p53 mutation, expression, and DNA ploidy in evolving gliomas: evidence for two pathways of progression.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Journal of the National Cancer Institute

• Publication date

  1994-07-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1093/JNCI/86.13.1011PMID 8007011
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Supratentorial recurrences of gliomas. Morphological studies in relation to time intervals with astrocytomas

  2005cited by this paper
• Histologic and non-histologic factors correlated with survival time in supratentorial astrocytic tumors

  2005cited by this paper
• p53 protein expression in central nervous system tumors: an immunohistochemical study with CM1 polyvalent and DO-7 monoclonal antibodies

  2004cited by this paper
• The p53 Gene and Protein in Human Brain Tumors

  1994cited by this paper
• Absence of hereditary mutations in exons 5 through 9 of the p53 gene and exon 24 of the neurofibromin gene in families with glioma

  1994cited by this paper
• Comparative Study of p53 Gene and Protein Alterations in Human Astrocytic Tumors

  1993cited by this paper
• Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations.

  1993cited by this paper
• Mutations in the p53 gene in human astrocytomas: detection by single-strand conformation polymorphism analysis and direct DNA sequencing.

  1993cited by this paper
• p53 is required for radiation-induced apoptosis in mouse thymocytes

  1993cited by this paper
• Association of p53 protein expression with tumor cell proliferation rate and clinical outcome in node-negative breast cancer.

  1993cited by this paper
• Gene and chromosomal alterations associated with the development of human gliomas

  1993cited by this paper
• The New WHO Classification of Brain Tumours

  1993cited by this paper
• Mutations of the p53 tumor suppressor gene in neoplasms of the human nervous system

  1993cited by this paper
• p53 and the Li-Fraumeni syndrome.

  1993cited by this paper
• Frequency of p53 tumor suppressor gene mutations in human primary brain tumors.

  1993cited by this paper
• Accumulation of wild type p53 protein in human astrocytomas.

  1993cited by this paper
• Sensitivity of single-strand conformation polymorphism (SSCP) analysis in detecting p53 point mutations in tumors with mixed cell populations.

  1993cited by this paper
• Thymocyte apoptosis induced by p53-dependent and independent pathways

  1993cited by this paper
• A Correlative Study of p53 Protein Alteration and p53 Gene Mutation in Glioblastoma Multiforme

  1993cited by this paper
• Timing of p53 mutations during astrocytoma tumorigenesis.

  1993cited by this paper
• Correlation of cytogenetic analysis and loss of heterozygosity studies in human diffuse astrocytomas and mixed oligo‐astrocytomas

  1992cited by this paper
• Clonal expansion of p53 mutant cells is associated with brain tumour progression

  1992cited by this paper
• Evidence for the involvement of a potential second tumor suppressor gene on chromosome 17 distinct from p53 in malignant astrocytomas.

  1992cited by this paper
• TP53 tumor suppressor gene: A model for investigating human mutagenesis

  1992cited by this paper
• Accumulation of p53 tumor suppressor gene protein: an independent marker of prognosis in breast cancers.

  1992cited by this paper
• Nucleotide sequence polymorphism in a hotspot mutation region of the p53 gene.

  1992cited by this paper
• Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53.

  1992cited by this paper
• p53 mutations in human malignant gliomas: comparison of loss of heterozygosity with mutation frequency.

  1992cited by this paper
• Mutation spectrum of the p53 gene in bone and soft tissue sarcomas.

  1992cited by this paper
• Small subgroup of aggressive, highly proliferative prostatic carcinomas defined by p53 accumulation.

  1992cited by this paper
• Suspected low‐grade glioma: Is deferring treatment safe?

  1992cited by this paper
• p53 mutations are associated with 17p allelic loss in grade II and grade III astrocytoma.

  1992cited by this paper
• Molecular characterization of areas with low grade tumor or satellitosis in human malignant astrocytomas.

  1992cited by this paper
• p53 mutation and loss of heterozygosity on chromosomes 17 and 10 during human astrocytoma progression.

  1992cited by this paper
• Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells.

  1992cited by this paper
• Cancer. p53, guardian of the genome.

  1992cited by this paper
• Multiple sequential molecular abnormalities in the evolution of human gliomas.

  1991cited by this paper
• Detection of p53 gene mutations in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products.

  1991cited by this paper
• Timing and role of p53 gene mutation in the recurrence of glioma.

