Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  DNA Repair

• Publication date

  2004-11-02

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.DNAREP.2004.06.015PMID 15380106
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DNA Replication Fidelity*

  2004cited by this paper
• Xeroderma pigmentosum variant and error-prone DNA polymerases.

  2003cited by this paper
• Sequence context-dependent replication of DNA templates containing UV-induced lesions by human DNA polymerase iota.

  2003cited by this paper
• Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

  2003cited by this paper
• Localization of DNA polymerases eta and iota to the replication machinery is tightly co-ordinated in human cells.

  2003cited by this paper
• Ribozyme-mediated REV1 inhibition reduces the frequency of UV-induced mutations in the human HPRT gene.

  2003cited by this paper
• Rev1 is essential for DNA damage tolerance and non‐templated immunoglobulin gene mutation in a vertebrate cell line

  2003cited by this paper
• Structure-based interpretation of missense mutations in Y-family DNA polymerases and their implications for polymerase function and lesion bypass.

  2002cited by this paper
• Localization of DNA polymerases η and ι to the replication machinery is tightly co‐ordinated in human cells

  2002cited by this paper
• hREV3 is essential for error-prone translesion synthesis past UV or benzo[a]pyrene diol epoxide-induced DNA lesions in human fibroblasts.

  2002cited by this paper
• Error-prone repair DNA polymerases in prokaryotes and eukaryotes.

  2002cited by this paper
• Translesion synthesis by human DNA polymerase kappa on a DNA template containing a single stereoisomer of dG-(+)- or dG-(-)-anti-N(2)-BPDE (7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene).

  2002cited by this paper
• Polκ protects mammalian cells against the lethal and mutagenic effects of benzo[a]pyrene

  2002cited by this paper
• Accuracy of lesion bypass by yeast and human DNA polymerase η

  2001cited by this paper
• Response of human DNA polymerase iota to DNA lesions.

  2001cited by this paper
• Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells.

  2001cited by this paper
• Response of human DNA polymerase ι to DNA lesions

  2001cited by this paper
• Physical and functional interactions of human DNA polymerase eta with PCNA.

  2001cited by this paper
• Role of DNA Polymerase η in the Bypass of a (6-4) TT Photoproduct

  2001cited by this paper
• Translesion synthesis by yeast DNA polymerase from templates containing lesions of ultraviolet radiation and acetylaminofluorene

  2001cited by this paper
• Biochemical characterization of human DNA polymerase iota provides clues to its biological function.

  2001cited by this paper
• Interactions in the Error-prone Postreplication Repair Proteins hREV1, hREV3, and hREV7*

  2001cited by this paper
• Accuracy of lesion bypass by yeast and human DNA polymerase eta.

  2001cited by this paper
• Physical and Functional Interactions of Human DNA Polymerase η with PCNA

  2001cited by this paper
• Targeting of human DNA polymerase ι to the replication machinery via interaction with PCNA

  2001cited by this paper
• Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites.

  2001cited by this paper
• The Y-family of DNA polymerases.

  2001cited by this paper
• Role of DNA polymerase eta in the bypass of a (6-4) TT photoproduct.

  2001cited by this paper
• Eukaryotic polymerases iota and zeta act sequentially to bypass DNA lesions.

  2000cited by this paper
• Error-free and error-prone lesion bypass by human DNA polymerase κ in vitro

  2000cited by this paper
• Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions

  2000cited by this paper
• A Human REV7 Homolog That Interacts with the Polymerase ζ Catalytic Subunit hREV3 and the Spindle Assembly Checkpoint Protein hMAD2*

  2000cited by this paper
• Evidence for a second function for Saccharomyces cerevisiae Rev1p

  2000cited by this paper
• Error-free and error-prone lesion bypass by human DNA polymerase kappa in vitro.

  2000cited by this paper
• Error-prone lesion bypass by human DNA polymerase eta.

  2000cited by this paper
• Mechanisms of accurate translesion synthesis by human DNA polymerase η

  2000cited by this paper
• The function of the human homolog of Saccharomyces cerevisiae REV1 is required for mutagenesis induced by UV light.

  2000cited by this paper
• Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa.

  2000cited by this paper
• Roles of DNA polymerase zeta and Rev1 protein in eukaryotic mutagenesis and translesion replication.

