Brief Definitive Report Strand-biased Defect in C/g Transversions in Hypermutating Immunoglobulin Genes in Rev1-defi Cient Mice

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• The catalytic activity of REV1 is employed during immunoglobulin gene diversification in DT40.

  2006cited by this paper
• The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis

  2005cited by this paper
• An update on the role of translesion synthesis DNA polymerases in Ig hypermutation.

  2005cited by this paper
• The Relative Roles in Vivo of Saccharomyces cerevisiae Pol η, Pol ζ, Rev1 Protein and Pol32 in the Bypass and Mutation Induction of an Abasic Site, T-T (6-4) Photoadduct and T-T cis-syn Cyclobutane Dimer

  2005cited by this paper
• Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouse

  2005cited by this paper
• Eukaryotic translesion synthesis DNA polymerases: specificity of structure and function.

  2005cited by this paper
• Complex Formation of Yeast Rev1 and Rev7 Proteins: a Novel Role for the Polymerase-Associated Domain

  2005cited by this paper
• Co-localization in replication foci and interaction of human Y-family members, DNA polymerase pol eta and REVl protein.

  2004cited by this paper
• Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation.

  2004cited by this paper
• Interaction of hREV1 with three human Y‐family DNA polymerases

  2004cited by this paper
• 129-derived Strains of Mice Are Deficient in DNA Polymerase ι and Have Normal Immunoglobulin Hypermutation

  2003cited by this paper
• Mouse Rev1 protein interacts with multiple DNA polymerases involved in translesion DNA synthesis

  2003cited by this paper
• Rev1 is essential for DNA damage tolerance and non‐templated immunoglobulin gene mutation in a vertebrate cell line

  2003cited by this paper
• Immunity through DNA deamination.

  2003cited by this paper
• Response of human REV1 to different DNA damage: preferential dCMP insertion opposite the lesion.

  2002cited by this paper
• Involvement of Mouse Rev3 in Tolerance of Endogenous and Exogenous DNA Damage

  2002cited by this paper
• Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice.

  2002cited by this paper
• Mechanisms of dCMP Transferase Reactions Catalyzed by Mouse Rev1 Protein*

  2002cited by this paper
• Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.

  2000cited by this paper
• Hypermutation of Immunoglobulin Genes in Memory B Cells of DNA Repair–deficient Mice

  1998cited by this paper
• Clonal selection and learning in the antibody system

  1996cited by this paper
• ATTEMPTS TO LOCATE COMPLEMENTARITY‐DETERMINING RESIDUES IN THE VARIABLE POSITIONS OF LIGHT AND HEAVY CHAINS *

  1971cited by this paper

• Roles of trans-lesion synthesis (TLS) DNA polymerases in tumorigenesis and cancer therapy

  2023influential citation
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  2023cites this paper
• Somatic mutation patterns at Ig and Non-Ig Loci.

  2023cites this paper
• Leveraging the replication stress response to optimize cancer therapy

  2022cites this paper
• CRISPR-based genome editing through the lens of DNA repair.

  2022cites this paper
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  2022cites this paper
• Division of labor within the DNA damage tolerance system reveals non-epistatic and clinically actionable targets for precision cancer medicine

  2022cites this paper
• SARS-CoV-2 hijacks host cell genome instability pathways

  2022cites this paper
• Tandem Substitutions in Somatic Hypermutation

  2022cites this paper
• Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1

  2021cites this paper
• Human Rev1 relies on insert-2 to promote selective binding and accurate replication of stabilized G-quadruplex motifs

  2021cites this paper
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  2020cites this paper
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  2020cites this paper
• Translesion synthesis polymerases are dispensable for C. elegans reproduction but suppress genome scarring by polymerase theta-mediated end joining

  2020cites this paper
• A Tale of Two Moieties: Rapidly Evolving CRISPR/Cas-Based Genome Editing.

  2020cites this paper
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  2020cites this paper
• Genome-wide mutational signatures revealed distinct developmental paths for human B cell lymphomas

  2020cites this paper
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  2020cites this paper
• REV7 is required for processing AID initiated DNA lesions in activated B cells

  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2019cites this paper
• Regulation of the Germinal Center Reaction and Somatic Hypermutation Dynamics by Homologous Recombination

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  2019cites this paper
• Base Excision DNA Repair Deficient Cells: From Disease Models to Genotoxicity Sensors.

  2019cites this paper
• Simultaneous discovery of candidate imprinted genes and Imprinting Control Regions in the mouse genome

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• What Targets Somatic Hypermutation to the Immunoglobulin Loci?

  2019cites this paper
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  2019cites this paper
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  2019influential citation
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
• Molecular Mechanisms of Somatic Hypermutation and Class Switch Recombination.

  2017cites this paper
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  2017cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Rev1 is a base excision repair enzyme with 5′-deoxyribose phosphate lyase activity

  2016cites this paper
• Cell Cycle Regulates Nuclear Stability of AID and Determines the Cellular Response to AID

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  2015cites this paper
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  2015cites this paper
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  2013cites this paper
• Translesion DNA synthesis and mutagenesis in eukaryotes.

  2013cites this paper
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