  1991cited by this paper
• The p53 tumour suppressor gene

  1991cited by this paper
• p53 mutations in human cancers.

  1991cited by this paper
• Antigen retrieval in formalin-fixed, paraffin-embedded tissues: an enhancement method for immunohistochemical staining based on microwave oven heating of tissue sections.

  1991cited by this paper
• TP53 Gene Mutations and 17p Deletions in Human Astrocytomas

  1991cited by this paper
• Germ-line transmission of a mutated p53 gene in a cancer-prone family with Li–Fraumeni syndrome

  1990cited by this paper
• Increased expression of mutant forms of p53 oncogene in primary lung cancer.

  1990cited by this paper
• Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms.

  1990cited by this paper
• Cytologic composition of the untreated glioblastoma with implications for evaluation of needle biopsies

  1989cited by this paper
• Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction.

  1989cited by this paper
• Mitotic recombination of chromosome 17 in astrocytomas.

  1989cited by this paper
• Supratentorial anaplastic gliomas in adults. The prognostic importance of extent of resection and prior low-grade glioma.

  1989cited by this paper
• Mutations in the p53 gene occur in diverse human tumour types

  1989cited by this paper
• Loss of distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human astrocytomas.

  1989cited by this paper
• Clonal genomic alterations in glioma malignancy stages.

  1988cited by this paper
• Activating mutations for transformation by p53 produce a gene product that forms an hsc70-p53 complex with an altered half-life

  1988cited by this paper
• Mechanisms of tumor progression.

  1986cited by this paper
• Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry.

  1983cited by this paper

• Patient-Derived Xenotransplant of CNS Neoplasms in Zebrafish: A Systematic Review

  2022cites this paper
• TP53 Mutation Is a Prognostic Factor in Lower Grade Glioma and May Influence Chemotherapy Efficacy

  2021cites this paper
• Stepwise crosstalk between aberrant Nf1, Tp53 and Rb signalling pathways induces gliomagenesis in zebrafish

  2020cites this paper
• A comprehensive overview on the molecular biology of human glioma: what the clinician needs to know

  2020influential citation
• Developmental origins and oncogenic pathways in malignant brain tumors

  2019cites this paper
• Contemporary Diagnosis of Gliomas using Biomarkers

  2016cites this paper
• Expression and Prognostic Significance of p53 in Glioma Patients: A Meta-analysis

  2016cites this paper
• Molecular Pathways in Gliomagenesis and Their Relevance to Neuropathologic Diagnosis

  2015cites this paper
• The proteomic landscape of glioma stem-like cells

  2015cites this paper
• Biomarker-driven diagnosis of diffuse gliomas.

  2015cites this paper
• Case presentation - A five-year survival of the patient with glioblastoma brain tumor.

  2014cites this paper
• Dissecting the role of Toll-like receptors in microglia-glioma crosstalk

  2014cites this paper
• Molecular genetics of gliomas.

  2014cites this paper
• IDH/MGMT-driven molecular classification of low-grade glioma is a strong predictor for long-term survival.

  2013cites this paper
• Dissection of Complex Genetic and Epigenetic Interactions Underlying NF1 Cancer Susceptibility Using Mouse Models

  2012cites this paper
• Mechanistic Studies On the Role of Polyamines and Microvesicles in Tumor Growth and Hypoxia-mediated Angiogenesis

  2012cites this paper
• Factors predicting progression of low-grade diffusely infiltrating astrocytoma.

  2011cites this paper
• Roles of p53 and p27 Kip1 in the regulation of neurogenesis in the murine adult subventricular zone

  2011cites this paper
• Zytogenetische Grundlage der malignen Progression anaplastischer Astrozytome: Chromosomale Aberrationen von Primärtumoren, Rezidiven und ihr Einfluss auf das Überleben

  2011cites this paper
• Gliomagenesis and the use of neural stem cells in brain tumor treatment.

  2010cites this paper
• Analysis of 2 Antiapoptotic Factors in Gliomas

  2009cites this paper
• The Nf1–/+; Trp53–/+cis Mouse Model of Anaplastic Astrocytoma and Secondary Glioblastoma: Dissecting Genetic Susceptibility to Brain Cancer

  2009cites this paper
• [Update on the molecular biology of gliomas: towards a pathomolecular classification of gliomas].

