Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis.

No abstract is available for this paper.

• Publication year

  2016

• Venue

  Biochemistry

• Publication date

  2016-03-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1021/acs.biochem.5b01282PMID 26982350PMCID PMC4898654
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The structural basis of XRCC1-mediated DNA repair.

  2015cited by this paper
• A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands.

  2015cited by this paper
• Polymerase δ replicates both strands after homologous recombination-dependent fork restart

  2015cited by this paper
• Eukaryotic DNA polymerase ζ.

  2015cited by this paper
• Def1 Promotes the Degradation of Pol3 for Polymerase Exchange to Occur During DNA-Damage–Induced Mutagenesis in Saccharomyces cerevisiae

  2014cited by this paper
• Structural basis of recruitment of DNA polymerase ζ by interaction between REV1 and REV7

  2014cited by this paper
• Molecular basis of aflatoxin-induced mutagenesis-role of the aflatoxin B1-formamidopyrimidine adduct.

  2014cited by this paper
• Error-prone Replication Bypass of the Primary Aflatoxin B1 DNA Adduct, AFB1-N7-Gua*

  2014cited by this paper
• Human Pol ζ purified with accessory subunits is active in translesion DNA synthesis and complements Pol η in cisplatin bypass

  2014cited by this paper
• Insights into the regulation of human Rev1 for translesion synthesis polymerases revealed by the structural studies on its polymerase-interacting domain.

  2013cited by this paper
• XRCC1 interaction with the REV1 C-terminal domain suggests a role in post replication repair.

  2013cited by this paper
• NMR mapping of PCNA interaction with translesion synthesis DNA polymerase Rev1 mediated by Rev1-BRCT domain.

  2013cited by this paper
• Causes and consequences of replication stress

  2013cited by this paper
• The architecture of yeast DNA polymerase ζ.

  2013cited by this paper
• Structural basis of recruitment of DNA polymerase ζ by interaction between REV1 and REV7 proteins.

  2012cited by this paper
• Bypass of a psoralen DNA interstrand cross-link by DNA polymerases β, ι, and κ in vitro.

  2012cited by this paper
• NMR structure and dynamics of the C-terminal domain from human Rev1 and its complex with Rev1 interacting region of DNA polymerase η.

  2012cited by this paper
• A four-subunit DNA polymerase ζ complex containing Pol δ accessory subunits is essential for PCNA-mediated mutagenesis

  2012cited by this paper
• Y-family DNA polymerases and their role in tolerance of cellular DNA damage

  2012cited by this paper
• Structural insights into the assembly of human translesion polymerase complexes

  2012cited by this paper
• Regulation of error-prone translesion synthesis by Spartan/C1orf124

  2012cited by this paper
• Multifaceted Recognition of Vertebrate Rev1 by Translesion Polymerases ζ and κ*

  2012cited by this paper
• Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) ζ, and Pol κ*

  2012cited by this paper
• DNA Polymerase δ and ζ Switch by Sharing Accessory Subunits of DNA Polymerase δ*

  2012cited by this paper
• The C‐terminal domain of human Rev1 contains independent binding sites for DNA polymerase η and Rev7 subunit of polymerase ζ

  2012cited by this paper
• Pol31 and Pol32 subunits of yeast DNA polymerase δ are also essential subunits of DNA polymerase ζ

  2012cited by this paper
• The Non-canonical Protein Binding Site at the Monomer-Monomer Interface of Yeast Proliferating Cell Nuclear Antigen (PCNA) Regulates the Rev1-PCNA Interaction and Polζ/Rev1-dependent Translesion DNA Synthesis*

  2011cited by this paper
• Eukaryotic DNA polymerases require an iron-sulfur cluster for the formation of active complexes

  2011cited by this paper
• PCNA binding domains in all three subunits of yeast DNA polymerase δ modulate its function in DNA replication

  2011cited by this paper
• Sequential assembly of translesion DNA polymerases at UV-induced DNA damage sites

  2011cited by this paper
• The DNA Polymerase Activity of Saccharomyces cerevisiae Rev1 is Biologically Significant

  2011cited by this paper
• Multiple two-polymerase mechanisms in mammalian translesion DNA synthesis

