Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos.

No abstract is available for this paper.

• Publication year

  1998

• Venue

  Genes & Development

• Publication date

  1998-12-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1101/GAD.12.23.3728PMID 9851979PMCID PMC317253
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Nuclear access and action of notch in vivo.

  1998cited by this paper
• The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes.

  1998cited by this paper
• FlyBase: a Drosophila database.

  1998cited by this paper
• Indirect evidence for Delta-dependent intracellular processing of notch in Drosophila embryos.

  1998cited by this paper
• Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

  1998influential reference
• The Notch1 receptor is cleaved constitutively by a furin-like convertase.

  1998cited by this paper
• A histone deacetylase corepressor complex regulates the Notch signal transduction pathway.

  1998cited by this paper
• LIN-12/Notch signaling: lessons from worms and flies.

  1998cited by this paper
• Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane.

  1997cited by this paper
• Involvement of RBP-J in biological functions of mouse Notch1 and its derivatives.

  1997cited by this paper
• The Xenopus homolog of Drosophila Suppressor of Hairless mediates Notch signaling during primary neurogenesis.

  1997cited by this paper
• Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis.

  1997cited by this paper
• The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor.

  1997cited by this paper
• Suppressor of Hairless-independent events in Notch signaling imply novel pathway elements.

  1997cited by this paper
• The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage.

  1996cited by this paper
• How Proteolysis Drives the Cell Cycle

  1996cited by this paper
• The autosomal FLP-DFS technique for generating germline mosaics in Drosophila melanogaster.

  1996cited by this paper
• Subcellular localization of Suppressor of Hairless in Drosophila sense organ cells during Notch signalling.

  1996cited by this paper
• Signal transduction by activated mNotch: importance of proteolytic processing and its regulation by the extracellular domain.

  1996cited by this paper
• Delta is a ventral to dorsal signal complementary to Serrate, another Notch ligand, in Drosophila wing formation.

  1996cited by this paper
• Roles of the RAM and ANK domains in signaling by the C. elegans GLP‐1 receptor.

  1996cited by this paper
• Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats.

  1995cited by this paper
• Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity.

  1995cited by this paper
• Notch signaling.

  1995cited by this paper
• Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H)

  1995cited by this paper
• Signalling downstream of activated mammalian Notch

  1995cited by this paper
• Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-J kappa/Su(H).

  1995cited by this paper
• Developmental Signalling: Vertebrate ligands for Notch

  1995cited by this paper
• Complementary and combinatorial patterns of Notch gene family expression during early mouse development.

  1995cited by this paper
• The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.

  1995cited by this paper
• Modifications of the notch function by Abruptex mutations in Drosophila melanogaster.

  1994cited by this paper
• The Notch signalling pathway is required for Enhancer of split bHLH protein expression during neurogenesis in the Drosophila embryo.

  1994cited by this paper
• Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis.

  1994cited by this paper
• The suppressor of hairless protein participates in notch receptor signaling.

  1994cited by this paper
• Targeted gene expression as a means of altering cell fates and generating dominant phenotypes.

  1993influential reference
• Analysis of genetic mosaics in developing and adult Drosophila tissues.

  1993cited by this paper
• Delta function is required for bristle organ determination and morphogenesis in Drosophila.

  1993cited by this paper
• Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo.

  1993cited by this paper
• tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila.

  1993cited by this paper
• Autosomal P[ovoD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras.

  1993cited by this paper
• Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.

  1993cited by this paper
• Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

  1993influential reference
• Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins.

  1992cited by this paper
• Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates.

  1992cited by this paper
• Human homologs of a Drosophila Enhancer of Split gene product define a novel family of nuclear proteins

  1992cited by this paper
• Specific EGF repeats of Notch mediate interactions with Delta and Serrate: implications for Notch as a multifunctional receptor.

  1991cited by this paper
• The choice of cell fate in the epidermis of Drosophila.

  1991cited by this paper
• A rapid micropreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells.

  1991cited by this paper
• Structure and distribution of the Notch protein in developing Drosophila.

  1989cited by this paper
• Cell autonomy of lin-12 function in a cell fate decision in C. elegans.

  1989cited by this paper
• Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus.

  1987cited by this paper
• Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors

  1986cited by this paper
• Local function of the Notch gene for embryonic ectodermal pathway choice in Drosophila.

  1986cited by this paper
• Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis.

  1986cited by this paper
• Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats.

  1985cited by this paper
• Developmental genetics of the 2E-F region of the Drosophila X chromosome: a region rich in "developmentally important" genes.

  1984cited by this paper
• Identification of herpes simplex virus DNA sequences which encode a trans-acting polypeptide responsible for stimulation of immediate early transcription.

  1984influential reference
• LexA protein is a repressor of the colicin E1 gene.

  1983cited by this paper
• Negative complementation at the notch locus of Drosophila melanogaster.

  1975cited by this paper
• Allelic negative complementation at the Abruptex locus of Drosophila melanogaster.

  1975cited by this paper

• Kuzbanian expression levels dictate Notch signaling outcomes via interplay between cis- and trans-Delta.

  2026cites this paper
• An in vivo screen identifies diverse domains that can act as force-dependent proteolytic switches for Notch activation.

  2025cites this paper
• An in vivo screen for proteolytic switch domains that can mediate Notch activation by force

  2024cites this paper
• Apical-basal polarity precisely determines intestinal stem cell number by regulating Prospero threshold.

  2023cites this paper
• Par3/Bazooka binds NICD and promotes Notch signalling during Drosophila development

  2023cites this paper
• Synthetic Notch Activation Patterns in a Proliferating Tissue

  2023cites this paper
• Par3/Bazooka promotes Notch pathway target gene activation

  2022cites this paper
• Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor

  2020cites this paper
• Notch signaling: Its essential roles in bone and craniofacial development

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• Role of Ash1l in Tourette syndrome and other neurodevelopmental disorders

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• Histidine is selectively required for the growth of Myc‐dependent dedifferentiation tumours in the Drosophila CNS

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  2018cites this paper
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  2017cites this paper
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  2017cites this paper
• Control of Adhesion GPCR Function Through Proteolytic Processing.

  2016cites this paper
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  2015cites this paper
• Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo

  2015cites this paper
• Ligand-Independent Mechanisms of Notch Activity.

  2015cites this paper
• O-Fucosylation of DLL3 Is Required for Its Function during Somitogenesis

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• Bidirectional Notch signaling regulates Drosophila intestinal stem cell multipotency

  2015cites this paper
• O-fucosylation of the Notch Ligand mDLL1 by POFUT1 Is Dispensable for Ligand Function

  2014cites this paper
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  2014influential citation
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  2014cites this paper
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  2014influential citation
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  2014cites this paper
• Novel Regulation of CD80/CD86-induced Phosphatidylinositol 3-Kinase Signaling by NOTCH1 Protein in Interleukin-6 and Indoleamine 2,3-Dioxygenase Production by Dendritic Cells*♦

  2014influential citation
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• Proteolytic cleavage of Notch: "HIT and RUN".

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