Convergence of Notch and β-catenin signaling induces arterial fate in vascular progenitors

The Notch intracellular domain and β-catenin team up with RBP-J to regulate gene transcription and promote the development of arterial endothelial cells.

• Publication year

  2010

• Venue

  Journal of Cell Biology

• Publication date

  2010-04-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1083/jcb.200904114PMID 20404113PMCID 2856895
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries.

  2009influential reference
• Enhancement of vascular progenitor potential by protein kinase A through dual induction of Flk-1 and Neuropilin-1.

  2009cited by this paper
• Notch mediates Wnt and BMP signals in the early separation of smooth muscle progenitors and blood/endothelial common progenitors

  2009cited by this paper
• Deciphering the function of canonical Wnt signals in development and disease: conditional loss- and gain-of-function mutations of beta-catenin in mice.

  2008cited by this paper
• Stabilized β-Catenin Functions through TCF/LEF Proteins and the Notch/RBP-Jκ Complex To Promote Proliferation and Suppress Differentiation of Neural Precursor Cells

  2008cited by this paper
• Notch signaling is essential for ventricular chamber development.

  2007cited by this paper
• Wnt/beta-catenin signaling in development and disease.

  2006cited by this paper
• Adrenomedullin/Cyclic AMP Pathway Induces Notch Activation and Differentiation of Arterial Endothelial Cells From Vascular Progenitors

  2006cited by this paper
• Jagged 1 is a β-catenin target gene required for ectopic hair follicle formation in adult epidermis

  2006cited by this paper
• Activated Notch1 alters differentiation of embryonic stem cells into mesodermal cell lineages at multiple stages of development.

  2006cited by this paper
• Prospective identification of cardiac progenitors by a novel single cell‐based cardiomyocyte induction

  2005cited by this paper
• Notch modulates Wnt signalling by associating with Armadillo/β-catenin and regulating its transcriptional activity

  2005cited by this paper
• Wnt signaling in disease and in development

  2005cited by this paper
• Integration of Notch and Wnt signaling in hematopoietic stem cell maintenance

  2005cited by this paper
• Faculty Opinions recommendation of Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

  2005cited by this paper
• Self-Renewal and Cancer of the Gut: Two Sides of a Coin

  2005cited by this paper
• Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

  2005cited by this paper
• The role of CXCL12 in the organ-specific process of artery formation.

  2005cited by this paper
• Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice.

  2005cited by this paper
• Notch signaling: control of cell communication and cell fate

  2004cited by this paper
• Dosage-sensitive requirement for mouse Dll4 in artery development.

  2004influential reference
• The Wnt/β-catenin pathway directs neuronal differentiation of cortical neural precursor cells

  2004cited by this paper
• Wnt signaling in the vasculature

  2004cited by this paper
• Haploinsufficient lethality and formation of arteriovenous malformations in Notch pathway mutants.

  2004cited by this paper
• The conditional inactivation of the β-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility

  2003influential reference
• Regulation of Angiogenesis by Glycogen Synthase Kinase-3β*

  2002cited by this paper
• Role of Akt Signaling in Vascular Homeostasis and Angiogenesis

  2002cited by this paper
• Construction of first-generation adenoviral vectors.

  2002cited by this paper
• The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells.

  2002cited by this paper
• Mouse Wnt receptor gene Fzd5 is essential for yolk sac and placental angiogenesis.

  2001cited by this paper
• Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways

  2001cited by this paper
• Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels.

  2001influential reference
• Notch signaling is required for arterial-venous differentiation during embryonic vascular development.

  2001cited by this paper
• Identification of Tyrosine Residues in Vascular Endothelial Growth Factor Receptor-2/FLK-1 Involved in Activation of Phosphatidylinositol 3-Kinase and Cell Proliferation*

  2001cited by this paper
• Gridlock signalling pathway fashions the first embryonic artery

  2001cited by this paper
• She Made Me Go out of My Mind: Marital violence from the male point of view

  2001cited by this paper
• Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors

  2000cited by this paper
• VISTA : visualizing global DNA sequence alignments of arbitrary length

  2000cited by this paper
• Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.