  2010cited by this paper
• Crystal Structure of Human REV7 in Complex with a Human REV3 Fragment and Structural Implication of the Interaction between DNA Polymerase ζ and REV1*

  2010cited by this paper
• Identification of a novel REV1‐interacting motif necessary for DNA polymerase κ function

  2009cited by this paper
• TALOS+: a hybrid method for predicting protein backbone torsion angles from NMR chemical shifts

  2009cited by this paper
• Yeast Rev1 protein promotes complex formation of DNA polymerase ζ with Pol32 subunit of DNA polymerase δ

  2009cited by this paper
• Eukaryotic Translesion Polymerases and Their Roles and Regulation in DNA Damage Tolerance

  2009cited by this paper
• Interaction with DNA polymerase eta is required for nuclear accumulation of REV1 and suppression of spontaneous mutations in human cells.

  2009cited by this paper
• Y-family DNA polymerases in mammalian cells

  2009cited by this paper
• DNA polymerase zeta (pol zeta) in higher eukaryotes.

  2008cited by this paper
• Regulation of polymerase exchange between Polη and Polδ by monoubiquitination of PCNA and the movement of DNA polymerase holoenzyme

  2008cited by this paper
• Novel conserved motifs in Rev1 C-terminus are required for mutagenic DNA damage tolerance.

  2008cited by this paper
• DNA polymerase zeta (pol ζ) in higher eukaryotes

  2008cited by this paper
• X-ray structure of the complex of regulatory subunits of human DNA polymerase delta

  2008cited by this paper
• Dividing the workload at a eukaryotic replication fork.

  2008cited by this paper
• Translesion synthesis: Y-family polymerases and the polymerase switch.

  2007cited by this paper
• Complex Formation of Yeast Rev1 with DNA Polymerase η

  2007cited by this paper
• What a difference a decade makes: Insights into translesion DNA synthesis

  2007cited by this paper
• PCNA, the maestro of the replication fork.

  2007cited by this paper
• A Novel DNA Damage Response

  2007cited by this paper
• Ubiquitin-Binding Motifs in REV1 Protein Are Required for Its Role in the Tolerance of DNA Damage

  2006cited by this paper
• DNA Repair and Mutagenesis

  2006cited by this paper
• A single amino acid governs enhanced activity of DinB DNA polymerases on damaged templates

  2006cited by this paper
• REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo.

  2006cited by this paper
• Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1

  2005cited by this paper
• Trading places: how do DNA polymerases switch during translesion DNA synthesis?

  2005cited by this paper
• Complex Formation of Yeast Rev1 and Rev7 Proteins: a Novel Role for the Polymerase-Associated Domain

  2005cited by this paper
• Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis

  2005cited by this paper
• Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage.

  2004cited by this paper
• Efficient and error-free replication past a minor-groove DNA adduct by the sequential action of human DNA polymerases iota and kappa.

  2004cited by this paper
• Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination

  2004cited by this paper
• Efficient and Error-Free Replication Past a Minor-Groove DNA Adduct by the Sequential Action of Human DNA Polymerases ι and κ

  2004cited by this paper
• Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein.

  2004cited by this paper
• Quantitative Analysis of Translesion DNA Synthesis across a Benzo[a]pyrene-Guanine Adduct in Mammalian Cells

  2004cited by this paper
• The Pol32 Subunit of DNA Polymerase δ Contains Separable Domains for Processive Replication and Proliferating Cell Nuclear Antigen (PCNA) Binding*

  2004cited by this paper
• Interaction of hREV1 with three human Y‐family DNA polymerases

  2004cited by this paper
• The Computer Aided Resonance Assignment Tutorial

  2004cited by this paper
• Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

  2003cited by this paper
• Automated NMR protein structure calculation

  2003cited by this paper
• Yeast DNA polymerase zeta (zeta) is essential for error-free replication past thymine glycol.

  2003cited by this paper
• RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

  2002cited by this paper
• Mutagenesis in the spotlight.

  2002cited by this paper
• Translesion DNA synthesis in eukaryotes: a one- or two-polymerase affair.

