Trading places: how do DNA polymerases switch during translesion DNA synthesis?

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Molecules and Cells

• Publication date

  2005-05-27

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.MOLCEL.2005.03.032PMID 15916957
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DNA Repair and Mutagenesis

  2006cited by this paper
• DNA polymerase V and RecA protein, a minimal mutasome.

  2005cited by this paper
• Interaction of hREV1 with three human Y‐family DNA polymerases

  2004cited by this paper
• Switching from high-fidelity replicases to low-fidelity lesion-bypass polymerases.

  2004cited by this paper
• Properties and functions of Escherichia coli: Pol IV and Pol V.

  2004cited by this paper
• Post-replication repair in DT40 cells: translesion polymerases versus recombinases.

  2004cited by this paper
• Preferential cis–syn thymine dimer bypass by DNA polymerase η occurs with biased fidelity

  2004cited by this paper
• Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination

  2004cited by this paper
• Cellular functions of DNA polymerase zeta and Rev1 protein.

  2004cited by this paper
• Functions of DNA polymerases.

  2004cited by this paper
• Identification of specific amino acid residues in the E. coli beta processivity clamp involved in interactions with DNA polymerase III, UmuD and UmuD'.

  2004cited by this paper
• Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein.

  2004cited by this paper
• Defining the position of the switches between replicative and bypass DNA polymerases

  2004cited by this paper
• The biochemical requirements of DNA polymerase V-mediated translesion synthesis revisited.

  2004cited by this paper
• Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage.

  2004cited by this paper
• Proliferating cell nuclear antigen (PCNA): a dancer with many partners

  2003cited by this paper
• Functions of human DNA polymerases η, κ and ι suggested by their properties, including fidelity with undamaged DNA templates

  2003cited by this paper
• Functions of human DNA polymerases eta, kappa and iota suggested by their properties, including fidelity with undamaged DNA templates.

  2003cited by this paper
• Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

  2003cited by this paper
• Damage repair DNA polymerases Y.

  2003cited by this paper
• Biological functions of translesion synthesis proteins in vertebrates.

  2003cited by this paper
• Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

  2003cited by this paper
• Error-prone DNA polymerases: when making a mistake is the only way to get ahead.

  2003cited by this paper
• 129-derived Strains of Mice Are Deficient in DNA Polymerase ι and Have Normal Immunoglobulin Hypermutation

  2003cited by this paper
• Uncoupling of Leading- and Lagging-Strand DNA Replication During Lesion Bypass in Vivo

  2003cited by this paper
• Xeroderma pigmentosum variant and error-prone DNA polymerases.

  2003cited by this paper
• Translesion DNA synthesis in eukaryotes: a one- or two-polymerase affair.

  2002cited by this paper
• Error-prone repair DNA polymerases in prokaryotes and eukaryotes.

  2002cited by this paper
• Specialized DNA Polymerases, Cellular Survival, and the Genesis of Mutations

  2002cited by this paper
• Genetics of mutagenesis in E. coli: various combinations of translesion polymerases (Pol II, IV and V) deal with lesion/sequence context diversity.

  2002cited by this paper
• Pivotal role of the beta-clamp in translesion DNA synthesis and mutagenesis in E. coli cells.

  2002cited by this paper
• Replication of damaged DNA in mammalian cells: new solutions to an old problem.

  2002cited by this paper
• How DNA lesions are turned into mutations within cells?

  2002cited by this paper
• Efficiency and Accuracy of SOS-induced DNA Polymerases Replicating Benzo[a]pyrene-7,8-diol 9,10-Epoxide A and G Adducts*

  2002cited by this paper
• Eukaryotic DNA polymerases.

  2002cited by this paper
• Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation.

  2002cited by this paper
• The role of deoxycytidyl transferase activity of yeast Rev1 protein in the bypass of abasic sites.

  2002cited by this paper
• DNA polymerase κ deficiency does not affect somatic hypermutation in mice

  2002cited by this paper
• Cutting Edge: DNA Polymerases μ and λ Are Dispensable for Ig Gene Hypermutation1

  2002cited by this paper
• Pivotal role of the β-clamp in translesion DNA synthesis and mutagenesis in E. coli cells

  2002cited by this paper
• RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

  2002cited by this paper
• Roles of E. coli DNA polymerases IV and V in lesion-targeted and untargeted SOS mutagenesis

  2000cited by this paper
• All three SOS‐inducible DNA polymerases (Pol II, Pol IV and Pol V) are involved in induced mutagenesis

  2000cited by this paper
• Xeroderma pigmentosum variant: from a human genetic disorder to a novel DNA polymerase.

