater horseshoe bat

  2018cites this paper
• MARCH1-mediated ubiquitination of MHC II impacts the MHC I antigen presentation pathway

  2018cites this paper
• the and from in

  2018cites this paper
• MARCH1 protects the lipid raft and tetraspanin web from MHCII proteotoxicity in dendritic cells

  2018cites this paper
• MARCH2 is upregulated in HIV-1 infection and inhibits HIV-1 production through envelope protein translocation or degradation.

  2018cites this paper
• JCB_201611141 1395..1410

  2018cites this paper
• Sh-MARCH8 Inhibits Tumorigenesis via PI3K Pathway in Gastric Cancer

  2018cites this paper
• Molecular cloning of the MARCH family in grass carp (Ctenopharyngodon idellus) and their response to grass carp reovirus challenge

  2017cites this paper
• Intra-membrane substrate recognition by membrane-tethered E3 ligases

  2017cites this paper
• MARCH9‐mediated ubiquitination regulates MHC I export from the TGN

  2017cites this paper
• HIV‐1 Nef: Taking Control of Protein Trafficking

  2016cites this paper
• The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages

  2016cites this paper
• Expression of USP 7 and MARCH 7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer

  2016cites this paper
• Expression of USP7 and MARCH7 Is Correlated with Poor Prognosis in Epithelial Ovarian Cancer.

  2016cites this paper
• Major Histocompatibility Complex Class II HLA-DRα Is Downregulated by Kaposi's Sarcoma-Associated Herpesvirus-Encoded Lytic Transactivator RTA and MARCH8

  2016cites this paper
• The mitochondrial ubiquitin ligase MARCH5 resolves MAVS aggregates during antiviral signalling

  2015cites this paper
• Viral Inhibition of the Transporter Associated with Antigen Processing (TAP): A Striking Example of Functional Convergent Evolution

  2015cites this paper
• The Missing Link in Epstein-Barr Virus Immune Evasion: the BDLF3 Gene Induces Ubiquitination and Downregulation of Major Histocompatibility Complex Class I (MHC-I) and MHC-II

  2015cites this paper
• A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I

  2015cites this paper
• Co-expression of march5b and tlr7 in large yellow croaker Larimichthys crocea in response to Cryptocaryon irritans infection.

  2015cites this paper
• University of Birmingham The missing link in EBV immune evasion

  2015cites this paper
• A novel membrane-bound E3 ubiquitin ligase enhances the thermal resistance in plants.

  2014cites this paper
• Kaposi's Sarcoma-Associated Herpesvirus: Biology of a Human Tumor Virus

  2014cites this paper
• Atypical Ubiquitylation in Yeast Targets Lysine-less Asi2 for Proteasomal Degradation*

  2014cites this paper
• Immune escape of γ‐herpesviruses from adaptive immunity

  2014cites this paper
• Immune escape of adaptive immunity

  2014cites this paper
• Ubiquitination in apoptosis signaling

  2014influential citation
• The Membrane Associated RING-CH Proteins: A Family of E3 Ligases with Diverse Roles through the Cell

  2014influential citation
• Prospects for Designing ‘Universal’ Stem Cell Lines

  2013cites this paper
• Altered MARCH1 ubiquination-regulated dendritic cell immune functions during the early stage of zymosan-induced multiple organ dysfunction syndrome (MODS) in mice.

  2013cites this paper
• Possible TAP inhibitors in HHV-6 and HHV-7 based on known characteristics of TAP inhibitors and their evolutionary development in herpesviruses.

  2013cites this paper
• Ubiquitination by MARCH-8 controls TRAIL-R1

  2013influential citation
• What pathogens have taught us about posttranslational modifications.

  2013cites this paper
• Ubiquitination and Degradation of CFTR by the E3 Ubiquitin Ligase MARCH2 through Its Association with Adaptor Proteins CAL and STX6

  2013cites this paper
• The Immunological Barriers to Regenerative Medicine

  2013cites this paper
• The antiviral activities of tetherin.

  2013cites this paper
• Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor

  2013cites this paper
• Cellular targets of HIV-1 VPU

  2013cites this paper
• Haploid Genetic Screens Identify an Essential Role for PLP2 in the Downregulation of Novel Plasma Membrane Targets by Viral E3 Ubiquitin Ligases

  2013cites this paper
• Ubiquitination by the Membrane-associated RING-CH-8 (MARCH-8) Ligase Controls Steady-state Cell Surface Expression of Tumor Necrosis Factor-related Apoptosis Inducing Ligand (TRAIL) Receptor 1*

  2013cites this paper
• Identification of a novel motif that affects the conformation and activity of the MARCH1 E3 ubiquitin ligase

  2013cites this paper
• Newly Discovered Viral E3 Ligase pK3 Induces Endoplasmic Reticulum-associated Degradation of Class I Major Histocompatibility Proteins and Their Membrane-bound Chaperones*

  2012cites this paper
• Modulation of Immune System by Kaposi’s Sarcoma-Associated Herpesvirus: Lessons from Viral Evasion Strategies