  2002cited by this paper
• Yeast Rev1 Protein Is a G Template-specific DNA Polymerase*

  2002cited by this paper
• Human DINB1-encoded DNA polymerase kappa is a promiscuous extender of mispaired primer termini.

  2002cited by this paper
• Human DINB1-encoded DNA polymerase κ is a promiscuous extender of mispaired primer termini

  2002cited by this paper
• Deoxycytidyl Transferase Activity of the Human REV1 Protein Is Closely Associated with the Conserved Polymerase Domain*

  2001cited by this paper
• Evidence for a second function for Saccharomyces cerevisiae Rev1p

  2000cited by this paper
• Stable proline box motif at the N‐terminal end of α‐helices

  1999cited by this paper
• Heteronuclear multidimensional NMR experiments for the structure determination of proteins in solution employing pulsed field gradients

  1999cited by this paper
• Efficient bypass of a thymine-thymine dimer by yeast DNA polymerase, Poleta.

  1999cited by this paper
• Crystallography & NMR system: A new software suite for macromolecular structure determination.

  1998cited by this paper
• Methods for Measurement of Intermolecular NOEs by Multinuclear NMR Spectroscopy: Application to a Bacteriophage λ N-Peptide/boxB RNA Complex

  1997cited by this paper
• Thymine-Thymine Dimer Bypass by Yeast DNA Polymerase ζ

  1996cited by this paper
• Deoxycytidyl transferase activity of yeast REV1 protein

  1996cited by this paper
• N‐ and C‐capping preferences for all 20 amino acids in α‐helical peptides

  1995cited by this paper
• Stability of alpha-helices.

  1995cited by this paper
• NMRPipe: A multidimensional spectral processing system based on UNIX pipes

  1995cited by this paper
• Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites.

  1994cited by this paper
• Stability of alpha-helices

  1987cited by this paper
• Brief Definitive Report Strand-biased Defect in C/g Transversions in Hypermutating Immunoglobulin Genes in Rev1-defi Cient Mice

  year unknowncited by this paper

• Enzymatic and Structural Roles of Candida albicans Rev1 in DNA Damage Response and Disseminated Candidiasis

  2025cites this paper
• Sensitization of cancer cells to DNA-damaging agents by expression of the REV1 C-terminal domain: Implications for chemotherapy.

  2025cites this paper
• A sophisticated mechanism governs Pol ζ activity in response to replication stress

  2024cites this paper
• A RAD18–UBC13–PALB2–RNF168 axis mediates replication fork recovery in BRCA1-deficient cancer cells

  2024cites this paper
• Protein Assemblies in Translesion Synthesis

  2024cites this paper
• Cryo-EM structure of the Rev1–Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis

  2024cites this paper
• Lead compound profiling for small molecule inhibitors of the REV1-CT/RIR Translesion synthesis Protein-Protein interaction.

  2024cites this paper
• POLD3 as Controller of Replicative DNA Repair

  2024influential citation
• Mitotic DNA synthesis in response to replication stress requires the sequential action of DNA polymerases zeta and delta in human cells

  2023cites this paper
• POLD3 deficiency is associated with severe combined immunodeficiency, neurodevelopmental delay, and hearing impairment.

  2023cites this paper
• REV7 in Cancer Biology and Management

  2023cites this paper
• Roles of trans-lesion synthesis (TLS) DNA polymerases in tumorigenesis and cancer therapy

  2023influential citation
• DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target

  2022cites this paper
• Computational Analysis of Short Linear Motifs in the Spike Protein of SARS-CoV-2 Variants Provides Possible Clues into the Immune Hijack and Evasion Mechanisms of Omicron Variant

  2022cites this paper
• Polymerase ζ Is Involved in Mitochondrial DNA Maintenance Processes in Concert with APE1 Activity

  2022influential citation
• Beyond the Lesion: Back to High Fidelity DNA Synthesis

  2022cites this paper
• REV7 directs DNA repair pathway choice.

  2021cites this paper
• Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells

  2021cites this paper
• Determination of DNA lesion bypass using a ChIP-based assay.

  2021cites this paper
• Protein–Protein Interactions in Translesion Synthesis

  2021cites this paper
• REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps.