  2000cited by this paper
• The SOS response: recent insights into umuDC-dependent mutagenesis and DNA damage tolerance.

  2000cited by this paper
• Two RING finger proteins mediate cooperation between ubiquitin‐conjugating enzymes in DNA repair

  2000cited by this paper
• The Saccharomyces cerevisiae RAD6 group is composed of an error-prone and two error-free postreplication repair pathways.

  2000cited by this paper
• UmuD'(2)C is an error-prone DNA polymerase, Escherichia coli pol V.

  1999cited by this paper
• The Mutagenesis Protein UmuC Is a DNA Polymerase Activated by UmuD′, RecA, and SSB and Is Specialized for Translesion Replication*

  1999cited by this paper
• Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair.

  1999cited by this paper
• Yeast DNA Repair Proteins Rad6 and Rad18 Form a Heterodimer That Has Ubiquitin Conjugating, DNA Binding, and ATP Hydrolytic Activities*

  1997cited by this paper
• The RAD6 DNA repair pathway in Saccharomyces cerevisiae: What does it do, and how does it do it?

  1994cited by this paper
• RecA protein of Escherichia coli has a third essential role in SOS mutator activity

  1990cited by this paper
• New recA mutations that dissociate the various RecA protein activities in Escherichia coli provide evidence for an additional role for RecA protein in UV mutagenesis

  1989cited by this paper
• The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

  1987cited by this paper
• Influence of RecA protein on induced mutagenesis.

  1982cited by this paper
• Uvm mutants of Escherichia coli K12 deficient in UV mutagenesis

  1979cited by this paper
• Uvm mutants of Escherichia coli K12 deficient in UV mutagenesis. I. Isolation of uvm mutants and their phenotypical characterization in DNA repair and mutagenesis.

  1978cited by this paper
• Isolation and characterization of mutants of Escherichia coli deficient in induction of mutations by ultraviolet light

  1977cited by this paper

• Opposing regulation by Rev1 of DNA polymerase zeta activity on damaged versus undamaged DNA

  2026cites this paper
• Residues in the little finger domain of the Y-family Dpo4 DNA polymerase communicate to restrict synthesis past 8-oxoguanine lesions

  2025cites this paper
• Translesion-synthesis-mediated bypass of DNA lesions occurs predominantly behind replication forks restarted by PrimPol

  2025cites this paper
• USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that can temporarily enrich for monoubiquitinated PCNA

  2025cites this paper
• Nick sealing of polβ mismatch insertion products by LIG1 and LIG3α during 8-oxoG bypass leads to mutagenic or error-free base excision repair

  2025cites this paper
• Few-Shot Generalization to Novel Compounds in Single-Cell Drug Response via Graph-Infused Meta-Pretraining

  2025cites this paper
• SCREP: Towards Single-Cell Drug Response Prediction by Pharmacogenomic Embedding Enhanced Meta-Pretraining and Few-Shot Transfer Learning

  2024cites this paper
• Dual role of proliferating cell nuclear antigen monoubiquitination in facilitating Fanconi anemia-mediated interstrand crosslink repair

  2024influential citation
• Protein Assemblies in Translesion Synthesis

  2024cites this paper
• RAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair

  2024cites this paper
• Mutagenic ligation of polβ mismatch insertion products during 8-oxoG bypass by LIG1 and LIG3α at the downstream steps of base excision repair pathway

  2024cites this paper
• DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1α

  2024cites this paper
• (Single-stranded DNA) gaps in understanding BRCAness.

  2024cites this paper
• Chemical Insights into Oxidative and Nitrative Modifications of DNA

  2023cites this paper
• Ubiquitin-specific peptidase 1: assessing its role in cancer therapy

  2023cites this paper
• Identification of Nanog as a novel inhibitor of Rad51

  2022cites this paper
• Identification of Nanog as a novel inhibitor of Rad51

  2022cites this paper
• The Kynurenine Pathway and Cancer: Why Keep It Simple When You Can Make It Complicated

  2022cites this paper
• Division of labor of Y-family polymerases in translesion-DNA synthesis for distinct types of DNA damage

  2021cites this paper
• Wine yeast species show strong inter- and intra-specific variability in their sensitivity to ultraviolet radiation.