  2000cited by this paper
• Fidelity of human DNA polymerase eta.

  2000cited by this paper
• Misinsertion and bypass of thymine–thymine dimers by human DNA polymerase ι

  2000cited by this paper
• Fidelity of Human DNA Polymerase η*

  2000cited by this paper
• Low fidelity DNA synthesis by human DNA polymerase-η

  2000cited by this paper
• The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase η

  1999cited by this paper
• Novel human and mouse homologs of Saccharomyces cerevisiae DNA polymerase eta.

  1999cited by this paper
• Increased ultraviolet sensitivity and chromosomal instability related to P53 function in the xeroderma pigmentosum variant.

  1999cited by this paper
• Replication of damaged DNA: molecular defect in xeroderma pigmentosum variant cells.

  1999cited by this paper
• hRAD30 mutations in the variant form of xeroderma pigmentosum.

  1999cited by this paper
• Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily.

  1999cited by this paper
• The human REV1 gene codes for a DNA template-dependent dCMP transferase.

  1999cited by this paper
• A human homolog of the Saccharomyces cerevisiae REV3 gene, which encodes the catalytic subunit of DNA polymerase zeta.

  1998cited by this paper
• From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

  1997cited by this paper
• Xeroderma pigmentosum variant: generation and characterization of fibroblastic cell lines transformed with SV40 large T antigen.

  1995cited by this paper
• Pathways of ultraviolet mutability in Saccharomyces cerevisiae. II. The effect of rev genes on recombination.

  1971cited by this paper

• Identification of a PCNA-binding motif in human translesion DNA polymerase REV1 and structural basis of its interaction with PCNA.

  2025cites this paper
• Versatile enhancement of the killing potential of anti-cancer agents achieved by peptide mimetics of the PCNA interface towards specialized DNA polymerases

  2025cites this paper
• A RAD18–UBC13–PALB2–RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells

  2024cites this paper
• Cryo-EM structure of the Rev1–Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis

  2024cites this paper
• REV1 coordinates a multi-faceted tolerance response to DNA alkylation damage and prevents chromosome shattering in Drosophila melanogaster

  2024cites this paper
• REV1 Coordinates a Multi-Faceted Tolerance Response to DNA Alkylation Damage and Prevents Chromosome Shattering in Drosophila melanogaster

  2024cites this paper
• Protein Assemblies in Translesion Synthesis

  2024cites this paper
• Rev1 overexpression accelerates N‐methyl‐N‐nitrosourea (MNU)‐induced thymic lymphoma by increasing mutagenesis

  2024cites this paper
• Detection of endogenous translesion DNA synthesis in single mammalian cells

  2023cites this paper
• Tandem Substitutions in Somatic Hypermutation

  2022cites this paper
• REV1: A novel biomarker and potential therapeutic target for various cancers

  2022cites this paper
• Protein–Protein Interactions in Translesion Synthesis

  2021cites this paper
• Enhanced Antitumor Response to Immune Checkpoint Blockade Exerted by Cisplatin-Induced Mutagenesis in a Murine Melanoma Model

  2021cites this paper
• Evaluation and modulation of DNA lesion bypass in an SV40 large T antigen‐based in vitro replication system

  2021cites this paper
• A Catalytically Independent Function of Human DNA Polymerase Kappa Controls the Stability and Abundance of Checkpoint Kinase 1

  2021cites this paper
• Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells

  2021cites this paper
• Identification and prognostic analysis of the cetuximab resistance-related gene REV1 in RAS wild-type metastatic colorectal cancer.

  2021cites this paper
• Carcinogenesis Models Using Small Fish.

  2021cites this paper
• DNA-damage tolerance through PCNA ubiquitination and sumoylation.

  2020cites this paper
• Synthetic lethal interaction between PCNA K164- and REV1-dependent DNA damage tolerance brings polymerase iota into focus

  2020cites this paper
• The in vivo role of Rev1 in mutagenesis and carcinogenesis

  2020cites this paper
• Involvement of Rev1 in alkylating agent‐induced loss of heterozygosity in Oryzias latipes

  2020cites this paper
• CARM1 regulates replication fork speed and stress response by stimulating PARP1.