  1999cited by this paper
• Notch Signaling : Cell Fate Control and Signal Integration in Development

  1999cited by this paper
• Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation

  1999cited by this paper
• Notch signaling: cell fate control and signal integration in development.

  1999cited by this paper
• Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1.

  1999influential reference
• Vascular endothelial (VE)-cadherin: only an intercellular glue?

  1999cited by this paper
• The Role of Glycogen Synthase Kinase 3β in Insulin-stimulated Glucose Metabolism*

  1999cited by this paper
• Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos.

  1998cited by this paper
• Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4.

  1998cited by this paper
• The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract

  1998cited by this paper
• lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H).

  1996cited by this paper
• Targeted disruption of the Wnt2 gene results in placentation defects.

  1996influential reference
• Cell-cell signalling: Wingless lands at last.

  1996cited by this paper
• Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

  1995influential reference
• CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

  1994cited by this paper

• Decoding 'Wntch': the intertwined Wnt and Notch pathways in development and disease.

  2026cites this paper
• Notch Signaling as a Way to Control the Endothelial-To-Mesenchymal Transition

  2025cites this paper
• Evaluating the transcriptional regulators of arterial gene expression via a catalogue of characterized arterial enhancers

  2025cites this paper
• Optimizing extracellular matrix for endothelial differentiation using a design of experiments approach

  2025cites this paper
• Notch2 Regulates the Function of Bovine Follicular Granulosa Cells via the Wnt2/β-Catenin Signaling Pathway

  2024cites this paper
• CD32 captures committed haemogenic endothelial cells during human embryonic development

  2024cites this paper
• p21 Regulates Wnt-Notch balance via DREAM/MMB/Rb-E2F1 and maintains intestinal stem cell homeostasis

  2024cites this paper
• Efficient generation of liver sinusoidal endothelial-like cells secreting coagulation factor VIII from human induced pluripotent stem cells

  2024cites this paper
• CD32 allows capturing blood cells emergence in slow motion during human embryonic development

  2023cites this paper
• GSK3β Inhibition Reduced Vascular Calcification in Ins2Akita/+ Mice

  2023influential citation
• Transcription factors regulating vasculogenesis and angiogenesis

  2023cites this paper
• Activation of mTOR signaling in adult lung microvascular progenitor cells accelerates lung aging

  2023cites this paper
• Molecular Mechanisms in Genetic Aortopathy–Signaling Pathways and Potential Interventions

  2023cites this paper
• Pioneering therapies for post-infarction angiogenesis: Insight into molecular mechanisms and preclinical studies.

  2023cites this paper
• Direct differentiation of human pluripotent stem cells into vascular network along with supporting mural cells

  2023cites this paper
• Transcriptional regulators of arterial and venous identity in the developing mammalian embryo

  2023cites this paper
• miR-342-5p downstream to Notch enhances arterialization of endothelial cells in response to shear stress by repressing MYC

  2023cites this paper
• PI(4,5)P2-dependent regulation of endothelial tip cell specification contributes to angiogenesis

  2023cites this paper
• GSK3β Inhibition Ameliorates Atherosclerotic Calcification

  2023cites this paper
• Gypensapogenin I Suppresses Cell Proliferation in Triple-Negative Breast Cancer Via Triggering the Closure of AKT/GSK3β/β-Catenin and Notch-1 Signaling Pathways.

  2022cites this paper
• Epithelial–mesenchymal transition in organ fibrosis development: current understanding and treatment strategies

  2022cites this paper
• Laminin 411 mediates endothelial specification via multiple signaling axes that converge on β-catenin

  2022cites this paper
• Spatial regulation and generation of diversity in signaling pathways

  2021cites this paper
• SOX17 integrates HOXA and arterial programs in hemogenic endothelium to drive definitive lympho-myeloid hematopoiesis

  2021cites this paper
• In Silico Logical Modelling to Uncover Cooperative Interactions in Cancer

  2021cites this paper
• Spatial regulation and generation of diversity in signaling pathways

  2021cites this paper
• When Viruses Cross Developmental Pathways

  2021cites this paper
• Role of Goblet Cells in Intestinal Barrier and Mucosal Immunity

  2021cites this paper
• Shifting osteogenesis in vascular calcification

  2021cites this paper
• A High-Efficiency Method for the Production of Endothelial Cells from Human Induced Pluripotent Stem Cells.

