Ubiquitin-Binding Motifs in REV1 Protein Are Required for Its Role in the Tolerance of DNA Damage

No abstract is available for this paper.

• Publication year

  2006

• Venue

  Molecular and Cellular Biology

• Publication date

  2006-09-18

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/MCB.01118-06PMID 16982685PMCID PMC1636806
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Lines

  2006cited by this paper
• Analyses of ultraviolet‐induced focus formation of hREV1 protein

  2006cited by this paper
• REV1 protein interacts with PCNA: significance of the REV1 BRCT domain in vitro and in vivo.

  2006cited by this paper
• Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function.

  2005cited by this paper
• Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis

  2005cited by this paper
• Ubiquitylation and cell signaling

  2005cited by this paper
• Multiple Roles of Vertebrate REV Genes in DNA Repair and Recombination

  2005cited by this paper
• The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis

  2005cited by this paper
• Trading places: how do DNA polymerases switch during translesion DNA synthesis?

  2005cited by this paper
• How to activate a damage-tolerant polymerase: consequences of PCNA modifications by ubiquitin and SUMO.

  2004cited by this paper
• Cellular functions of DNA polymerase zeta and Rev1 protein.

  2004cited by this paper
• Rad18 guides polη to replication stalling sites through physical interaction and PCNA monoubiquitination

  2004cited by this paper
• Functions of DNA polymerases.

  2004cited by this paper
• Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage.

  2004cited by this paper
• Interaction of hREV1 with three human Y‐family DNA polymerases

  2004influential reference
• How to Activate a Damage-Tolerant Polymerase

  2004cited by this paper
• Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein.

  2004influential reference
• Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

  2003cited by this paper
• Structure and Enzymatic Properties of a Stable Complex of the Human REV1 and REV7 Proteins*

  2003cited by this paper
• Multiple roles of Rev3, the catalytic subunit of polζ in maintaining genome stability in vertebrates

  2003cited by this paper
• Rev1 is essential for DNA damage tolerance and non‐templated immunoglobulin gene mutation in a vertebrate cell line

  2003cited by this paper
• Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

  2003cited by this paper
• RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

  2002cited by this paper
• Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion.

  2002cited by this paper
• Interactions in the Error-prone Postreplication Repair Proteins hREV1, hREV3, and hREV7*

  2001cited by this paper
• Roles of yeast DNA polymerases delta and zeta and of Rev1 in the bypass of abasic sites.

  2001cited by this paper
• Domain structure, localization, and function of DNA polymerase eta, defective in xeroderma pigmentosum variant cells.

  2001cited by this paper
• The Y-family of DNA polymerases.

  2001cited by this paper
• Evidence for a second function for Saccharomyces cerevisiae Rev1p

  2000cited by this paper
• Distinct roles for Rev1p and Rev7p during translesion synthesis in Saccharomyces cerevisiae

  1999cited by this paper
• Deoxycytidyl transferase activity of yeast REV1 protein

  1996cited by this paper
• Increased ratio of targeted to random integration after transfection of chicken B cell lines.

  1991cited by this paper

• A RAD18 SAP domain PIP motif enables PCNA mono-ubiquitination and USP1-BRCA1 synthetic lethality

  2026cites this paper
• USP1 inhibition: A journey from target discovery to clinical translation.

  2025cites this paper
• Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae.

  2025cites this paper
• Transcriptom Analysis of Auricularia auriculla-judae Fruit Body Treated with Gamma Radiation on Mycelium

  2025cites this paper
• REV1 Coordinates a Multi-Faceted Tolerance Response to DNA Alkylation Damage and Prevents Chromosome Shattering in Drosophila melanogaster

  2024cites this paper
• DNA polymerase η is regulated by mutually exclusive mono-ubiquitination and mono-NEDDylation

  2024cites this paper
• Single-Stranded DNA Gap Accumulation Is a Functional Biomarker for USP1 Inhibitor Sensitivity

  2024cites this paper
• Proliferating Cell Nuclear Antigen: A Novel Growth and Therapeutic Biomarker

  2024cites this paper
• ATR limits Rad18-mediated PCNA monoubiquitination to preserve replication fork and telomerase-independent telomere stability

  2024cites this paper
• REV1 coordinates a multi-faceted tolerance response to DNA alkylation damage and prevents chromosome shattering in Drosophila melanogaster

  2024cites this paper
• REV7 in Cancer Biology and Management

  2023cites this paper
• Rev1 deficiency induces a metabolic shift in MEFs that can be manipulated by the NAD+ precursor nicotinamide riboside

  2023cites this paper
• Two independent DNA repair pathways cause mutagenesis in template switching deficient Saccharomyces cerevisiae

  2023cites this paper
• Role of Translesion DNA Synthesis in the metabolism of replication-associated nascent strand gaps.