  2021cites this paper
• Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells

  2021cites this paper
• SerpinB10, a Serine Protease Inhibitor, Is Implicated in UV-Induced Cellular Response

  2021cites this paper
• Targeting protein–protein interactions in the DNA damage response pathways for cancer chemotherapy

  2021cites this paper
• Investigating the Conformational Dynamics of a Y-Family DNA Polymerase during Its Folding and Binding to DNA and a Nucleotide

  2021cites this paper
• Sequence context effects of replication of Fapy•dG in three mutational hot spot sequences of the p53 gene in human cells.

  2021cites this paper
• Deaminated purine bypass by DNA polymerase η

  2021cites this paper
• Pold4, the fourth subunit of replicative polymerase δ, suppresses gene conversion in the immunoglobulin-variable gene in avian DT40 cells.

  2021cites this paper
• The Mitochondrial Response to DNA Damage

  2021cites this paper
• Exploring the multiple roles of guardian of the genome: P53

  2020cites this paper
• DNA-Histone Cross-Links: Formation and Repair

  2020cites this paper
• DNA polymerase eta: A potential pharmacological target for cancer therapy

  2020influential citation
• DNA-damage tolerance through PCNA ubiquitination and sumoylation.

  2020cites this paper
• Systematic Analysis of Targets of Pumilio-Mediated mRNA Decay Reveals that PUM1 Repression by DNA Damage Activates Translesion Synthesis.

  2020cites this paper
• Distinct requirements for budding yeast Rev1 and Polη in translesion DNA synthesis across different types of DNA damage

  2020cites this paper
• DNA Damage Response Pathways and Cancer

  2020cites this paper
• Achieving sterility in biomedical and pharmaceutical products (part-II): radiation sterilization

  2020cites this paper
• Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers

  2020cites this paper
• Synthetic lethal interaction between PCNA K164- and REV1-dependent DNA damage tolerance brings polymerase iota into focus

  2020cites this paper
• DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy

  2019cites this paper
• Redox Regulation in the Base Excision Repair Pathway: Old and New Players as Cancer Therapeutic Targets.

  2019cites this paper
• Local Determinants of the Mutational Landscape of the Human Genome.

  2019cites this paper
• Rev1 plays central roles in mammalian DNA‐damage tolerance in response to UV irradiation

  2019cites this paper
• RAD18 contributes to the migration and invasion of human cervical cancer cells via the interleukin‑1β pathway.

  2019cites this paper
• Targeting translesion DNA synthesis in the context of cancer therapy

  2019cites this paper
• The DNA Replication Machinery as Therapeutic Targets

  2019cites this paper
• The Rev1-Polζ translesion synthesis mutasome: Structure, interactions and inhibition.

  2019cites this paper
• Simultaneous disruption of two DNA polymerases ,

  2019influential citation
• Systematic Analysis of Targets of Pumilio (PUM)-Mediated mRNA Decay Identifies a Role of PUM1 in Regulating DNA Damage Response Pathway

  2018cites this paper
• Molecular mechanisms of DNA replication across UV-induced DNA lesions and novel approaches to suppress UV mutagenesis

  2018cites this paper
• The efficiency and fidelity of 8-oxo-guanine bypass by DNA polymerases delta and eta

  2018cites this paper
• SPARTAN promotes genetic diversification of the immunoglobulin-variable gene locus in avian DT40 cells.

  2018cites this paper
• Identification of Functional Targets Reveals that the Suppression of Pumilio-mediated mRNA Decay Increases Cell Resistance to DNA Damage in Human Cells

  2018cites this paper
• Structural Basis for the Interaction of Mutasome Assembly Factor REV1 with Ubiquitin.

  2018cites this paper
• 5-Formylcytosine mediated DNA–protein cross-links block DNA replication and induce mutations in human cells

  2018cites this paper
• Ubiquitylation at the Fork: Making and Breaking Chains to Complete DNA Replication

  2018cites this paper
• Identification of small molecule translesion synthesis inhibitors that target the Rev 1-CT / RIR protein-protein interaction

  2018cites this paper
• Cellular Responses to DNA Damage

  2018cites this paper
• Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

  2018cites this paper
• Bulky Lesion Bypass Requires Dpo4 Binding in Distinct Conformations

  2017cites this paper
• The Multiple Roles of Ubiquitylation in Regulating Challenged DNA Replication.