  2021cites this paper
• CAFs‐derived MFAP5 promotes bladder cancer malignant behavior through NOTCH2/HEY1 signaling

  2020cites this paper
• MicroRNA-24-3p Targets Notch and Other Vascular Morphogens to Regulate Post-ischemic Microvascular Responses in Limb Muscles

  2020cites this paper
• Notch signaling requiem : orchestral role of notch signaling in cancer and developmental disease

  2020cites this paper
• Notch signalling pathway in development of cholangiocarcinoma

  2020cites this paper
• Modulation of the Notch System in Response to Wnt Inhibition Induces Restoration of the Rat Luteal Function

  2020cites this paper
• Multi-layered Spatial Transcriptomics Identify Secretory Factors Promoting Human Hematopoietic Stem Cell Development

  2020cites this paper
• Arterial endothelium creates a permissive niche for expansion of human cord blood hematopoietic stem and progenitor cells

  2020cites this paper
• Dickkopf 2–Expressing Adenovirus Increases the Survival of Random-Pattern Flaps and Promotes Vasculogenesis in a Rat Model

  2019cites this paper
• cAMP/EPAC Signaling Enables ETV2 to Induce Endothelial Cells with High Angiogenesis Potential.

  2019cites this paper
• Akt and Notch pathways mediate polyhexamethylene guanidine phosphate-induced epithelial-mesenchymal transition via ZEB2.

  2019cites this paper
• Environmental Specification of Pluripotent Stem Cell Derived Endothelial Cells Toward Arterial and Venous Subtypes

  2019cites this paper
• Convergence of Wnt and Notch signaling controls ovarian cancer cell survival

  2019cites this paper
• BOISE STATE UNIVERSITY GRADUATE COLLEGE DEFENSE COMMITTEE AND FINAL READING APPROVALS

  2019cites this paper
• Control of Blood Vessel Formation by Notch Signaling.

  2018cites this paper
• Multivalent biomaterial platform to control the distinct arterial venous differentiation of pluripotent stem cells.

  2018cites this paper
• LEF-1 gene silencing inhibits pulmonary vascular remodeling and occurrence of pulmonary arterial hypertension through the β-catenin signaling pathway.

  2018cites this paper
• Notch and Wnt Dysregulation and Its Relevance for Breast Cancer and Tumor Initiation

  2018cites this paper
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  2018influential citation
• New developments in mechanotransduction: Cross talk of the Wnt, TGF-β and Notch signalling pathways in reaction to shear stress

  2018cites this paper
• Tales from the crypt: new insights into intestinal stem cells

  2018cites this paper
• The Regulation of Notch Signaling by Src Kinase and Polyphenolic Compounds

  2018cites this paper
• Arterial Venous Differentiation for Vascular Bioengineering.

  2018cites this paper
• Neuropilin-1 Mediated Arterial Differentiation of Murine Pluripotent Stem Cells

  2018cites this paper
• Deubiquitinase inhibitor b‐AP15 activates endoplasmic reticulum (ER) stress and inhibits Wnt/Notch1 signaling pathway leading to the reduction of cell survival in hepatocellular carcinoma cells

  2018cites this paper
• Activation of the Arterial Program Drives Development of Definitive Hemogenic Endothelium with Lymphoid Potential.

  2018cites this paper
• Crosstalk between Notch, HIF-1α and GPER in Breast Cancer EMT

  2018cites this paper
• Investigation of human embryonic stem cell differentiation towards endothelial lineages

  2017influential citation
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017influential citation
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  2017cites this paper
• Notch: A multi-functional integrating system of microenvironmental signals.

  2016cites this paper
• Stress-Induced Premature Senescence of Endothelial and Endothelial Progenitor Cells.

  2016cites this paper
• β-Catenin is required for T cell leukemia 1 initiation and MYC transcription downstream of 2 Notch 1 3 4

  2016cites this paper
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  2016influential citation
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Arterial specification of endothelial cells derived from human induced pluripotent stem cells in a biomimetic flow bioreactor.

  2015cites this paper
• Efficient differentiation of human embryonic stem cells to arterial and venous endothelial cells under feeder- and serum-free conditions

  2015cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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