  2020influential citation
• Transient activation of tumoral DNA damage tolerance pathway coupled with immune checkpoint blockade exerts durable tumor regression in mouse melanoma

  2020cites this paper
• Inhibition of the translesion synthesis polymerase REV1 exploits replication gaps as a cancer vulnerability

  2020cites this paper
• Rev1 plays central roles in mammalian DNA‐damage tolerance in response to UV irradiation

  2019cites this paper
• Rad6/Rad18 competes with DNA polymerases η and δ for PCNA encircling DNA.

  2019cites this paper
• Targeting translesion DNA synthesis in the context of cancer therapy

  2019cites this paper
• DNA damage tolerance in stem cells, ageing, mutagenesis, disease and cancer therapy

  2019cites this paper
• The Rev1-Polζ translesion synthesis mutasome: Structure, interactions and inhibition.

  2019cites this paper
• DNA polymerase ζ in DNA replication and repair

  2019cites this paper
• Mutating for Good: DNA Damage Responses During Somatic Hypermutation

  2019cites this paper
• Polymerase iota - an odd sibling among Y family polymerases.

  2019cites this paper
• Simultaneous disruption of two DNA polymerases ,

  2019cites this paper
• Effect of sequence context on Polζ-dependent error-prone extension past (6-4) photoproducts.

  2019cites this paper
• 4 DNA Replication in Repair

  2018cites this paper
• Structure and function of the disordered regions within translesion synthesis DNA polymerases

  2018cites this paper
• Title Chromatin modification and NBS 1 : Their relationship in DNAdouble-strand break repair

  2018influential citation
• Translesion DNA Synthesis

  2018cites this paper
• Filling gaps in translesion DNA synthesis in human cells.

  2018cites this paper
• Eukaryotic translesion synthesis: Choosing the right tool for the job.

  2018cites this paper
• Elevated expression of REV 1 is a predictor of unfavorable prognosis in patients with prostate cancer

  2018cites this paper
• Cellular Responses to DNA Damage

  2018cites this paper
• Regulation of DNA damage tolerance in mammalian cells by post-translational modifications of PCNA.

  2017cites this paper
• Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases

  2017cites this paper
• Real-Time Investigation Of Bulky Lesion Bypass By Y-Family Dna Polymerase, Dpo4, Using Single Molecule Fret

  2017cites this paper
• Translesion DNA polymerases in eukaryotes: what makes them tick?

  2017cites this paper
• DNA damage tolerance in hematopoietic stem and progenitor cells in mice

  2017cites this paper
• Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?

  2017cites this paper
• Coordination and Substitution of DNA Polymerases in Response to Genomic Obstacles.

  2017cites this paper
• Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis.

  2016cites this paper
• Using ultra-sensitive next generation sequencing to dissect DNA damage-induced mutagenesis

  2016cites this paper
• Aberrant Kynurenine Signaling Modulates DNA Replication Stress Factors and Promotes Genomic Instability in Gliomas.

  2016cites this paper
• Functional interaction between the DNA damage tolerance pathway and the DNA damage checkpoint : implications for genome stability and oncogenesis

  2016influential citation
• Eukaryotic TLS polymerases.

  2016cites this paper
• REV1 promotes PCNA monoubiquitylation through interacting with ubiquitylated RAD18

  2016cites this paper
• DNA Polymerase Zeta-Dependent Mutagenesis: Molecular Specificity, Extent of Error-Prone Synthesis, and the Role of dNTP Pools

  2016cites this paper
• Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1.

  2016cites this paper
• Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations.

  2016cites this paper
• Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics.

  2016cites this paper
• PCNA-Ub polyubiquitination inhibits cell proliferation and induces cell-cycle checkpoints

  2016cites this paper
• Pre-steady-state kinetic investigation of bypass of a bulky guanine lesion by human Y-family DNA polymerases.

  2016cites this paper
• Interaction between the Rev 1 C-Terminal Domain and the PolD 3 Subunit of Pol Suggests a Mechanism of Polymerase Exchange upon Rev 1 / Pol-Dependent

  2016cites this paper
• Analysis of the Genetic Requirements for Rad51-Mediated 3’ Polymerization during DNA Repair by Homologous Recombination

  2016cites this paper
• Translesion DNA Synthesis and Damage Tolerance Pathways

  2016cites this paper
• Yeast DNA polymerase ζ maintains consistent activity and mutagenicity across a wide range of physiological dNTP concentrations

  2016cites this paper
• Structural Insight into the Mechanisms of Activation and Substrate Specificity of Human Deubiquitinating Enzyme USP7

  2016influential citation
• Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins.