  2017cites this paper
• Regulation and Modulation of Human DNA Polymerase δ Activity and Function

  2017cites this paper
• Advances in Structural and Single-Molecule Methods for Investigating DNA Lesion Bypass and Repair Polymerases.

  2017cites this paper
• 1 ROLE OF DNA POLYMERASES η , ι AND ζ IN UV RESISTANCE AND UV-INDUCED MUTAGENESIS IN A HUMAN CELL LINE .

  2017cites this paper
• Estimation of Biological Effects of Tritium.

  2017cites this paper
• Limited ability of DNA polymerase kappa to suppress benzo[a]pyrene‐induced genotoxicity in vivo

  2017cites this paper
• Translesion DNA polymerases and genome maintenance in Trypanosoma brucei

  2017cites this paper
• Etude du rôle du corégulateur transcriptionnel RIP140 dans le contrôle de l'instabilité microsatellitaire des cancers colorectaux héréditaires

  2017cites this paper
• DNA polymerase kappa protects human cells against MMC-induced genotoxicity through error-free translesion DNA synthesis

  2017cites this paper
• Epigenetic Instability Induced by DNA Base Lesion via DNA Base Excision Repair

  2017influential citation
• Coordination and Substitution of DNA Polymerases in Response to Genomic Obstacles.

  2017cites this paper
• DNA damage related crosstalk between the nucleus and mitochondria.

  2017cites this paper
• Chloroethylating nitrosoureas in cancer therapy: DNA damage, repair and cell death signaling.

  2017cites this paper
• Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases

  2017cites this paper
• Structural basis for the molecular interactions in DNA damage tolerances

  2017cites this paper
• Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein-Protein Interaction.

  2017cites this paper
• Structural dynamics and protein interactions within the E. coli DNA polymerase III holoenzyme

  2017cites this paper
• Multiple repair pathways mediate cellular tolerance to resveratrol-induced DNA damage.

  2017cites this paper
• Structural insight into inhibition of REV7 protein interaction revealed by docking, molecular dynamics and MM/PBSA studies

  2017cites this paper
• NGS-based analysis of base-substitution signatures created by yeast DNA polymerase eta and zeta on undamaged and abasic DNA templates in vitro.

  2017cites this paper
• Inhibiting DNA Polymerases as a Therapeutic Intervention against Cancer

  2017influential citation
• Role of replicative primase in lesion bypass during DNA replication

  2017cites this paper
• Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1 alpha axis

  2017cites this paper
• Rev1 contributes to proper mitochondrial function via the PARP-NAD+-SIRT1-PGC1α axis

  2017cites this paper
• Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells

  2016cites this paper
• Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis.

  2016cites this paper
• Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases*

  2016cites this paper
• Using ultra-sensitive next generation sequencing to dissect DNA damage-induced mutagenesis

  2016cites this paper
• Determination of genotoxic potential by comparison of structurally related azo dyes using DNA repair-deficient DT40 mutant panels.

  2016cites this paper
• REV1 promotes PCNA monoubiquitylation through interacting with ubiquitylated RAD18

  2016cites this paper
• Cytotoxic and genotoxic profiles of benzo[a]pyrene and N-nitrosodimethylamine demonstrated using DNA repair deficient DT40 cells with metabolic activation.

  2016cites this paper
• Translesion Synthesis of 2′-Deoxyguanosine Lesions by Eukaryotic DNA Polymerases

  2016cites this paper
• Chemotherapeutic intervention by inhibiting DNA polymerases

  2016cites this paper
• Eukaryotic TLS polymerases.

  2016cites this paper
• Translesion Synthesis of the N2-2′-Deoxyguanosine Adduct of the Dietary Mutagen IQ in Human Cells: Error-Free Replication by DNA Polymerase κ and Mutagenic Bypass by DNA Polymerases η, ζ, and Rev1

  2016cites this paper
• The E. coli DNA Replication Fork.

  2016cites this paper
• Interaction between the Rev 1 C-Terminal Domain and the PolD 3 Subunit of Pol Suggests a Mechanism of Polymerase Exchange upon Rev 1 / Pol-Dependent

  2016cites this paper
• Structural Insight into the Mechanisms of Activation and Substrate Specificity of Human Deubiquitinating Enzyme USP7

  2016cites this paper
• The Impact of dUTPase on Ribonucleotide Reductase-Induced Genome Instability in Cancer Cells.

  2016cites this paper
• TopBP1-mediated DNA processing during mitosis

  2016cites this paper
• Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics.

  2016cites this paper