  2012cites this paper
• Construction and Manipulation of a New Kaposi's Sarcoma-Associated Herpesvirus Bacterial Artificial Chromosome Clone

  2012cites this paper
• Autoregulation of MARCH1 Expression by Dimerization and Autoubiquitination

  2012cites this paper
• The E3 ubiquitin ligase MARCH8 negatively regulates IL-1β-induced NF-κB activation by targeting the IL1RAP coreceptor for ubiquitination and degradation

  2012cites this paper
• Ubiquitination of Substrates by Esterification

  2012cites this paper
• Ubiquitination-mediated regulation of interferon responses

  2012cites this paper
• Retroperitoneal Fibromatosis Herpesvirus and Kaposi’s Sarcoma-Like Tumors in Macaques

  2012cites this paper
• What Has the Study of the K3 and K5 Viral Ubiquitin E3 Ligases Taught Us about Ubiquitin-Mediated Receptor Regulation?

  2011cites this paper
• MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation

  2011cites this paper
• Ubiquitin-mediated Regulation of CD86 Protein Expression by the Ubiquitin Ligase Membrane-associated RING-CH-1 (MARCH1)*

  2011cites this paper
• Vpu, Tetherin and Innate Immunity: Antiviral Restriction of Retroviral Particle Release

  2010cites this paper
• Palmitoylation of MIR2 Is Required for Its Function

  2010cites this paper
• Contribution of Lysine 11-linked Ubiquitination to MIR2-mediated Major Histocompatibility Complex Class I Internalization*

  2010cites this paper
• The RING-CH Ligase K5 Antagonizes Restriction of KSHV and HIV-1 Particle Release by Mediating Ubiquitin-Dependent Endosomal Degradation of Tetherin

  2010influential citation
• The E3 Ligase Axotrophin/MARCH-7: Protein Expression Profiling of Human Tissues Reveals Links to Adult Stem Cells

  2010cites this paper
• RING-CH Family E3 Ligase Ligand Mult1 by a Membrane-Associated Stress-Regulated Targeting of the NKG2D

  2010cites this paper
• Identification of a Lysosomal Pathway Regulating Degradation of the Bone Morphogenetic Protein Receptor Type II

  2010cites this paper
• REGULATION AND FUNCTION OF MARCH1: MODULATION OF IMMUNITY THROUGH UBIQUITINATION

  2010influential citation
• Stabilization of an E3 Ligase–E2–Ubiquitin Complex Increases Cell Surface MHC Class I Expression

  2010cites this paper
• Stress-Regulated Targeting of the NKG2D Ligand Mult1 by a Membrane-Associated RING-CH Family E3 Ligase

  2010cites this paper
• I Complex Increases Cell Surface MHC Class Ubiquitin - E2 - Stabilization of an E3 Ligase

  2010cites this paper
• Immune evasion by Kaposi's sarcoma-associated herpesvirus.

  2010cites this paper
• This information is current as Expression IComplex Increases Cell Surface MHC Class Ubiquitin − E 2 − Stabilization of an E 3 Ligase

  2010cites this paper
• Antiviral properties of BST-2 and Kaposi's sarcoma-associated herpesvirus countermeasures.

  2010cites this paper
• Equus caballus Major Histocompatibility Complex Class I Is an Entry Receptor for Equine Herpesvirus Type 1

  2010cites this paper
• The cell biology of major histocompatibility complex class I assembly: towards a molecular understanding.

  2010cites this paper
• MARCH-I: A new regulator of dendritic cell function

  2010cites this paper
• HIV-1 Vpu Neutralizes the Antiviral Factor Tetherin/BST-2 by Binding It and Directing Its Beta-TrCP2-Dependent Degradation

  2009cites this paper
• The trafficking and regulation of membrane receptors by the RING-CH ubiquitin E3 ligases.

  2009cites this paper
• Viral avoidance and exploitation of the ubiquitin system

  2009cites this paper
• Specific Targeting of the EBV Lytic Phase Protein BNLF2a to the Transporter Associated with Antigen Processing Results in Impairment of HLA Class I-Restricted Antigen Presentation1

  2009cites this paper
• E3 ubiquitin ligases for MHC molecules.

  2009cites this paper
• Ube2j2 ubiquitinates hydroxylated amino acids on ER-associated degradation substrates

  2009cites this paper
• Efficient Internalization of MHC I Requires Lysine-11 and Lysine-63 Mixed Linkage Polyubiquitin Chains

  2009cites this paper
• Régulation des chaperons de la présentation antigénique par ubiquitination

  2009cites this paper
• Targeting proteins to distinct subcellular compartments reveals unique requirements for MHC class I and II presentation

  2009cites this paper
• Stable Isotope Labeling by Amino Acids in Cell Culture and Differential Plasma Membrane Proteome Quantitation Identify New Substrates for the MARCH9 Transmembrane E3 Ligase

  2009influential citation
• Posttranslational regulation of the NKG2D ligand Mult1 in response to cell stress

  2009cites this paper