  2007cites this paper
• Genetically distinct astrocytic and oligodendroglial components in oligoastrocytomas

  2007cites this paper
• Actualización sobre la biología molecular de los gliomas: hacia una clasificación patomolecular de los gliomas

  2007cites this paper
• Apaf1 in Chronic Myelogenous Leukemia (CML) Progression: Reduced Apaf1 Expression is Correlated with a H179R p53 Mutation During Clinical Blast Crisis

  2007cites this paper
• Cytogenetic and molecular genetic analyses of giant cell glioblastoma multiforme reveal distinct profiles in giant cell and non-giant cell subpopulations.

  2007cites this paper
• Incidence of the main genetic markers in glioblastoma multiforme is independent of tumor topology.

  2007cites this paper
• Supratentorial glioblastoma in adults: Identification of subsets and their clinical correlation

  2006cites this paper
• Immunohistochemical analysis of p53 and p21 in human primary glioblastomas in relation to proliferative potential and apoptosis

  2006cites this paper
• Brief Wild-Type p53 Renders Mouse Astrocytes Resistant to l,3-Bis(2-chloroethyl)-l-nitrosourea despite the Absence of a p53-dependent Cell Cycle Arrest1

  2006cites this paper
• Stage-specific gene expression during hepatocarcinogenesis in the rat

  2005cites this paper
• Molecular Pathology of Nervous System Tumors

  2005cites this paper
• Clarifying the diffuse gliomas: an update on the morphologic features and markers that discriminate oligodendroglioma from astrocytoma.

  2005cites this paper
• Genetics of glioblastoma multiforme: mitogenic signaling and cell cycle pathways converge.

  2005cites this paper
• DETECCIÓN DE HIPERMETILACIÓN DE GENES SUPRESORES TUMORALES EN ASTROCITOMAS

  2005cites this paper
• Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma.

  2005cites this paper
• Genetic Pathways in the Evolution of Gliomas

  2005cites this paper
• [Towards a molecular classification of gliomas].

  2005cites this paper
• Prognostic Significance of p 53 Immunoreactivity in Patients with Glioma 1

  2005cites this paper
• Risk of Brain Tumours in Firemen

  2005cites this paper
• Clarifying the Diffuse Gliomas

  2005cites this paper
• Predictive Value of p 53 Mutations Analyzed in Bladder Washings for Progression of High-Risk Superficial Bladder Cancer 1

  2005cites this paper
• Primary and secondary glioblastomas : From concept to clinical diagnosis 1

  2005cites this paper
• The role of transforming growth factor Β in glioma progression

  2004cites this paper
• Development of novel targeted therapies in the treatment of malignant glioma

  2004cites this paper
• Prognostic impact of TP53 mutation status for adult patients with supratentorial World Health Organization Grade II astrocytoma or oligoastrocytoma

  2004cites this paper
• Parathyroid hormone–related protein expression is correlated with clinical course in patients with glial tumors

  2004cites this paper
• Relaçăo entre imunomarcaçăo das proteínas Ki-67 e p53 com grau de malignidade e variante histológica em neoplasias astrocitárias /

  2004cites this paper
• Molecular prognostic factors in bladder cancer

  2004cites this paper
• Association of p53 tumor suppressor gene with paraclinical and clinical modalities of gliomas patients in Malaysia

  2004cites this paper
• The role of apoptosis, cell proliferation index, bcl-2, and p53 in glioblastoma prognosis.

  2004cites this paper
• The effect of p53 gene mutational status, EGFR expression and proliferative potential on clinical outcome in patients with astrocytic glial tumours.

  2003cites this paper
• Modulation de l'incorporation de la 5-[¹²⁵I]-iodo-2'-désoxyuridine dans des glioblastomes

  2003cites this paper
• Sociodemographic indicators and risk of brain tumours.

  2003cites this paper
• Prognostic impact of TP53 mutations and P53 protein overexpression in supratentorial WHO grade II astrocytomas and oligoastrocytomas.

  2002cites this paper
• The influence of chronic pancreatitis on carcinogenesis: an experimental study in rats

  2002cites this paper
• Recurrent astrocytic tumours - a study of p53 immunoreactivity and malignant progression

  2002cites this paper
• The Molecular and Genetic Basis of Neurological Tumours

  2002cites this paper
• Evaluation of Molecular Markers in Low-Grade Diffuse Astrocytomas: Loss of p16 and Retinoblastoma Protein Expression Is Associated With Short Survival

  2002cites this paper
• Genetic alterations associated with adult diffuse astrocytic tumors.

