Efficiency and Accuracy of SOS-induced DNA Polymerases Replicating Benzo[a]pyrene-7,8-diol 9,10-Epoxide A and G Adducts*

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Journal of Biological Chemistry

• Publication date

  2002-02-15

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1074/jbc.M109575200PMID 11734560
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Adaptive mutation in Escherichia coli.

  2004cited by this paper
• Adaptive Mutation in Escherichia coli

  2004cited by this paper
• The Y-family of DNA polymerases.

  2001cited by this paper
• A new class of errant DNA polymerases provides candidates for somatic hypermutation.

  2001cited by this paper
• SOS mutator DNA polymerase IV functions in adaptive mutation and not adaptive amplification.

  2001cited by this paper
• A model for SOS-lesion-targeted mutations in Escherichia coli

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• The importance of repairing stalled replication forks

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• All three SOS‐inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis

  2000cited by this paper
• Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis

  2000cited by this paper
• Visualization of two binding sites for the Escherichia coli UmuD'(2)C complex (DNA pol V) on RecA-ssDNA filaments.

  2000cited by this paper
• The expanding polymerase universe

  2000cited by this paper
• Sloppier copier DNA polymerases involved in genome repair.

  2000cited by this paper
• The Mutagenesis Protein UmuC Is a DNA Polymerase Activated by UmuD′, RecA, and SSB and Is Specialized for Translesion Replication*

  1999cited by this paper
• A phenotype for enigmatic DNA polymerase II: a pivotal role for pol II in replication restart in UV-irradiated Escherichia coli.

  1999cited by this paper
• UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V.

  1999cited by this paper
• Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily.

  1999cited by this paper
• Recombinational repair of DNA damage in Escherichia coli and bacteriophage lambda.

  1999cited by this paper
• Recombinational Repair of DNA Damage inEscherichia coli and Bacteriophage λ

  1999cited by this paper
• The dinB gene encodes a novel E. coli DNA polymerase, DNA pol IV, involved in mutagenesis.

  1999cited by this paper
• Mutational consequences of replication of M13mp7L2 constructs containing cis-opened benzo[a]pyrene 7,8-diol 9, 10-epoxide-deoxyadenosine adducts.

  1999cited by this paper
• Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta.

  1999cited by this paper
• Sequence context profoundly influences the mutagenic potency of trans-opened benzo[a]pyrene 7,8-diol 9,10-epoxide-purine nucleoside adducts in site-specific mutation studies.

  1998cited by this paper
• Biochemical basis of SOS-induced mutagenesis in Escherichia coli: reconstitution of in vitro lesion bypass dependent on the UmuD'2C mutagenic complex and RecA protein.

  1998cited by this paper
• Mutagenesis and more: umuDC and the Escherichia coli SOS response.

  1998cited by this paper
• The Escherichia coli polB Locus Is Identical to dinA, the Structural Gene for DNA Polymerase II

  1997cited by this paper
• Abasic translesion synthesis by DNA polymerase beta violates the "A-rule". Novel types of nucleotide incorporation by human DNA polymerase beta at an abasic lesion in different sequence contexts.

  1997cited by this paper
• Genetic requirements and mutational specificity of the Escherichia coli SOS mutator activity

  1997cited by this paper
• Fidelity of Escherichia coli DNA Polymerase III Holoenzyme

  1997cited by this paper
• Replication Fork Bypass of a Pyrimidine Dimer Blocking Leading Strand DNA Synthesis*

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• Damage inducible mutagenesis: recent insights into the activities of the Umu family of mutagenesis proteins.

  1996cited by this paper
• A molecular switch in a replication machine defined by an internal competition for protein rings.

  1996cited by this paper
• Regulation of SOS mutagenesis by proteolysis.

  1996cited by this paper
• Purification of a Soluble UmuD′C Complex from Escherichia coli

  1996cited by this paper
• In vitro replication by prokaryotic and eukaryotic polymerases on DNA templates containing site-specific and stereospecific benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide adducts.

  1995cited by this paper
• Proofreading-defective DNA polymerase II increases adaptive mutation in Escherichia coli.

  1995cited by this paper
• Gel fidelity assay measuring nucleotide misinsertion, exonucleolytic proofreading, and lesion bypass efficiencies.

  1995cited by this paper
• Purification and Properties of Wild-type and Exonuclease-deficient DNA Polymerase II from Escherichia coli(*)

  1995cited by this paper
• Primer extension by various polymerases using oligonucleotide templates containing stereoisomeric benzo[a]pyrene-deoxyadenosine adducts.

  1994cited by this paper
• DNA polymerase II of Escherichia coli in the bypass of abasic sites in vivo.

  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
• Compilation, alignment, and phylogenetic relationships of DNA polymerases.

  1993cited by this paper
• Biochemical basis of DNA replication fidelity.

  1993cited by this paper
• DNA polymerase action on benzo[a]pyrene-DNA adducts.

  1992cited by this paper
• Construction of a umuDC operon substitution mutation in Escherichia coli.

  1992cited by this paper
• Compilation and alignment of DNA polymerase sequences.

  1991cited by this paper
• Covalent bonding of bay-region diol epoxides to nucleic acids.

  1991cited by this paper
• The RecA Protein: Structure and Function

  1990cited by this paper
• Base mispair extension kinetics. Comparison of DNA polymerase alpha and reverse transcriptase.

  1990cited by this paper
• DNA polymerase II is encoded by the DNA damage-inducible dinA gene of Escherichia coli.

  1990cited by this paper
• The Escherichia coli polB gene, which encodes DNA polymerase II, is regulated by the SOS system

  1990cited by this paper
• The RecA protein: structure and function.

  1990cited by this paper
• Mutagenesis by transient misalignment.

  1988cited by this paper
• Purification and characterization of an inducible Escherichia coli DNA polymerase capable of insertion and bypass at abasic lesions in DNA.

  1988cited by this paper
• Role of RecA protein in untargeted UV mutagenesis of bacteriophage lambda: evidence for the requirement for the dinB gene.

  1986cited by this paper
• Frameshift mutagenesis by eucaryotic DNA polymerases in vitro.

  1986cited by this paper
• Uvm mutants of Escherichia coli K12 deficient in UV mutagenesis

  1979cited by this paper
• Uvm mutants of Escherichia coli K12 deficient in UV mutagenesis. I. Isolation of uvm mutants and their phenotypical characterization in DNA repair and mutagenesis.

  1978cited by this paper
• Tumorigenicity of the optical enantiomers of the diastereomeric benzo[a]pyrene 7,8-diol-9,10-epoxides in newborn mice: exceptional activity of (+)-7beta,8alpha-dihydroxy-9alpha,10alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene.

  1978cited by this paper
• Detection of messenger RNA from the isoleucine-valine operons of Salmonella typhimurium by heterologous DNA-RNA hybridization: Involvement of transfer RNA in transcriptional repression

  1977cited by this paper
• Isolation and characterization of mutants of Escherichia coli deficient in induction of mutations by ultraviolet light

  1977cited by this paper
• Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides.

  1976cited by this paper

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  2016cites this paper
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• Translesion DNA synthesis and mutagenesis in prokaryotes.

  2013influential citation
• Specificity and regulation of Escherichia coli Y family DNA polymerase V

  2013cites this paper
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  2013cites this paper
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  2012cites this paper
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  2009cites this paper
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  2009cites this paper
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  2008cites this paper
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  2008cites this paper
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  2007cites this paper
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  2005cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper
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  2004cites this paper