  2023cites this paper
• Drug Discovery Targeting Post-Translational Modifications in Response to DNA Damages Induced by Space Radiation

  2023cites this paper
• Mechanistic insights into the multiple activities of the Rad5 family of enzymes.

  2022cites this paper
• Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer

  2022cites this paper
• Genetic and physical interactions between Polη and Rev1 in response to UV-induced DNA damage in mammalian cells

  2021cites this paper
• Protein–Protein Interactions in Translesion Synthesis

  2021cites this paper
• REV7 directs DNA repair pathway choice.

  2021cites this paper
• DNA damage bypass pathways and their effect on mutagenesis in yeast.

  2020cites this paper
• Distinct requirements for budding yeast Rev1 and Polη in translesion DNA synthesis across different types of DNA damage

  2020cites this paper
• A Multifunctional Protein PolDIP2 in DNA Translesion Synthesis.

  2020cites this paper
• Mechanisms of Genome Protection and Repair

  2020cites this paper
• Ubiquitinated-PCNA protects replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly

  2020cites this paper
• Regulation of Translesion DNA Synthesis in Mammalian Cells.

  2020cites this paper
• DNA-damage tolerance through PCNA ubiquitination and sumoylation.

  2020cites this paper
• The ubiquitin ligase RFWD3 is required for translesion DNA synthesis.

  2020cites this paper
• Ubiquitin and Ubiquitin-Like Proteins Are Essential Regulators of DNA Damage Bypass

  2020cites this paper
• Rev1 plays central roles in mammalian DNA‐damage tolerance in response to UV irradiation

  2019cites this paper
• PCNA ubiquitination protects stalled replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly

  2019cites this paper
• Targeting translesion DNA synthesis in the context of cancer therapy

  2019cites this paper
• Simultaneous disruption of two DNA polymerases ,

  2019cites this paper
• The Rev1-Polζ translesion synthesis mutasome: Structure, interactions and inhibition.

  2019cites this paper
• Mechanisms of DNA Damage Tolerance: Post-Translational Regulation of PCNA

  2018cites this paper
• Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction.

  2018cites this paper
• Maneuvers on PCNA Rings during DNA Replication and Repair

  2018cites this paper
• Small-molecules that bind to the ubiquitin-binding motif of REV1 inhibit REV1 interaction with K164-monoubiquitinated PCNA and suppress DNA damage tolerance.

  2018cites this paper
• Structural Basis for the Interaction of Mutasome Assembly Factor REV1 with Ubiquitin.

  2018cites this paper
• Elevated expression of REV 1 is a predictor of unfavorable prognosis in patients with prostate cancer

  2018cites this paper
• Ubiquitylation at the Fork: Making and Breaking Chains to Complete DNA Replication

  2018influential citation
• Coordination and Substitution of DNA Polymerases in Response to Genomic Obstacles.

  2017cites this paper
• SUMO a la retina: expressió gènica i rellevància en la modificació posttaducciontal del factor de transcripció NRE3

  2017cites this paper
• Parkin regulates translesion DNA synthesis in response to UV radiation

  2017cites this paper
• Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork.

  2017cites this paper
• RBM45 competes with HDAC1 for binding to FUS in response to DNA damage

  2017cites this paper
• Functions of Multiple Clamp and Clamp-Loader Complexes in Eukaryotic DNA Replication.

  2017cites this paper
• Translesion DNA polymerases in eukaryotes: what makes them tick?

  2017cites this paper
• Potential Strategies to Target Protein-Protein Interactions in the DNA Damage Response and Repair Pathways.

  2017cites this paper
• Maintenance of Genome Integrity: How Mammalian Cells Orchestrate Genome Duplication by Coordinating Replicative and Specialized DNA Polymerases

  2017cites this paper
• Structural Insight into the Mechanisms of Activation and Substrate Specificity of Human Deubiquitinating Enzyme USP7

  2016cites this paper
• Translesion DNA Synthesis and Damage Tolerance Pathways

  2016cites this paper
• The regulation of translesion synthesis through the binding and activation of polymerases by PCNA

  2016cites this paper
• iTRAQ-based chromatin proteomic screen reveals CHD4-dependent recruitment of MBD2 to sites of DNA damage.

  2016cites this paper
• USP7 is essential for maintaining Rad18 stability and DNA damage tolerance

  2016cites this paper
• REV1 promotes PCNA monoubiquitylation through interacting with ubiquitylated RAD18

  2016influential citation
• Aberrant Kynurenine Signaling Modulates DNA Replication Stress Factors and Promotes Genomic Instability in Gliomas.

  2016cites this paper
• Interaction between the Rev 1 C-Terminal Domain and the PolD 3 Subunit of Pol Suggests a Mechanism of Polymerase Exchange upon Rev 1 / Pol-Dependent

  2016cites this paper
• Targeting the Translesion Synthesis Pathway for the Development of Anti-Cancer Chemotherapeutics.