  2015cites this paper
• Chromatin modification and NBS1: their relationship in DNA double-strand break repair.

  2015influential citation
• Aberrant C-terminal domain of polymerase η targets the functional enzyme to the proteosomal degradation pathway.

  2015cites this paper
• Translesion synthesis and mutations: On the mutagenic properties of the two DNA lesions, 8-oxo-G and Pt-GG, and the functions of Y-family DNA polymerases and Rev3L on the bypass of each of the DNA lesions in mammalian cells

  2015cites this paper
• Roles of mutagenic translesion synthesis in mammalian genome stability, health and disease.

  2015cites this paper
• Functional Role of NBS1 in Radiation Damage Response and Translesion DNA Synthesis

  2015cites this paper
• FF483–484 motif of human Polη mediates its interaction with the POLD2 subunit of Polδ and contributes to DNA damage tolerance

  2015cites this paper
• Translesion Polymerase Genes Polymorphisms and Haplotypes Influence Survival of Osteosarcoma Patients

  2015cites this paper
• 5. DNA polymerase eta

  2015influential citation
• FF 483–484 motif of human Pol (cid:2) mediates its interaction with the POLD2 subunit of Pol (cid:3) and contributes to DNA damage tolerance

  2015cites this paper
• FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress

  2015cites this paper
• Posttranslational Regulation of Human DNA Polymerase ι*

  2015cites this paper
• Mycobacterium tuberculosis class II apurinic/apyrimidinic‐endonuclease/3′‐5′ exonuclease III exhibits DNA regulated modes of interaction with the sliding DNA β‐clamp

  2015cites this paper
• Many Bacteria Use a Special Mutagenic Pol III in Place of Pol V

  2015cites this paper
• Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ

  2015cites this paper
• Implication de l’ADN polymérase spécialisée zêta au cours de la réplication de l’hétérochromatine dans les cellules de mammifères

  2015cites this paper
• Eukaryotic Y-Family Polymerases: A Biochemical and Structural Perspective

  2014cites this paper
• HIJM 59-10 Generation and Evaluation of an Anti-REVl Monoclonal Antibody

  2013cites this paper
• XRCC1 interaction with the REV1 C-terminal domain suggests a role in post replication repair.

  2013cites this paper
• DNA-damage tolerance mediated by PCNA•Ub fusions in human cells is dependent on Rev1 but not Polη

  2013cites this paper
• Translesion DNA synthesis and mutagenesis in eukaryotes.

  2013cites this paper
• The roles of DNA polymerase ζ and the Y family DNA polymerases in promoting or preventing genome instability.

  2013cites this paper
• Translesion DNA polymerases.

  2013cites this paper
• Studies of Proliferating Cell Nuclear Antigen Mutant Proteins Defective in Translesion Synthesis and Mismatch Repair

  2013cites this paper
• Regulatory role of ubiquitin in eukaryotic DNA translesion synthesis.

  2013cites this paper
• Novel Mechanisms through which translesion synthesis protects genome integrity

  2013influential citation
• Role of NBS1 in DNA damage response and its relationship with cancer development

  2013cites this paper
• A non-catalytic role of DNA polymerase η in recruiting Rad18 and promoting PCNA monoubiquitination at stalled replication forks

  2013cites this paper
• REV1 and DNA polymerase zeta in DNA interstrand crosslink repair

  2012cites this paper
• Structural Basis of Rev 1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev 1 , Heterodimeric Polymerase ( Pol )

  2012cites this paper
• Stalled Polη at its cognate substrate initiates an alternative translesion synthesis pathway via interaction with REV1

  2012cites this paper
• NMR structure and dynamics of the C-terminal domain from human Rev1 and its complex with Rev1 interacting region of DNA polymerase η.

  2012cites this paper
• Regulation of error-prone translesion synthesis by Spartan/C1orf124

  2012cites this paper