  2002cites this paper
• Genetic alterations associated with development of human diffusely infiltrating astrocytomas = Alterações genéticas associadas com o desenvolvimento dos astrocitomas infiltrativos difusos humanos

  2001cites this paper
• TP53 Gene Mutations, Nuclear p53 Accumulation, Expression of Waf/p21, Bcl-2, and CD95 (APO-1/Fas) Proteins are not Prognostic Factors in De Novo Glioblastoma Multiforme

  2001cites this paper
• Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas

  2001cites this paper
• Genetically engineered mouse models of astrocytoma: GEMs in the rough?

  2001cites this paper
• Neuropathology and Molecular Pathogenesis of Primary Brain Tumors

  2001cites this paper
• Animal Models of Cell Cycle Dysregulation and the Pathogenesis of Gliomas

  2001cites this paper
• Second Primary Glioblastoma

  2001cites this paper
• Analysis of 2 antiapoptotic factors in gliomas: bcl-2 overexpression and p53 mutations.

  2001cites this paper
• Mutation analysis of hBUB1, hBUBR1 and hBUB3 genes in glioblastomas

  2001cites this paper
• Gliomagenesis: genetic alterations and mouse models

  2001cites this paper
• Genetic alterations in adult diffuse glioma: occurrence, significance, and prognostic implications.

  2000cites this paper
• Early genetic events in the formation of astrocytomas

  2000cites this paper
• Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects

  2000cites this paper
• evidence of strain-specific effects

  2000cites this paper
• Pathologic significance of proliferative activity and oncoprotein expression in astrocytic tumors.

  2000cites this paper
• Overexpression of p53 in prostate carcinoma is associated with improved overall survival but not predictive of response to radiotherapy.

  2000cites this paper
• Investigation of germline PTEN, p53, p16(INK4A)/p14(ARF), and CDK4 alterations in familial glioma.

  2000cites this paper
• A Mouse Model for Glioma: Biology, Pathology, and Therapeutic Opportunities

  2000cites this paper
• O(6)-methylguanine-DNA methyltransferase activity, p53 gene status and BCNU resistance in mouse astrocytes.

  1999cites this paper
• p53 and the CNS

  1999cites this paper
• Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression.

  1999cites this paper
• Molecular analysis of microdissected de novo glioblastomas and paired astrocytic tumors.

  1999cites this paper
• p53 and the CNS: tumors and developmental abnormalities.

  1999cites this paper
• Cells with TP53 mutations in low grade astrocytic tumors evolve clonally to malignancy and are an unfavorable prognostic factor

  1999cites this paper
• p53 protein overexpression is a prognostic indicator of poor survival in stage I endometrial carcinoma.

  1999cites this paper
• Primary and secondary glioblastomas: from concept to clinical diagnosis.

  1999cites this paper
• Implications of prognostic markers in brain tumors.

  1999cites this paper
• Evaluation of p53 protein expression and proliferative potential based on the MIB‐1 positive index in astrocytic gliomas

  1998cites this paper
• Accumulation of p53 and Ki-67 expression do not predict survival in patients with fibrillary astrocytomas or the response of these tumors to radiotherapy.

  1998cites this paper
• Correlation of bcl-2, p53, and MIB-1 expression with ependymoma grade and subtype.

  1998cites this paper
• Genetic instability leads to loss of both p53 alleles in a human glioblastoma

  1998cites this paper
• p53 and Brain Tumors: From Gene Mutations to Gene Therapy

  1998cites this paper
• p53 protein expression in grade II astrocytomas: immunohistochemical study of 100 cases with long-term follow-up.

  1998cites this paper
• Chemosensitivity of human malignant glioma: modulation by p53 gene transfer

  1998cites this paper
• A constitutively active epidermal growth factor receptor cooperates with disruption of G1 cell-cycle arrest pathways to induce glioma-like lesions in mice.

  1998cites this paper
• The role of transforming growth factor beta in glioma progression.

  1998cites this paper
• Modeling mutations in the G1 arrest pathway in human gliomas: overexpression of CDK4 but not loss of INK4a-ARF induces hyperploidy in cultured mouse astrocytes.

  1998cites this paper
• Patterns of tumor progression after radiotherapy for low-grade gliomas: analysis from the computed tomography/magnetic resonance imaging era.

  1998cites this paper
• Survival of Patients with Glioblastoma Multiforme is not Influenced by Altered Expression of P16, P53, EGFR, MDM2 or Bcl‐2 Genes

  1998cites this paper