  2021cites this paper
• Targeting protein–protein interactions in the DNA damage response pathways for cancer chemotherapy

  2021cites this paper
• Mechanisms for Maintaining Eukaryotic Replisome Progression in the Presence of DNA Damage

  2021cites this paper
• Evaluation and modulation of DNA lesion bypass in an SV40 large T antigen‐based in vitro replication system

  2021cites this paper
• A stapled POL κ peptide targets REV1 to inhibit mutagenic translesion synthesis

  2020cites this paper
• Regulation of Translesion DNA Synthesis in Mammalian Cells.

  2020cites this paper
• Quaternary structural diversity in eukaryotic DNA polymerases: monomeric to multimeric form

  2020cites this paper
• Translesion DNA Synthesis and Carcinogenesis

  2020cites this paper
• A hand-off of DNA between archaeal polymerases allows high-fidelity replication to resume at a discrete intermediate three bases past 8-oxoguanine

  2020cites this paper
• Structure and Mechanism of B-family DNA Polymerase ζ Specialized for Translesion DNA Synthesis

  2020cites this paper
• Translesion synthesis inhibitors as a new class of cancer chemotherapeutics

  2020cites this paper
• Structure‐Based Drug Design of Phenazopyridine Derivatives as Inhibitors of Rev1 Interactions in Translesion Synthesis

  2020cites this paper
• The Rev1-Polζ translesion synthesis mutasome: Structure, interactions and inhibition.

  2019cites this paper
• DNA polymerase ζ in DNA replication and repair

  2019cites this paper
• Virtual Pharmacophore Screening Identifies Small‐Molecule Inhibitors of the Rev1‐CT/RIR Protein–Protein Interaction

  2019cites this paper
• Structure and function relationships in mammalian DNA polymerases

  2019cites this paper
• Structure and function of the disordered regions within translesion synthesis DNA polymerases

  2018cites this paper
• APIM-Mediated REV3L–PCNA Interaction Important for Error Free TLS Over UV-Induced DNA Lesions in Human Cells

  2018cites this paper
• Structural Approach To Identify a Lead Scaffold That Targets the Translesion Synthesis Polymerase Rev1

  2018cites this paper
• Small molecule scaffolds that disrupt the Rev1-CT/RIR protein-protein interaction.

  2018cites this paper
• Rev7 dimerization is important for assembly and function of the Rev1/Polζ translesion synthesis complex

  2018cites this paper
• Impact of tobacco-specific nitrosamine–derived DNA adducts on the efficiency and fidelity of DNA replication in human cells

  2018cites this paper
• Eukaryotic DNA polymerases.

  2018cites this paper
• Identification of small molecule translesion synthesis inhibitors that target the Rev 1-CT / RIR protein-protein interaction

  2018cites this paper
• Mechanisms of DNA damage, repair, and mutagenesis

  2017cites this paper
• The CysB motif of Rev3p involved in the formation of the four‐subunit DNA polymerase ζ is required for defective‐replisome‐induced mutagenesis

  2017cites this paper
• Avoidance of APOBEC3B-induced mutation by error-free lesion bypass

  2017influential citation
• Identification of Small Molecule Translesion Synthesis Inhibitors That Target the Rev1-CT/RIR Protein-Protein Interaction.

  2017cites this paper
• Inhibition of mutagenic translesion synthesis: A possible strategy for improving chemotherapy?

  2017cites this paper
• Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases

  2017cites this paper
• Single-molecule studies contrast ordered DNA replication with stochastic translesion synthesis

  2017cites this paper
• Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication

  2017cites this paper
• Potential Strategies to Target Protein-Protein Interactions in the DNA Damage Response and Repair Pathways.

  2017cites this paper
• Translesion DNA polymerases in eukaryotes: what makes them tick?

  2017influential citation
• Translesion Synthesis: Insights into the Selection and Switching of DNA Polymerases

  2017influential citation
• Translesion Synthesis: An emerging new target during chemotherapy

  2017cites this paper
• Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics.

  2016cites this paper
• R.I.P. to the PIP: PCNA‐binding motif no longer considered specific

  2016cites this paper