  2016cites this paper
• Kynurenine Signaling Increases DNA Polymerase Kappa Expression and Promotes Genomic Instability in Glioblastoma Cells.

  2016cites this paper
• Interaction between the Rev1 C-Terminal Domain and the PolD3 Subunit of Polζ Suggests a Mechanism of Polymerase Exchange upon Rev1/Polζ-Dependent Translesion Synthesis.

  2016cites this paper
• Eukaryotic TLS polymerases.

  2016cites this paper
• The Many Roles of PCNA in Eukaryotic DNA Replication.

  2016cites this paper
• The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line.

  2016cites this paper
• Eukaryotic DNA Polymerases in Homologous Recombination.

  2016cites this paper
• Erratum: The Regulation of DNA Damage Tolerance by Ubiquitin and Ubiquitin-Like Modifiers

  2016cites this paper
• FF483–484 motif of human Polη mediates its interaction with the POLD2 subunit of Polδ and contributes to DNA damage tolerance

  2015cites this paper
• Translesion synthesis and mutations: On the mutagenic properties of the two DNA lesions, 8-oxo-G and Pt-GG, and the functions of Y-family DNA polymerases and Rev3L on the bypass of each of the DNA lesions in mammalian cells

  2015cites this paper
• Starvation promotes REV1 SUMOylation and p53-dependent sensitization of melanoma and breast cancer cells.

  2015cites this paper
• FF 483–484 motif of human Pol (cid:2) mediates its interaction with the POLD2 subunit of Pol (cid:3) and contributes to DNA damage tolerance

  2015cites this paper
• A novel role for the mono-ADP-ribosyltransferase PARP14/ARTD8 in promoting homologous recombination and protecting against replication stress

  2015cites this paper
• Starvation Promotes REV 1 SUMOylation and p 53-Dependent Sensitization of Melanoma and Breast Cancer Cells

  2015cites this paper
• Eukaryotic DNA polymerase ζ.

  2015cites this paper
• REV1 is important for the ATR-Chk1 DNA damage response pathway in Xenopus egg extracts.

  2015cites this paper
• Regulation of translesion DNA synthesis: Posttranslational modification of lysine residues in key proteins.

  2015cites this paper
• Regulation of the Rev1–pol ζ complex during bypass of a DNA interstrand cross‐link

  2015cites this paper
• Les fonctions et rôles régulateurs de l'acétylation dans le maintien de l'intégrité du génome

  2015cites this paper
• Roles of mutagenic translesion synthesis in mammalian genome stability, health and disease.

  2015cites this paper
• FANCD2 and REV1 cooperate in the protection of nascent DNA strands in response to replication stress

  2015influential citation
• Organizing the Ubiquitin-dependent Response to DNA Double-Strand Breaks

  2014cites this paper
• A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) Inhibits Repair of Interstrand DNA Cross-link, Enhances DNA Double Strand Break, and Sensitizes Cancer Cells to Cisplatin*

  2014cites this paper
• A small molecule inhibitor of monoubiquitinated proliferating cell nuclear antigen (PCNA) inhibits repair of interstrand DNA crosslink, enhances DNA double-strand break, and sensitizes cancer cells to cisplatin

  2014cites this paper
• DNA repair systems

  2014cites this paper
• Anti-cancer implications of small molecule compounds targeting proliferating cell nuclear antigen

  2014cites this paper
• The role of ubiquitin-binding domains in human pathophysiology

  2014cites this paper
• Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage

  2014cites this paper
• The ADP-ribosyltransferase PARP10/ARTD10 Interacts with Proliferating Cell Nuclear Antigen (PCNA) and Is Required for DNA Damage Tolerance*

  2014cites this paper
• DNA-damage tolerance mediated by PCNA•Ub fusions in human cells is dependent on Rev1 but not Polη

  2013cites this paper
• DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures

  2013cites this paper
• Readers of PCNA modifications

  2013cites this paper
• REV7 is required for anaphase-promoting complex-dependent ubiquitination and degradation of translesion DNA polymerase REV1

  2013cites this paper
• Studies of Proliferating Cell Nuclear Antigen Mutant Proteins Defective in Translesion Synthesis and Mismatch Repair

  2013cites this paper
• Translesion DNA synthesis and mutagenesis in eukaryotes.

  2013influential citation
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  2013cites this paper
• A non-catalytic function of Rev1 in translesion DNA synthesis and mutagenesis is mediated by its stable interaction with Rad5.

  2013cites this paper
• Mouse DNA polymerase kappa has a functional role in the repair of DNA strand breaks.

  2013cites this paper
• Amot130 Adapts Atrophin-1 Interacting Protein 4 to Inhibit Yes-associated Protein Signaling and Cell Growth*

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• THE INHIBITION OF MAMMARY EPITHELIAL CELL GROWTH BY THE LONG ISOFORM OF ANGIOMOTIN

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  2013cites this paper